hydroxyindoleacetic acid has been researched along with Migraine Disorders in 49 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the platelet and plasma levels of serotonin and its metabolite, 5-hydroxyindoleacetic acid, in patients suffering from episodic tension-type headache and migraine with and without aura, during a headache-free period." | 3.69 | Metabolism and menstrual cycle rhythmicity of serotonin in primary headaches. ( Alecci, M; Cananzi, AR; D'Andrea, G; Hasselmark, L; Perini, F; Welch, KM; Zamberlan, F, 1995) |
| " Main abnormalities in 5-HIAA excretion have been observed in carcinoid tumors (elevation) or hyperphenylalaninemia (diminution) as well as in migraine." | 3.67 | [5-HIAA: perspectives in nephrology]. ( Elghozi, JL; Laude, D, 1989) |
| "Attempts to study the biochemistry of migraine began as early as the 1960s and were primarily directed at serotonin metabolism after an increase of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin was observed in urine of migraineurs." | 2.55 | Genetic and biochemical changes of the serotonergic system in migraine pathobiology. ( Gasparini, CF; Griffiths, LR; Smith, RA, 2017) |
| "The biochemistry of migraine is complex." | 2.38 | Biochemistry of migraine. ( Ferrari, MD, 1992) |
| "It is proposed that the migraine attack is explicable by an interaction between the brain and the cranial circulation in subjects with unstable vascular and pain-control mechanisms." | 2.38 | The pathophysiology of migraine: a tentative synthesis. ( Lance, JW, 1992) |
| "A nitroglycerin-induced migraine model in rats and a reserpine-induced migraine model in mice were established to investigate the effects of RCXTAs on monoamine neurotransmitters in brain tissue, including 5-hydroxytryptamine (5-HT) and its metabolite (5-HIAA)." | 1.51 | Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT ( Feng, R; Luo, M; Peng, C; Pu, ZH; Xie, XF; Xiong, L; Zhu, H, 2019) |
| "Hemiplegic migraine is a rare subtype of migraine that is associated with reversible motor weakness in the aura phase." | 1.46 | [Childhood sporadic type of hemiplegic migraine with arteria cerebri media hypoperfusion]. ( Bajzik, G; Balogh, G; Csorba, E; Lajtai, A; Nagy, C; Nagy, F; Skobrák, A; Vajda, Z, 2017) |
| "These findings suggest that in migraine KYN is unidirectionally metabolized into ANA at expenses of KYNA and 3-HK." | 1.42 | Altered kynurenine pathway metabolites in serum of chronic migraine patients. ( Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M, 2015) |
| "To evaluate the analgesic and anti-migraine activities of senkyunolide I from Ligusticum chuanxiong." | 1.37 | Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. ( Feng, Y; He, CY; Hong, YL; Liang, S; Lin, X; Wang, YH; Xu, DS, 2011) |
| "Fifty children suffering from migraine as per Prensky's criteria were recruited over a period of 1 year." | 1.29 | Migraine in children. ( Banu, K; Chellaraj, M; Thilothammal, N, 1994) |
| "Platelets may be linked to migraine." | 1.29 | Platelet models and their possible usefulness in the study of migraine pathogenesis. ( Cananzi, AR; D'Andrea, G; Hasselmark, L; Perini, F, 1995) |
| "These data support the concept that migraine is at least in part a disorder of central neurotransmission." | 1.29 | Cerebrospinal fluid analyses in migraine patients and controls. ( Golbeck, A; Mar, KR; Moore, AC; Rothrock, JF; Yaksh, TL, 1995) |
| "In menstrual migraine 5HIAA levels and MAO activity showed similar changes with higher values in the luteal than in the follicular phase." | 1.29 | Platelet serotonin pathway in menstrual migraine. ( Alecci, M; Andrea, GD; Cananzi, A; Facchinetti, F; Fioroni, L, 1996) |
