hydroxyindoleacetic acid has been researched along with Lesch-Nyhan Syndrome in 11 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 7.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, were studied in a boy with the Lesch-Nyhan syndrome." | 7.65 | The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1976) |
| "Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period." | 3.67 | Lesch-Nyhan syndrome: CSF neurotransmitter abnormalities. ( Edwards, NL; Hutchinson, RJ; Johnston, MV; Silverstein, FS, 1985) |
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 3.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, were studied in a boy with the Lesch-Nyhan syndrome." | 3.65 | The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bavaresco, CS | 1 |
| Chiarani, F | 1 |
| Duringon, E | 1 |
| Ferro, MM | 1 |
| Cunha, CD | 1 |
| Netto, CA | 1 |
| Wyse, AT | 1 |
| Jinnah, HA | 1 |
| Wojcik, BE | 1 |
| Hunt, M | 1 |
| Narang, N | 1 |
| Lee, KY | 1 |
| Goldstein, M | 1 |
| Wamsley, JK | 1 |
| Langlais, PJ | 1 |
| Friedmann, T | 1 |
| Nyhan, WL | 3 |
| Sweetman, L | 1 |
| Borden, M | 1 |
| Kulovich, S | 1 |
| Kaufman, I | 1 |
| Castells, S | 1 |
| Chakrabarti, C | 1 |
| Winsberg, BG | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Ciaranello, RD | 1 |
| Anders, TF | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Cann, HM | 1 |
| Edwards, NL | 2 |
| Silverstein, FS | 2 |
| Johnston, MV | 2 |
| Van Praag, HM | 1 |
| Plutchik, R | 1 |
| Conte, H | 1 |
| Jankovic, J | 1 |
| Caskey, TC | 1 |
| Stout, JT | 1 |
| Butler, IJ | 1 |
| Hutchinson, RJ | 1 |
| Mizuno, TI | 1 |
| Yugari, Y | 1 |
1 review available for hydroxyindoleacetic acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Dopamine function in Lesch-Nyhan disease.
Topics: Dopamine; Humans; Hydroxyindoleacetic Acid; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Synd | 2000 |
1 trial available for hydroxyindoleacetic acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Letter: Self mutilation in Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Administration, Oral; Child; Dihydroxyphenylalanine; Humans; Hydroxyindoleaceti | 1974 |
9 other studies available for hydroxyindoleacetic acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Intrastriatal injection of hypoxanthine reduces striatal serotonin content and impairs spatial memory performance in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindole | 2007 |
Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Caudate Nucleus; Disease Models, Animal; Dopa | 1994 |
Altered excreton of 5-hydroxyindoleacetic acid and glycine in patients with the Lesch-Nyhan disease.
Topics: 5-Hydroxytryptophan; Adolescent; Carbidopa; Child; Child, Preschool; Glycine; Humans; Hydroxyindolea | 1977 |
Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Amino Acids; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1979 |
The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Child, Preschool; Cold Temperature; Crying; Dopamine beta-Hydroxylase; Dose-Res | 1976 |
Purine and monoamine metabolites in cerebrospinal fluid.
Topics: Age Factors; Child; Child, Preschool; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; I | 1986 |
The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence.
Topics: Aggression; Brain; Depressive Disorder; Hostility; Humans; Hydroxyindoleacetic Acid; Lesch-Nyhan Syn | 1986 |
Lesch-Nyhan syndrome: a study of motor behavior and cerebrospinal fluid neurotransmitters.
Topics: Carbidopa; Catecholamines; Child; Child, Preschool; Fluphenazine; Glycols; Homovanillic Acid; Humans | 1988 |
Lesch-Nyhan syndrome: CSF neurotransmitter abnormalities.
Topics: Adolescent; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Ac | 1985 |