hydroxyindoleacetic acid has been researched along with Obesity in 40 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined whether reductions in body fat stores and insulin resistance in Syrian hamsters induced by bromocriptine are associated with reductions in daily norepinephrine (NE) and serotonin activities as indicated by their extracellular metabolite levels in the ventromedial hypothalamus (VMH)." | 7.70 | Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters. ( Cincotta, AH; Luo, S; Meier, AH, 1998) |
| "When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity (monosodium glutamate-treated obesity; MSG-OB) were observed as these rats grew." | 7.70 | Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines. ( Gomita, Y; Nakagawa, T; Ohyama, T; Okamura, H; Ukai, K, 2000) |
| " In this study, dehydroepiandrosterone's effect at decreasing food intake and body weight in the obese Zucker rat was investigated." | 7.68 | Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. ( Abadie, JM; Browne, ES; Correa, G; Porter, JR; Svec, F; Wright, B, 1993) |
| "Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects." | 5.07 | Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. ( Antonucci, F; Cangiano, C; Cascino, A; Ceci, F; Del Ben, M; Laviano, A; Muscaritoli, M; Rossi-Fanelli, F, 1992) |
| "Treatments of human and rodent obesity frequently involve administration of amphetamine derivatives, much like phenylpropanolamine, which suppress food intake." | 3.72 | The effects of phenylpropanolamine on Zucker rats selected for fat food preference. ( Muehlenhein, M; Porter, J; Svec, F, 2003) |
| "We examined whether reductions in body fat stores and insulin resistance in Syrian hamsters induced by bromocriptine are associated with reductions in daily norepinephrine (NE) and serotonin activities as indicated by their extracellular metabolite levels in the ventromedial hypothalamus (VMH)." | 3.70 | Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters. ( Cincotta, AH; Luo, S; Meier, AH, 1998) |
| " Since disturbances of both energy intake and expenditure can contribute to obesity, the objective of the present study was to evaluate the serotonergic response stimulated by food ingestion in two different models of obesity: the hyperphagic Zucker and the hypophagic and hypometabolic, monosodium glutamate (MSG) obese Wistar rat." | 3.70 | Lateral hypothalamic serotonergic responsiveness to food intake in rat obesity as measured by microdialysis. ( Guimarães, RB; Mori, RC; Nascimento, CM; Ribeiro, EB, 1999) |
| "When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity (monosodium glutamate-treated obesity; MSG-OB) were observed as these rats grew." | 3.70 | Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines. ( Gomita, Y; Nakagawa, T; Ohyama, T; Okamura, H; Ukai, K, 2000) |
| " When administered to obese, hypercorticosteronemic Zucker rats, it causes a diminution of food intake and a reduction in their rate of weight gain." | 3.69 | The effect of DHEA given chronically to Zucker rats. ( Browne, E; Hilton, CW; Porter, JR; Svec, F; Wright, B, 1995) |
| "Dehydroepiandrosterone (DHEA) decreases body weight and food intake of the obese Zucker rat, a model of youth-onset obesity associated with hyperphagia." | 3.69 | The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters. ( Abadie, JM; Browne, ES; Porter, JR; Svec, F; Wright, BE, 1995) |
