hydroxyindoleacetic acid has been researched along with Psychotic Disorders in 55 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metabolism of the monoamines dopamine, serotonin and noradrenaline, is altered in the central nervous system of people with schizophrenia, and their major metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively, have been intensively studied as indirect measures of these neurotransmitters in cerebrospinal fluid (CSF)." | 3.88 | No major influence of regular tobacco smoking on cerebrospinal fluid monoamine metabolite concentrations in patients with psychotic disorder and healthy individuals. ( Agartz, I; Andreou, D; Hjärpe, J; Jönsson, EG; Sedvall, GC; Söderman, E, 2018) |
| "Kynurenine was significantly lower in patients with PP and PD as compared to healthy postpartum women (p=0." | 1.43 | Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression. ( Bergink, V; Burgerhout, KM; Drexhage, HA; Hoogendijk, WJ; Kushner, SA; Myint, AM; Schütze, G; Schwarz, MJ; Veen, C, 2016) |
| "Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are present during the disease course of nearly all AD patients and consist of psychosis, agitation/aggression, and depression, among others." | 1.40 | Brain region-specific monoaminergic correlates of neuropsychiatric symptoms in Alzheimer's disease. ( Aerts, T; De Deyn, PP; Engelborghs, S; Van Dam, D; Vermeiren, Y, 2014) |
| "Psychosis was associated with significantly increased densities of senile plaques and neurofibrillary tangles in the prosubiculum and middle frontal cortex, respectively, with trends toward increased densities of these lesions in the other areas examined." | 1.28 | Neuropathologic and neurochemical correlates of psychosis in primary dementia. ( Claassen, D; Kopp, U; Martinez, AJ; Moossy, J; Rao, G; Rosen, J; Zubenko, GS, 1991) |
| "In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised." | 1.27 | Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (70.91) | 18.7374 |
| 1990's | 7 (12.73) | 18.2507 |
| 2000's | 3 (5.45) | 29.6817 |
| 2010's | 6 (10.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hjärpe, J | 1 |
| Söderman, E | 2 |
| Andreou, D | 2 |
| Sedvall, GC | 2 |
| Agartz, I | 2 |
| Jönsson, EG | 3 |
| Curto, M | 1 |
| Lionetto, L | 1 |
| Fazio, F | 1 |
| Corigliano, V | 1 |
| Comparelli, A | 1 |
| Ferracuti, S | 1 |
| Simmaco, M | 1 |
| Nicoletti, F | 1 |
| Baldessarini, RJ | 1 |
| Shilov, IuE | 1 |
| Bezrukov, MV | 1 |
| Vermeiren, Y | 1 |
| Van Dam, D | 1 |
| Aerts, T | 1 |
| Engelborghs, S | 1 |
| De Deyn, PP | 1 |
| Axelsson, T | 1 |
| Terenius, L | 1 |
| Veen, C | 1 |
| Myint, AM | 1 |
| Burgerhout, KM | 1 |
| Schwarz, MJ | 1 |
| Schütze, G | 1 |
| Kushner, SA | 1 |
| Hoogendijk, WJ | 1 |
| Drexhage, HA | 1 |
| Bergink, V | 1 |
| Goldstein, TR | 1 |
| Carlborg, A | 1 |
| Jokinen, J | 1 |
| Nordström, AL | 1 |
| Nordström, P | 2 |
| Klejbor, I | 1 |
| Kucinski, A | 1 |
| Wersinger, SR | 1 |
| Corso, T | 1 |
| Spodnik, JH | 1 |
| Dziewiatkowski, J | 1 |
| Moryś, J | 1 |
| Hesse, RA | 1 |
| Rice, KC | 1 |
| Miletich, R | 1 |
| Stachowiak, EK | 1 |
| Stachowiak, MK | 1 |
| BUSCAINO, GA | 1 |
| STEFANACHI, L | 1 |
| LJUNGBERG, E | 1 |
| PELICIER, Y | 1 |
| KIRBERGER, E | 1 |
