hydroxyindoleacetic acid and Body Weight studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
"In 46 inpatients with severe DSM III depression, blood counts, serum and red cell folate, serum vitamin B12, total plasma homocysteine, and, in 28 patients, CSF folate, S-adenosylmethionine, and the monoamine neurotransmitter metabolites 5HIAA, HVA, and MHPG were examined."	9.09	Homocysteine, folate, methylation, and monoamine metabolism in depression. ( Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK, 2000)
"In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study."	9.04	Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976)
"When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity (monosodium glutamate-treated obesity; MSG-OB) were observed as these rats grew."	7.70	Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines. ( Gomita, Y; Nakagawa, T; Ohyama, T; Okamura, H; Ukai, K, 2000)
" In this study, dehydroepiandrosterone's effect at decreasing food intake and body weight in the obese Zucker rat was investigated."	7.68	Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. ( Abadie, JM; Browne, ES; Correa, G; Porter, JR; Svec, F; Wright, B, 1993)
"The present experiments describe the effects of continuous SC infusion, via osmotic minipump, of dexfenfluramine on food intake and body weight of male and female rats."	7.67	Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats. ( Rowland, NE, 1986)
"The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine."	7.67	Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988)
" In an effort to determine whether indoleamine systems had any role in the etiology of cancer anorexia the anorectic effects of cancer (Walker 256 carcinosarcoma) were investigated in immature female rats that had been depleted of brain serotonin (5-HT) by the intracisternal injection of 5,7-dihydroxytryptamine (5,7-DHT) or the systemic injection of para-chloramphetamine (PCA)."	7.66	Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia. ( Chance, WT; Fischer, JE; von Meyenfeldt, M, 1983)
"Loss of body weight was proved to be a convenient and reliable way to predict the degree of reserpine-induced amine depletion after i."	7.65	Loss of body weight as a predictor of reserpine-induced amine depletion. ( Freedman, DX; Halaris, AE, 1975)
"In 46 inpatients with severe DSM III depression, blood counts, serum and red cell folate, serum vitamin B12, total plasma homocysteine, and, in 28 patients, CSF folate, S-adenosylmethionine, and the monoamine neurotransmitter metabolites 5HIAA, HVA, and MHPG were examined."	5.09	Homocysteine, folate, methylation, and monoamine metabolism in depression. ( Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK, 2000)
"In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study."	5.04	Negative effects of melatonin on depression. ( Buswell, R; Carman, JS; Goodwin, FK; Post, RM, 1976)
" Serum corticosterone and corticotrophin-releasing hormone levels were significantly higher for mothers with CUS before pregnancy and their foetuses than for the controls."	3.78	Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat. ( Chen, Y; Huang, Y; Li, H; Shi, X; Xu, H; Yang, H, 2012)
"We have established an animal model for olanzapine-induced body weight gain, and used it to explore the relation between this weight gain, excessive food consumption, gross motor activity, and macronutrient choice."	3.72	An animal model of antipsychotic-induced weight gain. ( Adamson, B; Arjona, AA; Wurtman, RJ; Zhang, SX, 2004)
"When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity (monosodium glutamate-treated obesity; MSG-OB) were observed as these rats grew."	3.70	Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines. ( Gomita, Y; Nakagawa, T; Ohyama, T; Okamura, H; Ukai, K, 2000)
"Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)."	3.69	Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995)
" Cerebrospinal fluid levels of L-tryptophan, quinolinic acid, kynurenic acid, L-kynurenine, and 5-hydroxyindoleacetic acid were measured in medication-free female patients meeting DSM-III-R criteria for either anorexia nervosa (n = 10) or normal-weight bulimia nervosa (n = 22), studied at varying stages of nutritional recovery."	3.69	Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable. ( Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA, 1995)
"Dehydroepiandrosterone (DHEA) decreases body weight and food intake of the obese Zucker rat, a model of youth-onset obesity associated with hyperphagia."	3.69	The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters. ( Abadie, JM; Browne, ES; Porter, JR; Svec, F; Wright, BE, 1995)
"It is known that deaths attributable to pellagra, which is considered to be a disease caused by the disturbance of tryptophan metabolism, have been approximately two-fold higher in women than in men."	3.69	Effects of sex hormones on the metabolism of tryptophan to niacin and to serotonin in male rats. ( Shibata, K; Toda, S, 1997)
"Phenelzine (PLZ), a nonselective monoamine oxidase inhibitor, is widely used in psychiatry for the treatment of panic disorder and depression."	3.68	Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function. ( Baker, GB; Coutts, RT; Greenshaw, AJ; McKenna, KF, 1992)
"They assessed the relationship between lateral ventricle enlargement (ventricle-brain ratio, VBR) and CSF neurotransmitter metabolite concentrations (HVA and 5-hydroxyindoleacetic acid [5-HIAA]) in 45 patients with schizophrenia, 28 with affective disorders (19 patients with major depression and nine with bipolar disorder), and 91 normal comparison subjects."	3.68	Lateral ventricle-brain ratio and balance between CSF HVA and 5-HIAA in schizophrenia. ( Caudle, J; Eccard, M; Jewart, RD; Lewine, RR; Pollard, W; Risby, E; Risch, SC; Stipetic, M, 1991)
"In male Syrian hamsters daily evening melatonin injections resulted in increased circulating levels of growth hormone (GH), as well as a modest increase in body weight."	3.68	Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. ( Borer, KT; Sheppard, MS; Vriend, J, 1990)
" In comparison with healthy controls (N = 17), hospitalized bulimic patients with a history of binge eating more frequently than twice daily (N = 11) had significantly lower CSF concentrations of 5-hydroxyindoleacetic acid and homovanillic acid."	3.68	Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. ( Brewerton, TD; Jimerson, DC; Kaye, WH; Lesem, MD, 1992)
" In this study, we examined cerebrospinal fluid levels of the major monoamine metabolites and beta-endorphin in patients with eating disorders (11 with anorexia nervosa, 16 with bulimia nervosa), while they were acutely ill."	3.68	Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: a pilot study. ( Altemus, M; Demitrack, MA; Gold, PW; Krahn, DD; Pigott, TA; Putnam, FW; Rubinow, DR, 1993)
" In this study, dehydroepiandrosterone's effect at decreasing food intake and body weight in the obese Zucker rat was investigated."	3.68	Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. ( Abadie, JM; Browne, ES; Correa, G; Porter, JR; Svec, F; Wright, B, 1993)
"Patients with idiopathic pain syndromes were compared with healthy volunteers and with patients suffering from chronic pain syndromes of neurogenic origin, with respect to the concentrations of the metabolites 5-hydroxy-indole-acetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF)."	3.67	5-HIAA and HVA in CSF in patients with idiopathic pain disorders. ( Almay, BG; Häggendal, J; Oreland, L; von Knorring, L, 1987)
"The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine."	3.67	Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988)
"CSF concentrations of serotonin and dopamine metabolites in 16 patients with anorexia nervosa were measured before and after probenecid administration, and the patients were studied before and at intervals after weight recovery."	3.67	Differences in brain serotonergic metabolism between nonbulimic and bulimic patients with anorexia nervosa. ( Ebert, MH; Gwirtsman, HE; Kaye, WH; Weiss, SR, 1984)
" This is based on weight gains of the dams during pregnancy, the mean number of pups (F2) per litter, the mean pup (F2) body weight and brain weight at birth, growth curves, levels of brain tryptophan (TRP), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) from birth to weaning, and the levels of certain plasma constituents, especially non-esterified fatty acids (NEFA)."	3.67	Generational effects of protein malnutrition in the rat. ( Morgane, PJ; Resnick, O, 1984)
"The present experiments describe the effects of continuous SC infusion, via osmotic minipump, of dexfenfluramine on food intake and body weight of male and female rats."	3.67	Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats. ( Rowland, NE, 1986)
" In an effort to determine whether indoleamine systems had any role in the etiology of cancer anorexia the anorectic effects of cancer (Walker 256 carcinosarcoma) were investigated in immature female rats that had been depleted of brain serotonin (5-HT) by the intracisternal injection of 5,7-dihydroxytryptamine (5,7-DHT) or the systemic injection of para-chloramphetamine (PCA)."	3.66	Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia. ( Chance, WT; Fischer, JE; von Meyenfeldt, M, 1983)
"Loss of body weight was proved to be a convenient and reliable way to predict the degree of reserpine-induced amine depletion after i."	3.65	Loss of body weight as a predictor of reserpine-induced amine depletion. ( Freedman, DX; Halaris, AE, 1975)
"Influences of hyper- and hypothyroidism on MAOI (tranylcypromine) were studied by measuring the effects on rectal temperature and 5-HT, 5-HIAA and norepiniphrine levels and tyramine uptake in the brain."	3.65	[Influences of deviations of thyroid functions on the effects of MAOI in rats--changes of 5-HT, 5-HIAA and norepinephrine contents and tyramine uptake by the brain and fluctuation of the rectal temperature]. ( Fukuyo, S; Higuchi, H; Kobayashi, M; Takeuchi, T, 1976)
"Random urinary 5-OH IAA levels of colicky infants were found to be higher than those in the control group."	2.68	5-Hydroxy-3-indole acetic acid levels in infantile colic: is serotoninergic tonus responsible for this problem? ( Coskum, A; Hallac, IK; Kurtoglu, S; Uzüm, K, 1997)
" Microdialysis technique was used to detect the extracellular levels of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in rat brain following the acute administration of the extract dosed at 100mg/kg."	1.37	Influence of Griffonia simplicifolia on male sexual behavior in rats: behavioral and neurochemical study. ( Benelli, A; Carnevale, G; Di Viesti, V; Zanoli, P; Zavatti, M, 2011)
"Fluoxetine and buspirone were significantly effective in reducing rates of self-biting during treatment weeks 1 to 8 and self-directed stereotypic behavior during weeks 5 to 12 and post-treatment."	1.33	The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. ( De Petrillo, PB; Dupuy, AM; Fontenot, MB; Higley, JD; Lynch, CR; Padgett, EE, 2005)
"Treatment with imipramine (10mg/kg i."	1.33	Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. ( Antoniou, K; Bekris, S; Daskas, S; Papadopoulou-Daifoti, Z, 2005)
" This dosing regimen also produces deficits in sequential learning as measured in the Cincinnati water maze (CWM)."	1.32	Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. ( Blankenmeyer, TL; Brown-Strittholt, CA; Gudelsky, GA; Skelton, MR; Vorhees, CV; Williams, MT, 2004)
" PHEN also significantly enhanced FEN's long-term toxic effects on 5-HT axons."	1.30	Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain. ( McCann, UD; Ricaurte, GA; Yuan, J, 1998)
"Hyperthyroidism was accompanied by significant reductions in 5HT, while urinary norepinephrine excretion paralleled 5HT."	1.30	Bulbospinal serotonergic activity during changes in thyroid status. ( Bellush, LL; Henley, WN; Tressler, M, 1998)
"Carbaryl and aldicarb were injected in ovo on day 15 of incubation at 6, 16 and 65 mg kg-1 egg weight and at 0."	1.28	Chick embryo exposure to carbamates alters neurochemical parameters and behavior. ( Blaker, WD; Farage-Elawar, M, 1992)
"Carbaryl was administered at total doses (over 6 days) of either 50, 125 or 250 mg/kg by gastric gavage."	1.28	Carbaryl-induced changes in indoleamine synthesis in the pineal gland and its effects on nighttime serum melatonin concentrations. ( Attia, AM; el-Sebae, AH; Mostafa, MH; Nonaka, KO; Reiter, RJ; Soliman, SA, 1991)
"Body weight was reduced 2-4 weeks after fenfluramine injection in 1 week old animals; however 2 week animals showed only a small transient reduction during the first week following fenfluramine."	1.27	Biochemical and functional effects of fenfluramine in maturing mice. ( Baker, PC; Bauman, GP; Goodrich, CA, 1986)
" Reserpine did not alter survival time after NMTB or ANTU and did not shift the 14-day LD50 of NMTB."	1.27	The involvement of serotonin in the pneumotoxicity induced by N-methylthiobenzamide. ( Feny, FJ; Gibbs, LS; Traiger, GJ, 1988)
"Thus, in pyridoxine deficiency one would expect a decrease of serotonin as well as the catecholamines of the brain."	1.26	Nonparallel changes in brain monoamines of pyridoxine-deficient growing rats. ( Dakshinamurti, K; Havlicek, V; Herchl, R; LeBlancq, WD, 1976)
" Rats were made dependent on diazepam by the chronic administration of this drug in the diet."	1.26	Effect of p-chlorophenylalanine on diazepam withdrawal signs in rats. ( Fukumori, R; Kitagawa, H; Satoh, T; Suzuki, T; Yanaura, S; Yoshii, T, 1980)
"An experimental phenylketonuria-like syndrome was produced in rats by oral administration of 1-phenylalanine (Phe, 500 mg/kg) and dl-p-chloro-phenylalanine (pCPA, 100-125 mg/kg) daily from the 2nd-3rd day of life to the age of 42 days."	1.25	Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats. ( Airaksinen, MM; MacDonald, EJ; Marvola, M; Turakka, H, 1975)

