hydroxyindoleacetic acid has been researched along with Depression in 318 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also known as serotonin transporter (SERT1) gene." | 9.41 | SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition. ( Bravo, R; Castaño, MY; Kirsch, P; Plieger, T; Reuter, M; Rodríguez, AB; Ugartemendia, L; Zamoscik, V, 2021) |
| " Depression could result from changes in tryptophan availability caused by activation of the kynurenine pathway as a result of inflammation." | 9.14 | Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. ( Bridel, MA; Christofides, J; Cowlard, R; Darlington, LG; Forrest, CM; Mackay, GM; Mitchell, S; Stone, TW, 2009) |
| "Utilising total plasma homocysteine as a sensitive measure of functional folate deficiency, a biological subgroup of depression with folate deficiency, impaired methylation, and monoamine neurotransmitter metabolism has been identified." | 9.09 | Homocysteine, folate, methylation, and monoamine metabolism in depression. ( Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK, 2000) |
| "Bifemelane hydrochloride (BH) is widely employed in Japan in the treatment of cerebral infarction patients with depressive symptoms and its antidepressant action is considered to be caused by the normalizing effects of neurotransmitters." | 9.08 | Effects of bifemelane hydrochloride on plasma neuropeptide Y, 3-methoxy-4-hydroxyphenylethylene glycol and 5-hydroxy-indole acetic acid concentrations in patients with cerebral infarction. ( Hashimoto, H; Kai, T; Katayama, M; Koide, S; Onishi, H; Yamagami, S, 1995) |
| "16 patients with organic depression were treated with low doses of trazodone (100 mg/day) by i." | 9.04 | Trazodone by intravenous infusion in depressions secondary to organic disease. ( Abbruzzese, G; Albano, C; Cocito, L; Gandolfo, C; Roccatagliata, G, 1977) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 9.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| "BDI-II scores were significantly higher following 24 months of nitisinone therapy in patients that were followed up, however the majority of these patients remained in the minimal category of depression." | 7.88 | Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. ( Davison, AS; Devine, J; Gallagher, JA; Harrold, JA; Hughes, AT; Hughes, G; J C G, H; Khedr, M; Milan, AM; Norman, BP; Ranganath, LR; Usher, J, 2018) |
| "In this study we investigated the cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in Alzheimer (AD) patients (n=75), patients with mild cognitive impairment (MCI, n=9) and patients with depression (n=7)." | 7.72 | 5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment. ( Ganzer, S; Müller-Thomsen, T; Stuerenburg, HJ, 2004) |
| " We measured severity of depression with Beck's Depression Inventory (BDI) and Hamilton's Depression Rating Scale (HDRS), plasma concentrations of cortisol, DHEA and DHEA-S, and CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and the dopamine metabolite homovanillic acid (HVA) in 21 abstinent alcoholics after 4 weeks of abstinence and in 11 age-matched healthy control subjects." | 7.70 | Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. ( George, D; Heinz, A; Hommer, D; Linnoila, M; Weingartner, H; Wolkowitz, OM, 1999) |
| " To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied." | 7.69 | Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994) |
| "Treatment of endogenous depression with nortriptyline (NT), at a daily dose of 150 mg, resulted in a pronounced improvement of seven of ten patients investigated." | 7.67 | Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. ( Aberg-Wistedt, A; Bertilsson, L; Malmgren, R, 1987) |
| "Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 7.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 5.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HTAA) in serum and hypothalamus, and the reduced expressions of 5-HT1A receptor and 5-HT2A receptor in hypothalamus were observed after AF and fluoxetine oral administration indicating that AF-mediated antidepressant-like effect may be related to the normalization of serotonergic system." | 5.42 | Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. ( Hou, X; Hu, X; Liu, C; Liu, W; Lu, C; Song, J; Teng, L; Wang, D; Wang, J, 2015) |
| "In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also known as serotonin transporter (SERT1) gene." | 5.41 | SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition. ( Bravo, R; Castaño, MY; Kirsch, P; Plieger, T; Reuter, M; Rodríguez, AB; Ugartemendia, L; Zamoscik, V, 2021) |
| "Depression was evaluated in relation to cardiac structural and functional phenotypes assessed by transthoracic echocardiography in 42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years." | 5.40 | Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. ( Groban, L; Kitzman, DW; Register, TC; Shively, CA, 2014) |
| "Caffeine was injected at doses of 80 mg/kg daily for five days." | 5.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
| " Depression could result from changes in tryptophan availability caused by activation of the kynurenine pathway as a result of inflammation." | 5.14 | Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. ( Bridel, MA; Christofides, J; Cowlard, R; Darlington, LG; Forrest, CM; Mackay, GM; Mitchell, S; Stone, TW, 2009) |
| "Utilising total plasma homocysteine as a sensitive measure of functional folate deficiency, a biological subgroup of depression with folate deficiency, impaired methylation, and monoamine neurotransmitter metabolism has been identified." | 5.09 | Homocysteine, folate, methylation, and monoamine metabolism in depression. ( Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK, 2000) |
| "Bifemelane hydrochloride (BH) is widely employed in Japan in the treatment of cerebral infarction patients with depressive symptoms and its antidepressant action is considered to be caused by the normalizing effects of neurotransmitters." | 5.08 | Effects of bifemelane hydrochloride on plasma neuropeptide Y, 3-methoxy-4-hydroxyphenylethylene glycol and 5-hydroxy-indole acetic acid concentrations in patients with cerebral infarction. ( Hashimoto, H; Kai, T; Katayama, M; Koide, S; Onishi, H; Yamagami, S, 1995) |
| "16 patients with organic depression were treated with low doses of trazodone (100 mg/day) by i." | 5.04 | Trazodone by intravenous infusion in depressions secondary to organic disease. ( Abbruzzese, G; Albano, C; Cocito, L; Gandolfo, C; Roccatagliata, G, 1977) |
| "In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study." | 5.04 | Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976) |
| "In a double-blind study of 24 patients with endogenous depressiona group treated with clomipramine hydrochloride (chlorimipramine) plus tryptophan was compared with a group treated with clomipramine plus placebo." | 5.04 | Potentiation of the antidepressant action of clomipramine by tryptophan. ( Bjorn-Erik, R; Carlsson, A; Nagy, A; Skott, A; Walinder, J, 1976) |
| "BDI-II scores were significantly higher following 24 months of nitisinone therapy in patients that were followed up, however the majority of these patients remained in the minimal category of depression." | 3.88 | Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. ( Davison, AS; Devine, J; Gallagher, JA; Harrold, JA; Hughes, AT; Hughes, G; J C G, H; Khedr, M; Milan, AM; Norman, BP; Ranganath, LR; Usher, J, 2018) |
| "The authors conducted a retrospective chart review of patients with carcinoid tumors and elevated serotonin levels (as measured by 24-hour urine 5-hydroxyindoleacetic acid [5-HIAA]) at Dana-Farber/Brigham and Women's Cancer Center who initiated treatment with serotonergic antidepressants after a carcinoid diagnosis from 2003 to 2016." | 3.85 | Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome. ( Brais, LK; Braun, IM; Chan, JA; Dutton, T; Kulke, MH; Meyer, FL; Minden, SL; Shi, DD; Yuppa, DP, 2017) |
| " Elevated activity of the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase (IDO) has been proposed to mediate depression in inflammatory disorders." | 3.85 | Intracerebroventricular Administration of Streptozotocin as an Experimental Approach to Depression: Evidence for the Involvement of Proinflammatory Cytokines and Indoleamine-2,3-Dioxygenase. ( Boeira, SP; de Gomes, MG; Jesse, CR; Mattos, E; Silva, NC; Souza, LC; Viana, CE, 2017) |
| " Using a genetic animal model of depression, this study investigated the long-term effects of pre-pubertal administration of fluoxetine (FLX) on depressive-like behaviour in early adulthood, as well as on central monoaminergic response to an acute stressor." | 3.85 | Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats. ( Badenhorst, NJ; Brand, L; Brink, CB; Ellis, SM; Harvey, BH, 2017) |
| "One of the most striking discoveries in the treatment of major depression was the finding that infusion of a single sub-anesthetic dose of ketamine induces rapid and sustained antidepressant effects in treatment-resistant depressed patients." | 3.83 | Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice. ( Mauch, J; Pandit, R; Pitychoutis, PM; Sens, J; Thelen, C, 2016) |
| " IDO activation and subsequent generation of neuroactive kynurenine metabolites may have a pivotal role in the development of depression." | 3.79 | Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice. ( Corona, AW; Dantzer, R; Godbout, JP; Huang, Y; Kelley, KW; Lawson, M; Norden, DM; O'Connor, JC; Skendelas, JP, 2013) |
| "On the basis of these findings, norepinephrine (NE), epinephrine (E), dopamine (DOP), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and vanillylmandelic acid (VMA) concentrations were determined in the cerebrospinal fluid (CSF) in patients with acute (20), chronic (27), and episodic pain syndrome (44) in a prospective study." | 3.73 | [Monoaminergic transmitters in the cerebrospinal fluid of patients with acute, chronic, and intermittent pain. Interface between pain and depression?]. ( Fischer, C; Hoffmann, KH; Meyer, S; Ostertag, D; Paulus, C; Strittmatter, M, 2005) |
| "In this study we investigated the cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in Alzheimer (AD) patients (n=75), patients with mild cognitive impairment (MCI, n=9) and patients with depression (n=7)." | 3.72 | 5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment. ( Ganzer, S; Müller-Thomsen, T; Stuerenburg, HJ, 2004) |
