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hydroxyindoleacetic acid and Hepatic Encephalopathy

hydroxyindoleacetic acid has been researched along with Hepatic Encephalopathy in 41 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Serotonergic systems were investigated in the frontal cortex of rats with thioacetamide (TAA)-induced acute hepatic encephalopathy (HE)."7.70Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy. ( Kaneko, K; Kurumaji, A; Toru, M; Watanabe, A; Yamada, S, 1998)
"The increase of the brain levels of 5-hydroxyindoleacetic acid (5-HIAA) in hepatic encephalopathy (HE) suggests an increased turnover of serotonin (5-HT)."7.70Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy. ( Ferenci, P; Herneth, AM; Hörtnagl, H; Roth, E; Steindl, P, 1998)
"In the present study, effects of citalopram (CIT) on brain 5-hydroxytryptamine (5-HT) release in experimental chronic hepatic encephalopathy (HE) were investigated."7.69Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Hjorth, S; Wikell, C, 1997)
"The results of this study indicate that hepatic encephalopathy in thioacetamide-induced acute liver failure in rats is associated with neurochemical changes, suggesting an increased activity of the noradrenergic and serotoninergic neurotransmitter systems."5.28Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure. ( Ferenci, P; Hörtnagl, H; Pifl, C; Roth, E; Singer, EA; Steindl, P; Yurdaydin, C; Zimmermann, C, 1990)
" The aim of this study was to evaluate serotonin levels in blood and ascitic fluid as well as excretion of 5-hydroxyindoleacetic acid (5-HIAA) in urine in patients with hepatic encephalopathy (HE)."3.79Serum and ascitic fluid serotonin levels and 5-hydroxyindoleacetic acid urine excretion in the liver of cirrhotic patients with encephalopathy. ( Chojnacki, C; Chojnacki, J; Pawlowicz, M; Stepien, A; Wachowska-Kelly, P; Walecka-Kapica, E, 2013)
"Serotonergic systems were investigated in the frontal cortex of rats with thioacetamide (TAA)-induced acute hepatic encephalopathy (HE)."3.70Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy. ( Kaneko, K; Kurumaji, A; Toru, M; Watanabe, A; Yamada, S, 1998)
"The increase of the brain levels of 5-hydroxyindoleacetic acid (5-HIAA) in hepatic encephalopathy (HE) suggests an increased turnover of serotonin (5-HT)."3.70Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy. ( Ferenci, P; Herneth, AM; Hörtnagl, H; Roth, E; Steindl, P, 1998)
"Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)."3.69Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995)
"In the present study, effects of citalopram (CIT) on brain 5-hydroxytryptamine (5-HT) release in experimental chronic hepatic encephalopathy (HE) were investigated."3.69Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Hjorth, S; Wikell, C, 1997)
"The concentrations of catecholamines, serotonin, histamine and GABA as well as some of their precursors and metabolites were measured in the CSF and the serum of human patients at different grades of hepatic encephalopathy."3.66Neurotransmitter modifications in human cerebrospinal fluid and serum during hepatic encephalopathy. ( Borg, J; Imler, M; Mack, G; Marescaux, C; Schlienger, JL; Warter, JM, 1982)
