hydroxyindoleacetic acid has been researched along with Irritable Bowel Syndrome in 19 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to evaluate the effect of a tryptophan-lowering diet (TRP) on abdominal and mental symptoms in patients with irritable bowel syndrome with predominant diarrhea (IBS-D)." | 8.12 | A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites. ( Blonska, A; Chojnacki, C; Chojnacki, J; Medrek-Socha, M; Poplawski, T; Zajdel, R, 2022) |
| "To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and those with ulcerative colitis (UC) in remission and to relate these differences with changes in the 5-hydroxytryptophan (5-HT) signaling pathway." | 7.83 | Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. ( Chi, HG; Huang, SG; Lv, RX; Ye, H; Yu, FY; Zhang, HY; Zheng, XB; Zou, Y, 2016) |
| " The purpose of this study was to evaluate the effect of a tryptophan-lowering diet (TRP) on abdominal and mental symptoms in patients with irritable bowel syndrome with predominant diarrhea (IBS-D)." | 4.12 | A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites. ( Blonska, A; Chojnacki, C; Chojnacki, J; Medrek-Socha, M; Poplawski, T; Zajdel, R, 2022) |
| "To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and those with ulcerative colitis (UC) in remission and to relate these differences with changes in the 5-hydroxytryptophan (5-HT) signaling pathway." | 3.83 | Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. ( Chi, HG; Huang, SG; Lv, RX; Ye, H; Yu, FY; Zhang, HY; Zheng, XB; Zou, Y, 2016) |
| "jatamansi treating irritable bowel syndrome may be related to the regulation effect to the levels of 5-HT from Gastrointestinal to central nervous system." | 1.37 | [Influence of iridoid from Valeriana jatamansi on 5-HT and 5-HIAA in rats with irritable bowel syndrome]. ( Chen, Z; Cui, X; Gao, X; Hong, Y; Lin, Q; Qin, Y; Shi, J; Yan, X; Zhang, J; Zhao, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Chojnacki, C | 6 |
| Konrad, P | 2 |
| Kaczka, A | 2 |
| Mędrek-Sochab, M | 1 |
| Chojnacki, M | 2 |
| Błońska, A | 3 |
| Medrek-Socha, M | 2 |
| Blonska, A | 2 |
| Zajdel, R | 2 |
| Chojnacki, J | 4 |
| Poplawski, T | 3 |
| Podogrocki, M | 1 |
| Stępień, A | 1 |
| Gąsiorowska, A | 1 |
| Wu, SJ | 1 |
| Wang, RY | 1 |
| Xue, JX | 1 |
| Pan, JC | 1 |
| Keszthelyi, D | 3 |
| Troost, FJ | 1 |
| Jonkers, DM | 3 |
| van Eijk, HM | 1 |
| Lindsey, PJ | 1 |
| Dekker, J | 1 |
| Buurman, WA | 1 |
| Masclee, AA | 3 |
| Thijssen, AY | 2 |
| Mujagic, Z | 2 |
| Ludidi, S | 1 |
| Hesselink, MA | 1 |
| Clemens, CH | 1 |
| Conchillo, JM | 1 |
| Kruimel, JW | 1 |
| Quigley, EM | 1 |
| Yu, FY | 1 |
| Huang, SG | 1 |
| Zhang, HY | 1 |
| Ye, H | 1 |
| Chi, HG | 1 |
| Zou, Y | 1 |
| Lv, RX | 1 |
| Zheng, XB | 1 |
| Camilleri, M | 1 |
| Brown, PM | 1 |
| Drossman, DA | 1 |
| Wood, AJ | 1 |
| Cline, GA | 1 |
| Frazier, KS | 1 |
| Jackson, JI | 1 |
| Bronner, J | 1 |
| Freiman, J | 1 |
| Zambrowicz, B | 1 |
| Sands, A | 1 |
| Gershon, MD | 1 |
| Tack, J | 1 |
| Janssen, P | 1 |
| Wouters, M | 1 |
| Boeckxstaens, G | 1 |
| Yan, X | 1 |
| Hong, Y | 1 |
| Shi, J | 1 |
| Qin, Y | 1 |
| Zhang, J | 1 |
| Lin, Q | 1 |
| Chen, Z | 1 |
| Zhao, R | 1 |
| Cui, X | 1 |
| Gao, X | 1 |
| Yazar, A | 1 |
| Büyükafpar, K | 1 |
| Polat, G | 1 |
| Pata, C | 1 |
| Kanýk, A | 1 |
| Tiftik, EN | 1 |
| Bağdatoğlu, O | 1 |
| Atkinson, W | 1 |
| Lockhart, S | 1 |
| Whorwell, PJ | 1 |
| Keevil, B | 1 |
| Houghton, LA | 1 |
| Kemperman, RF | 1 |
| Muskiet, FD | 1 |
| Boutier, AI | 1 |
| Kema, IP | 1 |
| Muskiet, FA | 1 |
| Moskwa, A | 1 |
| Wiśiewska-Jarosińska, M | 1 |
| Stec-Michalska, K | 1 |
| Szadkowski, K | 1 |
| Smigielski, J | 1 |
| Zuo, XL | 1 |
| Li, YQ | 1 |
| Yang, XZ | 1 |
| Guo, M | 1 |
| Guo, YT | 1 |
| Lu, XF | 1 |
| Li, JM | 1 |
| Desmond, PV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and IBS Patients[NCT00731003] | 60 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| A Study on the Relationship Between Biodiversity of Intestinal Microbiota in Patients and Different Sedative-hypnotics Undergoing Mechanical Ventilation[NCT03401736] | 0 participants (Actual) | Interventional | 2018-03-01 | Withdrawn (stopped due to Can't get enough participant) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyindoleacetic acid and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Serotonin in the gastrointestinal tract.