Research

Studies (195)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change of Diastolic Blood Pressure (BP) in Response to the TSST

Timeframe	Studies, this research(%)	All Research%
pre-1990	90 (46.15)	18.7374
1990's	54 (27.69)	18.2507
2000's	33 (16.92)	29.6817
2010's	16 (8.21)	24.3611
2020's	2 (1.03)	2.80

Authors	Studies
Jalal, K	1
Khan, F	1
Nawaz, S	1
Afroz, R	1
Khan, K	1
Ali, SB	1
Hao, L	1
Khan, SA	1
Kazi, M	1
Uddin, R	1
Haleem, DJ	3
Sorokin, IE	1
Evsyukova, VS	1
Arefieva, AB	1
Sachkova, VV	1
Kulikov, PA	1
Kulikov, AV	1
Zhao, F	1
Ma, C	1
Zhao, G	1
Wang, G	1
Li, X	1
Yang, K	1
van Heesch, F	1
Prins, J	1
Korte-Bouws, GA	2
Westphal, KG	1
Lemstra, S	1
Olivier, B	2
Kraneveld, AD	1
Korte, SM	2
Ohta, K	1
Miki, T	1
Warita, K	1
Suzuki, S	1
Kusaka, T	1
Yakura, T	1
Liu, JQ	1
Tamai, M	1
Takeuchi, Y	1
Batzina, A	1
Dalla, C	1
Tsopelakos, A	1
Papadopoulou-Daifoti, Z	2
Karakatsouli, N	1
Takano, Y	1
Machida, T	1
Obara, Y	1
Hirano, M	1
Kudo, S	1
Takagi, M	1
Hamaue, N	1
Iizuka, K	1
Hirafuji, M	1
Pawlak, D	1
Oksztulska-Kolanek, E	1
Znorko, B	1
Domaniewski, T	1
Rogalska, J	1
Roszczenko, A	1
Brzóska, MM	1
Pryczynicz, A	1
Kemona, A	1
Pawlak, K	1
Ardis, TC	1
Cahir, M	1
Elliott, JJ	1
Bell, R	1
Reynolds, GP	1
Cooper, SJ	1
Jabeen, B	1
Alves, E	1
Binienda, Z	1
Carvalho, F	1
Alves, CJ	1
Fernandes, E	1
de Lourdes Bastos, M	1
Tavares, MA	1
Summavielle, T	1
Verhagen, LA	1
Luijendijk, MC	1
Adan, RA	1
Sibilia, V	1
Pagani, F	1
Lattuada, N	1
Greco, A	1
Guidobono, F	1
Oyama, G	1
Yoshimi, K	1
Natori, S	1
Chikaoka, Y	1
Ren, YR	1
Funayama, M	1
Shimo, Y	1
Takahashi, R	1
Nakazato, T	1
Kitazawa, S	1
Hattori, N	1
Tohei, A	1
Kojima, S	1
Ikeda, M	1
Hokao, R	1
Shinoda, M	1
Carnevale, G	1
Di Viesti, V	1
Zavatti, M	1
Benelli, A	1
Zanoli, P	1
Shen, EY	1
Ali, SF	1
Meyer, JS	1
Guzmán, DC	1
García, EH	1
Mejía, GB	1
Olguín, HJ	1
Jiménez, FT	1
Soto, EB	1
Del Angel, DS	1
Aparicio, LC	1
Huang, Y	1
Xu, H	1
Li, H	1
Yang, H	1
Chen, Y	1
Shi, X	1
Nagasawa, M	1
Murakami, T	1
Tomonaga, S	1
Furuse, M	1
Clarke, G	1
Grenham, S	1
Scully, P	1
Fitzgerald, P	1
Moloney, RD	1
Shanahan, F	1
Dinan, TG	1
Cryan, JF	1
Gutknecht, L	1
Araragi, N	1
Merker, S	1
Waider, J	1
Sommerlandt, FM	1
Mlinar, B	1
Baccini, G	1
Mayer, U	1
Proft, F	1
Hamon, M	3
Schmitt, AG	1
Corradetti, R	1
Lanfumey, L	2
Lesch, KP	1
Waters, RP	1
Pringle, RB	1
Forster, GL	1
Renner, KJ	1
Malisch, JL	1
Garland, T	1
Swallow, JG	1
Gamaro, GD	1
Manoli, LP	1
Torres, IL	1
Silveira, R	1
Dalmaz, C	1
Gehrke, BJ	1
Harrod, SB	1
Cass, WA	1
Bardo, MT	1
Czyrak, A	1
Maćkowiak, M	1
Chocyk, A	1
Fijał, K	1
Gadek-Michalska, A	1
Wedzony, K	1
Michna, L	1
Lu, YP	1
Lou, YR	1
Wagner, GC	2
Conney, AH	1
Arjona, AA	1
Zhang, SX	1
Adamson, B	1
Wurtman, RJ	2
Fairbanks, LA	1
Jorgensen, MJ	1
Huff, A	1
Blau, K	1
Hung, YY	1
Mann, JJ	3
Skelton, MR	1
Blankenmeyer, TL	1
Gudelsky, GA	1
Brown-Strittholt, CA	1
Vorhees, CV	1
Williams, MT	1
Fontenot, MB	2
Padgett, EE	1
Dupuy, AM	1
Lynch, CR	1
De Petrillo, PB	1
Higley, JD	2
van der Stelt, HM	1
Breuer, ME	1
Westenberg, HG	1
Bekris, S	1
Antoniou, K	1
Daskas, S	1
Wieczorek, M	1
Swiergiel, AH	1
Pournajafi-Nazarloo, H	1
Dunn, AJ	1
Taysse, L	1
Christin, D	1
Delamanche, S	1
Bellier, B	1
Breton, P	1
Tsunoda, M	1
Aizawa, Y	1
Konno, N	1
Kimura, K	1
Sugita-Konishi, Y	1
Hellweg, R	1
Zueger, M	1
Fink, K	1
Hörtnagl, H	1
Gass, P	1
Mayer, MA	1
Höcht, C	1
Opezzo, JA	1
Peredo, HA	1
Navacchia, D	1
Taira, CA	1
Fernández, BE	1
Puyó, AM	1
Koizumi, H	1
Hashimoto, K	1
Iyo, M	1
Oliveira-Silva, IF	1
Pinto, L	1
Pereira, SR	1
Ferraz, VP	1
Barbosa, AJ	1
Coelho, VA	1
Gualberto, FF	1
Souza, VF	1
Faleiro, RR	1
Franco, GC	1
Ribeiro, AM	1
Lavi-Avnon, Y	1
Weller, A	1
Finberg, JP	1
Gispan-Herman, I	1
Kinor, N	1
Stern, Y	1
Schroeder, M	1
Gelber, V	1
Bergman, SY	1
Overstreet, DH	1
Yadid, G	1
Gerald, MS	1
McGuire, MT	2
Naz, H	1
Baig, N	1
Haider, S	1
Mamiya, PC	1
Hennesy, Z	1
Zhou, R	1
Ahtee, L	3
Ohguri, S	1
Hisatomi, K	1
Niiyama, Y	1
Suzuki, T	1
Fukumori, R	1
Yoshii, T	1
Yanaura, S	2
Satoh, T	1
Kitagawa, H	1
Träskman-Bendz, L	1
Asberg, M	1
Bertilsson, L	1
Banki, CM	1
Molnar, G	1
Prasad, V	1
Sheard, MH	1
Leprohon, CE	1
Anderson, GH	1
Bánki, MC	1
Minkowski, A	1
Chanez, C	1
Priam, M	1
Flexor, MA	1
Bourgoin, S	1
Kordon, C	1
Nakayama, Y	1
Akiba, C	1
Sumita, T	1
Takagi, T	1
Berlatzky, Y	1
Chance, WT	4
Stinnett, JD	1
Trocki, O	1
Fischer, JE	4
Alexander, JW	1
Finkelstein, JA	1
von Meyenfeldt, M	1
Yocca, FD	1
de Paul Lynch, V	1
Friedman, E	1
Tagashira, E	1
Hiramori, T	1
Urano, T	1
Kaye, WH	6
Ebert, MH	4
Raleigh, M	1
Lake, R	1
Orosco, M	2
Bremond, J	1
Jacquot, C	3
Cohen, Y	2
Steger, RW	1
Avila-Jimenez, R	1
Amador, A	1
Johns, A	1
Resnick, O	2
Morgane, PJ	2
Fuenmayor, LD	1
García, S	1
Gerner, RH	1
Cohen, DJ	1
Fairbanks, L	1
Anderson, GM	1
Young, JG	1
Scheinin, M	1
Linnoila, M	3
Shaywitz, BA	1
Hare, TA	1
Gwirtsman, HE	3
Weiss, SR	1
Kimbrough, TD	2
Weekley, LB	2
Bellush, LL	2
Reid, SG	1
Demitrack, MA	2
Putnam, FW	1
Rubinow, DR	1
Pigott, TA	2
Altemus, M	2
Krahn, DD	1
Gold, PW	2
Squadrito, F	1
Calapai, G	1
Altavilla, D	1
Cucinotta, D	1
Zingarelli, B	1
Arcoraci, V	1
Campo, GM	1
Caputi, AP	1
Unkila, M	2
Pohjanvirta, R	2
MacDonald, E	2
Tuomisto, J	2
Routh, VH	1
Stern, JS	1
Horwitz, BA	1
Beard, JL	1
Chen, Q	1
Connor, J	1
Jones, BC	1
Amoroso, D	1
Kindel, G	1
Wülfert, E	1
Hanin, I	1
Bergqvist, PB	2
Vogels, BA	1
Bosman, DK	1
Maas, MA	1
Hjorth, S	2
Chamuleau, RA	1
Bengtsson, F	2
McBlane, JW	1
Handley, SL	1
Thibault, L	1
Heyes, MP	1
Porter, JK	1
Voss, KA	1
Chamberlain, WJ	1
Bacon, CW	1
Norred, WP	1
Castaño, A	1
Herrera, AJ	1
Cano, J	1
Machado, A	1
Abadie, JM	2
Wright, B	1
Correa, G	1
Browne, ES	2
Porter, JR	2
Svec, F	2
Trouvin, JH	1
Gardier, AM	1
Chanut, E	1
Pages, N	1
ThyagaRajan, S	2
Meites, J	1
Quadri, SK	2
Lerchl, A	1
Schlatt, S	1
Martinez, M	1
Arnalich, F	1
Vazquez, JJ	1
Hernanz, A	1
Denbow, DM	1
Hobbs, FC	1
Hulet, RM	1
Graham, PP	1
Potter, LM	1
Wright, BE	1
Heslop, KE	1
Goss-Sampson, MA	1
Muller, DP	1
Curzon, G	3
Cai, DF	1
Shen, ZY	1
Zhang, LJ	1
Mehlman, PT	1
Poland, RE	1
Taub, DM	1
Vickers, J	1
Suomi, SJ	1
Colado, MI	1
O'Shea, E	1
Granados, R	1
Misra, A	1
Murray, TK	1
Green, AR	1
Kurtoglu, S	1
Uzüm, K	1
Hallac, IK	1
Coskum, A	1
Shibata, K	1
Toda, S	1
Apelqvist, G	1
Zecca, L	1
Mantegazza, C	1
Margonato, V	1
Cerretelli, P	1
Caniatti, M	1
Piva, F	1
Dondi, D	1
Hagino, N	1
Rose, S	1
Hindmarsh, JG	1
Collins, P	1
Jenner, P	1
McCann, UD	1
Yuan, J	1
Ricaurte, GA	1
Greeno, CG	1
Moss, H	1
Fernstrom, J	1
Fernstrom, M	1
Lilenfeld, LR	1
Weltzin, TE	1
Lozeva, V	1
Valjakka, A	1
Anttila, E	1
Hippeläinen, M	1
Tuomisto, L	1
Nordholm, AF	2
Rossi, J	2
Ritchie, GD	2
McInturf, S	1
Hulme, ME	1
McCool, C	1
Narayanan, L	1
MacMahon, KL	1
Eggers, J	1
Leahy, HF	1
Wolfe, RE	1
Henley, WN	1
Tressler, M	1
Yeh, SY	1
Persico, AM	1
Altamura, C	1
Calia, E	1
Puglisi-Allegra, S	1
Ventura, R	1
Lucchese, F	1
Keller, F	1
Martin, CL	1
Duclos, M	1
Aguerre, S	1
Mormede, P	1
Manier, G	1
Chaouloff, F	2
Grimes, MA	1
Cameron, JL	1
Fernstrom, JD	1
Bottiglieri, T	1
Laundy, M	1
Crellin, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
"Proof-of-Concept Stress & Anxiety Dampening Effects of Lpc-37"[NCT03494725]		120 participants (Actual)	Interventional	2018-04-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Efficacy of the intake of Lpc-37 on reduction of the increase of the diastolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of Mood Scale Scores Over the Course of the Treatment