"Tyrosine (Tyr), tyrosine hydroxylase (TH), tryptophan (Trp), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were assayed spectrofluorometrically and radioenzymatically in various regions of post-mortem brains of human patients with hepatic, uremic, and diabetic coma, liver cirrhosis without coma, and hepatic coma treated with parenteral administration of L-valine, a branched-chain amino acid."3.66Brain monoamines in hepatic encephalopathy and other types of metabolic coma. ( Jellinger, K; Kothbauer, P; Rausch, WD; Riederer, P, 1978)
"The results of this study indicate that hepatic encephalopathy in thioacetamide-induced acute liver failure in rats is associated with neurochemical changes, suggesting an increased activity of the noradrenergic and serotoninergic neurotransmitter systems."1.28Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure. ( Ferenci, P; Hörtnagl, H; Pifl, C; Roth, E; Singer, EA; Steindl, P; Yurdaydin, C; Zimmermann, C, 1990)
"Clinical improvement of hepatic encephalopathy and of the underlying neurotransmitter (serotonin) and ammonia derangements by administration of L-valine suggest a possible role of this competitive amino acid on intermediary metabolism and ammonia detoxification."1.26Oral and parenteral nutrition with L-Valine: mode of action. ( Jellinger, K; Kleinberger, G; Riederer, P; Weiser, M, 1980)
"Patients with hepatic coma had an elevated concentration of 5-HIAA in the lumbar CSF which may reflect the increase in this compound and in serotonin reported by Jellinger and Riederer (1977)."1.26Tryptophan in hepatic coma. ( Sourkes, TL, 1978)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199025 (60.98)18.7374
1990's11 (26.83)18.2507
2000's3 (7.32)29.6817
2010's2 (4.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chojnacki, C1
Walecka-Kapica, E1
Stepien, A1
Pawlowicz, M1
Wachowska-Kelly, P1
Chojnacki, J1
Luo, J1
Wang, T1
Liang, S1
Hu, X1
Li, W1
Jin, F1
Holt, DE1
Washabau, RJ1
Djali, S1
Dayrell-Hart, B1
Drobatz, KJ1
Heyes, MP1
Robinson, MB1
Lozeva, V1
Montgomery, JA1
Tuomisto, L1
Rocheleau, B1
Pannunzio, M1
Huet, PM1
Butterworth, RF3
Riederer, P7
Jellinger, K7
Kleinberger, G4
Weiser, M1
Kamata, S1
Okada, A1
Watanabe, T1
Kawashima, Y1
Wada, H1
Delorme, ML1
Denis, J1
Nordlinger, B1
Boschat, M1
Opolon, P1
Ogihara, K1
Borg, J1
Warter, JM1
Schlienger, JL1
Imler, M1
Marescaux, C1
Mack, G1
Bergqvist, PB5
Vogels, BA1
Bosman, DK1
Maas, MA1
Hjorth, S5
Chamuleau, RA1
Bengtsson, F9
al Mardini, H1
Harrison, EJ1
Ince, PG1
Bartlett, K1
Record, CO1
Apelqvist, G4
Bergqvist, P1
Wikell, C2
Kaneko, K1
Kurumaji, A1
Watanabe, A1
Yamada, S1
Toru, M1
Herneth, AM1
Steindl, P2
Ferenci, P2
Roth, E2
Hörtnagl, H2
Michalak, A1
Chatauret, N1
Simert, G1
Mobin, A1
Rosengren, E2
Vang, J1
Rausch, WD3
Kothbauer, P3
Wuketich, S2
Lal, S3
Aronoff, A2
Garelis, E1
Sourkes, TL3
Young, SN2
de la Vega, CE1
Hutson, DG1
Ono, J1
Dombro, RS1
Levi, JU1
Livingstone, A1
Zeppa, R1
Livrea, P1
Di Reda, N1
De Blasi, A1
Bertolino, A1
Cummings, MG1
James, JH1
Soeters, PB1
Keane, JM1
Foster, J1
Fischer, JE1
Feldmuller, F1
Martin, JB1
Słomka, M1
Skrzydło-Radomańska, B1
Celiński, K1
Yurdaydin, C1
Zimmermann, C1
Pifl, C1
Singer, EA1
Gage, FH2
Jeppsson, B3
Nobin, A3
Moroni, F2
Lombardi, G2
Carlà, V2
Pellegrini, D1
Carassale, GL1
Cortesini, C1
Falck, B1
Etienne, P1
Nair, NP1
Bartelmess, P1
Herlin, P1
Bugge, M1
Bergeron, M1
Reader, TA1
Layrargues, GP1
Knell, AJ1
Davidson, AR1
Williams, R1
Kantamaneni, BD1
Curzon, G1

