hydroxyindoleacetic acid has been researched along with Nervous System Disorders in 34 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Main abnormalities in 5-HIAA excretion have been observed in carcinoid tumors (elevation) or hyperphenylalaninemia (diminution) as well as in migraine." | 3.67 | [5-HIAA: perspectives in nephrology]. ( Elghozi, JL; Laude, D, 1989) |
| "Maturation of monoamine neuronal systems was studied by measuring cerebrospinal fluid metabolites of dopamine (homovanillic acid) and serotonin (5-hydroxyindoleacetic acid) in 38 children with epilepsy and other neurological disorders, to whom probenecid had previously been administered." | 3.66 | Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. ( Bowers, MB; Cohen, DJ; Leckman, JF; Shaywitz, BA; Young, JG, 1980) |
| "A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome." | 3.66 | Dopaminergic dsyfunction in Tourette syndrome. ( Butler, IJ; Coyle, JT; Seifert, WE; Singer, HS; Tune, LE, 1982) |
| "Cadmium was found to significantly increase the levels of 5-HT and 5-HIAA in all the brain regions of adult rats while the levels of 5-HT and 5-HIAA were significantly decreased in most of the brain regions of growing rats." | 1.28 | Comparative neurotoxicity of cadmium in growing and adult rats after repeated administration. ( Chandra, SV; Dubey, MP; Gupta, A; Murthy, RC; Thakur, SR, 1990) |
| "Regulation of neurotoxicants is generally based on setting allowable doses (exposures) by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that hopefully account for interspecies and intraspecies differences for extrapolations of experimental results obtained in animals to humans." | 1.28 | Risk assessment for neurotoxic effects. ( Gaylor, DW; Slikker, W, 1990) |
| " However, a comparison of the relative toxic effects of MDMA and MBDB indicates that MBDB may be slightly less neurotoxic." | 1.28 | Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. ( Johnson, MP; Nichols, DE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (55.88) | 18.7374 |
| 1990's | 10 (29.41) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Vilanakis, E | 3 |
| Papakonstantinou, E | 3 |
| Paramera, E | 3 |
| Argyri, I | 3 |
| Drakou, E | 3 |
| Kokkinou, E | 3 |
| Zouvelou, V | 3 |
| Outsika, C | 3 |
| Pons, R | 3 |
| De Grandis, E | 1 |
| Serrano, M | 2 |
| Pérez-Dueñas, B | 2 |
| Ormazábal, A | 2 |
| Montero, R | 1 |
| Veneselli, E | 1 |
| Pineda, M | 2 |
| González, V | 2 |
| Sanmartí, F | 1 |
| Fons, C | 1 |
| Sans, A | 1 |
| Cormand, B | 1 |
| Puelles, L | 1 |
| Alonso, A | 1 |
| Campistol, J | 1 |
| Artuch, R | 1 |
| García-Cazorla, A | 2 |
| Shi, X | 1 |
| Zhang, L | 1 |
| Fu, S | 1 |
| Li, N | 1 |
| BUSCAINO, GA | 1 |
| STEFANACHI, L | 1 |
| PERRY, TL | 1 |
| HANSEN, S | 1 |
| HESTRIN, M | 1 |
| MACINTYRE, L | 1 |
| Fernández-Alvarez, E | 1 |
| Campistol, JM | 1 |
| Artuch, RM | 1 |
| Bottiglieri, T | 1 |
| Lim, CK | 1 |
| Peters, TJ | 1 |
| Shaywitz, BA | 1 |
| Cohen, DJ | 1 |
| Leckman, JF | 1 |
| Young, JG | 1 |
| Bowers, MB | 1 |
| Van Woert, MH | 1 |
| Magnussen, I | 1 |
| Lowe, YH | 1 |
| Hwang, EC | 1 |
| Potkin, SG | 1 |
| Weinberger, DR | 1 |
| Linnoila, M | 1 |
| Wyatt, RJ | 1 |
| Singer, HS | 1 |
| Butler, IJ | 1 |
| Tune, LE | 1 |
| Seifert, WE | 1 |
| Coyle, JT | 1 |
| Laakso, JT | 1 |
| Koskiniemi, ML | 1 |
| Wahlroos, O | 1 |
| Härkönen, M | 1 |
| Gagnieu, MC | 1 |
| Menouni-Foray, V | 1 |
