hydroxyindoleacetic acid has been researched along with Hepatic Encephalopathy in 41 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonergic systems were investigated in the frontal cortex of rats with thioacetamide (TAA)-induced acute hepatic encephalopathy (HE)." | 7.70 | Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy. ( Kaneko, K; Kurumaji, A; Toru, M; Watanabe, A; Yamada, S, 1998) |
| "The increase of the brain levels of 5-hydroxyindoleacetic acid (5-HIAA) in hepatic encephalopathy (HE) suggests an increased turnover of serotonin (5-HT)." | 7.70 | Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy. ( Ferenci, P; Herneth, AM; Hörtnagl, H; Roth, E; Steindl, P, 1998) |
| "In the present study, effects of citalopram (CIT) on brain 5-hydroxytryptamine (5-HT) release in experimental chronic hepatic encephalopathy (HE) were investigated." | 7.69 | Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Hjorth, S; Wikell, C, 1997) |
| "The results of this study indicate that hepatic encephalopathy in thioacetamide-induced acute liver failure in rats is associated with neurochemical changes, suggesting an increased activity of the noradrenergic and serotoninergic neurotransmitter systems." | 5.28 | Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure. ( Ferenci, P; Hörtnagl, H; Pifl, C; Roth, E; Singer, EA; Steindl, P; Yurdaydin, C; Zimmermann, C, 1990) |
| " The aim of this study was to evaluate serotonin levels in blood and ascitic fluid as well as excretion of 5-hydroxyindoleacetic acid (5-HIAA) in urine in patients with hepatic encephalopathy (HE)." | 3.79 | Serum and ascitic fluid serotonin levels and 5-hydroxyindoleacetic acid urine excretion in the liver of cirrhotic patients with encephalopathy. ( Chojnacki, C; Chojnacki, J; Pawlowicz, M; Stepien, A; Wachowska-Kelly, P; Walecka-Kapica, E, 2013) |
| "Serotonergic systems were investigated in the frontal cortex of rats with thioacetamide (TAA)-induced acute hepatic encephalopathy (HE)." | 3.70 | Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy. ( Kaneko, K; Kurumaji, A; Toru, M; Watanabe, A; Yamada, S, 1998) |
| "The increase of the brain levels of 5-hydroxyindoleacetic acid (5-HIAA) in hepatic encephalopathy (HE) suggests an increased turnover of serotonin (5-HT)." | 3.70 | Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy. ( Ferenci, P; Herneth, AM; Hörtnagl, H; Roth, E; Steindl, P, 1998) |
| "Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)." | 3.69 | Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995) |
| "In the present study, effects of citalopram (CIT) on brain 5-hydroxytryptamine (5-HT) release in experimental chronic hepatic encephalopathy (HE) were investigated." | 3.69 | Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. ( Apelqvist, G; Bengtsson, F; Bergqvist, PB; Hjorth, S; Wikell, C, 1997) |
| "The concentrations of catecholamines, serotonin, histamine and GABA as well as some of their precursors and metabolites were measured in the CSF and the serum of human patients at different grades of hepatic encephalopathy." | 3.66 | Neurotransmitter modifications in human cerebrospinal fluid and serum during hepatic encephalopathy. ( Borg, J; Imler, M; Mack, G; Marescaux, C; Schlienger, JL; Warter, JM, 1982) |
| "Tyrosine (Tyr), tyrosine hydroxylase (TH), tryptophan (Trp), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were assayed spectrofluorometrically and radioenzymatically in various regions of post-mortem brains of human patients with hepatic, uremic, and diabetic coma, liver cirrhosis without coma, and hepatic coma treated with parenteral administration of L-valine, a branched-chain amino acid." | 3.66 | Brain monoamines in hepatic encephalopathy and other types of metabolic coma. ( Jellinger, K; Kothbauer, P; Rausch, WD; Riederer, P, 1978) |
