hydroxyindoleacetic acid has been researched along with Multiple Sclerosis in 12 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ventricular fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), the respective metabolites of dopamine and serotonin, were measured in 57 patients undergoing thalamotomy for relief of movement disorders." | 7.66 | Ventricular fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in patients with movement disorders. ( Sharpless, NS; Tabaddor, K; Wolfson, LI, 1978) |
| "Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were measured in the cerebrospinal fluid from patients with multiple sclerosis and from healthy volunteers." | 3.66 | Monoamine metabolites in successive samples of spinal fluid. A comparison between healthy volunteers and patients with multiple sclerosis. ( Andersen, O; Johansson, BB; Svennerholm, L, 1981) |
| "Ventricular fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), the respective metabolites of dopamine and serotonin, were measured in 57 patients undergoing thalamotomy for relief of movement disorders." | 3.66 | Ventricular fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in patients with movement disorders. ( Sharpless, NS; Tabaddor, K; Wolfson, LI, 1978) |
| "The concentrations of homovanillic acid (HVA), 5-hydroxyindolylacetic acid (5-HIAA), and 4-hydroxy, 3-methoxyphenylethylene glycol (MHPG) were estimated in the lumbar cerebrospinal fluid (CSF) of control subjects and in some patients who probably, and others who definitely, suffered from multiple sclerosis (MS)." | 3.65 | Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. ( Davidson, D; Kinloch, N; Mawdsley, C; Pullar, IA; Yates, CM, 1977) |
| "Homovanillic acid levels were significantly lower only in the PRMS group, with a negative correlation to duration of illness, and a strong negative correlation to EDSS score, but not to MSSS." | 1.35 | Relationship of CSF neurotransmitter metabolite levels to disease severity and disability in multiple sclerosis. ( Evangelopoulos, ME; Karahalios, G; Koutsis, G; Mandellos, D; Markianos, M; Sfagos, C, 2009) |
| "A patient representing with palatal myoclonus was diagnosed as suffering from possible multiple sclerosis." | 1.26 | [Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam]. ( Baxter, DW; Gauthier, S; Young, SN, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Markianos, M | 2 |
| Koutsis, G | 2 |
| Evangelopoulos, ME | 2 |
| Mandellos, D | 1 |
| Karahalios, G | 1 |
| Sfagos, C | 2 |
| Andersen, O | 1 |
| Johansson, BB | 1 |
| Svennerholm, L | 1 |
| Gauthier, S | 1 |
| Young, SN | 1 |
| Baxter, DW | 1 |
| Cook, A | 1 |
| Nidzgorski, F | 1 |
| Hurwic, M | 1 |
| Winsberg, B | 1 |
| Klutch, A | 1 |
| Tabaddor, K | 1 |
| Wolfson, LI | 2 |
| Sharpless, NS | 2 |
| Davidson, D | 1 |
| Pullar, IA | 1 |
| Mawdsley, C | 1 |
| Kinloch, N | 1 |
| Yates, CM | 1 |
| Hyyppä, MT | 1 |
| Jolma, T | 1 |
| Riekkinen, P | 2 |
| Rinne, UK | 2 |
| Thal, LJ | 1 |
| Curzon, G | 2 |
| Sonninen, V | 1 |
| Claveria, LE | 1 |
| Harrison, MJ | 1 |
| Kantamaneni, BD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Examination of Potential Neurochemical and Cognitive Mediators of the Relationship Between Mindfulness and Emotion Regulation in Individuals With Multiple Sclerosis: An Internet Based Self-Guided Pilot Study.[NCT02391298] | 26 participants (Actual) | Interventional | 2014-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for hydroxyindoleacetic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Effects of L-tryptophan treatment on central indoleamine metabolism and short-lasting neurologic disturbances in multiple sclerosis.
Topics: Adult; Benserazide; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Middle Aged; Multiple Scler | 1975 |
11 other studies available for hydroxyindoleacetic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Relationship of CSF neurotransmitter metabolite levels to disease severity and disability in multiple sclerosis.
Topics: Adolescent; Adult; Disability Evaluation; Disease Progression; Female; Homovanillic Acid; Humans; Hy | 2009 |
Serum total cholesterol correlates positively to central serotonergic turnover in male but not in female subjects.
Topics: Adult; Central Nervous System; Cholesterol; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle A | 2010 |
Monoamine metabolites in successive samples of spinal fluid. A comparison between healthy volunteers and patients with multiple sclerosis.
Topics: Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglyc | 1981 |
[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam].
Topics: Benzodiazepinones; Clonazepam; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Multiple Scler | 1981 |
Monoamine accumulation among sclerotic patients receiving dorsal-column stimulation.
Topics: Amyotrophic Lateral Sclerosis; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Multiple Scleros | 1978 |
Ventricular fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in patients with movement disorders.
Topics: Adult; Aged; Cerebral Palsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Middle A | 1978 |
Monoamine metabolites in cerebrospinal fluid in multiple sclerosis.
Topics: Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglyc | 1977 |
Diminished levels of ventricular fluid norepinephrine metabolite and somatostatin in childhood-onset dystonia.
Topics: Adolescent; Adult; Age Factors; Cerebral Palsy; Child; Child, Preschool; Dystonia; Homovanillic Acid | 1988 |
Involuntary movements other than Parkinsonism: biochemical aspects.
Topics: Acute Disease; Animals; Athetosis; Basal Ganglia; Brain; Dopamine; Fecal Incontinence; Homovanillic | 1973 |
Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis.
Topics: Acute Disease; Adult; Brain; Chronic Disease; Demyelinating Diseases; Female; Homovanillic Acid; Hum | 1973 |
Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis.
Topics: Cerebellar Diseases; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Multiple Sclerosis; Phenyl | 1974 |