| Guardiola, P | 1 |
| Quincy, C | 1 |
| Renaud, B | 1 |
| Candito, M | 1 |
| Nagatsu, T | 1 |
| Chambon, P | 1 |
| Chatel, M | 1 |
| Ohmori, T | 1 |
| Koyama, T | 1 |
| Muraki, A | 1 |
| Yamashita, I | 1 |
| Mousseau, DD | 1 |
| Rao, VL | 1 |
| Butterworth, RF | 1 |
| Wakata, N | 1 |
| Araki, Y | 1 |
| Sugimoto, H | 1 |
| Iguchi, H | 1 |
| Kinoshita, M | 1 |
| Steele, TD | 1 |
| Katz, JL | 1 |
| Ricaurte, GA | 1 |
| Gupta, A | 2 |
| Murthy, RC | 1 |
| Thakur, SR | 1 |
| Dubey, MP | 1 |
| Chandra, SV | 1 |
| Gaylor, DW | 1 |
| Slikker, W | 1 |
| Paris, JM | 1 |
| Cunningham, KA | 1 |
| Zeman, J | 1 |
| Böswart, J | 1 |
| Davis, BA | 1 |
| Durden, DA | 1 |
| O'Reilly, RL | 1 |
| Young, SN | 1 |
| Carney, MW | 1 |
| Ichikawa, N | 1 |
| Johnson, M | 1 |
| Stone, DM | 1 |
| Bush, LG | 1 |
| Hanson, GR | 1 |
| Gibb, JW | 1 |
| Elghozi, JL | 1 |
| Laude, D | 1 |
| Johnson, MP | 1 |
| Nichols, DE | 1 |
| Scheinin, M | 1 |
| Curzon, G | 2 |
| Gumpert, J | 1 |
| Sharpe, D | 1 |
| Benda, L | 1 |
| Mori, I | 1 |
| Ishuin, Y | 1 |
| Tokuhisa, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hydroxyindoleacetic acid and Nervous System Disorders
| Article | Year |
|---|---|
Neuropharmacology of S-adenosyl methionine.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Brain; Dementia; Depressive Disorder; Epilepsy; Fol | 1986 |
Monoamine metabolites in human cerebrospinal fluid: indicators of neuronal activity?
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Biogenic Amines; Brain Diseases; Glycols; Homo | 1985 |
32 other studies available for hydroxyindoleacetic acid and Nervous System Disorders
| Article | Year |
|---|---|
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Topics: Biogenic Amines; Child; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Nervous | 2023 |
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Topics: Biogenic Amines; Child; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Nervous | 2023 |
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Topics: Biogenic Amines; Child; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Nervous | 2023 |
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Topics: Biogenic Amines; Child; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Nervous | 2023 |
Cerebrospinal fluid alterations of the serotonin product, 5-hydroxyindolacetic acid, in neurological disorders.
Topics: Case-Control Studies; Child; Child, Preschool; Developmental Disabilities; DNA Mutational Analysis; | 2010 |
Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anxiety; Checklist; Depression; Diagnostic Self Evaluation; Dopamine | 2011 |
[Metabolism of indolic substances in nervous system diseases. I. Behavior of 5-hydroxyindolacetic acid in urine (qualitative reactions)].
Topics: Hydroxyindoleacetic Acid; Indoleacetic Acids; Nervous System Diseases | 1957 |
EXOGENOUS URINARY AMINES OF PLANT ORIGIN.
Topics: 5-Hydroxytryptophan; Amines; Benzaldehydes; Biomedical Research; Chromatography; Coffee; Condiments; | 1965 |
Secondary abnormalities of neurotransmitters in infants with neurological disorders.
Topics: 5-Hydroxytryptophan; Atrophy; Brain; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Hu | 2007 |
Isocratic analysis of 3-methoxy-4-hydroxyphenyl glycol, 5-hydroxyindole-3-acetic acid and 4-hydroxy-3-methoxyphenylacetic acid in cerebrospinal fluid by high-performance liquid chromatography with amperometric detection.