Intervention	mmHg (Mean)
	Pre-TSST -3min	Post-TSST +1min
Lpc-37	79.13	90.38
Placebo	78.41	88.36

"Efficacy of the intake of Lpc-37 on the increase of mood scale scores over the course of the treatment~Measured with a daily online diary. Mood was rated by participants on an 11-point scale (0-10; very bad to very well) and monitored through the washout phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a better mood. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one average value for each week and participant. Values reflect summary measures for mood ratings on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of Perceived Health Status Scores Over the Course of the Treatment

Intervention	score (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	7.31	7.53	7.66	7.77	7.73	7.90	7.77
Placebo	7.27	7.49	7.46	7.53	7.50	7.40	7.55

"Efficacy of the intake of Lpc-37 on the increase of perceived health status scores over the course of the treatment.~Measured with a daily online diary. Health status was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a high perceived health.Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for perceived health status on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of Perceived Productivity Scores Over the Course of the Treatment

Intervention	score (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	7.80	7.89	7.88	7.91	8.05	8.11	7.91
Placebo	7.86	7.92	7.92	8.01	7.92	7.73	7.75

"Efficacy of the intake of Lpc-37 on the increase of perceived productivity scores over the course of the treatment~Measured with a daily online diary. Productivity was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a higher perceived productivity. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group.Time is coded as a continuous variable with one value for each day and participant. The values reflect summary measures for perceived productivity on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of Reported Number of Sleep Disruptions Over the Course of the Treatment

Intervention	score (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	6.98	7.34	7.53	7.48	7.59	7.57	7.50
Placebo	7.15	7.29	7.30	7.34	7.43	7.31	7.32

"Efficacy of the intake of Lpc-37 on the decrease of reported number of sleep disruptions over the course of the treatment measured with a daily online diary (mean of week summary).~Sleep disruptions were monitored through the wash-out phase (Week 1 and 2) and the subsequent treatment phase (Weeks 3-7). In the count version, the value can be 0 or a natural number for each day and each participant. Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for sleep disruptions (count) for the summed counts per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of Reported Sleep Disruptions Over the Course of the Treatment by Week (Proportion Yes/Total)

Intervention	sleep disruptions per participant & week (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	7.30	5.50	4.89	5.43	3.52	3.80	4.66
Placebo	6.09	5.49	5.11	4.30	3.53	4.02	5.83

"Efficacy of the intake of Lpc-37 on the decrease of sleep disruptions over the course of the treatment measured with a daily online diary (Proportion (yes/total)).~Sleep disruptions were monitored through the wash-out phase and the subsequent treatment phase for each week. In the binary version, the value is either Yes or No for each day and each participant.~Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant.~The proportion of participants with at least one sleep disruption by treatment group is given, treatment commenced after week 2. Data listed here reflect the proportion of participants who answered Yes (e.g. 0,477 * 44 = 20.99 participants answered with Yes in week 1 in the Lpc-37 group)." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of sAA in Response to the TSST

Intervention	Proportion of participants (yes/total) (Number)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	0.477	0.435	0.354	0.367	0.306	0.279	0.290
Placebo	0.465	0.426	0.418	0.310	0.292	0.331	0.389

Efficacy of the intake of Lpc-37 on reduction of the increase of salivary Alpha-Amylase (sAA) in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake

Change of Salivary Cortisol in Response to the TSST

Intervention	U/ml (Mean)
	Pre-TSST -2min	Post-TSST +1min	Post-TSST +10min	Post-TSST +20min	Post-TSST +30min	Post-TSST +45min
Lpc-37	154.04	246.29	146.53	130.11	125.19	141.13
Placebo	161.67	270.55	158.85	141.49	138.48	148.15

Efficacy of the intake of Lpc-37 on reduction of the increase of salivary cortisol in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake

Change of Sleep Duration Over the Course of the Treatment

Intervention	nmol/L (Mean)
	Pre-TSST -2min	Post-TSST +1min	Post-TSST +10min	Post-TSST +20min	Post-TSST +30min	Post-TSST +45min
Lpc-37	4.79	6.96	9.48	9.89	8.04	6.21
Placebo	4.82	6.85	8.97	9.21	7.71	6.16

"Efficacy of the intake of Lpc-37 on the increase of sleep duration over the course of the treatment.~Sleep duration was monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for Sleep duration for the averaged ratings per participant and week" (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of Sleep Related Recovery Scores Over the Course of the Treatment