Topics: Defecation; Eating; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Hydroxyindoleacetic A | 2009 |
2 trials available for hydroxyindoleacetic acid and Irritable Bowel Syndrome
| Article | Year |
|---|---|
Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Case-Control Studies; Cross-Over Studies; Double-Blind Metho | 2014 |
The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.
Topics: Abdominal Pain; Adult; Biomarkers; Biphenyl Compounds; Constipation; Double-Blind Method; Feces; Fem | 2011 |
16 other studies available for hydroxyindoleacetic acid and Irritable Bowel Syndrome
| Article | Year |
|---|---|
The role of serotonin in pathogenesis of unclassified irritable bowel syndrome.
Topics: Cyproheptadine; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Melatonin; Serotonin | 2022 |
A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites.
Topics: Diarrhea; Diet; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Quality of Life; Seroton | 2022 |
A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites.
Topics: Diarrhea; Diet; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Quality of Life; Seroton | 2022 |
A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites.
Topics: Diarrhea; Diet; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Quality of Life; Seroton | 2022 |
A Reduced Tryptophan Diet in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Improves Their Abdominal Symptoms and Their Quality of Life through Reduction of Serotonin Levels and Its Urinary Metabolites.
Topics: Diarrhea; Diet; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Quality of Life; Seroton | 2022 |
Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome.
Topics: Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Kynurenic Acid; | 2023 |
Evaluation of serotonin and dopamine secretion and metabolism in patients with irritable bowel syndrome.
Topics: Adult; Case-Control Studies; Constipation; Diarrhea; Dopamine; Female; Humans; Hydroxyindoleacetic A | 2018 |
[Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome].
Topics: Alkaloids; Animals; Benzodioxoles; Colon; Hippocampus; Hydroxyindoleacetic Acid; Irritable Bowel Syn | 2013 |
Alterations in serotonin metabolism in the irritable bowel syndrome.
Topics: Adult; Fasting; Female; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Male; Middle Age | 2016 |
Editorial: serotonin and irritable bowel syndrome--reconciling pharmacological effects with basic biology.
Topics: Female; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Male; Quality of Life; Serotonin | 2016 |
Editorial: serotonin and irritable bowel syndrome--reconciling pharmacological effects with basic biology; authors' reply.
Topics: Female; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Male; Quality of Life; Serotonin | 2016 |
Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis.
Topics: 5-Hydroxytryptophan; Abdominal Pain; Adult; Colitis, Ulcerative; Colon; Defecation; Diarrhea; Female | 2016 |
Targeting serotonin synthesis to treat irritable bowel syndrome.
Topics: Biphenyl Compounds; Female; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Male; Phenyl | 2011 |
[Influence of iridoid from Valeriana jatamansi on 5-HT and 5-HIAA in rats with irritable bowel syndrome].
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Hydroxyindoleacetic Acid; Hypothalamus; Iridoi | 2011 |
The urinary 5-hydroxyindole acetic acid and plasma nitric oxide levels in irritable bowel syndrome: a preliminary study.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Constipation; Diarrhea; Female; Humans; Hydrox | 2005 |
Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Constipation; Diarrhea; Fasting; | 2006 |
Brief report: normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curaçao (The Netherlands antilles).
Topics: Blood Platelets; Child; Child Development Disorders, Pervasive; Diarrhea; Female; Humans; Hydroxyind | 2008 |
[Serum serotonin concentration and urine 5-hydroxyindole acetic acid excretion in patients with irritable bowel syndrome].
Topics: Adult; Constipation; Diarrhea; Down-Regulation; Fasting; Female; Humans; Hydroxyindoleacetic Acid; I | 2007 |
Plasma and gastric mucosal 5-hydroxytryptamine concentrations following cold water intake in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Adult; Area Under Curve; Blood Platelets; Cold Temperature; Diarrhea; Drinking; Fasting; Female; Gas | 2007 |