| "Hypericum perforatum is considered an effective alternative to the synthetic antidepressants in the treatment of mild-to-moderate depression." | 3.71 | Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum. ( Calapai, G; Caputi, A; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A; Squadrito, F, 2001) |
| " We measured severity of depression with Beck's Depression Inventory (BDI) and Hamilton's Depression Rating Scale (HDRS), plasma concentrations of cortisol, DHEA and DHEA-S, and CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and the dopamine metabolite homovanillic acid (HVA) in 21 abstinent alcoholics after 4 weeks of abstinence and in 11 age-matched healthy control subjects." | 3.70 | Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. ( George, D; Heinz, A; Hommer, D; Linnoila, M; Weingartner, H; Wolkowitz, OM, 1999) |
| " To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied." | 3.69 | Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994) |
| "We have previously found that repeated phencyclidine (PCP) treatment enhances the immobility induced by forced swimming and suggested that this behavioral change could be used as a model of the negative symptoms, particularly depression, of schizophrenia." | 3.69 | Effects of antidepressants on phencyclidine-induced enhancement of immobility in a forced swimming test in mice. ( Furukawa, H; Mamiya, T; Nabeshima, T; Noda, Y, 1997) |
| "Tritiated imipramine binding in platelets has been used to evaluate serotonin activity in depression in previous studies." | 3.68 | Tritiated imipramine binding. A peripheral marker for serotonin in Parkinson's disease. ( Coté, L; Lawton, A; Marder, K; Mayeux, R; Sano, M; Stanley, M; Stern, Y; Williams, J, 1991) |
| "We have investigated the possible associations between the demographic, clinical and psychological characteristics of 80 patients with low back pain and the CSF levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the principal central nervous system metabolites of serotonin, dopamine and noradrenaline, and of tryptophan, the amino acid precursor of serotonin." | 3.67 | Neurotransmission and the experience of low back pain; no association between CSF monoamine metabolites and pain. ( Alaranta, H; Hurme, M; Hyyppä, MT; Lahtela, K; Scheinin, H; Scheinin, M, 1985) |
| "Treatment of endogenous depression with nortriptyline (NT), at a daily dose of 150 mg, resulted in a pronounced improvement of seven of ten patients investigated." | 3.67 | Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. ( Aberg-Wistedt, A; Bertilsson, L; Malmgren, R, 1987) |
| " Prompted by reports of elevated corticotropin releasing factor (CRF) and reduced 5-hydroxyindoleacetic acid (5-HIAA) concentrations in lumbar cerebrospinal fluid (CSF) of patients with major depression, these CSF constituents were examined in 56 nonmedicated patients who were in the early stages of HD." | 3.67 | Cerebrospinal fluid correlates of depression in Huntington's disease. ( Bissette, G; Caine, E; Coyle, J; Irvine, C; Kurlan, R; Nemeroff, CB; Rubin, A; Shoulson, I; Spielman, FJ; Zaczek, R, 1988) |
| "The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia." | 3.66 | CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980) |
| "5-Hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured in the lumbar cerebrospinal fluid of 57 drug-free female patients with DSM-III diagnoses of major unipolar or bipolar depression (n = 14), schizophrenic disorder (n = 18), alcohol dependence (n = 13) and a group of other disorders (n = 12)." | 3.66 | Amine metabolites and neuroendocrine responses related to depression and suicide. ( Arató, M; Banki, CM, 1983) |
| " The ratio of blood tyrosine and tryptophan is disturbed during depression and recovers during remission." | 3.65 | Biochemical post-mortem findings in depressed patients. ( Birkmayer, W; Riederer, P, 1975) |
| "Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 3.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
| "Women diagnosed with breast cancer received massage therapy or practiced progressive muscle relaxation (PMR) for 30-min sessions 3 times a week for 5 weeks or received standard treatment." | 2.71 | Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. ( Beutler, J; Field, T; Fletcher, MA; Fraser, M; Hernandez-Reif, M; Hurley, J; Ironson, G; Kuhn, C; Schanberg, S; Vera, Y, 2005) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 1.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Depression is a common illness in people with HIV (PWH) and is associated with substantial morbidity and mortality." | 1.91 | Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression. ( Anderson, AM; Farber, EW; Felger, JC; Franklin, D; Fu, R; Jinnah, H; Letendre, SL; Mckay, JL; Miller, AH; Moore, RC; Sharma, S; Whicker, N, 2023) |
| "Depression is a psychiatric disorder leading to anhedonia and lack of interest and motivation." | 1.72 | Antidepressive-Like Effect of ( Alhalmi, A; Kumar, G; Pathak, D; Sharma, A; Singh, T; Virmani, T, 2022) |
| "Depression is one of the main non-motor symptoms of PD." | 1.51 | Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction test and sucrose preference test. ( Haider, S; Madiha, S, 2019) |
| "Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare." | 1.48 | Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain. ( Ding, L; Jiang, X; Jing, C; Liu, F; Pang, C; Yan, Q; Zhang, L, 2018) |
| "Conversely, sleep deprivation impairs mood, cognition and functional performance." | 1.46 | Effects of exercise on depressive behavior and striatal levels of norepinephrine, serotonin and their metabolites in sleep-deprived mice. ( Daniele, TMDC; de Bruin, PFC; de Bruin, VMS; Rios, ERV, 2017) |
| "Depression is a chronic, recurring and potentially life-threatening illness." | 1.46 | Ziziphi spinosae lily powder suspension in the treatment of depression-like behaviors in rats. ( Huang, M; Lu, X; Wang, Y; Wei, R; Xu, J, 2017) |
| "Depression is one of the leading causes of disability in developing countries including Pakistan." | 1.46 | Depressive symptoms, monoamines levels, MAO-B activity and effect of treatment in a subset of depressed individuals from government sector hospital at Karachi. ( Farooq, AD; Naqvi, S; Rahman, R; Zeb, F, 2017) |
| "Compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HTAA) in serum and hypothalamus, and the reduced expressions of 5-HT1A receptor and 5-HT2A receptor in hypothalamus were observed after AF and fluoxetine oral administration indicating that AF-mediated antidepressant-like effect may be related to the normalization of serotonergic system." | 1.42 | Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. ( Hou, X; Hu, X; Liu, C; Liu, W; Lu, C; Song, J; Teng, L; Wang, D; Wang, J, 2015) |
| "Depression and aggression in Alzheimer's disease (AD) are 2 of the most severe and prominent neuropsychiatric symptoms (NPS)." | 1.40 | Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease. ( Aerts, T; De Deyn, PP; Engelborghs, S; Van Dam, D; Vermeiren, Y, 2014) |
| "Depression was evaluated in relation to cardiac structural and functional phenotypes assessed by transthoracic echocardiography in 42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years." | 1.40 | Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. ( Groban, L; Kitzman, DW; Register, TC; Shively, CA, 2014) |
| "Withdrawal of caffeine however produced memory deficits and significantly increases the immobility time of rats in FST." | 1.38 | Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. ( Haider, S; Haleem, DJ; Khaliq, S; Naqvi, F; Perveen, T; Saleem, S, 2012) |
| " Taken together, our data indicate that chronic use of stanozolol significantly affects brain monoamines leading to neurochemical modifications possibly involved in depression and stress-related states." | 1.38 | Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes. ( Colaianna, M; Cuomo, V; Morgese, MG; Schiavone, S; Trabace, L; Tucci, P; Zotti, M, 2012) |
| "In humans, depression is associated with altered rapid eye movement (REM) sleep." | 1.38 | Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. ( Huang, ZL; Li, R; Qu, WM; Tu, ZC; Urade, Y; Wang, YQ; Xu, XY, 2012) |
| "Depression is the most common psychiatric disorder in Huntington's disease (HD) patients." | 1.37 | Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. ( Chevarin, C; Du, X; Hannan, AJ; Lanfumey, L; Leang, L; Pang, TY; Renoir, T; Zajac, MS, 2011) |
| "Corticosterone serum levels were elevated in both sexes." | 1.32 | Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. ( Antoniou, K; Dalla, C; Drossopoulou, G; Kitraki, E; Papadopoulou-Daifoti, Z; Papalexi, E; Papathanasiou, G, 2004) |
| "Caffeine was injected at doses of 80 mg/kg daily for five days." | 1.29 | 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. ( Haleem, DJ; Haleem, MA; Yasmeen, A; Zafar, A, 1995) |
| " In 46 children from this sample it was dosed plasmatic cortisol and the urinary excretion of catecholamine, VMA, HVA and 5-HIAA." | 1.28 | Biochemical correlate of depression in children. ( Basques, JC; Fabre, ZL; Fernandes, ML; Furtado, CR; Lippi, JR; Lombardi, AB; Peixoto, CC; Queiroz, EA; Soares, TA, 1991) |
| "In a prospective study of patients with Parkinson's disease we found a continuum of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations." | 1.28 | Coexisting dementia and depression in Parkinson's disease. ( Coté, L; Mayeux, R; Rosenstein, R; Sano, M; Stern, Y; Williams, J, 1989) |
| "Patients with Parkinson's disease have a decrement in homovanillic acid that is reversed by treatment with L-3,4-dihydroxyphenylalanine." | 1.27 | Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method. ( Aguado, EG; de Yebenes, JG; Mena, MA, 1984) |
| "Depression is a common symptom in patients with Parkinson's disease." | 1.27 | Altered serotonin metabolism in depressed patients with parkinson's disease. ( Cote, L; Mayeux, R; Stern, Y; Williams, JB, 1984) |
| "50 pmol/ml) did not change after 1 wk of Li dosing (1." | 1.27 | Differences in lithium effects in depressed and healthy subjects. ( Karoum, F; Linnoila, M; Potter, WZ; Ross, RJ; Rudorfer, MV, 1985) |
| "A 67-year-old woman with metastatic carcinoid tumor developed neurologic signs and symptoms of left facial paralysis and progressive lower extremity weakness." | 1.27 | Carcinoid carcinomatous meningitis. ( Hedaya, R; Linnoila, M; Nagourney, RA; Schein, PS, 1985) |