Intervention	min (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	447.27	444.01	449.45	450.62	454.50	450.88	445.60
Placebo	447.45	448.13	456.90	459.81	457.26	450.16	459.66

"Efficacy of the intake of Lpc-37 on the increase of sleep related recovery scores over the course of the treatment.~Measured with a daily online diary. Sleep related recovery was rated by participants on an 11-point scale (0-10; not at all to very) and monitored throughout the wash-out phase (Week 1 and 2) and the subsequent treatment phase (weeks 3-7). High scores indicate a high recovery.~Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for sleep related recovery for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

Change of STAI-State Scores in Response to the TSST

Intervention	score (Mean)
	Week 1 (run-in)	Week 2 (run-in)	Week 3 (treatment)	Week 4 (treatment)	Week 5 (treatment)	Week 6 (treatment)	Week 7 (treatment)
Lpc-37	6.71	7.07	7.32	7.30	7.36	7.42	7.31
Placebo	6.91	7.15	7.27	7.29	7.36	7.10	7.28

"Efficacy of the intake of Lpc-37 on reduction of the increase of STAI-State scores in response to the TSST compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of Systolic BP in Response to the TSST

Intervention	score (Mean)
	Pre-TSST -10min	Post-TSST +1min
Lpc-37	36.09	42.38
Placebo	36.83	43.60

Efficacy of the intake of Lpc-37 on reduction of the increase of the systolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of the Heart Rate (HR) in Response to the Trier Social Stress Test (TSST)

Intervention	mmHg (Mean)
	Pre-TSST -3min	Post-TSST +1min
Lpc-37	115.11	127.47
Placebo	114.33	129.19

Efficacy was defined as a lower increase in HR in response to the TSST following intervention with Lpc-37, compared to placebo. (NCT03494725)
Timeframe: Continuous measurement starting 20 minutes before and ending 20 minutes after the TSST after 5 weeks of product intake. Mean values were calculated per group at seven-time windows before, during and after the TSST

Change of VAS Anxiety Scores in Response to the TSST

Intervention	bpm (Mean)
	Pre-TSST -20min	Pre-TSST -10min	Pre-TSST -3min	during TSST (Interview)	during TSST (Arithmetic)	Post-TSST +10min	Post-TSST +20min
Lpc-37	74.84	88.15	97.34	107.56	102.77	93.32	75.88
Placebo	74.34	86.69	97.62	105.66	100.81	90.81	74.97

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS anxiety scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of VAS Exhaustion Scores in Response to the TSST

Intervention	score (Mean)
	Pre-TSST -10min	Interview TSST (during)	Post-TSST +1min
Lpc-37	6.80	20.85	10.68
Placebo	8.50	22.47	11.74

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS exhaustion scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of VAS Insecurity Scores in Response to the TSST

Intervention	score (Mean)
	Pre-TSST -10min	Interview TSST (during)	Post-TSST +1min
Lpc-37	21.18	19.20	22.12
Placebo	19.79	21.30	25.68

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS insecurity scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

Change of VAS Stress Perception Scores in Response to the TSST

Intervention	score (Mean)
	Pre-TSST -10min	Interview TSST (during)	Post-TSST +1min
Lpc-37	14.47	45.08	23.92
Placebo	17.19	52.19	23.69

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS Stress perception scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

Changes in Pre and Post Treatment BAI Scores

Intervention	score (Mean)
	Pre-TSST -10min	Interview TSST (during)	Post-TSST +1min
Lpc-37	19.89	47.71	31.72
Placebo	18.52	51.51	32.85

"Efficacy of the intake of Lpc-37 on the reduction of Beck Anxiety Inventory (BAI) scores compared to placebo.~Measured with the german version of the Beck Anxiety Inventory as a self-rating scale designed to measure anxiety. It comprises 21 sentences describing feelings that can occur when being anxious. These sentences are rated on a four-point rating scale ranging from 0=not at all to 3=severely, considering the last 7 days. The score range is 0-63; Higher scores indicate higher anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment DASS Anxiety Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	5.51	4.75
Placebo	5.85	6.33

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) anxiety scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The items are 2, 4, 7, 9, 15, 19, 20, 23, 25, 28, 30, 36, 40, 41 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment DASS Depression Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	2.60	2.44
Placebo	3.07	3.45

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) depression scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The Depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest/involvement, anhedonia, and inertia. The items are 3, 5, 10, 13, 16, 17, 21, 24, 26, 31, 34, 37, 38, 42 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment DASS Stress Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	4.60	4.15
Placebo	5.21	5.10

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) stress scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The stress scale (items) is sensitive to levels of chronic non-specific arousal.The stress scale items are 1, 6, 8, 11, 12, 14, 18, 22, 27, 29, 32, 33, 35, 39 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment Diastolic BP

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	9.76	8.91
Placebo	9.41	10.09

Efficacy of the intake of Lpc-37 on the reduction of diastolic BP. (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment Perceived Stress Scale (PSS) Scores

Intervention	mmHg (Mean)
	Baseline	End of Study
Lpc-37	71.89	73.18
Placebo	71.68	74.62

"Efficacy of the intake of Lpc-37 on the reduction of Perceived Stress Scale (PSS) scores compared to placebo.~Measured with the german version of the PSS as a psychological instrument for measuring stress perception. It assesses how unpredictable, uncontrollable and overloaded participants perceived their lives to have been within the last month. The PSS comprises 14 items that are answered on a five-point rating scale ranging from 0 = never to 4 = very often. Individual scores on the PSS can range from 0 to 56 with higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment STAI-state Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	21.89	20.49
Placebo	20.72	21.56

"Efficacy of the intake of Lpc-37 on the reduction of State-Trait-Anxiety-Inventory (STAI)-state scores compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment Systolic BP

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	33.65	35.18
Placebo	34.33	35.33

Efficacy of the intake of Lpc-37 on the reduction of systolic blood pressure (BP). (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment VAS Anxiety Scores

Intervention	mmHg (Mean)
	Baseline	End of Study
Lpc-37	119.60	121.87
Placebo	119.66	122.86

"Efficacy of the intake of Lpc-37 on the reduction of VAS anxiety scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment VAS Exhaustion Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	7.29	9.26
Placebo	7.58	7.85

"Efficacy of the intake of Lpc-37 on the reduction of VAS exhaustion scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment VAS Insecurity Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	29.56	24.66
Placebo	23.19	18.45

"Efficacy of the intake of Lpc-37 on the reduction of VAS insecurity scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

Changes in Pre and Post Treatment VAS Stress Perception Scores

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	13.58	16.44
Placebo	15.91	17.30

"Efficacy of the intake of Lpc-37 on the reduction of Visual Analog Scale (VAS) stress perception scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of CAR 8pm Measures

Intervention	score (Mean)
	Baseline	End of Study
Lpc-37	19.11	23.32
Placebo	19.34	20.67

"Efficacy of the intake of Lpc-37 on the reduction of the difference of cortisol at 8 pm values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at 8 pm is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of CAR AUCg Measures

Intervention	number of participants (Number)
	Baseline (<25% quantile)	Baseline (25% - 75% quantile)	Baseline (>75% quantile)	End of Study (<25% quantile)	End of Study (25% - 75% quantile)	End of Study (>75% quantile)
Lpc-37	4	20	29	3	28	22
Placebo	6	23	26	7	18	30

"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol Awakening Response (CAR) area under the curve with respect to the ground (AUCg) values to the respective mean before and after 5 weeks of treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCg is the total area under the curve of all measurements (i.e., the intensity or magnitude of the response).~Efficacy for the CAR variables AUCg is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of Cortisol at Awakening Measures

Intervention	number of participants (Number)
	Baseline (<25% quantile)	Baseline (25% - 75% quantile)	Baseline (>75% quantile)	End of Study (<25% quantile)	End of Study (25% - 75% quantile)	End of Study (>75% quantile)
Lpc-37	6	36	11	11	28	14
Placebo	12	30	13	7	35	13

"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol at Awakening values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at awakening is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of Cortisol Awakening Response (CAR) AUCi Measures

Intervention	number of participants (Number)
	Baseline (<25% quantile)	Baseline (25% - 75% quantile)	Baseline (>75% quantile)	End of Study (<25% quantile)	End of Study (25% - 75% quantile)	End of Study (>75% quantile)
Lpc-37	14	31	8	19	26	8
Placebo	16	26	13	12	34	9

"Efficacy of the intake of Lpc-37 on the reduction of the difference of CAR area under the curve with respect to the increase (AUCi) values to the respective mean before and after the treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCi is calculated with reference to the baseline measurement and it ignores the distance from zero for all measurements and emphasizes the changes over time. Efficacy for the CAR variables AUCi is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