| "Between attacks, migraineurs had lower plasma 5-HT and higher 5-HIAA levels than did healthy controls and patients with tension headache." | 1.28 | Serotonin metabolism in migraine. ( Bruyn, GW; Ferrari, MD; Odink, J; Pennings, EJ; Tapparelli, C; Van Kempen, GM, 1989) |
| "In one patient with complicated migraine no change was found, and in two patients, one with common migraine and one with migraine and associated symptoms, there was a rise in total blood 5-HI during migraine attacks." | 1.26 | Total 5-hydroxyindoles in blood related to migraine attacks. ( Berstad, JR, 1976) |
| "After migraine attack a very pronounced lowering in excretion rate of both 5-hydroxy-indoles occured." | 1.25 | Fluctuation of 5-hydroxy-indole compounds in the urine of migrainous patients. ( Deanović, Z; Dupelj, M; Iskrić, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (65.31) | 18.7374 |
| 1990's | 10 (20.41) | 18.2507 |
| 2000's | 2 (4.08) | 29.6817 |
| 2010's | 5 (10.20) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagy, C | 1 |
| Bajzik, G | 1 |
| Skobrák, A | 1 |
| Csorba, E | 1 |
| Lajtai, A | 1 |
| Balogh, G | 1 |
| Nagy, F | 1 |
| Vajda, Z | 1 |
| Pu, ZH | 1 |
| Peng, C | 1 |
| Xie, XF | 1 |
| Luo, M | 1 |
| Zhu, H | 1 |
| Feng, R | 1 |
| Xiong, L | 1 |
| Curto, M | 1 |
| Lionetto, L | 1 |
| Negro, A | 1 |
| Capi, M | 1 |
| Fazio, F | 1 |
| Giamberardino, MA | 1 |
| Simmaco, M | 1 |
| Nicoletti, F | 1 |
| Martelletti, P | 1 |
| Gasparini, CF | 1 |
| Smith, RA | 1 |
| Griffiths, LR | 1 |
| Wang, YH | 1 |
| Liang, S | 1 |
| Xu, DS | 1 |
| Lin, X | 1 |
| He, CY | 1 |
| Feng, Y | 1 |
| Hong, YL | 1 |
| Blandini, F | 1 |
| Rinaldi, L | 1 |
| Tassorelli, C | 1 |
| Sances, G | 1 |
| Motta, M | 1 |
| Samuele, A | 1 |
| Fancellu, R | 1 |
| Nappi, G | 5 |
| Leon, A | 1 |
| Nagata, E | 1 |
| Shibata, M | 1 |
| Hamada, J | 1 |
| Shimizu, T | 1 |
| Katoh, Y | 1 |
| Gotoh, K | 1 |
| Suzuki, N | 1 |
| Mück-Seler, D | 1 |
| Deanović, Z | 2 |
| Dupelj, M | 2 |
| Thilothammal, N | 1 |
| Chellaraj, M | 1 |
| Banu, K | 1 |
| D'Andrea, G | 4 |
| Hasselmark, L | 2 |
| Cananzi, AR | 2 |
| Alecci, M | 2 |
| Perini, F | 2 |
| Zamberlan, F | 1 |
| Welch, KM | 3 |
| Rothrock, JF | 1 |
| Mar, KR | 1 |
| Yaksh, TL | 1 |
| Golbeck, A | 1 |
| Moore, AC | 1 |
| Fioroni, L | 1 |
| Andrea, GD | 1 |
| Cananzi, A | 1 |
| Facchinetti, F | 1 |
| Lambert, GA | 1 |
| Shimomura, T | 1 |
| Boers, PM | 1 |
| Gordon, V | 1 |
| Donaldson, C | 1 |
| Zagami, AS | 1 |
| Milovanović, DD | 1 |
| Majkić-Sing, N | 1 |
| Mirković, D | 1 |
| Pavlović, J | 1 |
| Hyypp, MT | 1 |
| Kangasniemi, P | 2 |
| Berstad, JR | 1 |
| Kangasniemi, PJ | 1 |
| Iskrić, S | 1 |
| Hopf, HC | 1 |
| Johnson, EA | 1 |
| Gutmann, L | 1 |
| Ferrari, MD | 2 |
| Lance, JW | 5 |
| Bousser, MG | 1 |
| Elghozi, JL | 2 |
| Laude, D | 2 |
| Soisson, T | 1 |
| Grunfeld, S | 2 |
| Levine, SR | 1 |
| Nagel-Leiby, S | 1 |
| Joseph, R | 2 |
| Hayashi, T | 1 |
| Kovács, K | 1 |
| Bors, L | 1 |
| Tóthfalusi, L | 1 |
| Jelencsik, I | 1 |
| Bozsik, G | 1 |
| Kerényi, L | 1 |
| Komoly, S | 1 |
| Odink, J | 1 |
| Tapparelli, C | 1 |
| Van Kempen, GM | 1 |
| Pennings, EJ | 1 |
| Bruyn, GW | 1 |
| Riddle, JM | 1 |
| Sicuteri, F | 3 |
| Anselmi, B | 3 |
| Fanciullacci, M | 3 |
| Poloni, M | 4 |
| Tartara, A | 1 |
| Arrigo, A | 2 |
| Bono, G | 2 |
| Savoldi, F | 3 |
| Kauchtschischvili, G | 1 |
| Nath, K | 2 |
| Sur, BK | 2 |
| Tandon, RN | 2 |
| Sonninen, V | 1 |
| Rinne, UK | 1 |
| Curran, DA | 2 |
| Anthony, M | 2 |
| Hinterberger, H | 2 |
| Curzon, G | 3 |
| Barrie, M | 1 |
| Wilkinson, MI | 1 |
| Stein, W | 1 |
| Kawiak, W | 1 |
| Stelmasiak, Z | 1 |
| Gieracz, A | 1 |
| Sjaastad, O | 1 |
| Sjaastad, OV | 1 |
| Peltola, P | 1 |
| Periti, P | 1 |
| Theaker, P | 1 |
| Phillips, B | 1 |
3 reviews available for hydroxyindoleacetic acid and Migraine Disorders
| Article | Year |
|---|---|
Genetic and biochemical changes of the serotonergic system in migraine pathobiology.