| "To investigate whether dehydroepiandrosterone (DHEA), an adrenal/gonadal androgen, can act centrally to reduce energy intake in a model of genetic obesity, the Zucker fatty rat." | 3.69 | Central effects of dehydroepiandrosterone in Zucker rats. ( Porter, JR; Svec, F; Wright, BE, 1995) |
| " In this study, dehydroepiandrosterone's effect at decreasing food intake and body weight in the obese Zucker rat was investigated." | 3.68 | Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. ( Abadie, JM; Browne, ES; Correa, G; Porter, JR; Svec, F; Wright, B, 1993) |
| "Obesity is associated with increased risked factor for many diseases such as, diabetes, heart complications, arthritis and certain types of cancer." | 1.42 | Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese rats. ( Ahmed, A; Ahmed, M; Bano, F; Parveen, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (27.50) | 18.7374 |
| 1990's | 20 (50.00) | 18.2507 |
| 2000's | 8 (20.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bano, F | 1 |
| Ahmed, A | 1 |
| Ahmed, M | 1 |
| Parveen, T | 1 |
| Jabeen, B | 1 |
| Haleem, DJ | 1 |
| Svec, F | 6 |
| Thompson, H | 1 |
| Corll, C | 1 |
| Porter, J | 2 |
| Muehlenhein, M | 1 |
| Iuras, A | 1 |
| Telles, MM | 1 |
| Bertoncini, CR | 1 |
| Ko, GM | 1 |
| de Andrade, IS | 1 |
| Silveira, VL | 1 |
| Ribeiro, EB | 2 |
| Koizumi, H | 1 |
| Hashimoto, K | 1 |
| Iyo, M | 1 |
| Cramer, H | 1 |
| Warter, JM | 1 |
| Renaud, B | 1 |
| Krieger, J | 1 |
| Marescaux, CH | 1 |
| Hammers, R | 1 |
| Romsos, DR | 1 |
| Chee, KM | 1 |
| Bergen, WG | 1 |
| Orosco, M | 8 |
| Bremond, J | 1 |
| Jacquot, C | 4 |
| Cohen, Y | 4 |
| Squadrito, F | 1 |
| Calapai, G | 1 |
| Altavilla, D | 1 |
| Cucinotta, D | 1 |
| Zingarelli, B | 1 |
| Arcoraci, V | 1 |
| Campo, GM | 1 |
| Caputi, AP | 1 |
| Routh, VH | 1 |
| Stern, JS | 1 |
| Horwitz, BA | 1 |
| Björntorp, P | 2 |
| Hilton, CW | 1 |
| Wright, B | 2 |
| Browne, E | 1 |
| Porter, JR | 4 |
| Rouch, C | 5 |
| Meile, MJ | 2 |
| Nicolaidis, S | 4 |
| Abadie, JM | 2 |
| Correa, G | 1 |
| Browne, ES | 2 |
| Wright, BE | 2 |
| Gerozissis, K | 1 |
| Strömbom, U | 1 |
| Krotkiewski, M | 1 |
| Blennow, K | 1 |
| Månsson, JE | 2 |
| Ekman, R | 2 |
| Luo, S | 1 |
| Meier, AH | 1 |
| Cincotta, AH | 1 |
| Lemierre, S | 1 |
| Akefeldt, A | 1 |
| Gillberg, C | 1 |
| Mori, RC | 1 |
| Guimarães, RB | 1 |
| Nascimento, CM | 1 |
| Nakagawa, T | 1 |
| Ukai, K | 1 |
| Ohyama, T | 1 |
| Gomita, Y | 1 |
| Okamura, H | 1 |
| Kishi, E | 1 |
| Takahashi, A | 1 |
| Ishimaru, H | 1 |
| Ikarashi, Y | 1 |
| Maruyama, Y | 1 |
| Hassanain, M | 1 |
| Levin, BE | 1 |
| Coscina, DV | 3 |
| McArthur, RA | 1 |
| Stancer, HC | 3 |
| Godse, DD | 2 |
| Leigh, FS | 1 |
| Kaufman, LN | 1 |
| Young, JB | 1 |
| Cangiano, C | 3 |
| Ceci, F | 3 |
| Cascino, A | 3 |
| Del Ben, M | 3 |
| Laviano, A | 2 |
| Muscaritoli, M | 3 |
| Antonucci, F | 1 |
| Rossi-Fanelli, F | 2 |
| Gourch, A | 1 |
| Cairella, M | 2 |
| Gripois, D | 1 |
| Blouquit, MF | 1 |
| Roffi, J | 1 |
| Dawson, R | 1 |
| Callahan, MF | 1 |
| Annau, Z | 1 |
| Trouvin, JH | 1 |
| Rowland, NE | 1 |
| Carlton, J | 1 |
| Sibilia, L | 1 |
| Rossi Fanelli, F | 1 |
| Lozzio, CB | 1 |
| Jauregui, GR | 1 |
| Scornavachi, JC | 1 |
| Gambin, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Daily Supplementation of 5-HTP on Body Composition, a Randomized Investigation[NCT05216406] | 65 participants (Actual) | Interventional | 2021-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hydroxyindoleacetic acid and Obesity
| Article | Year |
|---|---|
Neuroendocrine abnormalities in human obesity.