| Bourgeois, M | 1 |
| Henry, P | 1 |
| Agnoli, A | 1 |
| Ruggieri, S | 1 |
| Falaschi, P | 1 |
| Baldassarre, M | 1 |
| D'Urso, R | 1 |
| Forchetti, C | 1 |
| Polleri, A | 1 |
| Sedvall, G | 6 |
| Leckman, JF | 1 |
| Bowers, MB | 7 |
| Sturges, JS | 1 |
| Van Woert, MH | 1 |
| Magnussen, I | 1 |
| Lowe, YH | 1 |
| Hwang, EC | 1 |
| Benson, KL | 1 |
| Zarcone, VP | 1 |
| Faull, KF | 4 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Korf, J | 1 |
| van den Burg, W | 1 |
| van den Hoofdakker, RH | 1 |
| Nybäck, H | 1 |
| Berggren, BM | 1 |
| Hindmarsh, T | 1 |
| Wiesel, FA | 1 |
| Cowdry, RW | 1 |
| Ebert, MH | 1 |
| van Kammen, DP | 1 |
| Post, RM | 1 |
| Goodwin, FK | 1 |
| Gillberg, C | 1 |
| Svennerholm, L | 1 |
| Hamilton-Hellberg, C | 1 |
| Beck, O | 1 |
| Borg, S | 1 |
| Edman, G | 1 |
| Fyrö, B | 2 |
| Oxenstierna, G | 1 |
| Lieberman, J | 1 |
| Sethi, BB | 1 |
| Dube, S | 1 |
| Sharma, M | 1 |
| Faustman, WO | 1 |
| Ringo, DL | 1 |
| Samuelsson, M | 1 |
| Asberg, M | 1 |
| Träskman-Bendz, L | 1 |
| Aberg-Wistedt, A | 1 |
| Nordin, C | 1 |
| Bertilsson, L | 1 |
| Kahn, RS | 1 |
| Davidson, M | 1 |
| Knott, P | 1 |
| Stern, RG | 1 |
| Apter, S | 1 |
| Davis, KL | 1 |
| Härnryd, C | 1 |
| Bjerkenstedt, L | 1 |
| Grimm, VE | 1 |
| Klawans, H | 1 |
| Takahashi, R | 1 |
| Banki, CM | 1 |
| Wode-Helgodt, B | 2 |
| Cohen, DJ | 2 |
| Caparulo, BK | 1 |
| Shaywitz, BA | 2 |
| Gullberg, B | 1 |
| Ackenheil, M | 1 |
| Blatt, B | 1 |
| Lampart, C | 1 |
| Lemus, CZ | 1 |
| Lieberman, JA | 1 |
| Johns, CA | 1 |
| Pollack, S | 1 |
| Bookstein, P | 1 |
| Cooper, TB | 1 |
| Lohr, JB | 1 |
| Kuczenski, R | 1 |
| Bracha, HS | 1 |
| Moir, M | 1 |
| Jeste, DV | 1 |
| Jibson, M | 1 |
| Csernansky, JG | 2 |
| Zubenko, GS | 1 |
| Moossy, J | 1 |
| Martinez, AJ | 1 |
| Rao, G | 1 |
| Claassen, D | 1 |
| Rosen, J | 1 |
| Kopp, U | 1 |
| Jennings, WS | 1 |
| Schulz, SC | 1 |
| Narasimhachari, N | 1 |
| Hamer, RM | 1 |
| Friedel, RO | 1 |
| Prilipko, LL | 1 |
| Joborn, C | 1 |
| Hetta, J | 1 |
| Johansson, H | 1 |
| Rastad, J | 1 |
| Agren, H | 1 |
| Akerström, G | 1 |
| Ljunghall, S | 1 |
| Pfefferbaum, A | 1 |
| Robinson, DS | 1 |
| Nies, A | 1 |
| Davis, JN | 1 |
| Bunney, WE | 1 |
| Davis, JM | 1 |
| Colburn, RW | 1 |
| Bourne, HR | 1 |
| Shaw, DM | 1 |
| Coppen, AJ | 1 |
| Sjöström, R | 1 |
| Johnson, WT | 1 |
| Bowers, M | 1 |
| Lowenbach, H | 1 |
| Shore, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for hydroxyindoleacetic acid and Psychotic Disorders
| Article | Year |
|---|---|
[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Topics: Humans; Hydroxyindoleacetic Acid; Kynurenine; Mental Disorders; Psychotic Disorders; Tryptophan; Xan | 2013 |
Suicidality in pediatric bipolar disorder.
Topics: Age of Onset; Bipolar Disorder; Child; Demography; Family; Humans; Hydroxyindoleacetic Acid; Intenti | 2009 |
Cerebrospinal fluid probenecid studies: a reinterpretation.
Topics: Biological Transport; Brain; Depressive Disorder; Dopamine; Homovanillic Acid; Humans; Hydroxyindole | 1983 |
Markers in psychoses: studies from India.
Topics: Adrenal Cortex Hormones; Affective Disorders, Psychotic; Blood Platelets; Body Constitution; Chromos | 1984 |
Amine precursors in neurologic disorders and the psychoses.
