hydroxyindoleacetic acid has been researched along with Rett Syndrome in 6 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metabolites of dopamine (homovanillic acid-HVA), noradrenaline (4-hydroxy-3-methoxy-phenylglycol-HMPG), and serotonin (5-hydroxyindoleacetic acid-5-HIAA) were measured in cerebrospinal fluid (CSF) from 38 patients and urine from 36 patients with typical Rett syndrome (RS) and compared with controls of similar age." | 3.68 | CSF and urine biogenic amine metabolites in Rett syndrome. ( Hagberg, B; Holmberg, B; Lekman, A; Percy, A; Svennerholm, L; Witt-Engerström, I, 1990) |
| "Rett syndrome is a progressive neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MeCP2) gene." | 1.36 | Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice. ( Chiyonobu, T; Hasegawa, T; Hosoi, H; Isoda, K; Matsui, F; Morimoto, M; Morioka, S; Nishimura, A; Tozawa, T; Yoshimoto, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Temudo, T | 1 |
| Rios, M | 1 |
| Prior, C | 1 |
| Carrilho, I | 1 |
| Santos, M | 1 |
| Maciel, P | 1 |
| Sequeiros, J | 1 |
| Fonseca, M | 1 |
| Monteiro, J | 1 |
| Cabral, P | 1 |
| Vieira, JP | 1 |
| Ormazabal, A | 1 |
| Artuch, R | 1 |
| Isoda, K | 1 |
| Morimoto, M | 1 |
| Matsui, F | 1 |
| Hasegawa, T | 1 |
| Tozawa, T | 1 |
| Morioka, S | 1 |
| Chiyonobu, T | 1 |
| Nishimura, A | 1 |
| Yoshimoto, K | 1 |
| Hosoi, H | 1 |
| Nielsen, JB | 2 |
| Bertelsen, A | 1 |
| Lou, HC | 2 |
| Lekman, A | 1 |
| Witt-Engerström, I | 1 |
| Holmberg, B | 1 |
| Percy, A | 1 |
| Svennerholm, L | 1 |
| Hagberg, B | 1 |
| Andresen, J | 1 |
| Budden, SS | 1 |
| Myer, EC | 1 |
| Butler, IJ | 1 |
2 trials available for hydroxyindoleacetic acid and Rett Syndrome
| Article | Year |
|---|---|
Evaluation of CSF neurotransmitters and folate in 25 patients with Rett disorder and effects of treatment.
Topics: Administration, Oral; Child; Child, Preschool; DNA Mutational Analysis; Female; Fluoxetine; Folic Ac | 2009 |
Biochemical and clinical effects of tyrosine and tryptophan in the Rett syndrome.
Topics: Adolescent; Child; Dopamine; Double-Blind Method; Female; Homovanillic Acid; Humans; Hydroxyindoleac | 1990 |
4 other studies available for hydroxyindoleacetic acid and Rett Syndrome
| Article | Year |
|---|---|
Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice.
Topics: Aging; Animals; Disease Models, Animal; Dopamine; Female; Hippocampus; Hydroxyindoleacetic Acid; Mal | 2010 |
Low CSF HVA levels in the Rett syndrome: a reflection of restricted synapse formation?
Topics: Adolescent; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Ma | 1992 |
CSF and urine biogenic amine metabolites in Rett syndrome.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Creatinine; Dopamine; Female; Glycols; Homo | 1990 |
Cerebrospinal fluid studies in the Rett syndrome: biogenic amines and beta-endorphins.
Topics: Adolescent; Biogenic Amines; Child; Child, Preschool; Endorphins; Female; Humans; Hydroxyindoleaceti | 1990 |