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Dioxin-induced perturbations in tryptophan homeostasis in laboratory animals. Advances in experimental medicine and biology, 1999, Volume: 467 Topics: Animals; Animals, Laboratory; Body Weight; Brain; Dioxins; Homeostasis; Hydroxyindoleacetic Acid; Po	1999
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The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular psychiatry, 2013, Volume: 18, Issue:6 Topics: Analysis of Variance; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Disease Models, Anima	2013
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Homocysteine, folate, methylation, and monoamine metabolism in depression. Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 69, Issue:2 Topics: Adult; Biogenic Monoamines; Blood Cell Count; Body Weight; Depression; Erythrocytes; Female; Folic A	2000
Negative effects of melatonin on depression. The American journal of psychiatry, 1976, Volume: 133, Issue:10 Topics: Adult; Anger; Anxiety; Body Temperature; Body Weight; Calcium; Clinical Trials as Topic; Depression;	1976
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Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152 Topics: Animals; Anti-Anxiety Agents; Body Weight; Brain; Hydroxyindoleacetic Acid; Lysine; Monoamine Oxidas	2022
Effect of Prolonged Exposure to Short Daylight and a Tryptophan Hydroxylase Inhibitor on the Behavior and Brain Serotonin System in Danio rerio. Bulletin of experimental biology and medicine, 2023, Volume: 175, Issue:6 Topics: Animals; Body Weight; Brain; Female; Fenclonine; Hydroxyindoleacetic Acid; Male; Serotonin; Tryptoph	2023
Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract. Medical science monitor : international medical journal of experimental and clinical research, 2019, May-15, Volume: 25 Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Animals; Aromatic-L-Amino-Acid Decarboxyla	2019
Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behavioural brain research, 2013, Sep-15, Volume: 253 Topics: 3,4-Dihydroxyphenylacetic Acid; Affect; Animals; Body Weight; Brain; Dopamine; Electric Stimulation;	2013
Prolonged maternal separation disturbs the serotonergic system during early brain development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2014, Volume: 33 Topics: Animals; Animals, Newborn; Biogenic Monoamines; Body Weight; Brain; Chromatography, High Pressure Li	2014
Environmental enrichment induces changes in brain monoamine levels in gilthead seabream Sparus aurata. Physiology & behavior, 2014, May-10, Volume: 130 Topics: Animals; Biogenic Monoamines; Body Weight; Brain; Catecholamines; Dopamine; Environment; Fatty Acids	2014
Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats. European journal of pharmacology, 2014, Oct-05, Volume: 740 Topics: Animals; Body Weight; Cyclooxygenase 1; Cyclooxygenase 2; Eating; Hydroxyindoleacetic Acid; Ileum; K	2014
The Association between Elevated Levels of Peripheral Serotonin and Its Metabolite - 5-Hydroxyindoleacetic Acid and Bone Strength and Metabolism in Growing Rats with Mild Experimental Chronic Kidney Disease. PloS one, 2016, Volume: 11, Issue:10 Topics: Alkaline Phosphatase; Animals; Biomechanical Phenomena; Body Weight; Cancellous Bone; Cortical Bone;	2016
Effect of acute tryptophan depletion on noradrenaline and dopamine in the rat brain. Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Essential; Animals; Body Weight; Brain Chemistry; Corpu	2009
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity. Pakistan journal of pharmaceutical sciences, 2008, Volume: 21, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro	2008
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain. Neuroscience, 2009, Jan-23, Volume: 158, Issue:2 Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucino	2009
Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Body Temperature; Body Weight; Chroma	2009
Linking chronic tryptophan deficiency with impaired bone metabolism and reduced bone accrual in growing rats. Journal of cellular biochemistry, 2009, Aug-01, Volume: 107, Issue:5 Topics: Absorptiometry, Photon; Amino Acids; Animals; Body Weight; Bone and Bones; Bone Development; Bone Re	2009
Impaired in vivo dopamine release in parkin knockout mice. Brain research, 2010, Sep-17, Volume: 1352 Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Body Weight; Corpus Striatum; Dopamine; Homovanillic	2010
Effects of cyclophosphamide on the kaolin consumption (pica behavior) in five strains of adult male rats. The Journal of veterinary medical science, 2011, Volume: 73, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cyclophosphamide; Eating; Hydroxyindoleacet	2011
Influence of Griffonia simplicifolia on male sexual behavior in rats: behavioral and neurochemical study. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Aug-15, Volume: 18, Issue:11 Topics: Animals; Body Weight; Brain Chemistry; Chromatography, High Pressure Liquid; Eating; Ejaculation; Fe	2011
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior	2011
Effect of sibutramine on 5-hydroxyindole acetic acid levels and selected oxidative biomarkers on brain regions of female rats in the presence of zinc. Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:5 Topics: Animals; Appetite Depressants; Biomarkers; Body Weight; Brain; Calcium; Cyclobutanes; Energy Intake;	2012
Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat. BMC neuroscience, 2012, Feb-28, Volume: 13 Topics: Analysis of Variance; Animals; Body Weight; Brain; Chromatography, High Pressure Liquid; Corticoster	2012
The impact of chronic imipramine treatment on amino acid concentrations in the hippocampus of mice. Nutritional neuroscience, 2012, Volume: 15, Issue:5 Topics: Amino Acids; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brain Chemistry; Cerebral Corte	2012
Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one, 2012, Volume: 7, Issue:8 Topics: Age Factors; Animals; Autoradiography; Body Weight; Brain; Gene Silencing; Growth and Development; H	2012
Selection for increased voluntary wheel-running affects behavior and brain monoamines in mice. Brain research, 2013, May-01, Volume: 1508 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines	2013
Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structures. Neurochemistry international, 2003, Volume: 42, Issue:2 Topics: Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Chronic Disease; Dopamine; Drinking; Fee	2003
The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats. Psychopharmacology, 2003, Volume: 166, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Body Weight; Brain Chemistry; Central Ner	2003
8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Animals; Anti-Inflammatory Agents; Autoradio	2003
Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice. Life sciences, 2003, Aug-01, Volume: 73, Issue:11 Topics: 3,4-Dihydroxyphenylacetic Acid; Adipose Tissue; Animals; Body Weight; Brain Chemistry; Caffeine; Dop	2003
An animal model of antipsychotic-induced weight gain. Behavioural brain research, 2004, Jun-04, Volume: 152, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Anima	2004
Adolescent impulsivity predicts adult dominance attainment in male vervet monkeys. American journal of primatology, 2004, Volume: 64, Issue:1 Topics: Age Factors; Animals; Behavior, Animal; Body Weight; Chlorocebus aethiops; Chromatography, High Pres	2004
Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. Synapse (New York, N.Y.), 2004, Dec-15, Volume: 54, Issue:4 Topics: Adrenal Glands; Age Factors; Animals; Biogenic Monoamines; Body Temperature; Body Weight; Enzyme Inh	2004
The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comparative medicine, 2005, Volume: 55, Issue:1 Topics: Animals; Behavior, Animal; Body Weight; Buspirone; Cerebrospinal Fluid; Fluoxetine; Hydroxyindoleace	2005
Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study. Biological psychiatry, 2005, May-01, Volume: 57, Issue:9 Topics: Animals; Area Under Curve; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Chromatography, Hi	2005
Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behavioural brain research, 2005, Jun-03, Volume: 161, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Beh	2005
Physiological and behavioral responses to interleukin-1beta and LPS in vagotomized mice. Physiology & behavior, 2005, Jul-21, Volume: 85, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Behavior	2005
Peripheral ChE inhibition modulates brain monoamines levels and c-fos oncogene in mice subjected to a stress situation. Neurochemical research, 2005, Volume: 30, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Cholines	2005
Subacute administration of tributyltin chloride modulates neurotransmitters and their metabolites in discrete brain regions of maternal mice and their F1 offspring. Toxicology and industrial health, 2006, Volume: 22, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Animals, Newborn; Body Weight; Brain;	2006
Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Neurobiology of disease, 2007, Volume: 25, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Brain-Deriv	2007
Role of hypothalamic alpha-adrenoceptor activity in fructose-induced hypertension. Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:10 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anterior Hypothalamic Nucleus; Antibody Formation; Blood Pr	2006
Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience, 2006, Volume: 24, Issue:8 Topics: Aggression; Animals; Anxiety; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Chro	2006
Age-related deficit in behavioural extinction is counteracted by long-term ethanol consumption: correlation between 5-HIAA/5HT ratio in dorsal raphe nucleus and cognitive parameters. Behavioural brain research, 2007, Jun-18, Volume: 180, Issue:2 Topics: Aging; Alcohol Drinking; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain Chemist	2007
The reward system and maternal behavior in an animal model of depression: a microdialysis study. Psychopharmacology, 2008, Volume: 196, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Weigh	2008
Secondary sexual coloration and CSF 5-HIAA are correlated in vervet monkeys (Cercopithecus aethiops sabaeus). Journal of medical primatology, 2007, Volume: 36, Issue:6 Topics: Animals; Body Weight; Chlorocebus aethiops; Hydroxyindoleacetic Acid; Male; Scrotum; Sex Characteris	2007
Subchronic treatment with mercuric chloride suppresses immune response, elicits behavioral deficits and increases brain serotonin and dopamine metabolism in rats. Pakistan journal of pharmaceutical sciences, 2008, Volume: 21, Issue:1 Topics: Analysis of Variance; Animals; Antibodies, Antinuclear; Behavior, Animal; Body Weight; Brain; Dopami	2008
