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hydroxyindoleacetic acid and Brain Ischemia

hydroxyindoleacetic acid has been researched along with Brain Ischemia in 24 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"The effects of citalopram, a serotonin (5-HT) reuptake inhibitor, on cerebral blood flow (CBF) and concentration of 5-HT and its metabolite were investigated in spontaneously hypertensives rats (SHR) subjected to forebrain ischemia."7.69Citalopram, a serotonin reuptake inhibitor, and brain ischemia in SHR. ( Fujishima, M; Ibayashi, S; Izumi, J; Nagao, T; Sadoshima, S, 1995)
"In rats with cerebral ischemia, a low dose (10 mg/kg, i."5.27Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985)
"The effects of citalopram, a serotonin (5-HT) reuptake inhibitor, on cerebral blood flow (CBF) and concentration of 5-HT and its metabolite were investigated in spontaneously hypertensives rats (SHR) subjected to forebrain ischemia."3.69Citalopram, a serotonin reuptake inhibitor, and brain ischemia in SHR. ( Fujishima, M; Ibayashi, S; Izumi, J; Nagao, T; Sadoshima, S, 1995)
"For understanding of the role of monoamines in cerebral ischemia, 3-methoxy-4-hydroxyphenylglycol (MHPG), hydroxyindoleacetic acid (5HIAA) homovanillic acid (HVA) the three major monoamine metabolites in CSF of 33 patients and 18 controls were measured with high-performance liquid chromatography."3.68[The changes of monoamine metabolites in CSF of patients with cerebral stroke]. ( Tang, HZ, 1991)
"Rat striatal extracellular fluid levels of dopamine, serotonin, 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were measured before, during and after transient, global cerebral ischemia in awake rats using in vivo brain microdialysis."3.67Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites. ( Clemens, JA; Phebus, LA, 1989)
"To clarify the rule of monoamine in cerebral ischemia, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) of 33 patients and 18 controls were measured with high performance liquid chromatography."3.67Monoamine metabolites in cerebrospinal fluid during acute cerebral ischemia. ( Huang, YQ; Lu, XF; Ou, YS; Tang, HZ; Wang, KJ, 1989)
"Vannucci, Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage, Pediatr."1.30Anoxic and hypoxic immature rat model for measurement of monoamine using in vivo microdialysis. ( Ishida, A; Nakajima, W; Takada, G, 1999)
"In rats with cerebral ischemia, idebenone (10 mg/kg, i."1.28Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1989)
"Our results indicate that during cerebral ischemia a large increase in extracellular dopamine concentration in the caudate nucleus occurs, probably as a result of energy failure of the cell membranes."1.27Striatal dopamine in acute cerebral ischemia of stroke-resistant rats. ( Kawano, T; Miyake, H; Mori, K; Tsutsumi, K, 1988)
"In rats with cerebral ischemia, a low dose (10 mg/kg, i."1.27Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199013 (54.17)18.7374
1990's10 (41.67)18.2507
2000's1 (4.17)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mitsuyo, T1
Adachi, N1
Yorozuya, T1
Tabo, E1
Nagaro, T1
Arai, T1
Pau, A1
Sehrobundt Viale, E1
Turtas, S1
Jellinger, K1
Riederer, P1
Stelmasiak, Z1
Kogure, K1
Nagao, T1
Ibayashi, S1
Sadoshima, S1
Izumi, J1
Fujishima, M1
Takagi, N1
Miyake, K1
Ohiwa, A1
Nukaga, R1
Takeo, S1
Thaminy, S1
Bellissant, E1
Maginn, M1
Decombe, R1
Allain, H1
Bentué-Ferrer, D1
Nakajima, W1
Ishida, A1
Takada, G1
Globus, MY1
Wester, P1
Busto, R1
Dietrich, WD1
Luthman, J1
Lindqvist, E1
Dell'Anna, E1
Kojima, H1
Shiotani, T1
Tachizawa, H1
Olson, L1
Haba, K1
Ogawa, N1
Asanuma, M1
Hirata, H1
Mori, A1
Heyes, MP1
Nowak, TS1
Tang, HZ2
Bao, WL1
Sun, FY1
Tong, JF1
Zhang, LM1
Zhang, AZ1
Ferrarese, C1
Bassi, S1
Frattola, L1
Locatelli, P1
Piolti, R1
Trabucchi, M1
Weinberger, J1
Nieves-Rosa, J1
Ogura, K1
Shibuya, M1
Kanamori, M1
Suzuki, Y1
Harada, T1
Okada, T1
Tanoi, C1
Kageyama, N1
Kawano, T2
Miyake, H2
Tsutsumi, K2
Mori, K2
Phebus, LA1
Clemens, JA1
Nagai, Y2
Narumi, S2
Kakihana, M2
Yamazaki, N2
Nagaoka, A2
Nagawa, Y2
Lu, XF1
Wang, KJ1
Ou, YS1
Huang, YQ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of F-18 Paclitaxel (FPAC) PET for Evaluating Drug Delivery of Solid Tumors in Breast, Lung, Renal, and Adrenal Cancers[NCT01086696]Early Phase 16 participants (Actual)Interventional2010-03-09Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

24 other studies available for hydroxyindoleacetic acid and Brain Ischemia

ArticleYear
Facilitation of ischemia-induced release of dopamine and neuronal damage by dexamethasone in the rat striatum.
    European journal of pharmacology, 2003, Apr-04, Volume: 465, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Cortex Hormones; Animals; Biogenic Monoamines; Blood Pressur