| "The results of this study indicate that hepatic encephalopathy in thioacetamide-induced acute liver failure in rats is associated with neurochemical changes, suggesting an increased activity of the noradrenergic and serotoninergic neurotransmitter systems." | 1.28 | Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure. ( Ferenci, P; Hörtnagl, H; Pifl, C; Roth, E; Singer, EA; Steindl, P; Yurdaydin, C; Zimmermann, C, 1990) |
| "Clinical improvement of hepatic encephalopathy and of the underlying neurotransmitter (serotonin) and ammonia derangements by administration of L-valine suggest a possible role of this competitive amino acid on intermediary metabolism and ammonia detoxification." | 1.26 | Oral and parenteral nutrition with L-Valine: mode of action. ( Jellinger, K; Kleinberger, G; Riederer, P; Weiser, M, 1980) |
| "Patients with hepatic coma had an elevated concentration of 5-HIAA in the lumbar CSF which may reflect the increase in this compound and in serotonin reported by Jellinger and Riederer (1977)." | 1.26 | Tryptophan in hepatic coma. ( Sourkes, TL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (60.98) | 18.7374 |
| 1990's | 11 (26.83) | 18.2507 |
| 2000's | 3 (7.32) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chojnacki, C | 1 |
| Walecka-Kapica, E | 1 |
| Stepien, A | 1 |
| Pawlowicz, M | 1 |
| Wachowska-Kelly, P | 1 |
| Chojnacki, J | 1 |
| Luo, J | 1 |
| Wang, T | 1 |
| Liang, S | 1 |
| Hu, X | 1 |
| Li, W | 1 |
| Jin, F | 1 |
| Holt, DE | 1 |
| Washabau, RJ | 1 |
| Djali, S | 1 |
| Dayrell-Hart, B | 1 |
| Drobatz, KJ | 1 |
| Heyes, MP | 1 |
| Robinson, MB | 1 |
| Lozeva, V | 1 |
| Montgomery, JA | 1 |
| Tuomisto, L | 1 |
| Rocheleau, B | 1 |
| Pannunzio, M | 1 |
| Huet, PM | 1 |
| Butterworth, RF | 3 |
| Riederer, P | 7 |
| Jellinger, K | 7 |
| Kleinberger, G | 4 |
| Weiser, M | 1 |
| Kamata, S | 1 |
| Okada, A | 1 |
| Watanabe, T | 1 |
| Kawashima, Y | 1 |
| Wada, H | 1 |
| Delorme, ML | 1 |
| Denis, J | 1 |
| Nordlinger, B | 1 |
| Boschat, M | 1 |
| Opolon, P | 1 |
| Ogihara, K | 1 |
| Borg, J | 1 |
| Warter, JM | 1 |
| Schlienger, JL | 1 |
| Imler, M | 1 |
| Marescaux, C | 1 |
| Mack, G | 1 |
| Bergqvist, PB | 5 |
| Vogels, BA | 1 |
| Bosman, DK | 1 |
| Maas, MA | 1 |
| Hjorth, S | 5 |
| Chamuleau, RA | 1 |
| Bengtsson, F | 9 |
| al Mardini, H | 1 |
| Harrison, EJ | 1 |
| Ince, PG | 1 |
| Bartlett, K | 1 |
| Record, CO | 1 |
| Apelqvist, G | 4 |
| Bergqvist, P | 1 |
| Wikell, C | 2 |
| Kaneko, K | 1 |
| Kurumaji, A | 1 |
| Watanabe, A | 1 |
| Yamada, S | 1 |
| Toru, M | 1 |
| Herneth, AM | 1 |
| Steindl, P | 2 |
| Ferenci, P | 2 |
| Roth, E | 2 |
| Hörtnagl, H | 2 |
| Michalak, A | 1 |
| Chatauret, N | 1 |
| Simert, G | 1 |
| Mobin, A | 1 |
| Rosengren, E | 2 |
| Vang, J | 1 |
| Rausch, WD | 3 |
| Kothbauer, P | 3 |
| Wuketich, S | 2 |
| Lal, S | 3 |
| Aronoff, A | 2 |
| Garelis, E | 1 |
| Sourkes, TL | 3 |
| Young, SN | 2 |
| de la Vega, CE | 1 |
| Hutson, DG | 1 |
| Ono, J | 1 |
| Dombro, RS | 1 |
| Levi, JU | 1 |
| Livingstone, A | 1 |
| Zeppa, R | 1 |
| Livrea, P | 1 |
| Di Reda, N | 1 |
| De Blasi, A | 1 |
| Bertolino, A | 1 |
| Cummings, MG | 1 |
| James, JH | 1 |
| Soeters, PB | 1 |
| Keane, JM | 1 |
| Foster, J | 1 |
| Fischer, JE | 1 |
| Feldmuller, F | 1 |
| Martin, JB | 1 |
| Słomka, M | 1 |
| Skrzydło-Radomańska, B | 1 |
| Celiński, K | 1 |
| Yurdaydin, C | 1 |
| Zimmermann, C | 1 |
| Pifl, C | 1 |
| Singer, EA | 1 |
| Gage, FH | 2 |
| Jeppsson, B | 3 |
| Nobin, A | 3 |
| Moroni, F | 2 |
| Lombardi, G | 2 |
| Carlà, V | 2 |
| Pellegrini, D | 1 |