Changes in attack behavior and activity in EphA5 knockout mice. Brain research, 2008, Apr-18, Volume: 1205 Topics: Aggression; Animals; Body Weight; Brain Chemistry; Data Interpretation, Statistical; Electroshock; H	2008
Chronic morphine administration decreases 5-hydroxytryptamine and 2-hydroxyindoleacetic acid content in the brain of rats. Medical biology, 1980, Volume: 58, Issue:1 Topics: Animals; Body Weight; Brain; Hydroxyindoleacetic Acid; Male; Morphine; Naloxone; Rats; Serotonin	1980
Effects of excess leucine on growth and tryptophan and niacin metabolism in rats. Journal of nutritional science and vitaminology, 1980, Volume: 26, Issue:2 Topics: Animals; Body Weight; Diet; Erythrocytes; Female; Hydroxyindoleacetic Acid; Isoleucine; Leucine; NAD	1980
Effects of postnatal undernutrition on the catecholamine and serotonin contents of suckling rat brain. Journal of nutritional science and vitaminology, 1980, Volume: 26, Issue:3 Topics: Animal Population Groups; Animals; Animals, Suckling; Body Weight; Brain Chemistry; Deficiency Disea	1980
Effect of p-chlorophenylalanine on diazepam withdrawal signs in rats. Psychopharmacology, 1980, Volume: 71, Issue:1 Topics: Animals; Body Weight; Brain Chemistry; Diazepam; Drug Synergism; Eating; Fenclonine; Humans; Hydroxy	1980
Serotonin and noradrenaline uptake inhibitors in the treatment of depression--relationship to 5-HIAA in spinal fluid. Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290 Topics: Antidepressive Agents, Tricyclic; Biogenic Amines; Body Weight; Depressive Disorder; Humans; Hydroxy	1981
The influence of age, height, and body weight on cerebrospinal fluid amine metabolites and tryptophan in women. Biological psychiatry, 1981, Volume: 16, Issue:8 Topics: Adult; Age Factors; Alcoholism; Body Height; Body Weight; Depressive Disorder; Female; Homovanillic	1981
The effect of cyproterone acetate on shock elicited aggression in rats. Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:5 Topics: Aggression; Animals; Body Weight; Brain Chemistry; Cyproterone; Cyproterone Acetate; Electroshock; H	1981
Relationships among maternal diet, serotonin metabolism at weaning, and protein selection of progeny. The Journal of nutrition, 1982, Volume: 112, Issue:1 Topics: Animals; Body Weight; Brain; Dietary Proteins; Feeding Behavior; Female; Hydroxyindoleacetic Acid; M	1982
[Measuring monoamine metabolites and tryptophan levels in the cerebrospinal fluid of alcohol-dependent patients]. Orvosi hetilap, 1981, Oct-04, Volume: 122, Issue:40 Topics: Age Factors; Alcoholism; Amines; Body Height; Body Weight; Female; Humans; Hydroxyindoleacetic Acid;	1981
Long lasting effects of intrauterine malnutrition on neurotransmitters metabolism in the brain of developing rats. Progress in clinical and biological research, 1981, Volume: 77 Topics: Animals; Body Weight; Brain; Dopamine; Female; Fetal Growth Retardation; Hydroxyindoleacetic Acid; N	1981
[An improved mouse metabolism cage and its performance tests (author's transl)]. Jikken dobutsu. Experimental animals, 1982, Volume: 31, Issue:1 Topics: Animals; Animals, Laboratory; Body Weight; Catecholamines; Drinking; Histamine; Housing, Animal; Hyd	1982
Analysis of brain indoleamines and catecholamines associated with burn-induced anorexia. The Journal of trauma, 1982, Volume: 22, Issue:10 Topics: Amino Acids; Animals; Anorexia; Body Weight; Brain Chemistry; Burns; Dopamine; Feeding and Eating Di	1982
Brain serotonergic activity and plasma amino acid levels in genetically obese Zucker rats. Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:5 Topics: Amino Acids; Animals; Body Weight; Brain; Eating; Hydroxyindoleacetic Acid; Male; Rats; Rats, Zucker	1982
Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia. Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:1 Topics: 5,7-Dihydroxytryptamine; Amphetamines; Animals; Anorexia; Body Weight; Brain; Carcinoma 256, Walker;	1983
Effect of chronic lithium treatment on rat pineal rhythms: N-acetyltransferase, N-acetylserotonin and melatonin. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3 Topics: 5-Hydroxytryptophan; Acetyltransferases; Animals; Body Weight; Circadian Rhythm; Cyclic AMP; Hydroxy	1983
Formation of physical dependence on barbiturates and cerebral monoamines. Japanese journal of pharmacology, 1983, Volume: 33, Issue:2 Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Biogenic Amines; Body Weight; Brain; Catechol	1983
Abnormalities in CNS monoamine metabolism in anorexia nervosa. Archives of general psychiatry, 1984, Volume: 41, Issue:4 Topics: Adolescent; Adult; Amino Acids; Anorexia Nervosa; Body Weight; Brain; Dopamine; Energy Intake; Femal	1984
Fenfluramine and brain transmitters in the obese Zucker rat. Neuropharmacology, 1984, Volume: 23, Issue:2A Topics: Animals; Body Weight; Brain Chemistry; Catecholamines; Dopamine; Feeding Behavior; Female; Fenfluram	1984
Altered hypothalamic monoamine metabolism and pituitary prolactin regulation in female spontaneously hypertensive rats. Life sciences, 1984, Apr-23, Volume: 34, Issue:17 Topics: Animals; Blood Pressure; Body Weight; Catecholamines; Female; Hydrazines; Hydroxyindoleacetic Acid;	1984
Generational effects of protein malnutrition in the rat. Brain research, 1984, Volume: 317, Issue:2 Topics: Animals; Body Weight; Brain; Brain Chemistry; Female; Hydroxyindoleacetic Acid; Litter Size; Male; P	1984
The effect of fasting on 5-hydroxytryptamine metabolism in brain regions of the albino rat. British journal of pharmacology, 1984, Volume: 83, Issue:2 Topics: Animals; Body Temperature; Body Weight; Brain; Fasting; Fenclonine; Hydroxyindoleacetic Acid; Male;	1984
CSF neurochemistry of women with anorexia nervosa and normal women. The American journal of psychiatry, 1984, Volume: 141, Issue:11 Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Calcium; Choline; Depressive Disorder; Female; gam	1984
Differences in brain serotonergic metabolism between nonbulimic and bulimic patients with anorexia nervosa. The American journal of psychiatry, 1984, Volume: 141, Issue:12 Topics: Anorexia Nervosa; Appetite; Body Weight; Brain; Brain Chemistry; Dopamine; Feeding and Eating Disord	1984
The effect of a high-fat diet on brainstem and duodenal serotonin (5-HT) metabolism in Sprague-Dawley and Osborne-Mendel rats. International journal of obesity, 1984, Volume: 8, Issue:4 Topics: Animals; Body Weight; Brain Stem; Dietary Fats; Duodenum; Hydroxyindoleacetic Acid; Rats; Rats, Inbr	1984
Metabolic and neurochemical profiles in insulin-treated diabetic rats. The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2 Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hydroxyi	1994
Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: a pilot study. Psychiatry research, 1993, Volume: 49, Issue:1 Topics: Adolescent; Adult; Anorexia Nervosa; beta-Endorphin; Body Weight; Brain; Bulimia; Dissociative Disor	1993
Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase. European journal of pharmacology, 1994, Apr-01, Volume: 255, Issue:1-3 Topics: Amino Acid Oxidoreductases; Animals; Appetite Depressants; Arginine; Body Weight; Brain; Eating; Hyd	1994
Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced brain serotonin metabolism in the rat. European journal of pharmacology, 1994, Apr-04, Volume: 270, Issue:2-3 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Body Weight; Brain Chemistry; Eating; Hydrazi	1994
Serotonergic activity is depressed in the ventromedial hypothalamic nucleus of 12-day-old obese Zucker rats. The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 2 Topics: Adipose Tissue; Animals; Animals, Newborn; Body Weight; Dopamine; Genotype; Heterozygote; Homozygote	1994
Altered monamine metabolism in caudate-putamen of iron-deficient rats. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Body Weight; Caudate Nucleus; Diet; Ho	1994
Long-term exposure to high levels of corticosterone aggravates AF64A-induced cholinergic hypofunction in rat hippocampus in vivo. Brain research, 1994, Oct-24, Volume: 661, Issue:1-2 Topics: Acetylcholinesterase; Adrenalectomy; Animals; Aziridines; Body Weight; Cerebral Ventricles; Choline;	1994
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. Journal of neurochemistry, 1995, Volume: 64, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; B	1995
Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT. Psychopharmacology, 1994, Volume: 116, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemi	1994
Dietary carbohydrates: effects on self-selection, plasma glucose and insulin, and brain indoleaminergic systems in rat. Appetite, 1994, Volume: 23, Issue:3 Topics: Animals; Blood Glucose; Body Weight; Brain; Brain Chemistry; Brain Stem; Dietary Carbohydrates; Eati	1994
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable. Biological psychiatry, 1995, Apr-15, Volume: 37, Issue:8 Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleaceti	1995
Neurotransmitters in rats fed fumonisin B1. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1993, Volume: 202, Issue:3 Topics: Animals; Body Weight; Brain; Dopamine; Dose-Response Relationship, Drug; Female; Fumonisins; Homovan	1993
Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat. Neuroscience, 1993, Volume: 53, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Corpus Striatum; Dendrites; Diet; Dopamine; Ea	1993
Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program. Diabetes, 1993, Volume: 42, Issue:5 Topics: Androgens; Animals; Appetite; Body Weight; Brain; Dehydroepiandrosterone; Dose-Response Relationship	1993
Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat. Life sciences, 1993, Volume: 52, Issue:18 Topics: Animals; Body Weight; Brain; Dose-Response Relationship, Drug; Fluoxetine; Hydroxyindoleacetic Acid;	1993
Underfeeding-induced suppression of mammary tumors: counteraction by estrogen and haloperidol. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1993, Volume: 203, Issue:2 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Dopamine; Estradiol; Female; Food Deprivatio	1993
Influence of photoperiod on pineal melatonin synthesis, fur color, body weight, and reproductive function in the female Djungarian hamster, Phodopus sungorus. Neuroendocrinology, 1993, Volume: 57, Issue:2 Topics: Animals; Body Weight; Circadian Rhythm; Cricetinae; Female; Hair Color; Hydroxyindoleacetic Acid; Me	1993
Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: relationship with biogenic amine metabolism. Life sciences, 1993, Volume: 53, Issue:21 Topics: Aged; Aged, 80 and over; Aging; Amino Acids; Anorexia; Biogenic Amines; Body Weight; Female; Homovan	1993