Topics: Acetylcholine; Corpus Striatum; Dopamine; Homovanillic Acid; Humans; Huntington Disease; Hydroxyindo | 1975 |
[Amines in mental disorders (author's transl)].
Topics: Aggression; Biogenic Amines; Bipolar Disorder; Brain; Catecholamines; Dopamine; Emotions; Humans; Hy | 1977 |
Clinical psychiatry.
Topics: Ambulatory Care; Anxiety Disorders; Brain Chemistry; Child; Community Mental Health Services; Depres | 1969 |
2 trials available for hydroxyindoleacetic acid and Psychotic Disorders
| Article | Year |
|---|---|
Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients.
Topics: Adult; Aged; Chlorpromazine; Ethylene Glycols; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1977 |
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines | 1973 |
46 other studies available for hydroxyindoleacetic acid and Psychotic Disorders
| Article | Year |
|---|---|
No major influence of regular tobacco smoking on cerebrospinal fluid monoamine metabolite concentrations in patients with psychotic disorder and healthy individuals.
Topics: Adolescent; Adult; Biogenic Monoamines; Biomarkers; Female; Homovanillic Acid; Humans; Hydroxyindole | 2018 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Ky | 2019 |
Brain region-specific monoaminergic correlates of neuropsychiatric symptoms in Alzheimer's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Biogenic Monoam | 2014 |
Cerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis.
Topics: Adult; Biogenic Monoamines; Biomarkers; Dopamine; Female; Glutamic Acid; Homovanillic Acid; Humans; | 2015 |
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; | 2016 |
CSF 5-HIAA, attempted suicide and suicide risk in schizophrenia spectrum psychosis.
Topics: Adult; Female; Follow-Up Studies; Humans; Hydroxyindoleacetic Acid; Male; Psychiatric Status Rating | 2009 |
Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Explorato | 2009 |
Urinary excretion of 5-hydroxyindoleacetic acid in psychotic and normal subjects; excretion after parenteral administration of serotonin.
Topics: Hydroxyindoleacetic Acid; Indoleacetic Acids; Mental Disorders; Psychotic Disorders; Serotonin | 1958 |
[Determination of 5-hydroxy-indolacetic acid in urine as a valuable clinicochemical method in modern psychiatric clinics].
Topics: Humans; Hydroxyindoleacetic Acid; Mental Disorders; Psychotic Disorders; Serotonin; Tranquilizing Ag | 1961 |
[SEROTONIN AND PSYCHIATRY].
Topics: Bipolar Disorder; Catecholamines; Drug Therapy; Hallucinations; Hallucinogens; Humans; Hydroxyindole | 1964 |
[Differential diagnostic considerations in increased 5-hydroxyindoleacetic acid excretion in the urine].
Topics: Diet; Hydroxyindoleacetic Acid; Indoleacetic Acids; Mental Disorders; Nutrition Assessment; Nuts; Ps | 1962 |
Brain amines, and their acids in the cerebrospinal fluid.
Topics: Amines; Brain Chemistry; Cerebrospinal Fluid; Humans; Hydroxyindoleacetic Acid; Indoles; Mandelic Ac | 1967 |
[Tryptaminuria and urinary 5-H.I.A.A. in neuropsychiatry (preliminary note)].
Topics: Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Monoamine Oxidase Inhibitors; Neurot | 1967 |
A neuropharmacological and neuroendocrine study on idiopathic and chronic pharmacological Parkinsonism.
Topics: Adult; Aged; Antipsychotic Agents; Chronic Disease; Circadian Rhythm; Homovanillic Acid; Humans; Hyd | 1980 |
Concentrations of monoamine metabolites and chlorpromazine in cerebrospinal fluid for prediction of therapeutic response in psychotic patients treated with neuroleptic drugs.
Topics: Antipsychotic Agents; Chlorpromazine; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; | 1980 |
Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Female; Homovanillic Acid; Humans; Hydroxyi | 1981 |
Study of serotonin in neuropsychiatric disorders.
Topics: 5-Hydroxytryptophan; Carbidopa; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kinetic | 1982 |
REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
Topics: Adult; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Psychot | 1983 |
Acid metabolites and precursor amino acids of 5-hydroxytryptamine and dopamine in affective and other psychiatric disorders.
Topics: Adjustment Disorders; Adult; Aged; Amino Acids; Bipolar Disorder; Depressive Disorder; Dopamine; Fem | 1983 |
Cerebroventricular size and cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy volunteers.
Topics: Adult; Age Factors; Cerebral Ventriculography; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1983 |
Childhood psychosis and monoamine metabolites in spinal fluid.
Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; | 1983 |
5-hydroxytryptophol in human cerebrospinal fluid: conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Depression; Female; Humans; Hydroxyindoleacetic Acid; Hy | 1984 |
Evidence for a biological hypothesis of obsessive-compulsive disorder.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Depressive Disorder; Dexamethasone; Diseases in Twins; | 1984 |
An association between low levels of 5-HIAA and HVA in cerebrospinal fluid and early mortality in a diagnostically mixed psychiatric sample.
Topics: Adult; Aged; Cause of Death; Depressive Disorder; Follow-Up Studies; Homovanillic Acid; Hospital Rec | 1993 |
CSF 5-HIAA predicts suicide risk after attempted suicide.
Topics: Adult; Aged; Anxiety Disorders; Bipolar Disorder; Cause of Death; Depressive Disorder; Female; Follo | 1994 |
Effect of neuroleptic medication on cerebrospinal fluid monoamine metabolite concentrations in schizophrenia. Serotonin-dopamine interactions as a target for treatment.
Topics: Adult; Dopamine; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Psychiatric | 1993 |
Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.
Topics: Biogenic Amines; Electroconvulsive Therapy; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindol | 1979 |
Alterations of cerebrospinal fluid 5-hydroxyindoleacetic acid, and total blood serotonin content during clozapine treatment.
Topics: Adult; Clozapine; Dibenzazepines; Female; Humans; Hydroxyindoleacetic Acid; Leukocyte Count; Middle | 1978 |
CSF acid monoamine metabolites in psychotic syndromes: what might they signify?
Topics: Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Prognosis; Psychotic Disorders; | 1978 |
Correlations between height of subject and concentrations of monoamine metabolites in cerebrospinal fluid from psychotic men and women.
Topics: Biogenic Amines; Body Height; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Met | 1978 |
Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Adolescent; Age Factors; Aphasia; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
Serotonin (5HT) systems in psychotic states.
Topics: Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Probenecid; Psychotic Disorders; Serotonin; Tim | 1975 |
Effect of clozapine on 5-HIAA excretion in urine and CSF of psychotic patients and on serotonin metabolism in rat brain.
Topics: Animals; Brain; Circadian Rhythm; Clozapine; Dibenzazepines; Humans; Hydroxyindoleacetic Acid; Male; | 1975 |
CSF 5-hydroxyindoleacetic acid levels and suicide attempts in schizophrenia.
Topics: Adult; Chronic Disease; Female; Humans; Hydroxyindoleacetic Acid; Male; Psychotic Disorders; Schizop | 1990 |
Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Antipsychotic Agents; Dyskinesia, Drug-Induced; Female; | 1990 |
Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
Topics: Acid-Base Equilibrium; Administration, Oral; Blood-Brain Barrier; Depressive Disorder; Dose-Response | 1990 |
Neuropathologic and neurochemical correlates of psychosis in primary dementia.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Female; Humans; Hydroxyindoleacetic Acid; Male; Neurofibri | 1991 |
Brain ventricular size and CSF monoamine metabolites in an adolescent inpatient population.
Topics: Adolescent; Adult; Age Factors; Cerebral Ventricles; Child; Dilatation, Pathologic; Female; Homovani | 1985 |
Biological studies of schizophrenia in Europe.
Topics: Brain; Brain Chemistry; Dopamine; Endorphins; Environment; Europe; Genetic Markers; HLA Antigens; Hu | 1986 |
Psychiatric morbidity in primary hyperparathyroidism.
Topics: Adult; Aged; Calcium; Female; Follow-Up Studies; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid | 1988 |
Seasonal changes of CSF monoamine metabolites in psychiatric patients: what is the source?
Topics: Bipolar Disorder; Depressive Disorder; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mental D | 1988 |
Ageing, monoamines, and monoamine-oxidase levels.
Topics: Adult; Aged; Aging; Autopsy; Blood Platelets; Brain Chemistry; Cerebellum; Depression; Humans; Hydro | 1972 |
Effects of -methyltyrosine on the cerebrospinal fluid content of HVA and 5-HIAA in man.
Topics: Cerebrospinal Fluid; Depression; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Methyltyrosin | 1971 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |
Acute psychosis induced by psychotomimetic drug abuse. II. Neurochemical findings.
Topics: Acute Disease; Adolescent; Adult; Animals; Brain Chemistry; Female; Hallucinogens; Humans; Hydroxyin | 1972 |
Deficient transport mechanism for the removal of acid monoamine metabolites from cerebrospinal fluid.
Topics: Adult; Biological Transport, Active; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetates; Probene | 1969 |