Topics: Animals; Corticotropin-Releasing Hormone; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Ma | 1995 |
Tolerance to fenfluramine anorexia: fact or fiction?
Topics: Animals; Behavior Therapy; Body Weight; Brain; Brain Chemistry; Drug Tolerance; Feeding Behavior; Fe | 1986 |
3 trials available for hydroxyindoleacetic acid and Obesity
| Article | Year |
|---|---|
Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Dietary Carbohydrates; Dietary Proteins; Energy Intake; Female; Humans; | 1992 |
Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects.
Topics: 5-Hydroxytryptophan; Adult; Anorexia; Diet, Reducing; Dietary Carbohydrates; Feeding Behavior; Femal | 1991 |
The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Double-Blind Method; Feeding Behavior; Female; Hum | 1989 |
35 other studies available for hydroxyindoleacetic acid and Obesity
| Article | Year |
|---|---|
Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese rats.
Topics: Administration, Oral; Anethum graveolens; Animals; Anti-Obesity Agents; Behavior, Animal; Brain; Dis | 2015 |
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro | 2008 |
Levels of hypothalamic neurotransmitters in lean and obese Zucker rats.
Topics: Analysis of Variance; Animals; Dietary Fats; Dopamine; Epinephrine; Female; Food Preferences; Hydrox | 2002 |
The effects of phenylpropanolamine on Zucker rats selected for fat food preference.
Topics: Animals; Behavior, Animal; Dietary Carbohydrates; Dietary Fats; Eating; Energy Intake; Female; Food | 2003 |
Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats.
Topics: Animals; Eating; Feeding Behavior; Hydroxyindoleacetic Acid; Hypothalamus; Interleukin-1; Microdialy | 2005 |
Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Chro | 2006 |
Cerebrospinal fluid adenosine 3',5'-monophosphate, 5-hydroxyindoleacetic acid and homovanillic acid in patients with sleep apnoea syndrome.
Topics: Cyclic AMP; Disorders of Excessive Somnolence; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1981 |
Protein intake regulation in adult obese (ob/ob) and lean mice: effects of nonprotein energy source and of supplemental tryptophan.
Topics: Animals; Brain; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Female; Food P | 1982 |
Fenfluramine and brain transmitters in the obese Zucker rat.
Topics: Animals; Body Weight; Brain Chemistry; Catecholamines; Dopamine; Feeding Behavior; Female; Fenfluram | 1984 |
Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Appetite Depressants; Arginine; Body Weight; Brain; Eating; Hyd | 1994 |
Serotonergic activity is depressed in the ventromedial hypothalamic nucleus of 12-day-old obese Zucker rats.
Topics: Adipose Tissue; Animals; Animals, Newborn; Body Weight; Dopamine; Genotype; Heterozygote; Homozygote | 1994 |
The effect of DHEA given chronically to Zucker rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Dehydroepiandro | 1995 |
Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Dopamine; Dorsomedial Hypothalamic Nuc | 1995 |
Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program.
Topics: Androgens; Animals; Appetite; Body Weight; Brain; Dehydroepiandrosterone; Dose-Response Relationship | 1993 |
The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters.