2003
Effect of omental transposition on to the brain on the cortical content of norepinephrine, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in experimental cerebral ischaemia.
    Acta neurochirurgica, 1982, Volume: 66, Issue:3-4

    Topics: Animals; Biogenic Amines; Brain; Brain Ischemia; Cerebral Cortex; Dopamine; Hydroxyindoleacetic Acid

1982
[Central neurotransmitters in cerebral ischemia and stroke].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cerebral Infarction; Cerebrovascular Diso

1983
Effect of ischemia on monoamine metabolism. Brain monoamine metabolites in cerebrospinal fluid of patients with recent cerebral infarction.
    Neuropatologia polska, 1982, Volume: 20, Issue:1-2

    Topics: Aged; Brain Ischemia; Cerebral Infarction; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Ac

1982
[Cerebral ischemia and changes in the brain monoamines].
    No to shinkei = Brain and nerve, 1983, Volume: 35, Issue:1

    Topics: Animals; Biogenic Amines; Brain; Brain Ischemia; Cyclic AMP; Dopamine; Epinephrine; Hydroxyindoleace

1983
Citalopram, a serotonin reuptake inhibitor, and brain ischemia in SHR.
    Brain research bulletin, 1995, Volume: 38, Issue:1

    Topics: Animals; Blood Pressure; Body Temperature; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulat

1995
Effects of delayed treatment with nafronyl oxalate on microsphere embolism-induced changes in monoamine levels of rat brain regions.
    British journal of pharmacology, 1996, Volume: 118, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Brain Ischemia; Dopamine; Hydro

1996
Effect of brain microdialysis on aminergic transmitter levels in repeated cerebral global transient ischemia in rat.
    Journal of neuroscience methods, 1996, Dec-28, Volume: 70, Issue:2

    Topics: Amphetamines; Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Carotid Arteries; Cerebrovasc

1996
Anoxic and hypoxic immature rat model for measurement of monoamine using in vivo microdialysis.
    Brain research. Brain research protocols, 1999, Volume: 3, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain; Brain Chemistry; Brain Ischemia; C

1999
Ischemia-induced extracellular release of serotonin plays a role in CA1 neuronal cell death in rats.
    Stroke, 1992, Volume: 23, Issue:11

    Topics: Animals; Brain Ischemia; Cell Survival; Corpus Striatum; Dialysis; Extracellular Space; Hippocampus;

1992
Effects of DM-9384, a pyrrolidone derivative, on ischemia-induced changes in the central monoamine systems.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain Chemistry; Brain Ischemia; Centr

1992
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.
    Journal of neural transmission. General section, 1992, Volume: 88, Issue:3

    Topics: Animals; Benzhydryl Compounds; Benzoquinones; Biogenic Monoamines; Brain Chemistry; Brain Ischemia;

1992
Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dopamin

1990
[The changes of monoamine metabolites in CSF of patients with cerebral stroke].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1991, Volume: 24, Issue:3

    Topics: Brain Ischemia; Cerebrovascular Disorders; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Ac

1991
[Antagonistic effect of phencyclidine on cerebral ischemic damage of rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Catecholamines; Cerebral Cortex; Dop

1991
Different patterns of CSF neurotransmitter metabolism in patients with left or right hemispheric stroke.
    Acta neurologica Scandinavica, 1986, Volume: 73, Issue:6

    Topics: Aged; Biogenic Amines; Brain Ischemia; Female; Functional Laterality; Homovanillic Acid; Humans; Hyd

1986
Metabolism of monoamine neurotransmitters in the evolution of infarction in ischemic striatum.
    Journal of neural transmission, 1987, Volume: 69, Issue:3-4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain Ischemia; Carotid Arteries; Cerebral

1987
[Measurements of monoamine neurotransmitter metabolism by in vivo voltammetry].
    No to shinkei = Brain and nerve, 1987, Volume: 39, Issue:12

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain; Brain Ischemia; Dopamine; Electrodi

1987
[Sequential changes in dopamine and monoamine metabolites in ischemic rat caudate nucleus. In vivo dialysis coupled with high-performance liquid chromatography with electrochemical detection].
    Neurologia medico-chirurgica, 1988, Volume: 28, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain Ischemia; Caudate Nucleus; Chromatog

1988
Striatal dopamine in acute cerebral ischemia of stroke-resistant rats.
    Stroke, 1988, Volume: 19, Issue:12

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Caudate Nucleus; Cerebrovascular Disorders;

1988
Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites.
    Life sciences, 1989, Volume: 44, Issue:19

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Corpus Striatum; Dopamine; Extracellular Sp

1989
Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats.
    Archives of gerontology and geriatrics, 1989, Volume: 8, Issue:3

    Topics: Animals; Benzoquinones; Biogenic Monoamines; Brain; Brain Ischemia; Cyclic AMP; Disease Models, Anim

1989
Monoamine metabolites in cerebrospinal fluid during acute cerebral ischemia.
    Chinese medical journal, 1989, Volume: 102, Issue:1

    Topics: Aged; Biogenic Monoamines; Brain Ischemia; Electronic Data Processing; Female; Homovanillic Acid; Hu

1989
Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
    Japanese journal of pharmacology, 1985, Volume: 37, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Biogenic Amines; Brain; Brain Ischemia; Chro

1985