hydroxyindoleacetic acid has been researched along with Friedreich Ataxia in 3 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Botez, MI | 1 |
| Young, SN | 1 |
| Rohmer, F | 1 |
| Warter, JM | 1 |
| Coquillat, G | 1 |
| Maitrot, D | 1 |
| Kurtz, D | 1 |
| Micheletti, G | 1 |
| Mack, G | 1 |
| Mandel, P | 1 |
| Robinson, N | 1 |
| Curzon, G | 1 |
| Theaker, P | 1 |
1 trial available for hydroxyindoleacetic acid and Friedreich Ataxia
| Article | Year |
|---|---|
[Pharmacological and biochemical approach to a syndrome of action and intention myoclonus in the course of degenerative disease of the nervous system].
Topics: 5-Hydroxytryptophan; Adult; Benzazepines; Cerebellar Ataxia; Clinical Trials as Topic; Diagnosis, Di | 1973 |
2 other studies available for hydroxyindoleacetic acid and Friedreich Ataxia
| Article | Year |
|---|---|
Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias.
Topics: Adult; Aged; Female; Friedreich Ataxia; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Magneti | 2001 |
Excretion of tryptophan metabolites in Friedreich's ataxia.
Topics: Friedreich Ataxia; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Tryptophan; Uri | 1965 |