| Carassale, GL | 1 |
| Cortesini, C | 1 |
| Falck, B | 1 |
| Etienne, P | 1 |
| Nair, NP | 1 |
| Bartelmess, P | 1 |
| Herlin, P | 1 |
| Bugge, M | 1 |
| Bergeron, M | 1 |
| Reader, TA | 1 |
| Layrargues, GP | 1 |
| Knell, AJ | 1 |
| Davidson, AR | 1 |
| Williams, R | 1 |
| Kantamaneni, BD | 1 |
| Curzon, G | 1 |
1 review available for hydroxyindoleacetic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Neuropsychiatric implications of brain tryptophan perturbations appearing in hepatic encephalopathy.
Topics: Animals; Brain; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Occupational Diseases; Ser | 1996 |
40 other studies available for hydroxyindoleacetic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Serum and ascitic fluid serotonin levels and 5-hydroxyindoleacetic acid urine excretion in the liver of cirrhotic patients with encephalopathy.
Topics: Adult; Ascites; Ascitic Fluid; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liv | 2013 |
Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.
Topics: Animals; Anxiety; Brain; Cognition Disorders; Dinoprostone; Disease Models, Animal; Enzyme-Linked Im | 2014 |
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts.
Topics: Alanine; Animals; Dietary Proteins; Dog Diseases; Dogs; Female; Glutamine; Hepatic Encephalopathy; H | 2002 |
Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis.
Topics: Animals; Brain; Constriction, Pathologic; Dopamine; Hepatic Encephalopathy; Histamine; Hydroxyindole | 2004 |
Oral and parenteral nutrition with L-Valine: mode of action.
Topics: Aged; Ammonia; Brain; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Male; Middle | 1980 |
Effects of dietary amino acids on brain amino acids and transmitter amines in rats with a portacaval shunt.
Topics: Amino Acids; Animals; Brain; Diet; Dopamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; | 1980 |
Relationship between plasma and brain tryptophan in pigs during experimental hepatic coma before and after hemodialysis with selective membranes.
Topics: Acrylic Resins; Acrylonitrile; Amino Acids; Ammonia; Animals; Brain; Cellulose; Copper; Hepatic Ence | 1981 |
[Tryptophan and hepatic coma; retrospection and prospects by the original reporter].
Topics: 5-Hydroxytryptophan; Animals; Brain; Dogs; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Indoles | 1982 |
Neurotransmitter modifications in human cerebrospinal fluid and serum during hepatic encephalopathy.
Topics: 5-Hydroxytryptophan; Blood-Brain Barrier; Catecholamines; gamma-Aminobutyric Acid; Hepatic Encephalo | 1982 |
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; B | 1995 |
Brain indoles in human hepatic encephalopathy.
Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Hy | 1993 |
Acute effects of L-tryptophan on brain extracellular 5-HT and 5-HIAA levels in chronic experimental portal-systemic encephalopathy.
Topics: Animals; Brain Chemistry; Chronic Disease; Extracellular Space; Hepatic Encephalopathy; Hydroxyindol | 1996 |
Potassium-evoked neuronal release of serotonin in experimental chronic portal-systemic encephalopathy.
Topics: Animals; Body Weight; Calcium; Chronic Disease; Extracellular Space; Frontal Lobe; Hepatic Encephalo | 1997 |
p-Chloroamphetamine- and d-fenfluramine-induced brain serotonin release in experimental portal-systemic encephalopathy.
Topics: Animals; Brain; Cerebral Cortex; Extracellular Space; Fenfluramine; Hepatic Encephalopathy; Hydroxyi | 1997 |
Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency.
Topics: Animals; Antidepressive Agents; Biotransformation; Brain Chemistry; Citalopram; Extracellular Space; | 1997 |
Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy.