Topics: Androstenedione; Animals; Body Weight; Dehydroepiandrosterone; Disease Models, Animal; Dopamine; Eat | 1995 |
Hypothalamic monoamines and insulin in relation to feeding in the genetically obese Zucker rat as revealed by microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Dialysis; Dopamine; Food; Glucose; Hyd | 1995 |
Rostromedial hypothalamic monoamine changes in response to intravenous infusions of insulin and glucose in freely feeding obese Zucker rats: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Blood Glucose; Dialysis; Dopamine; Eat | 1996 |
The concentrations of monoamine metabolites and neuropeptides in the cerebrospinal fluid of obese women with different body fat distribution.
Topics: Adipose Tissue; Adult; beta-Endorphin; Biogenic Monoamines; Body Composition; Body Constitution; Bod | 1996 |
Central effects of dehydroepiandrosterone in Zucker rats.
Topics: Animals; Biogenic Monoamines; Central Nervous System; Dehydroepiandrosterone; Disease Models, Animal | 1995 |
Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters.
Topics: Adipose Tissue; Animals; Biogenic Monoamines; Body Composition; Bromocriptine; Chromatography, High | 1998 |
Combined effect of obesity and aging on feeding-induced monoamine release in the rostromedial hypothalamus of the Zucker rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Dopamine; Eating; Food; Hydroxy | 1998 |
Cerebrospinal fluid monoamines in Prader-Willi syndrome.
Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Birth Weight; Body Mass Index; Child; Child, Pres | 1998 |
Lateral hypothalamic serotonergic responsiveness to food intake in rat obesity as measured by microdialysis.
Topics: Animals; Eating; Hydroxyindoleacetic Acid; Hypothalamic Area, Lateral; Male; Microdialysis; Obesity; | 1999 |
Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adipose Tissue; Animals; Animals, Newborn; Appetite Depressants; Arc | 2000 |
Development of obesity and neurochemical backing in aurothioglucose-treated mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Antineoplastic Combined Chemotherapy Protoco | 2001 |
Dysregulation of hypothalamic serotonin turnover in diet-induced obese rats.
Topics: Animals; Animals, Outbred Strains; Circadian Rhythm; Diet; Dietary Fats; Disease Susceptibility; Ene | 2002 |
Association of altered brain norephinephrine and serotonin with the obesity induced by goldthioglucose in mice.
Topics: Animals; Aurothioglucose; Body Weight; Brain; Dopamine; Female; Gold; Hydroxyindoleacetic Acid; Hypo | 1978 |
Selective blockade of hypothalamic hyperphagia and obesity in rats by serotonin-depleting midbrain lesions.
Topics: Animals; Brain; Brain Stem; Feeding Behavior; Female; Hydroxyindoleacetic Acid; Hypothalamus; Hypoth | 1977 |
Neurochemical correlates of hypothalamic obesity in rats.
Topics: Animals; Body Weight; Brain Chemistry; Dopamine; Female; Hydroxyindoleacetic Acid; Hypothalamus; Hyp | 1976 |
Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats.
Topics: Adrenal Medulla; Analysis of Variance; Animals; Catecholamines; Epinephrine; Female; Fenfluramine; H | 1992 |
Cholecystokinin-induced variations in hypothalamic serotonergic system of the "cafeteria" rat.
Topics: Animals; Female; Hydroxyindoleacetic Acid; Hypothalamus; Obesity; Rats; Rats, Inbred Strains; Satiat | 1990 |
Effects of insulin on brain monoamine metabolism in the Zucker rat: influence of genotype and age.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Biogenic Monoamines; Blood Glucose; Body Weigh | 1991 |
Hypothalamic monoamine metabolism in mice: evaluation of drug challenges and neurotoxic insult.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Animals, Newborn; Dopamine; Female; G | 1986 |
Ontogeny of brain monoamines in lean and obese female Zucker rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Biogenic Amines; Brain Chemistry; Dopamine; Fe | 1986 |
Chromosome mosaicism in a mentally retarded mother and her daughter.
Topics: Adolescent; Adult; Chromosomes, Human, 21-22 and Y; Female; Humans; Hydroxyindoleacetic Acid; Hypert | 1967 |