| "Nortriptyline is a preferential noradrenaline uptake inhibitor, while the dimethylated compound, chlorimipramine also has a profound influence on serotonin neurons." | 1.26 | Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. ( Asberg, M, 1976) |
| " Urinary MHPG dosage seems to be one of the most interesting in this field." | 1.26 | [Respective position of antidepressants in therapeutics (author's transl)]. ( Moussaoui, D, 1979) |
| "Two cases of depression are presented: One which responded to psychotherapy and the other which responded to medication." | 1.26 | Repertory grid and biochemical characterization of depression: a comparison of case reports. ( Berger, PA; Slater, P; Yesavage, JA, 1979) |
| "Psychogenic depression is characterized by a domination of desynchronized activity of low volts in the EEG and the existence of expressed sympathicotony of the peripheral vegetative system, while statistically significant shifts of the vascular tonus and catecholamine excreation are absent." | 1.26 | [Pathophysiologic mechanisms of depressive states of endogenous or exogenous origin]. ( Biriukovich, PV; Sinitskiĭ, VN; Usherenko, LS, 1978) |
| "Depression was by far the most important factor." | 1.26 | Cortisol in the CSF of depressed and suicidal patients. ( Asberg, M; Bertilsson, L; Lantto, O; Schalling, D; Träskman, L; Tybring, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 199 (62.58) | 18.7374 |
| 1990's | 23 (7.23) | 18.2507 |
| 2000's | 35 (11.01) | 29.6817 |
| 2010's | 49 (15.41) | 24.3611 |
| 2020's | 12 (3.77) | 2.80 |
| Authors | Studies |
|---|---|
| Bajaj, J | 1 |
| Dwivedi, J | 1 |
| Sahu, R | 1 |
| Dave, V | 1 |
| Verma, K | 1 |
| Joshi, S | 1 |
| Sati, B | 1 |
| Sharma, S | 2 |
| Seidel, V | 1 |
| Mishra, AP | 1 |
| Moncrieff, J | 1 |
| Cooper, RE | 1 |
| Stockmann, T | 1 |
| Amendola, S | 1 |
| Hengartner, MP | 1 |
| Horowitz, MA | 1 |
| Tian, P | 1 |
| Zhang, W | 1 |
| Li, KY | 1 |
| Li, HW | 1 |
| Ma, K | 1 |
| Han, DE | 1 |
| Becker, M | 1 |
| Abaev, K | 1 |
| Shmerkin, E | 1 |
| Weinstein-Fudim, L | 1 |
| Pinhasov, A | 1 |
| Ornoy, A | 1 |
| Sharma, A | 1 |
| Singh, T | 1 |
| Pathak, D | 1 |
| Virmani, T | 1 |
| Kumar, G | 1 |
| Alhalmi, A | 1 |
| Zhu, K | 1 |
| Xu, X | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| The Effects of Osteopathic Manipulations on the Expression Patterns of Immune Cell Biomarkers[NCT03250312] | 40 participants (Actual) | Interventional | 2017-09-13 | Terminated (stopped due to Study Partner Left. Samples degraded before analysis.) | |||
| Repetitive Transcranial Magnetic Stimulation (rTMS) for Motor and Mood Symptoms of Parkinson's Disease (MASTER-PD), a Multicenter Clinical Trial[NCT01080794] | 61 participants (Actual) | Interventional | 2010-05-31 | Completed | |||
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Study by 1H NMR of the Variations of the Metabolome During the Course of Electroconvulsive Therapy in Patients With Major Depressive Episode[NCT05973643] | 50 participants (Anticipated) | Interventional | 2023-10-15 | Not yet recruiting | |||
| Tryptophan Depletion PET Study in Remitted Depressed Subjects and Healthy Controls, and GABA MRS Study in Remitted and Currently Depressed Subjects and Healthy Controls[NCT00033787] | 450 participants | Observational | 2002-04-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To establish the safety and tolerability of rTMS in Parkinson's Disease. (NCT01080794)
Timeframe: Baseline through Month 6
| Intervention | incidents of an adverse event (Number) |
|---|---|
| Double rTMS | 18 |
| M1 Active rTMS + DLPFC Sham rTMS | 14 |
| DLPFC Active rTMS + M1 Sham rTMS | 1 |
| Double Sham rTMS | 1 |
To evaluate apathy in Parkinson's Disease. The AES mean scores were reported for each group at each time point. The AES Score Range is 0-42, where higher the score indicates greater severity of the apathy symptoms. (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 18.7 | 18.1 | 19.0 | 19.3 | 15.8 |
| Double rTMS | 15.6 | 16.2 | 17 | 16.9 | 17.8 |
| Double Sham rTMS | 16.3 | 15.5 | 15.0 | 16.1 | 16.2 |
| M1 Active rTMS + DLPFC Sham rTMS | 15.9 | 16.9 | 14.6 | 15.1 | 12.4 |
To assess mood symptoms in Parkinson's Disease. The BDI-II mean scores were reported for each group at each time point. The BDI-II Score Range is 0 - 63, where higher the score indicates greater severity of the mood symptoms. (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 21.7 | 18.2 | 20.2 | 19.0 | 15.7 |
| Double rTMS | 23.2 | 20.7 | 16.4 | 17.9 | 20.1 |
| Double Sham rTMS | 18.8 | 13.7 | 13.1 | 14.7 | 16.8 |
| M1 Active rTMS + DLPFC Sham rTMS | 18.5 | 16.5 | 16.7 | 19.1 | 16.3 |
To evaluate anxiety in Parkinson's Disease. The CAS mean scores were reported for each group at each time point. The CAS Score Range is 0 - 100, where higher the score indicates greater severity of the anxiety symptoms. (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 33.4 | 27.6 | 30.8 | 31.4 | 24.8 |
| Double rTMS | 36.3 | 34.2 | 31.7 | 33.1 | 33.4 |
| Double Sham rTMS | 37.5 | 32.4 | 28.2 | 28.5 | 35.0 |
| M1 Active rTMS + DLPFC Sham rTMS | 34.3 | 31.0 | 30.8 | 27.3 | 28.1 |
To assess symptom severity and treatment response in Parkinson's Disease. The CGI mean scores were reported for each group at each time point. The CGI Score Range is 1 - 8, where higher the score indicates greater severity of illness or worsening of illness. (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (Pre-Treatment): Severity | Week 1 Post Treatment: Severity | Week 1 Post Treatment: Improvement | Month 1 Post Treatment: Severity | Month 1 Post Treatment: Improvement | Month 3 Post Treatment: Severity | Month 3 Post Treatment: Improvement | Month 6 Post Treatment: Severity | Month 6 Post Treatment: Improvement | |
| DLPFC Active rTMS + M1 Sham rTMS | 4.3 | 4.7 | 3.5 | 4.4 | 3.7 | 4.4 | 3.6 | 4.3 | 3.7 |
| Double rTMS | 4.9 | 4.8 | 3.6 | 4.4 | 3.5 | 4.6 | 3.7 | 4.2 | 3.5 |
| Double Sham rTMS | 3.6 | 3.9 | 3.0 | 4.1 | 3.5 | 4.4 | 3.6 | 4.6 | 3.4 |
| M1 Active rTMS + DLPFC Sham rTMS | 4.7 | 4.9 | 3.5 | 4.8 | 3.8 | 3.8 | 3.4 | 5.0 | 4.2 |
"To evaluate the depressive mood symptoms in PD.~The HAM-D mean scores were reported for each group at each time point. The HAM-D Score Range is 0 - 56, where higher the score indicates greater severity of depressive mood symptoms." (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post-Treatment | Month 1 Post-Treatment | Month 3 Post-Treatment | Month 6 Post-Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 13.8 | 9.4 | 12.4 | 10.4 | 10.4 |
| Double rTMS | 15.2 | 11.3 | 10.6 | 10.7 | 10.4 |
| Double Sham rTMS | 14.1 | 9.3 | 8.0 | 11.1 | 10.4 |
| M1 Active rTMS + DLPFC Sham rTMS | 16.7 | 11.2 | 10.1 | 10.1 | 8.6 |
To screen and follow cognitive function in Parkinson's Disease. The MoCA mean scores were reported for each group at each time point. The MoCA Score Range is 0 - 30, where 26-30 indicates normal cognition. (NCT01080794)
Timeframe: pre-treatment; 0,1,3, and 6 months post-treatment
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 27.3 | 26.3 | 26.8 | 26.7 | 26.6 |
| Double rTMS | 28.2 | 26.8 | 28.8 | 26.5 | 28.0 |
| Double Sham rTMS | 26.2 | 27.8 | 28.7 | 24.9 | 28.0 |
| M1 Active rTMS + DLPFC Sham rTMS | 26.6 | 27.1 | 27.2 | 25.3 | 27.9 |
"To evaluate the motor symptoms in Parkinson's Disease.~The UPDRS-III mean scores were reported for each group at each time point. The UPDRS-III Score Range is 0 - 56, where higher the score indicates greater severity of the motor symptoms." (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post-Treatment | Month 1 Post-Treatment | Month 3 Post-Treatment | Month 6 Post-Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 32.8 | 30.3 | 29.3 | 31.5 | 28.8 |
| Double rTMS | 32.3 | 31.2 | 30.1 | 29.6 | 30.5 |
| Double Sham rTMS | 28.9 | 28.2 | 28.6 | 28.6 | 29.0 |
| M1 Active rTMS + DLPFC Sham rTMS | 33.1 | 27.4 | 28.1 | 33.2 | 30.6 |
To assess the quality of life (QOL) in Parkinson's Disease. The PDQ-39 mean scores were reported for each group at each time point. The PDQ-39 Score Range is 0 - 156, where higher the score indicates greater impact on quality of life. (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 51.9 | 46.8 | 49.4 | 49.4 | 49 |
| Double rTMS | 57.6 | 51.2 | 49.9 | 51.7 | 50.5 |
| Double Sham rTMS | 55.5 | 43.1 | 40.9 | 43.1 | 47.5 |
| M1 Active rTMS + DLPFC Sham rTMS | 61.5 | 60.7 | 56.8 | 53.1 | 48.3 |
"To assess apathy, cognition, depression, activities of daily living (ADL), quality of life (QOL), and motor symptoms in Parkinson's Disease.~The UPDRS I, II, IV total mean scores were reported for each group at each time point. The UPDRS I, II, IV scores were added together for each patient, with a total score range of 0 - 91, where higher the score indicates greater severity of the symptoms." (NCT01080794)
Timeframe: Pre-treatment; Post-treatment 0,1,3, and 6 months.
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline (Pre-Treatment) | Week 1 Post Treatment | Month 1 Post Treatment | Month 3 Post Treatment | Month 6 Post Treatment | |
| DLPFC Active rTMS + M1 Sham rTMS | 21.5 | 19.3 | 19.9 | 18.9 | 20.2 |
| Double rTMS | 25.4 | 23.3 | 21.8 | 21.1 | 23.8 |
| Double Sham rTMS | 19.6 | 15.5 | 16.5 | 16.9 | 18.8 |
| M1 Active rTMS + DLPFC Sham rTMS | 26.1 | 23.2 | 23.0 | 23.2 | 22.7 |
33 reviews available for hydroxyindoleacetic acid and Depression
| Article | Year |
|---|---|
The serotonin theory of depression: a systematic umbrella review of the evidence.
Topics: Antidepressive Agents; Depression; Humans; Hydroxyindoleacetic Acid; Receptor, Serotonin, 5-HT1A; Se | 2023 |
Smoking related diseases: the central role of monoamine oxidase.
Topics: Anxiety; Biomarkers; Cardiovascular Diseases; Depression; Epigenesis, Genetic; Humans; Hydroxyindole | 2011 |
Behavioral manifestations of movement disorders. Parkinson's and Huntington's disease.
Topics: Adult; Aged; Dementia; Depression; Depressive Disorder; Homovanillic Acid; Humans; Huntington Diseas | 1984 |
Neurotransmitter studies of neuroendocrine pathology in depression.
Topics: Acetylcholine; Adolescent; Animals; Brain; Cinanserin; Circadian Rhythm; Corticosterone; Cushing Syn | 1980 |
Central serotonin deficiency--a factor which increases depression vulnerability?
Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma | 1980 |
Cerebrospinal fluid 5-hydroxyindolacetic acid and aggression: a critical reappraisal of the clinical data.
