Page last updated: 2024-10-21

hydroxyindoleacetic acid and Down Syndrome

hydroxyindoleacetic acid has been researched along with Down Syndrome in 34 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (91.18)	18.7374
1990's	2 (5.88)	18.2507
2000's	1 (2.94)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Taşdemir, HA	1
Cetinkaya, MC	1
Polat, C	1
Belet, U	1
Kalayci, AG	1
Akbaş, S	1
Seidl, R	1
Kaehler, ST	1
Prast, H	1
Singewald, N	1
Cairns, N	1
Gratzer, M	1
Lubec, G	1
Ternaux, JP	1
Mattei, JF	1
Faudon, M	1
Barrit, MC	1
Ardissone, JP	1
Giraud, F	1
Tu, JB	1
Wong, CY	1
Komatsu, H	1
Nishimura, A	1
Okano, S	1
Miyanomae, Y	1
Takeuchi, Y	1
Sawada, T	1
Kay, AD	2
Schapiro, MB	2
Riker, AK	1
Haxby, JV	2
Rapoport, SI	2
Cutler, NR	1
Godridge, H	1
Reynolds, GP	1
Czudek, C	1
Calcutt, NA	1
Benton, M	1
May, C	1
Ryker, AK	1
Kaufman, S	1
Milstien, S	1
Adlard, BP	1
De Souza, SW	1
Tricklebank, MD	1
Bettschart, W	2
Broché, JP	1
Tissot, R	2
Guggisberg, M	1
Constantinidis, J	1
Paulson, GW	2
Nance, W	1
Son, C	1
Pare, CM	1
Son, CD	1
Nance, WE	1
Dubowitz, V	2
Rogers, K	1
Rogers, KJ	1
Coleman, M	1
Benson, PF	1
Southgate, J	1
Partington, MW	2
MacDonald, MR	1
Gordon, EK	2
Oliver, J	1
Tu, J	1
Lott, IT	1
Murphy, DL	1
Chase, TN	3
Papeschi, R	1
Molina-Negro, P	1
Sourkes, TL	1
Erba, G	1
Chiancone, FM	1
Andersson, H	1
Fällström, SP	1
Lundborg, P	1
Roos, BE	1
Boullin, DJ	1
O'Brien, RA	1
Ng, LK	1
Burger, PC	1
Vogel, FS	1
Airaksinen, EM	2
Kauko, K	1
Weise, P	1
Koch, R	1
Shaw, KN	1
Rosenfeld, MJ	1
Kamoun, P	1
Lafourcade, G	1
Jerome, H	1
Bazelon, M	1
Barnet, A	1
Lodge, A	1
Shelburne, SA	1

Reviews

1 review available for hydroxyindoleacetic acid and Down Syndrome

Article	Year
Serotonergic mechanisms and extrapyramidal function in man. Advances in neurology, 1974, Volume: 5 Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr	1974

Trials

3 trials available for hydroxyindoleacetic acid and Down Syndrome

Article	Year
[Correlation of the clinical and pharmaco-dynamic effects of Niamid in the treatment of severely mentally retarded children]. Annales paediatrici. International review of pediatrics, 1965, Volume: 205, Issue:3 Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Down Syndrome; Female; Huma	1965
5-hydroxytryptophan (5-HTP) in Down's syndrome. Developmental medicine and child neurology, 1971, Volume: 13, Issue:3 Topics: 5-Hydroxytryptophan; Child; Child, Preschool; Clinical Trials as Topic; Down Syndrome; Female; Human	1971
Platelet-rich plasma 5-hydroxytryptamine, urinary 5-hydroxyindoleacetic acid and tryptophan ingestion in mongols. Journal of mental deficiency research, 1971, Volume: 15 Pt 4, Issue:0 Topics: Adolescent; Adult; Blood Platelets; Blood Specimen Collection; Child; Child, Preschool; Chromosome A	1971