Topics: Adult; Brain; Female; Genetic Predisposition to Disease; Humans; Hydroxyindoleacetic Acid; Male; Mig | 2017 |
Biochemistry of migraine.
Topics: Aspartic Acid; beta-Endorphin; Catecholamines; Enkephalin, Methionine; Estrogens; Female; Glutamates | 1992 |
The pathophysiology of migraine: a tentative synthesis.
Topics: Brain Stem; Calcitonin Gene-Related Peptide; Cerebrovascular Circulation; Cerebrovascular Disorders; | 1992 |
4 trials available for hydroxyindoleacetic acid and Migraine Disorders
| Article | Year |
|---|---|
Peripheral levels of BDNF and NGF in primary headaches.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Cluster Headache; Female; Headache Disorders, | 2006 |
A therapeutic trial in migraine with parachlorophenylalanine, a specific serotonin depletor.
Topics: Chlorine; Clinical Trials as Topic; Female; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Ph | 1970 |
Investigations into the mechanism and treatment of chronic headache.
Topics: Amitriptyline; Clinical Trials as Topic; Headache; Humans; Hydroxyindoleacetic Acid; Hypertension; M | 1965 |
Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid excretion in normal and migrainous subjects.
Topics: Adult; Blood; Clinical Trials as Topic; Female; Humans; Hydroxyindoleacetic Acid; In Vitro Technique | 1965 |
42 other studies available for hydroxyindoleacetic acid and Migraine Disorders
| Article | Year |
|---|---|
[Childhood sporadic type of hemiplegic migraine with arteria cerebri media hypoperfusion].
Topics: Brain; Diagnosis, Differential; Hemiplegia; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Mu | 2017 |
Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT
Topics: Alkaloids; Animals; Brain; Female; Hydroxyindoleacetic Acid; Ligusticum; Male; Mice; Migraine Disord | 2019 |
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migr | 2015 |
Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong.
Topics: 5-Hydroxytryptophan; Acetates; Analgesics; Animals; Benzofurans; Brain; Dopamine; Drugs, Chinese Her | 2011 |
Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period.
Topics: 5-Hydroxytryptophan; Adult; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyindoleaceti | 2006 |
Serotonin-releasing factors in migrainous patients.
Topics: Adolescent; Adult; Biological Products; Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; M | 1982 |
Migraine in children.
Topics: Child; Child, Preschool; Cross-Sectional Studies; Electroencephalography; Family Health; Female; Hum | 1994 |
Metabolism and menstrual cycle rhythmicity of serotonin in primary headaches.
Topics: Adolescent; Adult; Blood Platelets; Child; Female; Humans; Hydroxyindoleacetic Acid; Male; Menstrual | 1995 |
Platelet models and their possible usefulness in the study of migraine pathogenesis.
Topics: Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; Male; Migraine Disorders; Platelet Aggreg | 1995 |
Cerebrospinal fluid analyses in migraine patients and controls.
Topics: Adult; Analysis of Variance; Case-Control Studies; Female; Glutamine; Glycine; Homovanillic Acid; Hu | 1995 |
Platelet serotonin pathway in menstrual migraine.
Topics: Adult; Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; Menstrual Cycle; Menstruation Dist | 1996 |
Serotonin infusions inhibit sensory input from the dural vasculature.
Topics: Action Potentials; Animals; Cats; Chromatography, High Pressure Liquid; Cranial Sinuses; Dura Mater; | 1999 |
Plasma and urinary serotonin and 5-hydroxyindol-3-acetic acid in adults with migraine and tension-type headache.
Topics: Adult; Age of Onset; Electroencephalography; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle | 1999 |
Variation of plasma free tryptophan and CSF 5-HIAA during migraine.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Migraine Disorders; Tryptophan | 1977 |
Total 5-hydroxyindoles in blood related to migraine attacks.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Hydroxytryptophol; Indoles; Male; Middle Aged; Migr | 1976 |
Changes in serotonin metabolism during migraine attacks.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Migraine Disorders; Serotonin; T | 1976 |
Fluctuation of 5-hydroxy-indole compounds in the urine of migrainous patients.
Topics: Adolescent; Adult; Creatinine; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Migraine Disor | 1975 |
Protective effect of serotonin on migraine attacks.