Topics: Behavior; Depression; Humans; Hydroxyindoleacetic Acid; Serotonin; Statistics as Topic | 1995 |
Do plasma polyunsaturates predict hostility and depression?
Topics: Adult; Cholesterol; Depression; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Homovanillic | 1997 |
Post stroke depression.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Communication Barriers; Depression; Diagnosis, | 2001 |
Specificity of depressive diseases.
Topics: Brain Chemistry; Depression; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Neurotran | 1978 |
Biogenic amine hypotheses of affective disorders.
Topics: Affective Symptoms; Antidepressive Agents; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipola | 1979 |
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1975 |
Therapy-resistant depressions: biochemical and pharmacological considerations.
Topics: Adjustment Disorders; Antidepressive Agents; Brain; Depression; Drug Resistance; Homovanillic Acid; | 1975 |
Metabolism of indole amines in depression.
Topics: Animals; Brain; Depression; Fatty Acids, Nonesterified; Female; Humans; Hydrocortisone; Hydroxyindol | 1976 |
Biogenic amines and depression. The potential value of biochemical parameters in the diagnosis and medication of affective disorders.
Topics: Antidepressive Agents; Biogenic Amines; Depression; Diagnosis, Differential; Humans; Hydroxyindoleac | 1976 |
Antidepressant treatments and alterations in central serotonin turnover in affective illness.
Topics: Affective Symptoms; Antidepressive Agents; Depression; Humans; Hydroxyindoleacetic Acid; Serotonin | 1976 |
Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine.
Topics: Animals; Brain; Clomipramine; Depression; Dopamine; Humans; Hydroxyindoleacetic Acid; Lithium; Model | 1976 |
Changes in monoamine oxidase and monoamines with human development and aging.
Topics: Adult; Age Factors; Aged; Aging; Amines; Benzyl Compounds; Biogenic Amines; Blood Platelets; Brain; | 1975 |
Pharmacotherapy of depression--a critical review.
Topics: Adjustment Disorders; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depression; Dopamin | 1975 |
[The importance of methylation reactions in the biochemistry of catecholaminergic and serotoninergic neurons].
Topics: Animals; Brain; Depression; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Methylatio | 1991 |
Depression, attempted suicide, and suicide in patients with chronic schizophrenia.
Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Atrophy; Brain; Chronic Disease; Del | 1986 |
[Biological markers of depression].
Topics: Antidepressive Agents; Apomorphine; Clonidine; Contingent Negative Variation; Depression; Dexamethas | 1986 |
Biochemical effects of antidepressant treatment--studies of monoamine metabolites in cerebrospinal fluid and platelet [3H]imipramine binding.
Topics: Antidepressive Agents; Blood Platelets; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic A | 1986 |
Simulated behavior states: an approach to specificity in psychobiological research.
Topics: Biology; Bipolar Disorder; Cyclic AMP; Depression; Emotions; Homovanillic Acid; Humans; Hydroxyindol | 1973 |
Biogenic amines and affective disorders.
Topics: Affective Symptoms; Biogenic Amines; Bipolar Disorder; Blood Platelets; Brain; Catechol O-Methyltran | 1974 |
[Biochemistry of depression].
Topics: Animals; Bipolar Disorder; Brain; Central Nervous System; Depression; Dihydroxyphenylalanine; Glycol | 1972 |
The current status of biological criteria for classifying the depressive disorders and predicting responses to treatment.
Topics: Adult; Aged; Catechol O-Methyltransferase; Depression; Dextroamphetamine; Dihydroxyphenylalanine; Do | 1974 |
Melancholia, a model in madness: a discussion of recent psychobiologic research into depressive illness.
Topics: Adaptation, Psychological; Biogenic Amines; Brain; Depression; Dihydroxyphenylalanine; Emotions; Env | 1973 |
[Biochemical aspects of human behaviour (author's transl)].
Topics: Animals; Athetosis; Behavior; Behavior, Animal; Biogenic Amines; Brain; Brain Chemistry; Catecholami | 1973 |
Neuropsychopharmacology and the affective disorders. (Third of three parts)
Topics: Affective Symptoms; Amines; Amphetamine; Animals; Antidepressive Agents; Brain; Catecholamines; Coca | 1969 |
Electrolytes and mental illness.
Topics: Affective Symptoms; Animals; Biological Transport; Bipolar Disorder; Calcium; Cell Membrane Permeabi | 1969 |
Tryptophan pyrrolase--a biochemical factor in depressive illness?
Topics: Animals; Brain; Cats; Depression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Pituit | 1969 |
Clinical psychiatry.
Topics: Ambulatory Care; Anxiety Disorders; Brain Chemistry; Child; Community Mental Health Services; Depres | 1969 |
Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain.
Topics: Amines; Animals; Basal Ganglia; Biological Transport, Active; Blood-Brain Barrier; Brain; Cerebral V | 1970 |
33 trials available for hydroxyindoleacetic acid and Depression
| Article | Year |
|---|---|
SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition.
Topics: Age Factors; Alleles; Depression; Diet; Diet Surveys; Eating; Empathy; Female; Genetic Association S | 2021 |
Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling.
Topics: Adult; Antidepressive Agents; Biomarkers; Counseling; Depression; Drug Therapy, Combination; Female; | 2009 |
Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Biogenic Monoamines; Case-Control Studies; Chrom | 2004 |
Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy.
Topics: Adult; Anger; Anxiety; Breast Neoplasms; Depression; Dopamine; Female; Humans; Hydroxyindoleacetic A | 2005 |
[Therapeutic effect of acupuncture on female's climacteric depression and its effects on DA, NE and 5-HIAA contents].
Topics: Acupuncture Therapy; Adult; Climacteric; Depression; Dopamine; Female; Humans; Hydroxyindoleacetic A | 2007 |
Fluvoxamine and clomipramine in depressed patients. A double-blind clinical study.
Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Clomipramine; Depression; Diazepam; Do | 1981 |
Effects of bifemelane hydrochloride on plasma neuropeptide Y, 3-methoxy-4-hydroxyphenylethylene glycol and 5-hydroxy-indole acetic acid concentrations in patients with cerebral infarction.
Topics: Aged; Antidepressive Agents; Benzhydryl Compounds; Cerebral Infarction; Chromatography, High Pressur | 1995 |
Homocysteine, folate, methylation, and monoamine metabolism in depression.
Topics: Adult; Biogenic Monoamines; Blood Cell Count; Body Weight; Depression; Erythrocytes; Female; Folic A | 2000 |
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
Topics: Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Hom | 1979 |
The indoleamine hypothesis of depression: an overview and pilot study.
Topics: 5-Hydroxytryptophan; Adult; Aged; Carbidopa; Clinical Trials as Topic; Depression; Female; Homovanil | 1977 |
Trazodone by intravenous infusion in depressions secondary to organic disease.
Topics: Adult; Aged; Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Infusio | 1977 |
Second-generation antidepressants as research tools--some preliminary findings with clomipramine and maprotiline.
Topics: Adolescent; Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazep | 1977 |
Imipramine and desipramine in plasma and spinal fluid: relationship to clinical response and serotonin metabolism.
Topics: Adult; Bipolar Disorder; Brain; Clinical Trials as Topic; Depression; Desipramine; Double-Blind Meth | 1978 |
Negative effects of melatonin on depression.
Topics: Adult; Anger; Anxiety; Body Temperature; Body Weight; Calcium; Clinical Trials as Topic; Depression; | 1976 |
Potentiation of the antidepressant action of clomipramine by tryptophan.
Topics: Adolescent; Adult; Aged; Anxiety; Clomipramine; Depression; Dibenzazepines; Drug Synergism; Drug The | 1976 |
Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients.
Topics: Adult; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Female; Homovanillic Acid; H | 1975 |
Levodopa and L-tryptophan therapy in Parkinsonism.
Topics: Aged; Depression; Dihydroxyphenylalanine; Female; Gait; Homovanillic Acid; Humans; Hydroxyindoleacet | 1972 |
Administration of a peripheral decarboxylase inhibitor with L-dopa to depressed patients.
Topics: Adult; Aged; Carboxy-Lyases; Catechols; Chemical Phenomena; Chemistry; Depression; Dihydroxyphenylal | 1970 |
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid.
Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans; | 1974 |
Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression.
Topics: Clomipramine; Depression; Dibenzazepines; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglyc | 1974 |
Effect of L-tryptophan on brain serotonin metabolism in depressed patients.
Topics: Brain; Brain Chemistry; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Humans; H | 1972 |
4-Chloramphetamines. Chance and trend in the development of new antidepressants.
Topics: Amines; Amphetamine; Antidepressive Agents; Behavior; Brain Chemistry; Carbon Isotopes; Chlorine; Cl | 1973 |
5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.
Topics: Clinical Trials as Topic; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenothiazines | 1973 |
Amitriptyline in man: decreased formation of central 5-hydroxyindoleacetic acid.
Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Homovanillic Acid; Humans; Hydrox | 1974 |
L-tryptophan in affective disorders: indoleamine changes and differential clinical effects.
Topics: Affective Symptoms; Blood Platelets; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacet | 1974 |
5-Hydroxytrytophan as an antidepressant. The predictive value of the probenecid test.
Topics: 5-Hydroxytryptophan; Biological Transport; Brain; Brain Chemistry; Clinical Trials as Topic; Depress | 1974 |
Serotonin metabolism in depression: clinical application of the probenecid test.
Topics: 5-Hydroxytryptophan; Adjustment Disorders; Administration, Oral; Clinical Trials as Topic; Depressio | 1974 |
Behavioral effects of a new dopamine-beta-hydroxylase inhibitor (fusaric acid) in man.
Topics: Administration, Oral; Bipolar Disorder; Clinical Trials as Topic; Depression; Dopamine beta-Hydroxyl | 1974 |
Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients.
Topics: Adult; Amitriptyline; Biological Transport; Brain Chemistry; Depression; Dopamine; Female; Homovanil | 1974 |
The action of reserpine in imipramine-resistant depressive patients. Clinical and biochemical study.
Topics: Adult; Bipolar Disorder; Blood Pressure; Body Temperature; Clinical Trials as Topic; Depression; Dru | 1967 |
Investigation into the possible influence of chlorinated amphetamine derivatives on 5-hydroxytryptamine synthesis in man.
Topics: 5-Hydroxytryptophan; Amphetamine; Antidepressive Agents; Brain; Carbon Isotopes; Clinical Trials as | 1970 |
The intravenous probenecid test: a possible aid in evaluation of the serotonin hypothesis on the pathogenesis of depressions.
Topics: Brain; Clinical Trials as Topic; Depression; Humans; Hydroxyindoleacetic Acid; Injections, Intraveno | 1970 |
The effect of L-DOPA treatment on brain serotonin metabolism in depressed patients.