Other Studies

30 other studies available for hydroxyindoleacetic acid and Down Syndrome

Article	Year
Gallbladder motility in children with Down syndrome. Journal of pediatric gastroenterology and nutrition, 2004, Volume: 39, Issue:2 Topics: Case-Control Studies; Child, Preschool; Confidence Intervals; Down Syndrome; Female; Gallbladder; Ga	2004
Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum, 1999, Volume: 57 Topics: Adult; Alzheimer Disease; Brain; Caudate Nucleus; Cerebellum; Chromatography, High Pressure Liquid;	1999
Peripheral and central 5-hydroxytryptamine in trisomy 21. Life sciences, 1979, Dec-03, Volume: 25, Issue:23 Topics: Adolescent; Albumins; Child; Down Syndrome; Fatty Acids, Nonesterified; Female; Humans; Hydroxyindol	1979
Serotonin metabolism in normal and abnormal infants during the perinatal period. Biology of the neonate, 1976, Volume: 29, Issue:3-4 Topics: Amniotic Fluid; Down Syndrome; Female; Fetal Blood; Humans; Hydroxyindoleacetic Acid; Infant, Newbor	1976
Neuroleptic malignant syndrome-like state in a patient with Down syndrome and basal ganglia calcification. Brain & development, 1992, Volume: 14, Issue:6 Topics: Adolescent; Basal Ganglia Diseases; Calcinosis; Down Syndrome; Homovanillic Acid; Humans; Hydroxyind	1992
Cerebrospinal fluid monoaminergic metabolites are elevated in adults with Down's syndrome. Annals of neurology, 1987, Volume: 21, Issue:4 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Catecholamines; Down Syndrome; Female; Homovanillic Aci	1987
Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue. Journal of neurology, neurosurgery, and psychiatry, 1987, Volume: 50, Issue:6 Topics: Acetylcholine; Adult; Age Factors; Alzheimer Disease; Brain; Choline O-Acetyltransferase; Dopamine;	1987
Cerebrospinal fluid monoamines in Down's syndrome adults at different ages. Journal of mental deficiency research, 1987, Volume: 31 ( Pt 3) Topics: Adult; Age Factors; Amines; Biopterins; Catecholamines; Cognition; Dementia; Down Syndrome; Female;	1987
Letter: 5-hydroxyindoleacetic acid in Down's syndrome. Lancet (London, England), 1974, May-11, Volume: 1, Issue:7863 Topics: Blood Cell Count; Blood Platelets; Child, Preschool; Chromosomes, Human, 21-22 and Y; Down Syndrome;	1974
[Urinary excretion of 5-hydroxyindoleacetic acid, vanillomandelic acid and xanthurenic acid in 18 Mongoloids]. Pathologie et biologie, 1966, Volume: 14, Issue:5 Topics: Down Syndrome; Humans; Hydroxyindoleacetic Acid; In Vitro Techniques; Mandelic Acids; Xanthurenates	1966
Neurologic aspects of typical and atypical Down's syndrome. Neurology, 1968, Volume: 18, Issue:3 Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Down Syndrome; Electroencepha	1968
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives. Advances in pharmacology, 1968, Volume: 6, Issue:Pt B Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy	1968
Neurologic aspects of typical and atypical Down's syndrome. Diseases of the nervous system, 1969, Volume: 30, Issue:9 Topics: Cataract; Chromosome Aberrations; Down Syndrome; Gait; Humans; Hydroxyindoleacetic Acid; Intelligenc	1969
5-Hydroxyindoles in mongolism and hydrocephalus. Archives of disease in childhood, 1969, Volume: 44, Issue:238 Topics: Down Syndrome; Humans; Hydrocephalus; Hydroxyindoleacetic Acid; Infant; Serotonin	1969
5-hydroxyindoles in the cerebrospinal fluid of infants with Down's syndrome and muscle hypotonia. Developmental medicine and child neurology, 1969, Volume: 11, Issue:6 Topics: Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Infant; Intellectu	1969
5-HIAA in cerebrospinal fluid. Developmental medicine and child neurology, 1970, Volume: 12, Issue:4 Topics: Down Syndrome; Humans; Hydroxyindoleacetic Acid; Serotonin	1970
Diminished activity of platelet monoamine oxidase in Down's syndrome. American journal of human genetics, 1971, Volume: 23, Issue:2 Topics: Blood Platelets; Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; I	1971
3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1 Topics: Chromatography, Gas; Depression; Dihydroxyphenylalanine; Down Syndrome; Ethers; Glycols; Humans; Hyd	1971
5-hydroxyindole levels in the blood and CSF in Down's syndrome, phenylketonuria and severe mental retardation. Developmental medicine and child neurology, 1972, Volume: 14, Issue:4 Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid;	1972
Down's syndrome. Central monoamine turnover in patients with diminished platelet serotonin. Neurology, 1972, Volume: 22, Issue:9 Topics: Adolescent; Adult; Blood Platelets; Child; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid;	1972
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases. Neurology, 1972, Volume: 22, Issue:11 Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp	1972
[Functional exploration at various levels of the tryptophan--nicotinic acid metabolic line]. Acta vitaminologica et enzymologica, 1972, Volume: 26, Issue:3 Topics: Diabetes Mellitus; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenin	1972
5-hydroxyindoleacetic acid in children with Down's syndrome. Acta paediatrica Scandinavica, 1973, Volume: 62, Issue:2 Topics: Age Factors; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Down Syndrom	1973
The metabolism of 5-hydroxytryptamine by blood platelets from children with mongolism. Biochemical pharmacology, 1973, Jul-01, Volume: 22, Issue:13 Topics: 5-Hydroxytryptophan; Blood Platelets; Child; Child, Preschool; Chromatography, Paper; Down Syndrome;	1973
Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid. Journal of neurochemistry, 1973, Volume: 21, Issue:3 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Carbon Radioisotopes; Cerebrospinal Fluid; Child;	1973
The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. The American journal of pathology, 1973, Volume: 73, Issue:2 Topics: Adolescent; Adult; Aged; Autopsy; Brain; Brain Chemistry; Child; Child, Preschool; Dementia; Down Sy	1973
Effect of probenecid on 5-hydroxyindoles in cerebrospinal fluid in Down's syndrome. Annals of clinical research, 1973, Volume: 5, Issue:6 Topics: Administration, Oral; Adolescent; Child; Chromatography, Gel; Depression, Chemical; Down Syndrome; F	1973
The use of 5-HTP in the treatment of Down's syndrome. Pediatrics, 1974, Volume: 54, Issue:2 Topics: 5-Hydroxytryptophan; Administration, Oral; Age Factors; Child Development; Child, Preschool; Chromat	1974
Catabolism of serotonin in Down's syndrome (tisomy 21). Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1974, Oct-10, Volume: 21, Issue:10 Topics: Blood Platelets; Carbon Radioisotopes; Child; Down Syndrome; Humans; Hydroxyindoleacetic Acid; Monoa	1974
The effect of high doses of 5-hydroxytryptophan on a patient with trisomy 21. Clinical, chemical and EEG correlations. Brain research, 1968, Volume: 11, Issue:2 Topics: 5-Hydroxytryptophan; Age Factors; Central Nervous System; Chromosomes, Human, 21-22 and Y; Down Synd	1968