Supplemental dietary L-tryptophan effects on growth, meat quality, and brain catecholamine and indoleamine concentrations in turkeys. British poultry science, 1993, Volume: 34, Issue:4 Topics: Animal Feed; Animals; Body Weight; Brain; Catecholamines; Eating; Hydroxyindoleacetic Acid; Male; Me	1993
The effect of discontinuing dehydroepiandrosterone supplementation on Zucker rat food intake and hypothalamic neurotransmitters. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1995, Volume: 19, Issue:7 Topics: Androstenedione; Animals; Body Weight; Dehydroepiandrosterone; Disease Models, Animal; Dopamine; Eat	1995
Serotonin metabolism and release in frontal cortex of rats on a vitamin E-deficient diet. Journal of neurochemistry, 1996, Volume: 66, Issue:2 Topics: Animals; Body Weight; Diet; Eating; Frontal Lobe; Hydroxyindoleacetic Acid; Male; Osmolar Concentrat	1996
[Effect of yougui yin on the content of monoaminic transmitters and body weight, food and fluid intake in corticosterone-rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1995, Volume: 15, Issue:12 Topics: Animals; Biogenic Monoamines; Body Weight; Corticosterone; Drinking; Drugs, Chinese Herbal; Eating;	1995
CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Biological psychiatry, 1996, Dec-01, Volume: 40, Issue:11 Topics: Aggression; Aging; Animals; Body Weight; Humans; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Soc	1996
A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy. British journal of pharmacology, 1997, Volume: 121, Issue:4 Topics: Animals; Body Temperature; Body Weight; Brain; Dopamine; Female; Hydroxyindoleacetic Acid; Lipid Per	1997
Effects of sex hormones on the metabolism of tryptophan to niacin and to serotonin in male rats. Bioscience, biotechnology, and biochemistry, 1997, Volume: 61, Issue:7 Topics: Animals; Appetite; Body Weight; Brain; Carboxy-Lyases; Eating; Estrone; Female; Gonadal Steroid Horm	1997
Potassium-evoked neuronal release of serotonin in experimental chronic portal-systemic encephalopathy. Metabolic brain disease, 1997, Volume: 12, Issue:3 Topics: Animals; Body Weight; Calcium; Chronic Disease; Extracellular Space; Frontal Lobe; Hepatic Encephalo	1997
Biological effects of prolonged exposure to ELF electromagnetic fields in rats: III. 50 Hz electromagnetic fields. Bioelectromagnetics, 1998, Volume: 19, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Body Weight; Brain; Dopamine; Dose-Respons	1998
The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:11-12 Topics: Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Eating; Fenfluramine; Hydro	1997
Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain. Synapse (New York, N.Y.), 1998, Volume: 30, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Depressants; Biogenic Monoamines; Body Weight; Bra	1998
Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa. Archives of general psychiatry, 1998, Volume: 55, Issue:10 Topics: Adolescent; Adult; Affect; Body Weight; Brain Chemistry; Bulimia; Feeding Behavior; Female; Follow-U	1998
Brain histamine levels and neocortical slow-wave activity in rats with portacaval anastomosis. Hepatology (Baltimore, Md.), 1999, Volume: 29, Issue:2 Topics: Animals; Body Weight; Brain; Electroencephalography; Frontal Lobe; Histamine; Hydroxyindoleacetic Ac	1999
Repeated exposure of rats to JP-4 vapor induces changes in neurobehavioral capacity and 5-HT/5-HIAA levels. Journal of toxicology and environmental health. Part A, 1999, Apr-09, Volume: 56, Issue:7 Topics: Adaptation, Ocular; Animals; Appetite Regulation; Biomarkers; Body Weight; Brain; Disease Models, An	1999
Bulbospinal serotonergic activity during changes in thyroid status. Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:12 Topics: Animals; Blood Glucose; Body Weight; Brain Stem; Diabetes Mellitus, Experimental; Hydroxyindoleaceti	1998
Effects of antihistamines on fenfluramine-induced depletion of indoles in the brain of rats. Synapse (New York, N.Y.), 1999, Jun-15, Volume: 32, Issue:4 Topics: Animals; Biomarkers; Body Temperature; Body Weight; Brain; Chlorpheniramine; Drug Interactions; Fenf	1999
L-deprenyl inhibits tumor growth, reduces serum prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced mammary tumors. Endocrine, 1999, Volume: 10, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Body Weight; Brain; Dopamine; Eating;	1999
Serotonin depletion and barrel cortex development: impact of growth impairment vs. serotonin effects on thalamocortical endings. Cerebral cortex (New York, N.Y. : 1991), 2000, Volume: 10, Issue:2 Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Fenclonine; Hydroxyindoleacetic Acid; Organ Si	2000
Corticotropic and serotonergic responses to acute stress with/without prior exercise training in different rat strains. Acta physiologica Scandinavica, 2000, Volume: 168, Issue:3 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Hydroxyindoleacet	2000
Cerebrospinal fluid concentrations of tryptophan and 5-hydroxyindoleacetic acid in Macaca mulatta: diurnal variations and response to chronic changes in dietary protein intake. Neurochemical research, 2000, Volume: 25, Issue:3 Topics: Animals; Body Weight; Brain; Circadian Rhythm; Dietary Proteins; Eating; Hydroxyindoleacetic Acid; M	2000
Alterations in hippocampal and hypothalamic monoaminergic neurotransmitter systems after alcohol exposure during all three trimester equivalents in adult rats. Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:7-8 Topics: Animals; Body Weight; Central Nervous System Depressants; Ethanol; Female; Hippocampus; Hydroxyindol	1999
Effects of chronic administration of sibutramine on body weight, food intake and motor activity in neonatally monosodium glutamate-treated obese female rats: relationship of antiobesity effect with monoamines. Experimental animals, 2000, Volume: 49, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Adipose Tissue; Animals; Animals, Newborn; Appetite Depressants; Arc	2000
Effects of repeated exposure of rats to JP-5 or JP-8 jet fuel vapor on neurobehavioral capacity and neurotransmitter levels. Journal of toxicology and environmental health. Part A, 2001, Jul-20, Volume: 63, Issue:6 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Avoidance Learning; Behavior, Animal; Body Weight; Brain; D	2001
Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:4 Topics: Animals; Biogenic Monoamines; Body Weight; Central Nervous System; Female; Homovanillic Acid; Hydrox	2002
Aversive prenatal stimulation: effects on behavioral, biochemical, and somatic ontogeny in the rat. Developmental psychobiology, 1977, Volume: 10, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Electroshock; Female;	1977
Effect on rats and mice of a diet with low tryptophan content (maize flour). Acta physiologica latino americana, 1979, Volume: 29, Issue:4-5 Topics: Aggression; Animals; Body Weight; Brain Stem; Diet; Female; Flour; Humans; Hydroxyindoleacetic Acid;	1979
Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats. Medical biology, 1975, Volume: 53, Issue:6 Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Body Weight; Brain; Female; Fenclonine; Humans; Hydr	1975
Effects of para-chlorophenylalanine and 5-hydroxytryptophan on mouse killing behavior in killer rats. Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:1 Topics: 5-Hydroxytryptophan; Aggression; Animals; Behavior, Animal; Body Weight; Brain; Dose-Response Relati	1978
Ontogenesis of serotonergic systems in rat brain. Research communications in chemical pathology and pharmacology, 1976, Volume: 14, Issue:1 Topics: Age Factors; Animals; Body Weight; Brain; Brain Chemistry; Female; Hydroxyindoleacetic Acid; Monoami	1976
Association of altered brain norephinephrine and serotonin with the obesity induced by goldthioglucose in mice. Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:1 Topics: Animals; Aurothioglucose; Body Weight; Brain; Dopamine; Female; Gold; Hydroxyindoleacetic Acid; Hypo	1978
Relationship between body temperature and brain monoamines during the development of tolerance to delat9-tetrahydrocannabinol in the rat. Psychopharmacology, 1978, Apr-11, Volume: 56, Issue:3 Topics: Animals; Biogenic Amines; Body Temperature; Body Weight; Brain Chemistry; Dopamine; Dronabinol; Drug	1978
The effects of reserpine upon body weight, brain weight and brain indoleamine stores in maturing mice. General pharmacology, 1979, Volume: 10, Issue:3 Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Orga	1979
Depletion of brain serotonin by chronic administration of p-chloramphetamine orally to rats and dogs. Toxicology and applied pharmacology, 1979, Volume: 48, Issue:3 Topics: Amphetamines; Animals; Body Weight; Brain; Dogs; Female; Hydroxyindoleacetic Acid; Male; p-Chloroamp	1979
Alterations of brain and intestine serotonin levels in hamsters pretreated with dietary aflatoxin. Cancer letters, 1978, Volume: 5, Issue:2 Topics: Aflatoxins; Animals; Body Weight; Brain; Cricetinae; Duodenum; Hydroxyindoleacetic Acid; Liver; Male	1978
A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation. Journal of neurochemistry, 1978, Volume: 31, Issue:5 Topics: Amino Acids; Animals; Biological Transport; Blood-Brain Barrier; Body Weight; Brain; Hydroxyindoleac	1978
Ontogeny of the levels of biogenic amines in various parts of the brain and in peripheral tissues in normal and protein malnourished rats. Experimental neurology, 1975, Volume: 49, Issue:1 Pt 1 Topics: Animals; Biogenic Amines; Body Weight; Brain; Diencephalon; Female; Hydroxyindoleacetic Acid; Male;	1975
[Influences of deviations of thyroid functions on the effects of MAOI in rats--changes of 5-HT, 5-HIAA and norepinephrine contents and tyramine uptake by the brain and fluctuation of the rectal temperature]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1976, Volume: 72, Issue:1 Topics: Animals; Body Temperature; Body Weight; Brain; Brain Chemistry; Eating; Hydroxyindoleacetic Acid; Hy	1976
Nonparallel changes in brain monoamines of pyridoxine-deficient growing rats. Experimental brain research, 1976, Nov-23, Volume: 26, Issue:4 Topics: Animals; Animals, Newborn; Body Weight; Brain; Brain Stem; Dopamine; Hydroxyindoleacetic Acid; Norep	1976
Effects of altered brain 5-hydroxytryptaminergic activity on brain tryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Neuropharmacology, 1976, Volume: 15, Issue:11 Topics: Animals; Body Weight; Brain; Brain Chemistry; Brain Stem; Electric Stimulation; Electrolysis; Hot Te	1976
Hormonal imputs and brain tryptophan metabolism: the effect of growth hormone. Experientia, 1975, Mar-15, Volume: 31, Issue:3 Topics: 5-Hydroxytryptophan; Animals; Body Weight; Brain; Brain Chemistry; Eating; Female; Growth Hormone; H	1975
