hydroxyindoleacetic acid has been researched along with Intellectual Disability in 28 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 7.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "In 8 cases of typical neuroleptic malignant syndrome (NMS), homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), noradrenaline (NA), and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels in the cerebrospinal fluid (CSF) were assayed during both the active phase of NMS and after recovery." | 3.68 | Neuroleptic malignant syndrome: a study of CSF monoamine metabolism. ( Ishiguro, T; Nisijima, K, 1990) |
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 3.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "All AADCD patients were affected by intellectual disability and psychiatric disorders." | 1.72 | Long-term neurological and psychiatric outcomes in patients with aromatic l-amino acid decarboxylase deficiency. ( Battini, R; Carducci, C; Fusco, C; Leuzzi, V; Manti, F; Mastrangelo, M; Spagnoli, C; Tolve, M, 2022) |
| "The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) gene leading to the absence of the encoded fragile X mental retardation protein 1 (FMRP)." | 1.31 | Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. ( Braun, K; Gruss, M, 2001) |
| "In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised." | 1.27 | Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (78.57) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Manti, F | 1 |
| Mastrangelo, M | 1 |
| Battini, R | 1 |
| Carducci, C | 2 |
| Spagnoli, C | 1 |
| Fusco, C | 1 |
| Tolve, M | 1 |
| Leuzzi, V | 1 |
| VALCOURT, AJ | 1 |
| HSIA, DY | 1 |
| ROWLEY, WA | 1 |
| HUANG, I | 1 |
| Gibson, KM | 1 |
| Gupta, M | 1 |
| Pearl, PL | 1 |
| Tuchman, M | 1 |
| Vezina, LG | 1 |
| Snead, OC | 1 |
| Smit, LM | 1 |
| Jakobs, C | 1 |
| Madej, A | 1 |
| Pakszys, W | 1 |
| Gillberg, C | 1 |
| Svennerholm, L | 1 |
| Hamilton-Hellberg, C | 1 |
| Gruss, M | 1 |
| Braun, K | 1 |
| Koslow, SH | 1 |
| Butler, IJ | 1 |
| Castells, S | 1 |
| Chakrabarti, C | 1 |
| Winsberg, BG | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Nyhan, WL | 1 |
| Martsinkevich, NE | 1 |
| Pozdeev, VK | 1 |
| Hanley, HG | 1 |
| Stahl, SM | 1 |
| Freedman, DX | 1 |
| Ritvo, ER | 1 |
| Greenberg, AS | 1 |
| Coleman, M | 1 |
| Martineau, J | 1 |
| Barthélémy, C | 1 |
| Jouve, J | 1 |
| Muh, JP | 1 |
| Lelord, G | 1 |
| Nisijima, K | 1 |
| Ishiguro, T | 1 |
| Zeman, J | 1 |
| Böswart, J | 1 |
| Percy, AK | 1 |
| Zoghbi, H | 1 |
| Riccardi, VM | 1 |
| Nalini, K | 1 |
| Aroor, AR | 1 |
| Rao, A | 1 |
| Bettschart, W | 1 |
| Broché, JP | 1 |
| Tissot, R | 1 |
| Pare, CM | 1 |
| Dubowitz, V | 1 |
| Rogers, KJ | 1 |
| Partington, MW | 3 |
| MacDonald, MR | 1 |
| Tu, J | 1 |
| Airaksinen, EM | 1 |
| Kauko, K | 1 |
| Himwich, WA | 1 |
| Fukuyama, GS | 1 |
| Tu, JB | 1 |
| Wong, CY | 1 |
| Lozzio, CB | 1 |
| Jauregui, GR | 1 |
| Scornavachi, JC | 1 |
| Gambin, MA | 1 |
| Pscheidt, GR | 1 |
| Berlet, HH | 1 |
| Spaide, J | 1 |
| Himwich, HE | 1 |
2 trials available for hydroxyindoleacetic acid and Intellectual Disability
| Article | Year |
|---|---|
[Correlation of the clinical and pharmaco-dynamic effects of Niamid in the treatment of severely mentally retarded children].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Down Syndrome; Female; Huma | 1965 |
5-hydroxytryptophan (5-HTP) in Down's syndrome.
Topics: 5-Hydroxytryptophan; Child; Child, Preschool; Clinical Trials as Topic; Down Syndrome; Female; Human | 1971 |
26 other studies available for hydroxyindoleacetic acid and Intellectual Disability
| Article | Year |
|---|---|
Long-term neurological and psychiatric outcomes in patients with aromatic l-amino acid decarboxylase deficiency.
