hydroxyindoleacetic acid has been researched along with Spasms, Infantile in 7 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six of them showed initial decrease of seizure frequency and severity and maintained improvement in some neurodevelopmental skills." | 1.72 | Monoamine neurotransmitters in early epileptic encephalopathies: New insights into pathophysiology and therapy. ( Aparicio, J; Artuch, R; Cortès-Saladelafont, E; Cuadras, D; Fons, C; García-Cazorla, À; Horvath, G; Juliá-Palacios, N; Molina-Anguita, C; Sigatulina Bondarenko, M, 2022) |
| "The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone." | 1.29 | Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites. ( Kawase, S; Matsuo, S; Mitsufuji, N; Nishimura, A; Sawada, T; Takeuchi, Y; Tominaga, M; Yamazoe, I, 1995) |
| "1) Only one of 27 children with West syndrome and related disorders pretreated using high-dose PAL-P alone before ACTH showed a clinically excellent response." | 1.28 | Combination treatment of high-dose pyridoxal phosphate and low-dose ACTH in children with West syndrome and related disorders. ( Seki, T, 1990) |
| "Homovanillic acid levels were significantly increased in these patients, while 3-methoxy-4-hydroxyphenylethylene glycol and 5-hydroxyindoleacetic acid were not significantly altered, as compared with controls." | 1.26 | Elevated homovanillic acid in cerebrospinal fluid of children with infantile spasms. ( Ito, M; Mikawa, H; Okuno, T; Osumi, Y, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Juliá-Palacios, N | 1 |
| Molina-Anguita, C | 1 |
| Sigatulina Bondarenko, M | 1 |
| Cortès-Saladelafont, E | 1 |
| Aparicio, J | 1 |
| Cuadras, D | 1 |
| Horvath, G | 1 |
| Fons, C | 1 |
| Artuch, R | 1 |
| García-Cazorla, À | 1 |
| Ito, M | 1 |
| Okuno, T | 1 |
| Mikawa, H | 1 |
| Osumi, Y | 1 |
| Silverstein, F | 1 |
| Johnston, MV | 1 |
| Takeuchi, Y | 1 |
| Tominaga, M | 1 |
| Mitsufuji, N | 1 |
| Yamazoe, I | 1 |
| Kawase, S | 1 |
| Nishimura, A | 1 |
| Matsuo, S | 1 |
| Sawada, T | 1 |
| Airaksinen, E | 1 |
| Tuomisto, L | 1 |
| Riikonen, R | 1 |
| Seki, T | 2 |
| Kimiya, S | 1 |
| Maezawa, M | 1 |
| Yamada, T | 1 |
| Tachibana, Y | 1 |
7 other studies available for hydroxyindoleacetic acid and Spasms, Infantile
| Article | Year |
|---|---|
Monoamine neurotransmitters in early epileptic encephalopathies: New insights into pathophysiology and therapy.
Topics: Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Female; Humans; Hydroxyin | 2022 |
Elevated homovanillic acid in cerebrospinal fluid of children with infantile spasms.
Topics: Adrenocorticotropic Hormone; Age Factors; Child, Preschool; Dopamine; Homovanillic Acid; Humans; Hyd | 1980 |
Cerebrospinal fluid monoamine metabolites in patients with infantile spasms.
Topics: Adolescent; Child; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetates | 1984 |
Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Humans; Hydrox | 1995 |
The concentrations of GABA, 5-HIAA and HVA in the cerebrospinal fluid of children with infantile spasms and the effects of ACTH treatment.
Topics: Adolescent; Adrenocorticotropic Hormone; Analysis of Variance; Child; Child, Preschool; gamma-Aminob | 1992 |
Combination treatment of high-dose pyridoxal phosphate and low-dose ACTH in children with West syndrome and related disorders.
Topics: Child, Preschool; Cosyntropin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 1990 |
Analysis of monamine metabolism in cerebrospinal fluid in childhood epilepsies.
Topics: Adolescent; Brain Damage, Chronic; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Epileps | 1989 |