Topics: Acute Disease; Amphetamines; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Fro | 1998 |
Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy.
Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Brain; Hepatic Encephalopathy; Hydroxyindoleaceti | 1998 |
Evidence for a serotonin transporter deficit in experimental acute liver failure.
Topics: Acute Disease; Animals; Binding Sites; Carrier Proteins; Citalopram; Hepatic Encephalopathy; Hydroxy | 2001 |
Neurotransmittor changes in the rat brain after portacaval anastomosis.
Topics: Animals; Blood Proteins; Brain; Dopamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Levodopa | 1978 |
[Biochemistry of hepatic encephalopathy].
Topics: Brain Chemistry; Dopamine; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cirrhosis | 1978 |
[Metabolic factors in the pathogenesis of consciousness disorders and coma].
Topics: Aged; Brain; Coma; Diabetic Coma; Dopamine; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid | 1979 |
Brain monoamines in hepatic encephalopathy and other types of metabolic coma.
Topics: Aged; Animals; Brain; Coma; Diabetic Coma; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacet | 1978 |
Cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, lactic acid, and pH before and after probenecid in hepatic coma.
Topics: Acid-Base Equilibrium; Adult; Aged; Dopamine; Hepatic Encephalopathy; Homovanillic Acid; Humans; Hyd | 1975 |
Tryptophan in hepatic coma.
Topics: Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cirrhosis; Tryptophan | 1978 |
A longitudinal study of tryptophan involvement in hepatic coma.
Topics: Adult; Amino Acids; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Remission | 1979 |
Brain monoamines in human hepatic encephalopathy.
Topics: Aged; Brain Chemistry; Brain Stem; Coma; Diabetic Coma; Dopamine; Hepatic Encephalopathy; Humans; Hy | 1978 |
Brain monoamines in metabolic coma and stroke.
Topics: Acute Disease; Aged; Biogenic Amines; Brain Chemistry; Coma; Diabetic Coma; Dopamine; Female; gamma- | 1978 |
Homovanillic acid and 5-hydroxyindoleacetic acid in human brain areas at autopsy. Effect of pre-death conditions with special attention to the state of consciousness and metabolic diseases.
Topics: Adult; Aged; Brain Chemistry; Coma; Diabetic Coma; Hepatic Encephalopathy; Homovanillic Acid; Humans | 1978 |
Brain monoamines in metabolic (endotoxic) coma. A preliminary biochemical study in human postmortem material.
Topics: Aged; Brain Chemistry; Coma; Dopamine; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic A | 1977 |
Regional brain study of indoleamine metabolism in the rat in acute hepatic failure.
Topics: Acute Disease; Animals; Brain; Fatty Acids; Female; Hepatic Encephalopathy; Hydroxyindoleacetic Acid | 1976 |
Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.
Topics: Adult; Biological Transport; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver | 1975 |
Blood serotonin (5-HT) level and 24 hrs urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) in patients with active liver cirrhosis and in patients with hepatic encephalopathy.
Topics: Adolescent; Adult; Aged; Female; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Liver Cir | 1991 |
Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide-induced acute liver failure.
Topics: Amino Acids; Animals; Brain Chemistry; Cerebral Cortex; Dopamine; Hepatic Encephalopathy; Hippocampu | 1990 |
Brain monoamine metabolism and behavior in portacaval-shunted rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Dopamine; Female; Hepatic Encephalopathy | 1985 |
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.
Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic E | 1986 |
Portacaval shunt in the rat: selective alterations in behavior and brain serotonin.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Brain Chemistry; Exploratory Behavior; Female | 1986 |
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.
Topics: Aged; Cerebral Cortex; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pyridi | 1986 |
The effect of blood ingestion on brain serotonin synthesis in portacaval-shunted rats.
Topics: 5-Hydroxytryptophan; Amino Acids; Ammonia; Animals; Blood; Brain; Disease Models, Animal; Explorator | 1987 |
Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.
Topics: Aged; Biogenic Monoamines; Brain; Caudate Nucleus; Cerebral Cortex; Chromatography, High Pressure Li | 1989 |
Dopamine and serotonin metabolism in hepatic encephalopathy.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Brain; Dopamine; Fatty Acids, Nonesterified; Female; Halo | 1974 |