Topics: Buffers; Chromatography, High Pressure Liquid; Depressive Disorder; Glycols; Homovanillic Acid; Huma | 1984 |
Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders.
Topics: Adolescent; Child; Child, Preschool; Dopamine; Epilepsy; Female; Homovanillic Acid; Humans; Hydroxyi | 1980 |
Study of serotonin in neuropsychiatric disorders.
Topics: 5-Hydroxytryptophan; Carbidopa; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kinetic | 1982 |
Low CSF 5-hydroxyindoleacetic acid in schizophrenic patients with enlarged cerebral ventricles.
Topics: Adult; Chronic Disease; Female; Humans; Hydrocephalus; Hydroxyindoleacetic Acid; Male; Nervous Syste | 1983 |
Dopaminergic dsyfunction in Tourette syndrome.
Topics: Adolescent; Dopamine; Female; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male | 1982 |
Simultaneous determination of tryptophan and its 5-hydroxy metabolites in human cerebrospinal fluid by reversed phase liquid chromatography with electrochemical detection.
Topics: 5-Hydroxytryptophan; Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Nervous System Diseas | 1983 |
Liquid chromatographic determination of homovanillic acid, 5-hydroxyindoleacetic acid and probenecid levels in human cerebrospinal fluid during probenecid test.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Electrochemistry; Homovanillic Acid; Humans | 1984 |
High-performance liquid chromatographic measurement of cerebrospinal fluid tetrahydrobiopterin, neopterin, homovanillic acid and 5-hydroxindoleacetic acid in neurological diseases.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Aged, 80 and over; Biopterins; Chromatography, High | 1994 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dopamine; Hydro | 1993 |
Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Autoradiography; Brain; Brain Chemistry; Ch | 1996 |
IDPN-induced monoamine and hydroxyl radical changes in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Dopamine; Homovanillic Acid; Hy | 2000 |
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Hallucinogens; Hydroxyindolea | 1992 |
Comparative neurotoxicity of cadmium in growing and adult rats after repeated administration.
Topics: Aging; Animals; Brain; Cadmium; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Hydroxyin | 1990 |
Risk assessment for neurotoxic effects.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Designer Drugs; Female; Hippocampus; Hydroxyindoleace | 1990 |
Lack of neurotoxicity after intra-raphe micro-injections of MDMA ("ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressu | 1990 |
[Metabolites of neurotransmitters in the cerebrospinal fluid in children].
Topics: Adolescent; Child; Child, Preschool; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; In | 1991 |
The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders.
Topics: Adult; Aged; Aging; Biogenic Monoamines; Body Height; Body Weight; Female; Homovanillic Acid; Humans | 1991 |
Acute effects of meals on brain tryptophan and serotonin in humans.
Topics: Adult; Affect; Amino Acids; Animals; Brain Chemistry; Dietary Carbohydrates; Dietary Proteins; Femal | 1991 |
Study on monoamine metabolite contents of cerebrospinal fluid in patients with neurodegenerative diseases.
Topics: Adult; Aged; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydr | 1986 |
Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Adrenalectomy; Amphetamines; Animals; Cerebral Cortex; Corticosterone | 1989 |
[5-HIAA: perspectives in nephrology].
Topics: Animals; Carcinoid Tumor; Humans; Hydroxyindoleacetic Acid; Intestinal Mucosa; Kidney; Metabolic Cle | 1989 |
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyi | 1989 |
Amine metabolites in the cerbrospinal fluid in Huntington's chorea.
Topics: Adult; Aged; Dopamine; Female; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Male; Mental Di | 1972 |
Involuntary movements other than Parkinsonism: biochemical aspects.
Topics: Acute Disease; Animals; Athetosis; Basal Ganglia; Brain; Dopamine; Fecal Incontinence; Homovanillic | 1973 |
[A neural-endocrine enteropathy].
Topics: Appendiceal Neoplasms; Biopsy; Carcinoid Tumor; Chronic Disease; Diarrhea; Endocrine System Diseases | 1967 |
[Autonomic nerve disorders in the puerperium].
Topics: Adult; Autonomic Nervous System; Female; Humans; Hydroxyindoleacetic Acid; Nervous System Diseases; | 1968 |