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hydroxyindoleacetic acid and Myoclonic Jerk

hydroxyindoleacetic acid has been researched along with Myoclonic Jerk in 42 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Research Excerpts

ExcerptRelevanceReference
"To study the purported role of central monoamine disturbances in the pathophysiology of the opsoclonus-myoclonus syndrome, the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid were measured in cerebrospinal fluid samples from 27 affected children and 47 age- and gender-matched control subjects by high-pressure liquid chromatography with electrochemical detection."9.08Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in the pediatric opsoclonus-myoclonus syndrome. ( Banasiak, K; Gospe, SM; Huang, Y; Noetzel, MJ; Pranzatelli, MR; Stanley, M; Tate, E, 1995)
"To study the purported role of central monoamine disturbances in the pathophysiology of the opsoclonus-myoclonus syndrome, the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid were measured in cerebrospinal fluid samples from 27 affected children and 47 age- and gender-matched control subjects by high-pressure liquid chromatography with electrochemical detection."5.08Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in the pediatric opsoclonus-myoclonus syndrome. ( Banasiak, K; Gospe, SM; Huang, Y; Noetzel, MJ; Pranzatelli, MR; Stanley, M; Tate, E, 1995)
"The administration of veratramine produced generalized tremor, myoclonus, hindlimb abduction, backward gait and Straub tail, similar to the "5-hydroxytryptamine (5-HT) syndrome", in mice."3.68Veratramine-induced behavior associated with serotonergic hyperfunction in mice. ( Izumi, K; Nagata, R, 1991)
"A single dose of p-chloroamphetamine, 10 mg per kilogram, produced postural abnormalities, tremor, myoclonus, and autonomic signs in rats 5 minutes after intraperitoneal injection."3.65Postural changes, tremor, and myoclonus in the rat immediately following injections of p-chloromaphetamine. ( Growdon, JH, 1977)
"Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor."3.65Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486. ( Sethy, VH; Van Woert, MH, 1975)
"In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased."2.64Serotonin and myoclonus. ( Bowers, MB; Jutkowitz, R; Rosenbaum, D; Van Woert, MH, 1976)
"The literature on myoclonus and serotonin neuropharmacology reveals evidence for serotonergic abnormalities in some human myoclonic disorders, new serotonin receptor subtypes and data on their molecular structure and function, more selective drugs, and experimental evidence linking certain serotonin receptor subtypes with myoclonus."2.39Serotonin and human myoclonus. Rationale for the use of serotonin receptor agonists and antagonists. ( Pranzatelli, MR, 1994)
"Clonazepam is a potent anticonvulsant 1,4-benzodiazepine that controls some types of myoclonus."2.37Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT. ( Jenner, P; Marsden, CD; Pratt, JA, 1986)
"Children with the opsoclonus-myoclonus syndrome (OMS) usually respond to corticotropin (adrenocorticotrophic hormone, ACTH) treatment but the mechanism of benefit is unknown."1.30Monoaminergic effects of high-dose corticotropin in corticotropin-responsive pediatric opsoclonus-myoclonus. ( Goldstein, DS; Goldstein, EM; Holmes, CS; Huang, YY; Ketner, K; Kinast, M; Lange, BM; Pranzatelli, MR; Sanz, A; Shevell, MI; Stanford, RE; Taff, IP; Tate, E, 1998)
"Some types of intention myoclonus respond to serotonin precursor therapy (e."1.27Fluoxetine in the treatment of intention myoclonus. ( Chung, E; Magnussen, I; Rosenbaum, D; Van Woert, MH, 1983)
"Indoleamine-induced myoclonus in guinea pigs is a specific model of brainstem 5-HT function that can be used to characterize the indoleamine systems initiating myoclonus."1.275-HT-mediated myoclonus in the guinea pig as a model of brainstem 5-HT and tryptamine receptor action. ( Jenner, P; Luscombe, G; Marsden, CD, 1986)
