hydroxyindoleacetic acid has been researched along with Dystonia in 20 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism." | 5.30 | Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Hyland, K, 1998) |
| "Two cases of severe dystonia and dyskinesia were treated with talipexole, a dopamine autoreceptor agonist, and the metabolites of dopamine, norepinephrine, and serotonin in cerebrospinal fluid (CSF) were determined." | 3.68 | Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans. ( Koga, I; Nishikawa, T; Tanaka, M; Tsuda, A; Uchida, Y; Yamada, S, 1990) |
| "Two pairs of siblings with severe dystonia with marked diurnal fluctuation had both reduced CSF concentration of biopterin and marked symptomatic improvement of the dystonia in response to levodopa." | 3.67 | Dystonia with marked diurnal variation associated with biopterin deficiency. ( Barton, N; Burns, RS; Cohen, W; Fink, JK; Hallett, M; Lovenberg, W, 1988) |
| "Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), the respective metabolites of dopamine and serotonin, were measured in ventricular fluid obtained from 20 patients with torsion dystonia at the time of ventriculography prior to thalamic surgery." | 3.66 | Diminished ventricular fluid dopamine metabolites in adult-onset dystonia. ( Sharpless, NS; Tabaddor, K; Wolfson, LI, 1978) |
| "Mitochondrial disorders are clinically heterogeneous." | 1.35 | Mitochondrial diseases mimicking neurotransmitter defects. ( Artuch, R; Briones, P; Carrilho, I; Duarte, S; Garcia-Cazorla, A; Garesse, R; Montoya, J; Nascimento, A; Ormazabal, A; Pineda, M; Sala-Castellvi, P; Serrano, M, 2008) |
| "The typical infantile form of dystonia is benign, resolving by 2 years of age in an otherwise normal child." | 1.31 | Infantile-onset paroxysmal dystonia: a diagnostic dilemma. ( Antony, J; Howman-Giles, R; Wilmshurst, JM, 2001) |
| "Childhood dystonia that does not respond to treatment with levodopa (dopa-nonresponsive dystonia, DND) has an unclear pathogenesis and is notoriously difficult to treat." | 1.31 | Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia. ( Assmann, B; Heales, S; Hoffmann, GF; Köhler, M; Surtees, R, 2002) |
| "Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism." | 1.30 | Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Hyland, K, 1998) |
| "Rapid-onset dystonia-parkinsonism (RDP) is an autosomal dominant disorder characterized by the rapid onset of dystonic spasms and parkinsonism over a period of a few hours to weeks after their onset." | 1.29 | Variable phenotype of rapid-onset dystonia-parkinsonism. ( Brashear, A; Butler, IJ; Dobyns, WB; Farlow, MR; Kasarskis, EJ, 1996) |
| "HVA levels in dystonia patients (30." | 1.29 | Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism. ( Götz, M; Lange, KW; Naumann, M; Reiners, K; Riederer, P, 1996) |
| "We describe two sporadic cases of dystonia-parkinsonism at different stages of disease progression." | 1.28 | Consideration on two cases of dystonia-parkinsonism. ( Balottin, U; Borgatti, R; Lanzi, G; Zambrino, CA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (45.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia-Cazorla, A | 1 |
| Duarte, S | 1 |
| Serrano, M | 1 |
| Nascimento, A | 1 |
| Ormazabal, A | 1 |
| Carrilho, I | 1 |
| Briones, P | 1 |
| Montoya, J | 1 |
| Garesse, R | 1 |
| Sala-Castellvi, P | 1 |
| Pineda, M | 1 |
| Artuch, R | 1 |
| Kurian, MA | 1 |
| Li, Y | 1 |
| Zhen, J | 1 |
| Meyer, E | 1 |
| Hai, N | 1 |
| Christen, HJ | 1 |
| Hoffmann, GF | 2 |
| Jardine, P | 1 |
| von Moers, A | 1 |
| Mordekar, SR | 1 |
| O'Callaghan, F | 1 |
| Wassmer, E | 1 |
| Wraige, E | 1 |
| Dietrich, C | 1 |
| Lewis, T | 1 |
| Hyland, K | 2 |
| Heales, S | 2 |
| Sanger, T | 1 |
| Gissen, P | 1 |
| Assmann, BE | 1 |
| Reith, ME | 1 |
| Maher, ER | 1 |
| Barnett, MH | 1 |
| Jarman, PR | 1 |
| Heales, SJ | 1 |
| Bhatia, KP | 1 |
| Willemse, J | 1 |
| van Nieuwenhuizen, O | 1 |
| Gooskens, RH | 1 |
| Westenberg, HG | 1 |
| Ledoux, MS | 1 |
| Lorden, JF | 1 |
| Ervin, JM | 1 |
| Brashear, A | 2 |
| Farlow, MR | 2 |
| Butler, IJ | 2 |
| Kasarskis, EJ | 1 |
| Dobyns, WB | 2 |
| Naumann, M | 1 |
| Götz, M | 1 |
| Reiners, K | 1 |
| Lange, KW | 1 |
| Riederer, P | 1 |
| Wilmshurst, JM | 1 |
| Howman-Giles, R | 1 |
| Antony, J | 1 |
| Assmann, B | 1 |
| Köhler, M | 1 |
| Surtees, R | 1 |
| Tabaddor, K | 1 |
| Wolfson, LI | 2 |
| Sharpless, NS | 2 |
| Ouvrier, RA | 1 |
| Nishikawa, T | 1 |
| Yamada, S | 1 |
| Tsuda, A | 1 |
| Tanaka, M | 1 |