Topics: Brain; Depression; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Placebo | 1971 |
252 other studies available for hydroxyindoleacetic acid and Depression
| Article | Year |
|---|---|
Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Bignoniaceae; Binding, Competitive; | 2021 |
[Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Chromatography, Liquid; Depression; | 2022 |
Prenatal SAMe Treatment Induces Changes in Brain Monoamines and in the Expression of Genes Related to Monoamine Metabolism in a Mouse Model of Social Hierarchy and Depression, Probably via an Epigenetic Mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Catecholamines; Depression; Dop | 2022 |
Antidepressive-Like Effect of
Topics: Aegle; Anhedonia; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal | 2022 |
Ratio Fluorescent Detecting of Tryptophan and Its Metabolite 5-Hydroxyindole-3-acetic Acid Relevant with Depression via Tb(III) Modified HOFs Hybrids: Further Designing Recyclable Molecular Logic Gate Connected by Back Propagation Neural Network.
Topics: Acetic Acid; Depression; Hydroxyindoleacetic Acid; Reproducibility of Results; Tryptophan | 2023 |
Dapagliflozin inhibits the activity of lateral habenula to alleviate diabetes mellitus-induced depressive-like behavior.
Topics: AMP-Activated Protein Kinases; Animals; Antidepressive Agents; Depression; Diabetes Mellitus; Habenu | 2023 |
Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression.
Topics: Depression; Dopamine; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Middle Aged; Neu | 2023 |
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Cogni | 2023 |
Use of selective serotonin reuptake inhibitors is associated with very low plasma-free serotonin concentrations in humans.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Case-Control Studies; Cross-Secti | 2020 |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Antidepressive Agents; Anxiety; Behav | 2021 |
Ziziphi spinosae lily powder suspension in the treatment of depression-like behaviors in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Depre | 2017 |
Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk.
Topics: Adolescent; Aggression; Depression; Female; Genome-Wide Association Study; Humans; Hydroxyindoleacet | 2018 |
Effects of exercise on depressive behavior and striatal levels of norepinephrine, serotonin and their metabolites in sleep-deprived mice.
Topics: Animals; Anxiety; Chromatography, High Pressure Liquid; Corpus Striatum; Depression; Disease Models, | 2017 |
Genistein, a dietary soy isoflavone, exerts antidepressant-like effects in mice: Involvement of serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Depression; Dose-Response Re | 2017 |
Effects of GABA microinjection into dorsal raphe nucleus on behavior and activity of lateral habenular neurons in mice.
Topics: Animals; Depression; Dorsal Raphe Nucleus; gamma-Aminobutyric Acid; Habenula; Hydroxyindoleacetic Ac | 2017 |
Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Pain; Cytokines; Depression; Hydroxyindoleacetic Acid | 2018 |
Depressive symptoms, monoamines levels, MAO-B activity and effect of treatment in a subset of depressed individuals from government sector hospital at Karachi.
Topics: Adolescent; Adult; Affect; Aged; Antidepressive Agents, Second-Generation; Biomarkers; Case-Control | 2017 |
Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice.
Topics: Animals; Anxiety; Depression; Dorsal Raphe Nucleus; Glucocorticoids; Hydroxyindoleacetic Acid; Male; | 2018 |
Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two monoamines in rat plasma by HPLC-ECD/DAD.
Topics: Amino Acids, Essential; Animals; Boron; Chemical Fractionation; Chromatography, High Pressure Liquid | 2018 |
Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone.
Topics: Adolescent; Adult; Aged; Alkaptonuria; Cyclohexanones; Depression; Dopamine; Female; Humans; Hydroxy | 2018 |
Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction test and sucrose preference test.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Choice Behavior; Corpus Striatum; Curcumi | 2019 |
Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity.
Topics: Animals; Depression; Exploratory Behavior; Hippocampus; Hydroxyindoleacetic Acid; Immobility Respons | 2019 |
Evidence for reduced homovanillic acid (HVA) in the cerebrospinal fluid of patients with depression.
Topics: Depression; Depressive Disorder; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Neurotransmitt | 2019 |
Low level of evidence for reduced homovanillic acid (HVA) in the cerebrospinal fluid of patients with depression compared to healthy non-psychiatric control individuals.
Topics: Depression; Depressive Disorder; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Neurotransmitt | 2019 |
Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calotropis; Dep | 2019 |
CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters.
Topics: Adult; Aged; Dehydroepiandrosterone Sulfate; Depression; Diagnostic and Statistical Manual of Mental | 2013 |
Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR.
Topics: Adult; Alleles; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Longitudina | 2013 |
Disruption of oral sensory relay to brain increased anxiety- and depression-like behaviours in rats.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Chorda Tympani Nerve; Chr | 2013 |
Exercise affects symptom severity but not biological measures in depression and somatization - results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA.
Topics: Adult; Case-Control Studies; Depression; Exercise; Female; Humans; Hydroxyindoleacetic Acid; Interle | 2013 |
Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system.
Topics: Animals; Chromatography, High Pressure Liquid; Depression; Drugs, Chinese Herbal; Hippocampus; Hydro | 2014 |
Effect of depression and sertraline treatment on cardiac function in female nonhuman primates.
Topics: Analysis of Variance; Animals; Atherosclerosis; Body Weights and Measures; Comorbidity; Depression; | 2014 |
Long-term consequences of neonatal fluoxetine exposure in adult rats.
Topics: Animals; Animals, Newborn; Brain; Dendrites; Depression; Fluoxetine; Hydroxyindoleacetic Acid; Male; | 2014 |
Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain; Chromatography, High Pressure Liquid; | 2014 |
Serotonin impairment in CSF of PD patients, without an apparent clinical counterpart.
Topics: Aged; Cohort Studies; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Parkinson Disease; | 2014 |
Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.
Topics: Animals; Anxiety; Brain; Depression; Hydroxyindoleacetic Acid; Learning; Male; Memory; Mice, Inbred | 2015 |
Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.
Topics: Animals; Anxiety; Cyclic AMP Response Element-Binding Protein; Dendrites; Depression; Fenclonine; Hi | 2015 |
Reduced plasma serotonin and 5-hydroxyindoleacetic acid levels in Parkinson's disease are associated with nonmotor symptoms.
Topics: Aged; Biomarkers; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Par | 2015 |
ATP-sensitive potassium channels: uncovering novel targets for treating depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Survival; Corticosterone; Depression; H | 2016 |
Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged-Ring Compounds; Depression; Dopamine; Hydr | 2015 |
[Effect of Acupuncture and Moxibustion Interventions on Ethological Changes and 5-HT/5-HIAA Levels in Prefrontal Cortex in Depression Rats].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Depression; Humans; Hydroxyindoleacetic Acid; Male | 2016 |
Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Depression; Female; Glutamic Acid; Hippocamp | 2016 |
Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depression; Hindlimb Suspension; Hydroxyind | 2016 |
Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.
Topics: Age Factors; Animals; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Hydroxyindol | 2017 |
Intracerebroventricular Administration of Streptozotocin as an Experimental Approach to Depression: Evidence for the Involvement of Proinflammatory Cytokines and Indoleamine-2,3-Dioxygenase.
Topics: Animals; Blood Glucose; Cytokines; Depression; Disease Models, Animal; Grooming; Hippocampus; Hydrox | 2017 |
Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome.
Topics: Anxiety; Carcinoid Tumor; Depression; Diarrhea; Female; Flushing; Humans; Hydroxyindoleacetic Acid; | 2017 |
Sex-related differential response to clomipramine treatment in a rat model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Disease Models, Animal; Female; | 2009 |
The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Cognition; Depression; Dietary Carbohydrates; Dietary Pr | 2010 |
[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice].
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Chromatography, High Pressure Liq | 2008 |
Association of MAOA gene functional promoter polymorphism with CSF dopamine turnover and atypical depression.
Topics: Case-Control Studies; Depression; Dopamine; Female; Genetic Predisposition to Disease; Genetic Varia | 2009 |
Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.
Topics: Adult; Analysis of Variance; Blood-Brain Barrier; Cytokines; Depression; Female; Homovanillic Acid; | 2009 |
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte | 2011 |
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell | 2012 |
Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anxiety; Checklist; Depression; Diagnostic Self Evaluation; Dopamine | 2011 |
Estrous cycle affects the neurochemical and neurobehavioral profile of carvacrol-treated female rats.
Topics: Animals; Brain; Cymenes; Depression; Estradiol; Estrous Cycle; Female; Grooming; Hydroxyindoleacetic | 2011 |
Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Disease Models, Anima | 2011 |
Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antidepressive Agents, Second-Generat | 2012 |
Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats.
Topics: Animals; Brain; Caffeine; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Immo | 2012 |
Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Depression; Dopamine; Hippocampus; Homovan | 2012 |
Acupuncture stimulation at HT7 alleviates depression-induced behavioral changes via regulation of the serotonin system in the prefrontal cortex of maternally-separated rat pups.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Brain-Derived Neurotrophic Factor; Depression; Hyd | 2012 |
Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.
Topics: Animals; Behavior, Animal; Brain; CX3C Chemokine Receptor 1; Depression; Hydroxyindoleacetic Acid; I | 2013 |
Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liqu | 2013 |
Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hippocampus; Hydroxyindoleacetic Acid; Hypoth | 2013 |
Influence of aging and social isolation on changes in brain monoamine turnover and biosynthesis of rats elicited by novelty stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Brain; Chromatography, High Pre | 2002 |
[Urinary excretion of 5-hydroxyindolacetic acid (5-HIAA) in 150 patients with depressive syndrome and maniacal agitation. (Its modifications by 5-hydroxy-tryptophan loading and therapy in the depressive states)].
Topics: Bipolar Disorder; Depression; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Indoleacetic Ac | 1963 |
[THE 5 HIAA EXCRETION IN URINE IN SLEEP AND WAKING].
Topics: Depression; Depressive Disorder; Hydroxyindoleacetic Acid; Indoleacetic Acids; Metabolism; Serotonin | 1964 |
[HUMORAL FACTORS IN THE ETIOLOGY OF DEPRESSION FOLLOWING TREATMENT WITH RAUWOLFIA ALKALOIDS AND IN ALCOHOLICS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alcoholics; Alcoholism; Alcohols; Antineoplast | 1964 |
Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test.
Topics: Animals; Depression; Diabetes Mellitus, Experimental; Hindlimb Suspension; Hydroxyindoleacetic Acid; | 2004 |
[Monoaminergic transmitters in the cerebrospinal fluid of patients with acute, chronic, and intermittent pain. Interface between pain and depression?].
