Page last updated: 2024-10-21

hydroxyindoleacetic acid and Rett Syndrome

hydroxyindoleacetic acid has been researched along with Rett Syndrome in 6 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)

Research Excerpts

ExcerptRelevanceReference
"The metabolites of dopamine (homovanillic acid-HVA), noradrenaline (4-hydroxy-3-methoxy-phenylglycol-HMPG), and serotonin (5-hydroxyindoleacetic acid-5-HIAA) were measured in cerebrospinal fluid (CSF) from 38 patients and urine from 36 patients with typical Rett syndrome (RS) and compared with controls of similar age."3.68CSF and urine biogenic amine metabolites in Rett syndrome. ( Hagberg, B; Holmberg, B; Lekman, A; Percy, A; Svennerholm, L; Witt-Engerström, I, 1990)
"Rett syndrome is a progressive neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MeCP2) gene."1.36Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice. ( Chiyonobu, T; Hasegawa, T; Hosoi, H; Isoda, K; Matsui, F; Morimoto, M; Morioka, S; Nishimura, A; Tozawa, T; Yoshimoto, K, 2010)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Temudo, T1
Rios, M1
Prior, C1
Carrilho, I1
Santos, M1
Maciel, P1
Sequeiros, J1
Fonseca, M1
Monteiro, J1
Cabral, P1
Vieira, JP1
Ormazabal, A1
Artuch, R1
Isoda, K1
Morimoto, M1
Matsui, F1
Hasegawa, T1
Tozawa, T1
Morioka, S1
Chiyonobu, T1
Nishimura, A1
Yoshimoto, K1
Hosoi, H1
Nielsen, JB2
Bertelsen, A1
Lou, HC2
Lekman, A1
Witt-Engerström, I1
Holmberg, B1
Percy, A1
Svennerholm, L1
Hagberg, B1
Andresen, J1
Budden, SS1
Myer, EC1
Butler, IJ1

Trials

2 trials available for hydroxyindoleacetic acid and Rett Syndrome

ArticleYear
Evaluation of CSF neurotransmitters and folate in 25 patients with Rett disorder and effects of treatment.
    Brain & development, 2009, Volume: 31, Issue:1

    Topics: Administration, Oral; Child; Child, Preschool; DNA Mutational Analysis; Female; Fluoxetine; Folic Ac

2009
Biochemical and clinical effects of tyrosine and tryptophan in the Rett syndrome.
    Brain & development, 1990, Volume: 12, Issue:1

    Topics: Adolescent; Child; Dopamine; Double-Blind Method; Female; Homovanillic Acid; Humans; Hydroxyindoleac

1990

Other Studies

4 other studies available for hydroxyindoleacetic acid and Rett Syndrome

ArticleYear
Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice.
    Neuroscience, 2010, Feb-17, Volume: 165, Issue:4

    Topics: Aging; Animals; Disease Models, Animal; Dopamine; Female; Hippocampus; Hydroxyindoleacetic Acid; Mal

2010
Low CSF HVA levels in the Rett syndrome: a reflection of restricted synapse formation?
    Brain & development, 1992, Volume: 14 Suppl

    Topics: Adolescent; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Ma

1992
CSF and urine biogenic amine metabolites in Rett syndrome.
    Clinical genetics, 1990, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Creatinine; Dopamine; Female; Glycols; Homo

1990
Cerebrospinal fluid studies in the Rett syndrome: biogenic amines and beta-endorphins.
    Brain & development, 1990, Volume: 12, Issue:1

    Topics: Adolescent; Biogenic Amines; Child; Child, Preschool; Endorphins; Female; Humans; Hydroxyindoleaceti

1990