| Koga, I | 1 |
| Uchida, Y | 1 |
| Zambrino, CA | 1 |
| Balottin, U | 1 |
| Borgatti, R | 1 |
| Lanzi, G | 1 |
| Fink, JK | 2 |
| Barton, N | 1 |
| Cohen, W | 1 |
| Lovenberg, W | 2 |
| Burns, RS | 2 |
| Hallett, M | 2 |
| Thal, LJ | 1 |
| LeWitt, PA | 1 |
| Miller, LP | 1 |
| Levine, RA | 2 |
| Newman, RP | 1 |
| Papavasiliou, A | 1 |
| Rayes, A | 1 |
| Eldridge, R | 1 |
| Maekawa, N | 1 |
| Hashimoto, T | 1 |
| Sasaki, M | 1 |
| Oishi, T | 1 |
| Tsuji, S | 1 |
| Ravin, P | 1 |
| Argoff, CE | 1 |
| Brady, RO | 1 |
| Barton, NW | 1 |
| Stahl, SM | 1 |
| Faull, KF | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage[NCT03987139] | 45 participants (Anticipated) | Interventional | 2019-06-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 other studies available for hydroxyindoleacetic acid and Dystonia
| Article | Year |
|---|---|
Mitochondrial diseases mimicking neurotransmitter defects.
Topics: Alanine; Brain; Child, Preschool; Consanguinity; Diagnosis, Differential; Dopamine Agents; Dystonia; | 2008 |
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.
Topics: Brain; Cell Line, Transformed; Child; Child, Preschool; Cohort Studies; Dopamine Plasma Membrane Tra | 2011 |
Further case of paroxysmal exercise-induced dystonia and some insights into pathogenesis.
Topics: Adult; Dopamine; Dystonia; Exercise; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Neur | 2002 |
Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach.
Topics: Adolescent; Basal Ganglia; Child; Chromatography, High Pressure Liquid; Dystonia; Female; Homovanill | 1984 |
Inferior olive serotonin and norepinephrine levels during development in the genetically dystonic rat.
Topics: Aging; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; Dystonia; Hydroxyindoleaceti | 1994 |
Variable phenotype of rapid-onset dystonia-parkinsonism.
Topics: Adolescent; Adult; Dopamine; Dystonia; Female; Follow-Up Studies; Genetic Carrier Screening; Homovan | 1996 |
Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Case-Control Studies; Dopamine; Dystonia; Female; Homo | 1996 |
Cerebrospinal fluid homovanillic acid levels in rapid-onset dystonia-parkinsonism.
Topics: Adult; Aged; Antiparkinson Agents; Biomarkers; Deglutition Disorders; Dopamine; Dysarthria; Dystonia | 1998 |
Infantile-onset paroxysmal dystonia: a diagnostic dilemma.
Topics: Brain; Consanguinity; Dominance, Cerebral; Dystonia; Homovanillic Acid; Humans; Hydroxyindoleacetic | 2001 |
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Topics: Adolescent; Central Nervous System; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine Agents | 2002 |
Diminished ventricular fluid dopamine metabolites in adult-onset dystonia.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Dystonia; Female; Homovanillic Acid; Humans | 1978 |
Progressive dystonia with marked diurnal fluctuation.
Topics: Child; Circadian Rhythm; Diagnosis, Differential; Dystonia; Female; Homovanillic Acid; Humans; Hydro | 1978 |
Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Azepines; Dopamine Agents; Dystonia; Homovanillic Acid; Humans | 1990 |
Consideration on two cases of dystonia-parkinsonism.
Topics: Carbidopa; Child; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; M | 1991 |
Dystonia with marked diurnal variation associated with biopterin deficiency.
Topics: Adolescent; Adult; Biopterins; Carbidopa; Child; Child, Preschool; Circadian Rhythm; Drug Combinatio | 1988 |
Diminished levels of ventricular fluid norepinephrine metabolite and somatostatin in childhood-onset dystonia.
Topics: Adolescent; Adult; Age Factors; Cerebral Palsy; Child; Child, Preschool; Dystonia; Homovanillic Acid | 1988 |
Pterin abnormalities in dystonia: a metabolic marker with therapeutic implications.
Topics: Adult; Biopterins; Central Nervous System; Dystonia; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1988 |
[A study on catecholamine metabolites in CSF in a patient with progressive dystonia with marked diurnal fluctuation].
Topics: Adolescent; Catecholamines; Circadian Rhythm; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyin | 1988 |
Tetrahydrobiopterin administration in biopterin-deficient progressive dystonia with diurnal variation.
Topics: Adult; Biopterins; Child; Circadian Rhythm; Dystonia; Female; Homovanillic Acid; Humans; Hydroxyindo | 1989 |
CSF monamine metabolites in movement disorders and normal aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Dyskinesia, Drug-Induced; Dystonia; Female; Glycols; Ho | 1985 |