Topics: Adolescent; Adult; Amino Acids; Aromatic-L-Amino-Acid Decarboxylases; Biogenic Amines; Child; Dopami | 2022 |
Study of excretion of 5-hydroxyindoleacetic acid in mental patients.
Topics: Biological Transport; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Intellectual Disability; | 1959 |
The excretion of 5-hydroxyindoleacetic acid in the heterozygous carrier for phenylketonuria.
Topics: Biological Transport; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Intellectual Disability; | 1961 |
Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria).
Topics: Adult; Aldehyde Oxidoreductases; Atrophy; Cerebellum; Chromatography, High Pressure Liquid; Chromato | 2003 |
Psychic and motor functions and serotonin (5 HT) metabolism in brain-damaged children before and after administration of Niamid and Raupasil.
Topics: Adolescent; Brain Damage, Chronic; Child; Child Behavior Disorders; Female; Humans; Hydroxyindoleace | 1967 |
Childhood psychosis and monoamine metabolites in spinal fluid.
Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; | 1983 |
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain St | 2001 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Amino Acids; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1979 |
[Serotonin metabolism in children with different forms of oligophrenia].
Topics: Child; Humans; Hydroxyindoleacetic Acid; Intellectual Disability; Reserpine; Serotonin | 1977 |
Hyperserotonemia and amine metabolites in autistic and retarded children.
Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Child; Child, Institutionalized; Child, Preschool | 1977 |
Biochemical studies of children with the syndromes of autism, childhood schizophrenia and related developmental disabilities: a review.
Topics: Autistic Disorder; Blood Platelets; Brain; Bufotenin; Child; Dopamine beta-Hydroxylase; Homovanillic | 1977 |
Depressed 5-hydroxyindole levels associated with hyperactive and aggressive behavior. Relationship to drug response.
Topics: Adolescent; Adult; Aggression; Child; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Intellectual D | 1976 |
Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: age-related changes and drug effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Autistic Disorder; Catecholamines; Child; Child Develop | 1992 |
Neuroleptic malignant syndrome: a study of CSF monoamine metabolism.
Topics: Adult; Biogenic Monoamines; Bipolar Disorder; Depressive Disorder; Female; Homovanillic Acid; Humans | 1990 |
[Metabolites of neurotransmitters in the cerebrospinal fluid in children].
Topics: Adolescent; Child; Child, Preschool; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; In | 1991 |
Rett syndrome: initial experience with an emerging clinical entity.
Topics: Adolescent; Biopsy; Child; Child Development; Child, Preschool; Electroencephalography; Female; Homo | 1985 |
Urinary levels of biogenic amine metabolites in mentally retarded children.
Topics: Adolescent; Biogenic Amines; Child; Creatinine; Female; Homovanillic Acid; Humans; Hydroxyindoleacet | 1988 |
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy | 1968 |
5-hydroxyindoles in the cerebrospinal fluid of infants with Down's syndrome and muscle hypotonia.
Topics: Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Infant; Intellectu | 1969 |
5-hydroxyindole levels in the blood and CSF in Down's syndrome, phenylketonuria and severe mental retardation.
Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; | 1972 |
Effect of probenecid on 5-hydroxyindoles in cerebrospinal fluid in Down's syndrome.
Topics: Administration, Oral; Adolescent; Child; Chromatography, Gel; Depression, Chemical; Down Syndrome; F | 1973 |
Genral neurophysiology (biochemical aspects).
Topics: Age Factors; Animals; Bipolar Disorder; Blood-Brain Barrier; Brain; Brain Diseases; Cerebrovascular | 1971 |
Blood serotonin levels in severe mental retardation.
Topics: Age Factors; Blood Pressure; Child; Child, Preschool; Defecation; Diazepam; Diet; Female; Humans; Hy | 1973 |
Chromosome mosaicism in a mentally retarded mother and her daughter.
Topics: Adolescent; Adult; Chromosomes, Human, 21-22 and Y; Female; Humans; Hydroxyindoleacetic Acid; Hypert | 1967 |
Variations of urinary creatinine and its correlation to excretion of indole metabolites in mental patients.
Topics: Chemistry, Clinical; Circadian Rhythm; Creatine; Humans; Hydroxyindoleacetic Acid; In Vitro Techniqu | 1966 |