Reviews

1 review available for hydroxyindoleacetic acid and Hepatic Encephalopathy

ArticleYear
Neuropsychiatric implications of brain tryptophan perturbations appearing in hepatic encephalopathy.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Brain; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Occupational Diseases; Ser

1996

Other Studies

40 other studies available for hydroxyindoleacetic acid and Hepatic Encephalopathy

ArticleYear
Serum and ascitic fluid serotonin levels and 5-hydroxyindoleacetic acid urine excretion in the liver of cirrhotic patients with encephalopathy.
    Advances in medical sciences, 2013, Volume: 58, Issue:2

    Topics: Adult; Ascites; Ascitic Fluid; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liv

2013
Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.
    Science China. Life sciences, 2014, Volume: 57, Issue:3

    Topics: Animals; Anxiety; Brain; Cognition Disorders; Dinoprostone; Disease Models, Animal; Enzyme-Linked Im

2014
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts.
    American journal of veterinary research, 2002, Volume: 63, Issue:8

    Topics: Alanine; Animals; Dietary Proteins; Dog Diseases; Dogs; Female; Glutamine; Hepatic Encephalopathy; H

2002
Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis.
    Journal of hepatology, 2004, Volume: 40, Issue:5

    Topics: Animals; Brain; Constriction, Pathologic; Dopamine; Hepatic Encephalopathy; Histamine; Hydroxyindole

2004
Oral and parenteral nutrition with L-Valine: mode of action.
    Nutrition and metabolism, 1980, Volume: 24, Issue:4

    Topics: Aged; Ammonia; Brain; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Male; Middle

1980
Effects of dietary amino acids on brain amino acids and transmitter amines in rats with a portacaval shunt.
    Journal of neurochemistry, 1980, Volume: 35, Issue:5

    Topics: Amino Acids; Animals; Brain; Diet; Dopamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male;

1980
Relationship between plasma and brain tryptophan in pigs during experimental hepatic coma before and after hemodialysis with selective membranes.
    Journal of neurochemistry, 1981, Volume: 36, Issue:3

    Topics: Acrylic Resins; Acrylonitrile; Amino Acids; Ammonia; Animals; Brain; Cellulose; Copper; Hepatic Ence

1981
[Tryptophan and hepatic coma; retrospection and prospects by the original reporter].
    Nihon rinsho. Japanese journal of clinical medicine, 1982, Volume: 40, Issue:7

    Topics: 5-Hydroxytryptophan; Animals; Brain; Dogs; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Indoles

1982
Neurotransmitter modifications in human cerebrospinal fluid and serum during hepatic encephalopathy.
    Journal of the neurological sciences, 1982, Volume: 57, Issue:2-3

    Topics: 5-Hydroxytryptophan; Blood-Brain Barrier; Catecholamines; gamma-Aminobutyric Acid; Hepatic Encephalo

1982
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt.
    Journal of neurochemistry, 1995, Volume: 64, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; B

1995
Brain indoles in human hepatic encephalopathy.
    Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:6

    Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Hy

1993
Acute effects of L-tryptophan on brain extracellular 5-HT and 5-HIAA levels in chronic experimental portal-systemic encephalopathy.
    Metabolic brain disease, 1996, Volume: 11, Issue:3

    Topics: Animals; Brain Chemistry; Chronic Disease; Extracellular Space; Hepatic Encephalopathy; Hydroxyindol

1996
Potassium-evoked neuronal release of serotonin in experimental chronic portal-systemic encephalopathy.
    Metabolic brain disease, 1997, Volume: 12, Issue:3

    Topics: Animals; Body Weight; Calcium; Chronic Disease; Extracellular Space; Frontal Lobe; Hepatic Encephalo

1997
p-Chloroamphetamine- and d-fenfluramine-induced brain serotonin release in experimental portal-systemic encephalopathy.
    Metabolic brain disease, 1997, Volume: 12, Issue:3

    Topics: Animals; Brain; Cerebral Cortex; Extracellular Space; Fenfluramine; Hepatic Encephalopathy; Hydroxyi

1997
Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency.
    Clinical neuropharmacology, 1997, Volume: 20, Issue:6

    Topics: Animals; Antidepressive Agents; Biotransformation; Brain Chemistry; Citalopram; Extracellular Space;

1997
Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy.
    Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:1

    Topics: Acute Disease; Amphetamines; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Fro

1998
Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy.
    Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:8-9

    Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Brain; Hepatic Encephalopathy; Hydroxyindoleaceti

1998
Evidence for a serotonin transporter deficit in experimental acute liver failure.
    Neurochemistry international, 2001, Volume: 38, Issue:2

    Topics: Acute Disease; Animals; Binding Sites; Carrier Proteins; Citalopram; Hepatic Encephalopathy; Hydroxy

2001
Neurotransmittor changes in the rat brain after portacaval anastomosis.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1978, Volume: 10, Issue:2

    Topics: Animals; Blood Proteins; Brain; Dopamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Levodopa

1978
[Biochemistry of hepatic encephalopathy].
    Zeitschrift fur Gastroenterologie, 1978, Volume: 16, Issue:12

    Topics: Brain Chemistry; Dopamine; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cirrhosis