"p,p'-DDT-induced myoclonus in mice has been proposed as a model of stimulus-sensitive action myoclonus responsive to L-5-HTP and clonazepam treatment."1.27p,p'-DDT-induced myoclonus in the rat and its application as an animal model of 5-HT-sensitive action myoclonus. ( Jenner, P; Marsden, CD; Pratt, JA; Rothwell, J, 1986)
"Posthypoxic action myoclonus is usually associated with impaired serotonin (5-HT) neurotransmission but in some patients 5-HT precursors aggravate and 5-HT blockers improve action myoclonus."1.27Clinical, biochemical, and pharmacological observation in a patient with postasphyxic myoclonus: association to serotonin hyperactivity. ( De Yebenes, JG; Giménez-Roldán, S; Mateo, D; Muradas, V, 1988)
"5-Hydroxyindoleacetic acid was significantly lower in patients with myoclonic DAT as compared to patients with nonmyoclonic DAT, but not significantly lower than in control subjects."1.27Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease. ( Atack, JR; Beal, MF; Daly, E; Friedland, RP; Kaufman, S; Kaye, JA; May, C; Milstien, S; Rapoport, SI; Sweeney, DL, 1988)
"6 Chloralose-induced myoclonus is not similar to 5-HT-sensitive reticular reflex myoclonus in man."1.26Observations on chloralose-induced myoclonus in guinea-pigs. ( Chadwick, D; Hallett, M; Jenner, P; Marsden, CD, 1980)
"A patient representing with palatal myoclonus was diagnosed as suffering from possible multiple sclerosis."1.26[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam]. ( Baxter, DW; Gauthier, S; Young, SN, 1981)
"Postanoxic myoclonus was first accepted as being related to a dysfunction of the ventrolateral thalamic nucleus."1.26Postanoxic myoclonus. Treatment of a case with 5-hydroxytryptophane and a decarboxylase inhibitor. ( Beretta, E; de Crousaz, G; Regli, F; Steck, AJ, 1981)
"This form of myoclonus therefore is not of relevance to the 5-HT-sensitive post-anoxic action myoclonus occurring in man."1.265-Hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig. ( Chadwick, D; Jenner, P; Marsden, CD, 1979)
"p,p'-DDT-treated rats had increased concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in seven regional areas, but serotonin was increased only in the midbrain and cerebellum."1.26p,p'-DDT-induced neurotoxic syndrome: experimental myoclonus. ( Hwang, EC; Van Woert, MH, 1978)
"The neurochemical basis of myoclonus responding to 5HT precursors and clonazepam is discussed."1.26Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. ( Chadwick, D; Hallett, M; Harris, R; Jenner, P; Marsden, CD; Reynolds, EH, 1977)
"In two patients with postanoxic action myoclonus, L-tryptophan or a monoamine oxidase inhibitor induced a moderate improvement, but L-5-hydroxytryptophan had greater therapeutic effect."1.26Beneficial effects of serotonin precursors in postanoxic action myoclonus. ( De Léan, J; Hornykiewicz, O; Richardson, JC, 1976)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199036 (85.71)18.7374
1990's6 (14.29)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chadwick, D6
Hallett, M3
Jenner, P10
Marsden, CD10
Gauthier, S1
Young, SN1
Baxter, DW1
Beretta, E1
Regli, F1
de Crousaz, G1
Steck, AJ1
Van Woert, MH8
Magnussen, I2
Lowe, YH1
Hwang, EC2
Rosenbaum, D3
Chung, E1
Luscombe, G2
Pranzatelli, MR3
Huang, Y1
Tate, E2
Stanley, M1
Noetzel, MJ1
Gospe, SM1
Banasiak, K1
Matsumoto, RR1
Aziz, N1
Truong, DD1
Huang, YY1
Goldstein, DS1
Holmes, CS1
Goldstein, EM1
Ketner, K1
Kinast, M1
Lange, BM1
Sanz, A1
Shevell, MI1
Stanford, RE1
Taff, IP1
Reynolds, EH3
Stewart, RM1
Campbell, A1
Sperk, G1
Baldessarini, RJ1
Levin, SL1
Harris, R1
Chung Hwang, E1
Jankovic, J1
Rivera, VM1
Growdon, JH1
McMillen, BA1
Isaac, L1
Jutkowitz, R1
Bowers, MB1
Koskiniemi, M1
Sethy, VH1
De Léan, J2
Richardson, JC2
Hornykiewicz, O1
Thal, L1
Sharpless, N1
Wolfson, L1
Engel, J1
Katzman, R1
Nagata, R2
Izumi, K2
Iwata, S1
Shimizu, T1
Fukuda, T1
Chung, EY2
Fahn, S1
Rewcastle, NB1
Pratt, JA2
Rothwell, J1
Giménez-Roldán, S1
Mateo, D1
Muradas, V1
De Yebenes, JG1
Kaye, JA1
May, C1
Atack, JR1
Daly, E1
Sweeney, DL1
Beal, MF1
Kaufman, S1
Milstien, S1
Friedland, RP1
Rapoport, SI1
Shohami, E1
Evron, S1
Fischer-Perroudon, C1
Mouret, J1
Jouvet, M1
Rohmer, F1
Warter, JM1
Coquillat, G1
Maitrot, D1
Kurtz, D1
Micheletti, G1
Mack, G1
Mandel, P1
Guilleminault, C1
Tharp, BR1
Cousin, D1