Topics: Carcinoid Tumor; Humans; Hydroxyindoleacetic Acid; Ileal Neoplasms; Male; Middle Aged; Migraine Diso | 1992 |
Urinary 5-HIAA in migraine: evidence of lowered excretion in young adult females.
Topics: Adult; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Mig | 1986 |
Reduced platelet turnover of serotonin in diet restricted migraine patients.
Topics: Adult; Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Serotonin | 1987 |
Asthma and migraine--is asthma a part of acephalgic migraine? A hypothesis.
Topics: Asthma; Child, Preschool; Female; Humans; Hydroxyindoleacetic Acid; Male; Medicine, Chinese Traditio | 1988 |
Cerebrospinal fluid (CSF) investigations in migraine.
Topics: Adult; Cerebrospinal Fluid Pressure; Cerebrospinal Fluid Proteins; Female; Homovanillic Acid; Humans | 1989 |
Serotonin metabolism in migraine.
Topics: 5-Hydroxytryptophan; Headache; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Monoamine Oxida | 1989 |
[5-HIAA: perspectives in nephrology].
Topics: Animals; Carcinoid Tumor; Humans; Hydroxyindoleacetic Acid; Intestinal Mucosa; Kidney; Metabolic Cle | 1989 |
Platelet serotonin metabolism and ultrastructure in migraine.
Topics: Adolescent; Adult; Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; Male; Migraine Disorde | 1989 |
Parachlorophenylalanine, an inhibitor of enteramine (serotonin) synthesis in migraine.
Topics: Evaluation Studies as Topic; Female; Fenclonine; Humans; Hydroxyindoleacetic Acid; Migraine Disorder | 1970 |
[Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid in patients with migraine during attacks and in the intercritical period].
Topics: Adult; Brain; Female; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Serotonin | 1974 |
[Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid in patients with migraine before and after treatment with L-tryptophan].
Topics: Adolescent; Adult; Brain; Female; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Serotonin; T | 1974 |
[CSF levels of 5-HIAA in migraine during tryptophan therapy (author's transl)].
Topics: Adult; Brain; Humans; Hydroxyindoleacetic Acid; Middle Aged; Migraine Disorders; Serotonin; Tryptoph | 1974 |
Cerebrospinal fluid 5-hydroxyindoleacetic acid level in migrainous patients during spontaneous attacks, during headache-free periods and following treatment with L-tryptophan.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Remission, Spontaneous; Tryptop | 1974 |
Migraine: a biochemical study.
Topics: Adult; Humans; Hydroxyindoleacetic Acid; Migraine Disorders | 1972 |
Excretion of free and conjugated 5-HIAA and VMA in urine and concentration of 5-HIAA and HVA in CSF during migraine attacks and free intervals.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Male; Migraine Disorders; Vanilmandelic Acid | 1972 |
Relationships between headache and amine changes after administration of reserpine to migrainous patients.
Topics: Adolescent; Adult; Age Factors; Creatinine; Female; Headache; Humans; Hydroxyindoleacetic Acid; Inje | 1969 |
Effect of reserpine injections in migrainous and normal control subjects, with estimations of urinary 5-hydroxyindoleacetic acid.
Topics: Adult; Headache; Humans; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Migraine Disorder | 1969 |
[Effect of Deseril-Retard and Migristen on the excretion of 5-hydroxy-indoloacetic acid and P-hydroxy-M-methoxymandelic acid in the urine of patients suffering from migraine].
Topics: Adolescent; Adult; Amines; Child; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Migra | 1969 |
The histaminuria in vascular headache.
Topics: Adult; Child; Female; Gastric Juice; Headache; Histamine; Humans; Hydroxyindoleacetic Acid; Male; Mi | 1970 |
Bradykinin induced release of serotonin in man.
Topics: Bradykinin; Dumping Syndrome; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Serotonin | 1970 |
Serotonin and migraine.
Topics: Humans; Hydroxyindoleacetic Acid; Methysergide; Migraine Disorders; Norepinephrine; Reserpine; Serot | 1967 |
5-hydroxyindoles and migraine.
Topics: Circadian Rhythm; Humans; Hydroxyindoleacetic Acid; Indoles; Mandelic Acids; Migraine Disorders; Ser | 1968 |
[Tryptaminuria and serotonin and catecholamine catabolism in the course of migraine].
Topics: Catecholamines; Humans; Hydroxyindoleacetic Acid; Mandelic Acids; Migraine Disorders; Serotonin; Try | 1965 |
Excretion of 5-hydroxyindolyl acetic acid (5HIAA) in migraine.
Topics: Creatine; Humans; Hydroxyindoleacetic Acid; Mandelic Acids; Migraine Disorders; Tryptophan; Urine | 1966 |
Studies in migraine.
Topics: Cyproheptadine; Ergotamine; Humans; Hydroxyindoleacetic Acid; Methysergide; Migraine Disorders; Phen | 1966 |