Topics: Acute Disease; Biogenic Monoamines; Biomarkers; Chronic Disease; Depression; Female; Humans; Hydroxy | 2005 |
Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Northern; Brain Chemistry; Corticosterone | 2004 |
Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Denervation; Depression; Dopamine; | 2004 |
Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit depressive-like symptomatology.
Topics: Animals; Anxiety; Aromatase; Behavior, Animal; Biogenic Monoamines; Brain; Brain Chemistry; Depressi | 2004 |
5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Depression; Dopamine; Female; Homovanillic Acid; Human | 2004 |
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Topics: Adult; Analysis of Variance; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pani | 2006 |
Plasma levels of homovanillic acid, 5-hydroxyindoleacetic acid and cortisol, and serotonin turnover in depressed patients.
Topics: Adult; Case-Control Studies; Depression; Electrochemistry; Female; Homovanillic Acid; Humans; Hydroc | 2006 |
CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence.
Topics: Adult; Alcoholism; Biogenic Monoamines; Depression; Female; Homovanillic Acid; Humans; Hydroxyindole | 2007 |
Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Brain-Deriv | 2007 |
Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Curcuma; Depression; Dopamine; Etha | 2007 |
Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression.
Topics: Animals; Biogenic Monoamines; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticoste | 2007 |
Effects of pre-germinated brown rice on depression-like behavior in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Depression; Diet; Helplessness, Learn | 2007 |
Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; D | 2007 |
In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs.
Topics: Animals; Behavior, Animal; Brain Chemistry; Depression; Female; Guinea Pigs; Hydroxyindoleacetic Aci | 2008 |
Serotonergic mediation effects of St John's wort in rats subjected to swim stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depression; Disease Models, Animal; Hydroxy | 2008 |
Antidepressant-like effect of agmatine is not mediated by serotonin.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2008 |
[A case of tranylcypromine and trifluoperazine (Jatrosom) addiction: psychopathological, sleep physiology and biochemical investigations].
Topics: Adolescent; Adult; Benzoates; Catechols; Child; Child, Preschool; Depression; Dreams; Electroencepha | 1967 |
[Tryptaminuria and urinary 5-H.I.A.A. in neuropsychiatry (preliminary note)].
Topics: Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Monoamine Oxidase Inhibitors; Neurot | 1967 |
Amine metabolism, thyroid function and response to clomipramine and maprotiline medication in depression.
Topics: Adolescent; Adult; Aged; Anthracenes; Clomipramine; Depression; Female; Humans; Hydroxyindoleacetic | 1980 |
Cortisol in the CSF of depressed and suicidal patients.
Topics: Adjustment Disorders; Clomipramine; Depression; Female; Homovanillic Acid; Humans; Hydrocortisone; H | 1980 |
Substances related to 5-hydroxytryptamine in plasma and in lumbar and ventricular fluids of psychiatric patients.
Topics: Adult; Affective Symptoms; Cerebral Ventricles; Depression; Fatty Acids, Nonesterified; Female; Homo | 1980 |
[Current biochemical conceptions of mental diseases. II. Role of changes in the biogenic amine system in the pathogenesis of affective disorders].
Topics: 3-Methoxy-4-hydroxyphenylethanol; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; | 1980 |
Depression vulnerability and 5-hydroxytryptophan prophylaxis.
Topics: 5-Hydroxytryptophan; Adult; Brain; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl | 1980 |
Urinary amine metabolites in depression: a combined biochemical and general practice study: II. Biochemical aspects.
Topics: Adolescent; Adult; Aged; Biogenic Amines; Clomipramine; Depression; Family Practice; Female; Humans; | 1980 |
Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls.
Topics: Blood Platelets; Depression; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; M | 1981 |
[Metabolism of peripheral catecholamines and indole amines in healthy persons. Clinico-biochemical correlates].
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carboxylic Acids; Catecholamines; Depression; Female; Glycols | 1981 |
[Changes in the levels of adrenergic and serotoninergic indices in patients with depressive states].
Topics: Adolescent; Adult; Biogenic Amines; Depression; Dihydroxyphenylalanine; Dopamine; Epinephrine; Homov | 1981 |
Serotonin metabolism of animal model of depression.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Psychological; Depression; Disease Models, Animal; D | 1981 |
Studies of CSF 5-HIAA in depression and suicidal behaviour.
Topics: Blood Platelets; Clomipramine; Depression; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortis | 1981 |
Psychic disturbances in adult coeliac disease. III. Reduced central monoamine metabolism and signs of depression.
Topics: Adult; Aged; Biogenic Amines; Celiac Disease; Depression; Dopamine; Homovanillic Acid; Humans; Hydro | 1982 |
[Clinical, biochemical and psychopharmacologic correlates in patients with depressive symptomatology].
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Hydroxyindoleacetic Acid; | 1980 |
A study of urinary 5-hydroxy indole acetic acid (5-HIAA) in cases of depression before and after treatment.
Topics: Antidepressive Agents; Depression; Humans; Hydroxyindoleacetic Acid | 1982 |
Amine metabolites and neuroendocrine responses related to depression and suicide.
Topics: Alcoholism; Depression; Depressive Disorder; Dexamethasone; Female; Homovanillic Acid; Humans; Hydro | 1983 |
Altered serotonin metabolism in depressed patients with parkinson's disease.
Topics: Aged; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyp | 1984 |
5-hydroxytryptophol in human cerebrospinal fluid: conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Depression; Female; Humans; Hydroxyindoleacetic Acid; Hy | 1984 |
Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; Chromatography, High Pressure Liquid; Depression; | 1984 |
CSF monoamine metabolites in depression and schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal | 1980 |
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression.
Topics: Analysis of Variance; Animals; Brain; Caffeine; Depression; Dose-Response Relationship, Drug; Drug A | 1995 |
Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Cerebral Cort | 1994 |
Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid.
Topics: Animals; Brain Chemistry; Depression; Extracellular Space; Hydroxyindoleacetic Acid; Male; Microdial | 1995 |
A longitudinal study of the relationships between psychometric test scores, offence history and the plasma concentrations of phenylacetic and 5-hydroxyindoleacetic acids in seven inmates of a prison for the psychiatrically disturbed.
Topics: Adult; Aggression; Anger; Anxiety; Crime; Depression; Hostility; Humans; Hydroxyindoleacetic Acid; M | 1993 |
Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication.
Topics: Age Factors; Alzheimer Disease; Antipsychotic Agents; Behavior; Biomarkers; Depression; Female; Huma | 1996 |
Sub-populations of alcohol-dependent patients: differences in psychological functioning between high- and low-frequency alcohol consumers.
Topics: Adaptation, Psychological; Adult; Alcoholism; Depression; Humans; Hydroxyindoleacetic Acid; Hydroxyt | 1996 |
Effects of antidepressants on phencyclidine-induced enhancement of immobility in a forced swimming test in mice.
Topics: Animals; Antidepressive Agents; Depression; Desipramine; Hallucinogens; Hydroxyindoleacetic Acid; Ma | 1997 |
High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desi | 1997 |
Fish consumption and depression.
Topics: Animals; Depression; Diet; Fishes; Humans; Hydroxyindoleacetic Acid | 1998 |
The effect of repeated exposure to forced swimming on extracellular levels of 5-hydroxytryptamine in the rat.
Topics: Animals; Behavior, Animal; Corpus Striatum; Corticosterone; Depression; Disease Models, Animal; Extr | 1998 |
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesics; Animals; Antidepressive Agents; Body T | 1999 |
Stressor-induced alterations in serotonergic activity in an animal model of depression.
Topics: Air; Animals; Depression; Extracellular Space; Hydroxyindoleacetic Acid; Lipopolysaccharides; Male; | 1999 |
Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Cortico | 1999 |
Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations.
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Depression; Ethanol; Female; Homovanillic Acid; | 1999 |
Increased septal 5-HIAA efflux in rats that do not develop learned helplessness after inescapable stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Depression; Dopamine; Helplessness, Learned; Hydroxyindolea | 2000 |
Salmon calcitonin potentiates the analgesia induced by antidepressants.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Antidepress | 2001 |
Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adaptation, Physiological; Animals; Depression; Disease Models, Anim | 2001 |
Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Brain Chemistry; Depressio | 2001 |
Cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in HIV-1 infection.
Topics: Adult; Anxiety; CD4 Lymphocyte Count; Depression; HIV Infections; HIV-1; Homosexuality, Male; Humans | 2001 |
Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression.
Topics: Adolescent; Adult; Aged; Blood Platelets; Depression; Female; Humans; Hydroxyindoleacetic Acid; Impu | 2001 |
Attenuating effects of the isolated rearing condition on increased brain serotonin and dopamine turnover elicited by novelty stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Depression; Dopamine; Exploratory Behavior; Homovani | 2002 |
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Homovanillic Acid; Humans; Hydroxyindole | 1976 |
Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramine.
Topics: Biogenic Amines; Clomipramine; Depression; Depression, Chemical; Dibenzazepines; Homovanillic Acid; | 1977 |
Delusional versus non-delusional depression: Neurochemical differences.
Topics: Adult; Delusions; Depression; Drug Resistance; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1978 |
[Clinical and biochemical contributions on the action of maprotiline and clomipramine in depressive states (preliminary observation)].
Topics: Adult; Bipolar Disorder; Clomipramine; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; M | 1979 |
[Clinical and biochemical contributions on the effect of maprotiline and clomipramine in depressive states (preliminary observation)].
Topics: Adjustment Disorders; Adult; Anthracenes; Blood Platelets; Clomipramine; Depression; Female; Humans; | 1979 |
[The role of serotonin in affective disorders (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depression; Humans; Hydroxyindoleacetic A | 1979 |
[Use of antidepressants: pharmacokinetic basis (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Biotransformation; Depression; Diseases in Twins; Dose-Response Re | 1979 |
[Indoleamine precursors in depression (author's transl)].
Topics: Depression; Drug Therapy, Combination; Humans; Hydroxyindoleacetic Acid; Middle Aged; Monoamine Oxid | 1979 |
[Respective position of antidepressants in therapeutics (author's transl)].
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Catechol O-Methyltransferase; Depression; H | 1979 |
Animal model of depression. III. Mechanism of action of tetrabenazine.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Depression; Disease Models, Animal; Dopamine; | 1978 |
Interactions between central monoaminergic systems: dopamine-serotonin.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Depression; Dopamine; Dyskinesia, Drug-Induced; Female; H | 1979 |
[Biochemistry of depression].
Topics: Adrenocorticotropic Hormone; Bipolar Disorder; Contraceptives, Oral; Cyclic AMP; Depression; Dopamin | 1976 |
[REM sleep deprivation in normal humans. Changes in anxiety, depression and aggressiveness, and HVA and 5-HIAA levels in the lumbar cerebrospinal fluid].