Reviews

2 reviews available for hydroxyindoleacetic acid and Myoclonic Jerk

ArticleYear
Serotonin and human myoclonus. Rationale for the use of serotonin receptor agonists and antagonists.
    Archives of neurology, 1994, Volume: 51, Issue:6

    Topics: 5-Hydroxytryptophan; Brain; Humans; Hydroxyindoleacetic Acid; Myoclonus; Receptors, Serotonin; Serot

1994
Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Clonazepam

1986

Trials

3 trials available for hydroxyindoleacetic acid and Myoclonic Jerk

ArticleYear
Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in the pediatric opsoclonus-myoclonus syndrome.
    Annals of neurology, 1995, Volume: 37, Issue:2

    Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Chromatography, High Pressure Liquid; Electrochemi

1995
Serotonin and myoclonus.
    Monographs in neural sciences, 1976, Volume: 3

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Clinical Trials as Topic; Epilepsy; Female; Homov

1976
[Pharmacological and biochemical approach to a syndrome of action and intention myoclonus in the course of degenerative disease of the nervous system].
    Revue neurologique, 1973, Volume: 128, Issue:5

    Topics: 5-Hydroxytryptophan; Adult; Benzazepines; Cerebellar Ataxia; Clinical Trials as Topic; Diagnosis, Di

1973

Other Studies

37 other studies available for hydroxyindoleacetic acid and Myoclonic Jerk

ArticleYear
Observations on chloralose-induced myoclonus in guinea-pigs.
    British journal of pharmacology, 1980, Volume: 69, Issue:3

    Topics: Animals; Brain Chemistry; Chloralose; Electroencephalography; Electromyography; Female; Guinea Pigs;

1980
[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam].
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1981, Volume: 8, Issue:1

    Topics: Benzodiazepinones; Clonazepam; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Multiple Scler

1981
Postanoxic myoclonus. Treatment of a case with 5-hydroxytryptophane and a decarboxylase inhibitor.
    Journal of neurology, 1981, Volume: 225, Issue:1

    Topics: 5-Hydroxytryptophan; Benserazide; Humans; Hydrazines; Hydroxyindoleacetic Acid; Hypoxia; Male; Middl

1981
Study of serotonin in neuropsychiatric disorders.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1982, Volume: 30, Issue:8

    Topics: 5-Hydroxytryptophan; Carbidopa; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kinetic

1982
Fluoxetine in the treatment of intention myoclonus.
    Clinical neuropharmacology, 1983, Volume: 6, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Blood Platelets; Carbidopa; Female; Fluoxetine; Humans; Hydroxyindoleace

1983
Alterations in brain 5HT and tryptamine content during indoleamine-induced myoclonus in guinea pigs.
    Biochemical pharmacology, 1983, Jun-15, Volume: 32, Issue:12

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Carbidopa; Drug Interactions; Female; Guinea

1983
Association between brain indole levels and severity of posthypoxic myoclonus in rats.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:4

    Topics: 5-Hydroxytryptophan; Analysis of Variance; Animals; Brain; Hydroxyindoleacetic Acid; Hypoxia, Brain;

1995
Monoaminergic effects of high-dose corticotropin in corticotropin-responsive pediatric opsoclonus-myoclonus.
    Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenocorticotropic Hormone; Catecholamines; Child, Preschool; Dihyd

1998
Proceedings: Clonazepam-induced changes in 5-hydroxytryptamine (5-HT) metabolism in aminals and man.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27 Suppl?-2

    Topics: Animals; Benzodiazepinones; Clonazepam; Humans; Hydroxyindoleacetic Acid; Mice; Myoclonus; Serotonin

1975
5-Hydroxytryptamine and myoclonus induced by 1,2-di-hydroxybenzene (catechol) in the guinea-pig.
    British journal of pharmacology, 1979, Volume: 66, Issue:3

    Topics: Animals; Brain Chemistry; Catechols; Female; Guinea Pigs; Hydroxyindoleacetic Acid; Male; Myoclonus;

1979
Receptor mechanisms in increased sensitivity to serotonin agonists after dihydroxytryptamine shown by electronic monitoring of muscle twitches in the rat.
    Psychopharmacology, 1979, Feb-28, Volume: 60, Issue:3

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Brain; Cyproheptadine; Denervation; Desiprami

1979
[Serotoninergic conception of myoclonic syndromes. (Review)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:6

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Carbidopa; Dogs; Electroencephalography; Elect

1979
Altered 5-HT metabolism with clonazepam, diazepam and diphenylhydantoin.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:9

    Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Diazepam; Humans; Hydroxyindoleacetic Acid; Male; Mic

1975
p,p'-DDT-induced neurotoxic syndrome: experimental myoclonus.
    Neurology, 1978, Volume: 28, Issue:10

    Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Clomipramine; DDT; Hydroxyindoleacetic Acid; Isomeris

1978
Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam.
    Brain : a journal of neurology, 1977, Volume: 100, Issue:3

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzodiazepinones; Carbidopa; Child, Preschool; Clonaz

