hydroxyindoleacetic acid has been researched along with Serotonin Syndrome in 7 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only." | 3.74 | Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. ( Fox, MA; French, HT; Huang, SJ; Jensen, CL; Murphy, DL; Stein, AR; Tolliver, TJ, 2008) |
| "Rats treated with haloperidol at a dose of 1 mg/kg twice a day for 2 weeks displayed VCMs with twitching of facial musculature that increased in a time dependent manner as the treatment continued to 5 weeks." | 1.34 | Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats. ( Haleem, DJ; Haleem, MA; Samad, N, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Brien, FE | 1 |
| O'Connor, RM | 1 |
| Clarke, G | 1 |
| Donovan, MD | 1 |
| Dinan, TG | 1 |
| Griffin, BT | 1 |
| Cryan, JF | 1 |
| Fox, MA | 1 |
| Jensen, CL | 1 |
| French, HT | 1 |
| Stein, AR | 1 |
| Huang, SJ | 1 |
| Tolliver, TJ | 1 |
| Murphy, DL | 1 |
| Jabeen, B | 1 |
| Haleem, DJ | 2 |
| Laine, K | 1 |
| Heikkinen, T | 1 |
| Ekblad, U | 1 |
| Kero, P | 1 |
| Nisijima, K | 1 |
| Nibuya, M | 1 |
| Sugiyama, H | 1 |
| Samad, N | 1 |
| Haleem, MA | 1 |
| Squires, LN | 1 |
| Talbot, KN | 1 |
| Rubakhin, SS | 1 |
| Sweedler, JV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127] | 20 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for hydroxyindoleacetic acid and Serotonin Syndrome
| Article | Year |
|---|---|
The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Brain; Citalopram; Cyclospori | 2014 |
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Catech | 2008 |
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro | 2008 |
Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations.
Topics: Adult; Depressive Disorder; Female; Fetal Blood; Humans; Hydroxyindoleacetic Acid; Infant, Newborn; | 2003 |
Abnormal CSF monoamine metabolism in serotonin syndrome.
Topics: Adult; Aged; Biogenic Monoamines; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; | 2003 |
Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Buspirone; Chromatography, Hi | 2007 |
Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Central Nervous System; Disease Models, Anima | 2007 |