Topics: Adult; Aggression; Anxiety; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; P | 1976 |
Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals.
Topics: Adult; Aged; Bipolar Disorder; Body Temperature; Calcium; Circadian Rhythm; Depression; Electroencep | 1979 |
Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.
Topics: Adolescent; Adult; Aged; Biogenic Amines; Chlorpromazine; Cyclic AMP; Depression; Female; Homovanill | 1979 |
Manipulation of neurotransmitters by acupuncture (?) (A preliminary communication).
Topics: Acupuncture Therapy; Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Depression; Fema | 1975 |
The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Autopsy; Bipolar Disorder; Brain Chemistry; C | 1977 |
Pituitary thyrotropin response to thyrotropin-releasing hormone in affective illness: relationship to spinal fluid amine metabolites.
Topics: Age Factors; Bipolar Disorder; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Ac | 1977 |
Naloxone (Narcan) treatment in depression: clinical observations and effects on CSF endorphins and monoamine metabolites.
Topics: Adult; Alcoholism; Biogenic Amines; Depression; Endorphins; Female; Homovanillic Acid; Humans; Hydro | 1977 |
Depression: new evidence in support of biological differentiation.
Topics: Adult; Bipolar Disorder; Carbidopa; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Meth | 1979 |
Repertory grid and biochemical characterization of depression: a comparison of case reports.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1979 |
Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression.
Topics: Adult; Age Factors; Aged; Animals; Biological Transport; Brain; Clomipramine; Depression; Female; Hu | 1979 |
Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.
Topics: Adult; Affective Symptoms; Aged; Biogenic Amines; Bipolar Disorder; Depression; Electroencephalograp | 1977 |
[Pathophysiologic mechanisms of depressive states of endogenous or exogenous origin].
Topics: Adult; Autonomic Nervous System; Biogenic Amines; Brain; Cerebral Cortex; Chlorpromazine; Depression | 1978 |
Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders.
Topics: Adult; Aged; Biogenic Amines; Bipolar Disorder; Depression; Female; Homovanillic Acid; Humans; Hydro | 1978 |
Cerebrospinal fluid amine metabolites after combined amitriptyline-triiodothyronine treatment of depressed women.
Topics: Adult; Amitriptyline; Biogenic Amines; Depression; Drug Therapy, Combination; Female; Homovanillic A | 1977 |
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.
Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pr | 1977 |
CSF amine metabolites, clinical symptoms, and body movement in psychiatric patients.
Topics: Adult; Anger; Anxiety; Arousal; Brain; Depression; Female; Homovanillic Acid; Humans; Hydroxyindolea | 1976 |
A dopaminergic mechanism in mania.
Topics: Bipolar Disorder; Depression; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Lithium | 1976 |
5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?
Topics: Adjustment Disorders; Adult; Aged; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl | 1976 |
Clinical and biochemical parameters during neuroleptic treatment. II. Antipsychotic effect of haloperidol in patients with chronic organic brain damage.
Topics: Adult; Aged; Brain Damage, Chronic; Depression; Female; Hallucinations; Haloperidol; Homovanillic Ac | 1976 |
Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients.
Topics: Adult; Aged; Anxiety Disorders; Brain Diseases; Cerebral Ventricles; Depression; Female; Homovanilli | 1976 |
[Repeated arousal during non-REM sleep in normal humans. Changes in anxiety, depression and aggressiveness and HVA and 5-HIAA levels in the lumbar cerebrospinal fluid].
Topics: Adult; Aggression; Anxiety; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; P | 1976 |
[Total sleep deprivation in normal humans. Changes in anxiety, depression and aggressiveness and HVA and 5-HIAA levels in the lumbar cerebrospinal fluid].
Topics: Adult; Anxiety; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Phenylacetate | 1976 |
Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients.
Topics: 5-Hydroxytryptophan; Adjustment Disorders; Adult; Aged; Blood Platelets; Brain; Depression; Female; | 1975 |
The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.
Topics: 3-Hydroxyanthranilic Acid; 5-Hydroxytryptophan; Animals; Brain; Depression; Diet; Drug Synergism; Hu | 1975 |
Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; | 1976 |
Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Depression; Female; Humans; Hydroxyind | 1976 |
Gradients of biogenic amine metabolites in cerebrospinal fluid.
Topics: Alzheimer Disease; Amphetamine; Brain Diseases; Brain Neoplasms; Depression; Homovanillic Acid; Huma | 1975 |
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania.
Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno | 1975 |
Central noradrenergic function in man: vanillylmandelic acid in CSF.
Topics: Acute Disease; Affective Symptoms; Bipolar Disorder; Depression; Homovanillic Acid; Humans; Hydroxyi | 1975 |
Biochemical post-mortem findings in depressed patients.
Topics: Aged; Brain Chemistry; Brain Mapping; Circadian Rhythm; Depression; Dopamine; Female; Homovanillic A | 1975 |
Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression.
Topics: Amitriptyline; Biogenic Amines; Depression; Desipramine; Dextroamphetamine; Humans; Hydroxyindoleace | 1975 |
[Biochemical findings in the brain in endogenous depression].
Topics: Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Catecholamines; Depression; Dopamine; | 1975 |
Effect of peripheral decarboxylase inhibition on HVA and 5HIAA in cerebrospinal fluid of depressed patients.
Topics: Adult; Aged; Benserazide; Depression; Female; Homovanillic Acid; Humans; Hydrazines; Hydroxyindoleac | 1975 |
Cerebrospinal fluid amine metabolites in affective illness and schizophrenia: clinical and pharmacological studies.
Topics: Affective Symptoms; Amines; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Imipram | 1975 |
"Serotonin depression"--a biochemical subgroup within the affective disorders?
Topics: Antidepressive Agents; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Serotonin; Sex Fa | 1976 |
Concentration of 5-hydroxyindoleacetic acid, homovanillic acid, and tryptophan in the cerebrospinal fluid of depressed patients before and after ECT.
Topics: Adult; Brain; Depression; Electroconvulsive Therapy; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1976 |
Effects of sleep deprivation on mood and central amine metabolism in depressed patients.
Topics: Adult; Affect; Aged; Brain; Depression; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleac | 1976 |
Neurochemical correlates of major depression in primary dementia.
Topics: Brain; Choline O-Acetyltransferase; Dementia; Depression; Homovanillic Acid; Humans; Hydroxyindoleac | 1990 |
Tritiated imipramine binding. A peripheral marker for serotonin in Parkinson's disease.
Topics: Aged; Biomarkers; Blood Platelets; Depression; Humans; Hydroxyindoleacetic Acid; Imipramine; Middle | 1991 |
Neuroendocrine responses to L-tryptophan as an index of brain serotonin function: effect of weight loss.
Topics: Adult; Biological Transport, Active; Brain Chemistry; Clomipramine; Depression; Diet, Reducing; Fema | 1991 |
Plasma free 5HT and platelet 5HT in depression: case-control studies and the effect of antidepressant therapy.
Topics: Antidepressive Agents; Bipolar Disorder; Blood Platelets; Case-Control Studies; Depression; Female; | 1991 |
Biochemical correlate of depression in children.
Topics: Adolescent; Age Factors; Analysis of Variance; Catecholamines; Child; Child, Abandoned; Depression; | 1991 |
[A multidisciplinary approach to the diagnostic problem of headache].
Topics: Depression; Headache; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Personality | 1987 |
Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites.
Topics: Adult; Blood Platelets; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kin | 1987 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid--methodological and clinical aspects.
Topics: Chromatography, High Pressure Liquid; Depression; Humans; Hydroxyindoleacetic Acid; Reference Values | 1987 |
Effect of moclobemide on clinical and neurochemical variables in depressed patients (preliminary findings).
Topics: Adult; Benzamides; Blood Platelets; Depression; Female; Growth Hormone; Humans; Hydroxyindoleacetic | 1988 |
[Determination of 3-methoxy-4-hydroxyphenyethylene-glycol and its urinary conjugates. Value in the diagnosis and therapeutic follow-up of depression].
Topics: Clomipramine; Depression; Drug Therapy, Combination; Follow-Up Studies; Glycols; Humans; Hydroxyindo | 1988 |
Cerebrospinal fluid correlates of depression in Huntington's disease.
Topics: Adult; Corticotropin-Releasing Hormone; Depression; Female; Humans; Huntington Disease; Hydroxyindol | 1988 |
Coexisting dementia and depression in Parkinson's disease.
Topics: Aged; Aging; Alzheimer Disease; Dementia; Depression; Humans; Hydroxyindoleacetic Acid; Middle Aged; | 1989 |
The effect of R-(-)-deprenyl in de novo parkinsonian patients pretreated with levodopa and decarboxylase inhibitor correlated to depression and MHPG, HIAA and HVA levels in the cerebrospinal fluid.
Topics: Benserazide; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Glycols; Homovanill | 1989 |
Differences in lithium effects in depressed and healthy subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Depression; Dopamine; Homovanillic Acid; Humans; Hydroxyindol | 1985 |
Neurotransmission and the experience of low back pain; no association between CSF monoamine metabolites and pain.
Topics: Adult; Anxiety; Back Pain; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; | 1985 |
Carcinoid carcinomatous meningitis.
Topics: Aged; Arachnoid; Carcinoid Tumor; Depression; Female; Humans; Hydroxyindoleacetic Acid; Meningeal Ne | 1985 |
Ageing, monoamines, and monoamine-oxidase levels.
Topics: Adult; Aged; Aging; Autopsy; Blood Platelets; Brain Chemistry; Cerebellum; Depression; Humans; Hydro | 1972 |
Modified amine hypothesis for the aetiology of affective illness.
Topics: Affective Symptoms; Amines; Animals; Antidepressive Agents; Binding Sites; Biogenic Amines; Bipolar | 1972 |
Total and free tryptophan concentration in the plasma of depressive patients.
Topics: Acids; Brain; Depression; Fatty Acids, Nonesterified; Female; Humans; Hydroxyindoleacetic Acid; Lith | 1973 |
Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness.
Topics: Adult; Affective Symptoms; Antipsychotic Agents; Biogenic Amines; Bipolar Disorder; Butyrophenones; | 1973 |
Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients.
Topics: Adolescent; Adult; Aged; Brain Chemistry; Cerebellum; Depression; Female; Humans; Hydroxyindoleaceti | 1968 |
The significance of brain-amine concentrations.
Topics: Amines; Brain; Brain Chemistry; Brain Stem; Depression; Humans; Hydroxyindoleacetic Acid; Suicide; T | 1969 |
Contraceptives, brain serotonin, and liver tryptophan pyrrolase.