1977
Antimyoclonic action of clonazepam: the role of serotonin.
    European journal of pharmacology, 1979, Nov-23, Volume: 60, Issue:1

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Clonazepam; DDT; Hydroxyindoleacetic Acid; Male; Mice;

1979
Hereditary myoclonus and progressive distal muscular atrophy.
    Annals of neurology, 1979, Volume: 6, Issue:3

    Topics: Adult; Aged; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Muscular Atrophy; My

1979
Postural changes, tremor, and myoclonus in the rat immediately following injections of p-chloromaphetamine.
    Neurology, 1977, Volume: 27, Issue:11

    Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Male; Motor Activ

1977
Relationship between kindled myoclonic seizures and feline brain dopamine metabolism.
    Brain research, 1978, Jul-14, Volume: 150, Issue:2

    Topics: Animals; Brain; Cats; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Female; Homovanil

1978
Findings in routine laboratory examination in progressive myoclonus epilepsy.
    Acta neurologica Scandinavica, 1975, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Age Factors; Blood Glucose; Blood Proteins; Cerebrospinal Fluid Proteins; Child;

1975
Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486.
    Neurology, 1975, Volume: 25, Issue:2

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Cer

1975
Beneficial effects of serotonin precursors in postanoxic action myoclonus.
    Neurology, 1976, Volume: 26, Issue:9

    Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Female; Humans; Hydroxyindoleacetic Acid; Hypoxia; Levodopa; M

1976
Clinical and metabolic observations on the treatment of myoclonus with L-5-HTP and carbidopa.
    Transactions of the American Neurological Association, 1976, Volume: 101

    Topics: 5-Hydroxytryptophan; Adult; Carbidopa; Drug Evaluation; Homovanillic Acid; Humans; Hydrazines; Hydro

1976
Veratramine-induced behavior associated with serotonergic hyperfunction in mice.
    Japanese journal of pharmacology, 1991, Volume: 55, Issue:1

    Topics: 5,6-Dihydroxytryptamine; Animals; Brain Chemistry; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbre

1991
Mechanisms of veratramine-induced 5-HT syndrome in mice.
    Japanese journal of pharmacology, 1991, Volume: 55, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Aci

1991
Biochemistry and therapeutics of posthypoxic myoclonus.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electro

1986
Treatment of posthypoxic action myoclonus: implications for the pathophysiology of the disorder.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Benzodiazepines; Clonazepam; Female; Fenclonine; Humans; Hydroxyindoleacetic Ac

1986
Newer drugs for posthypoxic action myoclonus: observations from a well-studied case.
    Advances in neurology, 1986, Volume: 43

    Topics: Clonazepam; Drug Therapy, Combination; Estrogens, Conjugated (USP); Fasting; Female; Humans; Hydroxy

1986
Pathological findings in a case of hypoxic myoclonus treated with 5-hydroxytryptophan and a decarboxylase inhibitor.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Aged; Brain; Carbidopa; Diazepam; Electroencephalography; Female; Fenclonine; H

1986
5-HT-mediated myoclonus in the guinea pig as a model of brainstem 5-HT and tryptamine receptor action.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Carbidopa; Disease Models, Animal; Guinea Pig

1986
p,p'-DDT-induced myoclonus in the rat and its application as an animal model of 5-HT-sensitive action myoclonus.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Clonazepam; DDT; Disease Models, Animal; Elec

1986
Possible mechanisms of action of valproic acid in myoclonus.
    Advances in neurology, 1986, Volume: 43

    Topics: 4-Aminobutyrate Transaminase; 5-Hydroxytryptophan; Animals; Brain; gamma-Aminobutyric Acid; Glycine;

1986
Clinical, biochemical, and pharmacological observation in a patient with postasphyxic myoclonus: association to serotonin hyperactivity.
    Clinical neuropharmacology, 1988, Volume: 11, Issue:2

    Topics: 5-Hydroxytryptophan; Aged; Humans; Hydroxyindoleacetic Acid; Hypoxia; Male; Methysergide; Myoclonus;

1988
Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease.
    Annals of neurology, 1988, Volume: 24, Issue:5

    Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Analysis of Variance; Biopterins; Female; Homovanilli

1988
Intrathecal morphine induces myoclonic seizures in the rat.
    Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:1

    Topics: Analgesics; Animals; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Injections, Spinal; Male

1985
[Case of agrypnia (4 months without sleep) in Morvan's disease. Favorable action of 5-hydroxytryptophan].
    Electroencephalography and clinical neurophysiology, 1974, Volume: 36, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Chorea; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Ele

1974
HVA and 5HIAA CSF measurements and 5HTP trials in some patients with involuntary movements.
    Journal of the neurological sciences, 1973, Volume: 18, Issue:4

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Chorea; Dopamine; Dystonia Musculorum Deformans; Femal

1973