1978
[Metabolic factors in the pathogenesis of consciousness disorders and coma].
    Klinische Anasthesiologie und Intensivtherapie, 1979, Volume: 19

    Topics: Aged; Brain; Coma; Diabetic Coma; Dopamine; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid

1979
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
    Journal of neural transmission. Supplementum, 1978, Issue:14

    Topics: Aged; Animals; Brain; Coma; Diabetic Coma; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacet

1978
Cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, lactic acid, and pH before and after probenecid in hepatic coma.
    Clinical neurology and neurosurgery, 1975, Volume: 77, Issue:2

    Topics: Acid-Base Equilibrium; Adult; Aged; Dopamine; Hepatic Encephalopathy; Homovanillic Acid; Humans; Hyd

1975
Tryptophan in hepatic coma.
    Journal of neural transmission. Supplementum, 1978, Issue:14

    Topics: Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cirrhosis; Tryptophan

1978
A longitudinal study of tryptophan involvement in hepatic coma.
    American journal of surgery, 1979, Volume: 137, Issue:2

    Topics: Adult; Amino Acids; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Remission

1979
Brain monoamines in human hepatic encephalopathy.
    Acta neuropathologica, 1978, Aug-07, Volume: 43, Issue:1-2

    Topics: Aged; Brain Chemistry; Brain Stem; Coma; Diabetic Coma; Dopamine; Hepatic Encephalopathy; Humans; Hy

1978
Brain monoamines in metabolic coma and stroke.
    Advances in neurology, 1978, Volume: 20

    Topics: Acute Disease; Aged; Biogenic Amines; Brain Chemistry; Coma; Diabetic Coma; Dopamine; Female; gamma-

1978
Homovanillic acid and 5-hydroxyindoleacetic acid in human brain areas at autopsy. Effect of pre-death conditions with special attention to the state of consciousness and metabolic diseases.
    Acta neurologica, 1978, Volume: 33, Issue:6

    Topics: Adult; Aged; Brain Chemistry; Coma; Diabetic Coma; Hepatic Encephalopathy; Homovanillic Acid; Humans

1978
Brain monoamines in metabolic (endotoxic) coma. A preliminary biochemical study in human postmortem material.
    Journal of neural transmission, 1977, Volume: 41, Issue:4

    Topics: Aged; Brain Chemistry; Coma; Dopamine; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic A

1977
Regional brain study of indoleamine metabolism in the rat in acute hepatic failure.
    Journal of neurochemistry, 1976, Volume: 27, Issue:3

    Topics: Acute Disease; Animals; Brain; Fatty Acids; Female; Hepatic Encephalopathy; Hydroxyindoleacetic Acid

1976
Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:4

    Topics: Adult; Biological Transport; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver

1975
Blood serotonin (5-HT) level and 24 hrs urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) in patients with active liver cirrhosis and in patients with hepatic encephalopathy.
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1991, Volume: 46

    Topics: Adolescent; Adult; Aged; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cir

1991
Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:4 Pt 1

    Topics: Amino Acids; Animals; Brain Chemistry; Cerebral Cortex; Dopamine; Hepatic Encephalopathy; Hippocampu

1990
Brain monoamine metabolism and behavior in portacaval-shunted rats.
    Experimental neurology, 1985, Volume: 90, Issue:1

    Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Dopamine; Female; Hepatic Encephalopathy

1985
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.
    Journal of neurochemistry, 1986, Volume: 46, Issue:3

    Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic E

1986
Portacaval shunt in the rat: selective alterations in behavior and brain serotonin.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Brain Chemistry; Exploratory Behavior; Female

1986
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Aged; Cerebral Cortex; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pyridi

1986
The effect of blood ingestion on brain serotonin synthesis in portacaval-shunted rats.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1987, Volume: 187, Issue:5

    Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood; Brain; Disease Models, Animal; Explorator

1987
Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.
    Neurochemical research, 1989, Volume: 14, Issue:9

    Topics: Aged; Biogenic Monoamines; Brain; Caudate Nucleus; Cerebral Cortex; Chromatography, High Pressure Li

1989
Dopamine and serotonin metabolism in hepatic encephalopathy.
    British medical journal, 1974, Mar-23, Volume: 1, Issue:5907

    Topics: Acetaminophen; Acute Disease; Adult; Aged; Brain; Dopamine; Fatty Acids, Nonesterified; Female; Halo

1974