Topics: Animals; Brain; Contraceptives, Oral; Corticosterone; Depression; Female; Humans; Hydroxyindoleaceti | 1970 |
Subtype of affective psychoses classified by response on amineprecursors and monoamine metabolism.
Topics: 5-Hydroxytryptophan; Amines; Depression; Dihydroxyphenylalanine; Female; Humans; Hydroxyindoleacetic | 1974 |
Effects of -methyltyrosine on the cerebrospinal fluid content of HVA and 5-HIAA in man.
Topics: Cerebrospinal Fluid; Depression; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Methyltyrosin | 1971 |
3 -Methoxy- 4 -hydroxyphenylethylene glycol in human cerebrospinal fluid.
Topics: Chromatography, Gas; Depression; Dihydroxyphenylalanine; Down Syndrome; Ethers; Glycols; Humans; Hyd | 1971 |
Brain serotonin, affective illness, and antidepressant drugs: cerebrospinal fluid studies with probenecid.
Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Depression; Fenclo | 1974 |
Some remarks concerning the possible role of brain monoamines (dopamine, noradrenaline, serotonin) in mental disorders.
Topics: Brain; Caudate Nucleus; Depression; Dopamine; Globus Pallidus; Humans; Huntington Disease; Hydroxyin | 1974 |
Serotonin now: clinical implications of inhibiting its synthesis with para-chlorophenylalanine.
Topics: Adult; Aged; Animals; Behavior; Brain Chemistry; Catechols; Cattle; Depression; Diarrhea; Dogs; Enzy | 1970 |
REM sleep and central monoamine oxidase inhibition.
Topics: Adolescent; Adult; Blood-Brain Barrier; Brain; Depression; Electroencephalography; Female; Humans; H | 1972 |
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi | 1973 |
Psychomotor activity, sleep, and biogenic amine metabolites in depression.
Topics: Adult; Biological Transport, Active; Circadian Rhythm; Depression; Electroencephalography; Electromy | 1974 |
The biochemistry of therapy-resistant depression. Contributions to biochemistry.
Topics: Acetylation; Antidepressive Agents; Brain; Depression; Drug Resistance; Histocytochemistry; Humans; | 1974 |
CSF monoamine metabolites in alcoholism: a comparative study with depression.
Topics: Adult; Aged; Alcoholism; Depression; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Ma | 1974 |
Fluorometric measurement of 5-hydroxyindoleacetic acid (5HIAA) and tryptophan in human CSF: effects of high doses of probenecid.
Topics: Administration, Oral; Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Depression; Female; Fluo | 1974 |
Noradrenaline and 5-hydroxytryptamine metabolism in six areas of rat brain during post-amphethamine depression.
Topics: Animals; Behavior, Animal; Brain; Depression; Depression, Chemical; Dextroamphetamine; Fluorometry; | 1974 |
Cerebrospinal fluid levels of MHPG in affective disorders.
Topics: Adjustment Disorders; Affective Symptoms; Bipolar Disorder; Carbonates; Catechols; Depression; Glyco | 1972 |
[Studies of indolamine metabolites in cerebrospinal fluid in depression].
Topics: Depression; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Indomethacin; Male; Mass S | 1972 |
Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness.
Topics: Adult; Affect; Affective Symptoms; Aged; Catechols; Depression; Dopamine; Female; Glycols; Humans; H | 1973 |
5-Hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration.
Topics: Adult; Affective Symptoms; Age Factors; Aged; Bipolar Disorder; Depression; Female; Humans; Hydroxyi | 1973 |
Metabolism of tryptophan in depressive disease.
Topics: Adult; Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Metabolic C | 1973 |
Carcinoid and psychiatric symptoms.
Topics: Adult; Affective Symptoms; Aged; Anxiety; Brain; Carcinoid Tumor; Cyclophosphamide; Depression; Huma | 1973 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid.
Topics: Adult; Age Factors; Brain Diseases; Brain Stem; Depression; Epilepsy; Humans; Hydroxyindoleacetic Ac | 1973 |
The effect of fat diet on reserpine-induced depression in mice.
Topics: Animals; Brain Chemistry; Brain Stem; Depression; Dietary Fats; Fasting; Humans; Hydroxyindoleacetic | 1973 |
Lumbar CSF 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes.
Topics: Adult; Affective Symptoms; Amitriptyline; Animals; Bipolar Disorder; Brain Chemistry; Cats; Depressi | 1974 |
Deductive approaches to the catecholamine hypothesis of affective disorders.
Topics: Affective Symptoms; Antidepressive Agents; Biogenic Amines; Bipolar Disorder; Brain; Brain Chemistry | 1974 |
The daily rhythm of HVA, VMA, (VA) and 5-HIAA in depression-syndrome.
Topics: Benzoates; Chromatography, Thin Layer; Circadian Rhythm; Depression; Homovanillic Acid; Humans; Hydr | 1974 |
Tryptophan metabolism in depressive illness.
Topics: Blood Proteins; Carbon Radioisotopes; Depression; Electroconvulsive Therapy; Female; Humans; Hydroxy | 1974 |
Depressive illness and oral contraceptives. A study of urinary 5-hydroxyindoleacetic acid excretion.
Topics: Contraceptives, Oral; Depression; Female; Humans; Hydroxyindoleacetic Acid; Menstruation; Spectromet | 1974 |
Mood and neuronal functions: a modified amine hypothesis for the etiology of affective illness.
Topics: Affective Symptoms; Animals; Biogenic Amines; Depression; Emotions; Exploratory Behavior; Humans; Hy | 1974 |
Toward a biochemical classification of depression.
Topics: Antidepressive Agents; Biogenic Amines; Brain; Brain Stem; Depression; Dopamine; Homovanillic Acid; | 1974 |
Relationship of age and mood to monoamine metabolites in cerebrospinal fluid in parkinsonism.
Topics: Age Factors; Aged; Biogenic Amines; Depression; Dihydroxyphenylalanine; Emotions; Female; Homovanill | 1974 |
Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline.
Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl | 1972 |
Abnormalities of indoleamines in affective disorders.
Topics: Adult; Affective Symptoms; Biogenic Amines; Brain Chemistry; Depression; Drug Combinations; Evaluati | 1972 |
Indoleamine metabolism in affective disorders: excretion of tryptamine, indoleacetic acid and 5-hydroxy-indoleacetic acid in depressive states.
Topics: Adult; Affective Symptoms; Aged; Creatine; Depression; Female; Humans; Hydroxyindoleacetic Acid; Ind | 1972 |
Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients.
Topics: Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Phenylacetates | 1972 |
6-Methoxy-1,2,3,4-tetrahydro- -carboline--a serotonin elevator.
Topics: Animals; Brain; Chromatography, Paper; Depression; Female; Humans; Hydroxyindoleacetic Acid; Indoles | 1972 |
Indoleamines and affective disorders.
Topics: Affective Symptoms; Brain Chemistry; Central Nervous System; Depression; Electroconvulsive Therapy; | 1972 |
Thyroid-imipramine clinical and chemical interaction: evidence for a receptor deficit in depression.
Topics: Adult; Catechols; Depression; Female; Glycols; Humans; Hydroxyindoleacetic Acid; Imipramine; Middle | 1972 |
A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients.
Topics: Administration, Oral; Biological Transport; Brain; Depression; Female; Humans; Hydroxyindoleacetic A | 1971 |
Effects of adrenal hormones and stress on brain serotonin.
Topics: Adrenal Cortex Hormones; Allopurinol; Animals; Brain; Corticosterone; Depression; Depression, Chemic | 1971 |
Homovanillic and 5-hydroxyindoleacetic acid in cerebrospinal fluid of depressed patients.
Topics: Adult; Age Factors; Depression; Dexamethasone; Humans; Hydroxyindoleacetic Acid; Imipramine; Middle | 1971 |
[Biochemical correlates of a 48 hour periodic psychosis].
Topics: 17-Ketosteroids; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Bipolar Dis | 1971 |
The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat.
Topics: Animals; Body Temperature; Brain; Depression; Humans; Hydroxyindoleacetic Acid; Male; Motor Activity | 1971 |
Initial mental disorders in carcinoma of pancreas and stomach.
Topics: Adult; Aged; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Mental Disorders; | 1971 |
Serotonin and severe affective disorders.
Topics: Affective Symptoms; Biogenic Amines; Brain Chemistry; Depression; Humans; Hydroxyindoleacetic Acid; | 1971 |
Tryptophan pyrrolase and depressive illness.
Topics: 5-Hydroxytryptophan; Depression; Humans; Hydroxyindoleacetic Acid; Psychiatric Status Rating Scales; | 1970 |
Amine metabolism in brain.
Topics: Amines; Animals; Brain; Cerebral Cortex; Depression; Dogs; Dopamine; Humans; Hydroxyindoleacetic Aci | 1969 |
Amines and abnormal mood.
Topics: Affective Symptoms; Blood-Brain Barrier; Catecholamines; Depression; Dihydroxyphenylalanine; Epineph | 1969 |
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid.
Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin | 1970 |
A controlled study of the antidepressant effect of p-Chloro-N-methylamphetamine, a compound with a selective effect on the central 5-hydroxytryptamine metabolism.
Topics: Antidepressive Agents; Brain Chemistry; Cerebral Cortex; Depression; Humans; Hydroxyindoleacetic Aci | 1970 |
Influence of convulsive therapy on 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid in endogenous depression.
Topics: Amines; Depression; Electroshock; Humans; Hydroxyindoleacetic Acid; Phenylacetates; Probenecid | 1971 |
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?
Topics: Brain; Depression; Humans; Hydroxyindoleacetic Acid; Probenecid; Serotonin | 1971 |
Indolealkylamines and behavior. Introductory remarks.
Topics: Animals; Behavior; Depression; Dogs; Humans; Hydroxyindoleacetic Acid; Indoles; Parkinson Disease; P | 1968 |
[Excretion of 3-methoxy-4-hydroxy-amygdalic acid and 5-hydroxyindoleacetic acid in the urine of patients with depressive states].
Topics: Adult; Bipolar Disorder; Catecholamines; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; | 1968 |
Relationship of monoamine metabolites in human cerebrospinal fluid to age.
Topics: Adult; Age Factors; Bipolar Disorder; Brain; Depression; Female; Humans; Hydroxyindoleacetic Acid; M | 1968 |
Biochemical aspects of depression.
Topics: Adrenal Glands; Brain Chemistry; Depression; Dopamine; Electrolytes; Epinephrine; Extracellular Spac | 1969 |
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania.
Topics: Adult; Aged; Bipolar Disorder; Depression; Fluorometry; Humans; Hydroxyindoleacetic Acid; Male; Midd | 1966 |