Loss of body weight as a predictor of reserpine-induced amine depletion. European journal of pharmacology, 1975, Volume: 32, Issue:1 Topics: Animals; Behavior, Animal; Body Weight; Hydroxyindoleacetic Acid; Injections, Intravenous; Injection	1975
Virus infections in infant mice causing persistent impairment of turnover of brain catecholamines. Journal of the neurological sciences, 1975, Volume: 26, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Catecholamines; Coxsackievirus Infection	1975
Selective effect of a maize diet in reducing serum and brain tryptophan contents and blood and brain serotonin levels. Life sciences, 1975, Dec-01, Volume: 17, Issue:11 Topics: Animals; Body Weight; Brain; Diet; Dopamine; Hydroxyindoleacetic Acid; Male; Nicotinic Acids; Norepi	1975
Prediction of radiosensitivity of a mouse from its physiological characteristics before x-irradiation. Radiation research, 1976, Volume: 65, Issue:3 Topics: Animals; Body Weight; Drinking; Fasting; Female; Hydroxyindoleacetic Acid; Radiation Effects; Urine;	1976
Neurochemical correlates of hypothalamic obesity in rats. Behavioral biology, 1976, Volume: 16, Issue:3 Topics: Animals; Body Weight; Brain Chemistry; Dopamine; Female; Hydroxyindoleacetic Acid; Hypothalamus; Hyp	1976
Chick embryo exposure to carbamates alters neurochemical parameters and behavior. Journal of applied toxicology : JAT, 1992, Volume: 12, Issue:6 Topics: 3,4-Dihydroxyphenylacetic Acid; Aldicarb; Animals; Body Weight; Brain; Carbaryl; Chick Embryo; Chick	1992
Individual differences in basal cisternal cerebrospinal fluid 5-HIAA and HVA in monkeys. The effects of gender, age, physical characteristics, and matrilineal influences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:4 Topics: Aging; Animals; Body Weight; Chlorocebus aethiops; Diet; Female; Homovanillic Acid; Hydroxyindoleace	1992
Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Archives of general psychiatry, 1992, Volume: 49, Issue:2 Topics: Adult; Body Weight; Bulimia; Dopamine; Eating; Female; Homovanillic Acid; Humans; Hydroxyindoleaceti	1992
[Effects of nutritional status on contents of tryptophan, serotonin and 5-hydroxyindoleacetic acid in rat brain]. Nihon eiseigaku zasshi. Japanese journal of hygiene, 1992, Volume: 47, Issue:2 Topics: Animals; Body Weight; Brain; Energy Metabolism; Hydroxyindoleacetic Acid; Male; Nutritional Status;	1992
Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:8 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Biogenic Amines; Body Weight; Brain;	1992
Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Body Weight; Brain Chemistry	1992
Dietary disproportions of amino acids in the rat: effects on food intake, plasma and brain amino acids and brain serotonin. The Journal of nutrition, 1990, Volume: 120, Issue:5 Topics: Amino Acids; Animals; Body Weight; Brain; Brain Chemistry; Diet; Energy Intake; Histidine; Hydroxyin	1990
Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenyly	1990
Carbaryl-induced changes in indoleamine synthesis in the pineal gland and its effects on nighttime serum melatonin concentrations. Toxicology, 1991, Volume: 65, Issue:3 Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Animals; Arylamine N-Acetyltransferase; Bo	1991
Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. Growth, development, and aging : GDA, 1990,Winter, Volume: 54, Issue:4 Topics: Animals; Body Weight; Cricetinae; Growth Hormone; Hydroxyindoleacetic Acid; Hypothalamus; Injections	1990
Lateral ventricle-brain ratio and balance between CSF HVA and 5-HIAA in schizophrenia. The American journal of psychiatry, 1991, Volume: 148, Issue:9 Topics: Adult; Age Factors; Bipolar Disorder; Body Height; Body Weight; Brain; Brain Chemistry; Cerebral Ven	1991
[Effects of ethanol and low-carbohydrate diet on contents of noradrenaline, dopamine, serotonin and their metabolites in rat brain]. Nihon eiseigaku zasshi. Japanese journal of hygiene, 1991, Volume: 46, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Brain; Diet; Dietary Carbohydrates; Dopamine;	1991
The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders. Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:4 Topics: Adult; Aged; Aging; Biogenic Monoamines; Body Height; Body Weight; Female; Homovanillic Acid; Humans	1991
Cytomegalovirus infection of the developing brain alters catecholamine and indoleamine metabolism. Brain research, 1991, Sep-20, Volume: 559, Issue:2 Topics: Animals; Biogenic Amines; Body Weight; Brain Chemistry; Brain Diseases; Catecholamines; Chromatograp	1991
Effects of insulin on brain monoamine metabolism in the Zucker rat: influence of genotype and age. Psychoneuroendocrinology, 1991, Volume: 16, Issue:6 Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Biogenic Monoamines; Blood Glucose; Body Weigh	1991
Effects of jejunoileal bypass on food intake, amino acid levels, and indoleamine metabolism in rats. American journal of surgery, 1985, Volume: 149, Issue:6 Topics: Amino Acids; Animals; Body Weight; Brain; Eating; Hydroxyindoleacetic Acid; Ileum; Jejunum; Male; Ra	1985
Development of tolerance to the wet-dog shake behaviour but not the increase in seizure threshold induced by L-5-hydroxytryptophan during continued treatment in rats. Psychopharmacology, 1985, Volume: 86, Issue:1-2 Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Body Weight; Brain Chemistry; Carbidopa; Drug Intera	1985
Effect of repeated dietary exposure of aflatoxin B1 on brain biogenic amines and metabolites in the rat. Toxicology and applied pharmacology, 1985, Sep-30, Volume: 80, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Aflatoxin B1; Aflatoxins; Animals; Biogenic Amines; Body Weight; Bra	1985
Diabetes-induced alteration in brain monoamine metabolism in rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:2 Topics: Animals; Biogenic Amines; Blood Glucose; Body Weight; Brain; Choline O-Acetyltransferase; Diabetes M	1986
Urinary monoamine metabolites as indices of mental stress in healthy males and females. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6 Topics: Adolescent; Body Height; Body Weight; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleaceti	1986
Biochemical and functional effects of fenfluramine in maturing mice. General pharmacology, 1986, Volume: 17, Issue:4 Topics: Age Factors; Animals; Body Temperature; Body Weight; Brain; Fenfluramine; Hydroxyindoleacetic Acid;	1986
5-Hydroxyindole acetic excretion in newborns, infants and children. Acta paediatrica Hungarica, 1986, Volume: 27, Issue:3 Topics: Adolescent; Body Weight; Child; Child, Preschool; Female; Humans; Hydroxyindoleacetic Acid; Infant;	1986
Effects of fenfluramine on food intake, body weight, gastric emptying and brain monoamines in Syrian hamsters. Brain research bulletin, 1986, Volume: 17, Issue:4 Topics: Animals; Biogenic Amines; Body Weight; Brain Chemistry; Cricetinae; Dopamine; Dose-Response Relation	1986
Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats. Life sciences, 1986, Dec-29, Volume: 39, Issue:26 Topics: Amines; Animals; Body Weight; Brain; Delayed-Action Preparations; Dopamine; Eating; Female; Fenflura	1986
The fall of homovanillic acid and 5-hydroxyindoleacetic acid concentrations in brains of mice withdrawn from repeated morphine treatment and their restoration by acute morphine administration. Journal of neural transmission, 1987, Volume: 68, Issue:1-2 Topics: Animals; Body Weight; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Morphine; M	1987
5-HIAA and HVA in CSF in patients with idiopathic pain disorders. Biological psychiatry, 1987, Volume: 22, Issue:4 Topics: Adult; Age Factors; Aged; Body Weight; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydro	1987
Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration. Psychopharmacology, 1987, Volume: 91, Issue:4 Topics: 5,7-Dihydroxytryptamine; Animals; Body Temperature; Body Weight; Brain Chemistry; Clenbuterol; Drug	1987
Urinary excretion of 5-hydroxyindoleacetic acid, delta-aminolevulinic acid and coproporphyrin isomers in rats and men exposed to lead. Toxicology letters, 1987, Volume: 38, Issue:1-2 Topics: Administration, Oral; Aminolevulinic Acid; Animals; Body Weight; Coproporphyrins; Environmental Expo	1987
CSF 5-HIAA concentrations in anorexia nervosa: reduced values in underweight subjects normalize after weight gain. Biological psychiatry, 1988, Jan-01, Volume: 23, Issue:1 Topics: Adult; Anorexia Nervosa; Behavior Therapy; Body Weight; Female; Humans; Hydroxyindoleacetic Acid	1988
The involvement of serotonin in the pneumotoxicity induced by N-methylthiobenzamide. Toxicology and applied pharmacology, 1988, Mar-30, Volume: 93, Issue:1 Topics: Amides; Animals; Body Weight; Hydroxyindoleacetic Acid; Lethal Dose 50; Lung; Male; Organ Size; Rats	1988
Serotonin uptake in the central nervous system of rats fed a corn-diet. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 89, Issue:2 Topics: Animals; Body Weight; Brain; Diet; Dietary Proteins; Hydroxyindoleacetic Acid; Male; Rats; Rats, Inb	1988
Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2 Topics: Animals; Appetite Depressants; Body Weight; Diet; Dogs; Eating; Feeding and Eating Disorders; Female	1988
Peripheral and central consequences of immobilization stress in genetically obese Zucker rats. The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 2 Topics: Animals; Body Weight; Corticosterone; Fatty Acids, Nonesterified; Feeding Behavior; Female; Hydroxyi	1989
Effect of latent iron deficiency on 5-hydroxytryptamine metabolism in rat brain. Journal of neurochemistry, 1989, Volume: 52, Issue:3 Topics: Aldehyde Dehydrogenase; Animals; Body Weight; Brain; Female; Hydroxyindoleacetic Acid; Iron; Iron De	1989
3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Body Weight; Brain Chemistry	1989
Ontogenetic alterations in the effects of food and/or maternal deprivation on 5-HT, 5-HIAA and 5-HIAA/5-HT ratios. Brain research, 1985, Volume: 350, Issue:1-2 Topics: Animals; Body Temperature; Body Weight; Brain Chemistry; Brain Stem; Cerebral Cortex; Fatty Acids, N	1985
Effect of prolonged isolation on learning, biogenic amine turnover and aggressive behaviour in three strains of mice. Neuropharmacology, 1973, Volume: 12, Issue:11 Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Biogenic Amines; Body Weight; Humans; Hyd	1973
[Effects of x-rays and food or water abstinence on 5-hydroxyindoleacetic acid excretion]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:4-5 Topics: Animals; Body Weight; Fasting; Female; Hydroxyindoleacetic Acid; Mice; Mice, Inbred Strains; Radiati	1974
Neonatal malnutrition: neurochemical, hormonal and behavioral manifestations. Brain research, 1974, Jan-18, Volume: 65, Issue:3 Topics: Acetylcholinesterase; Adrenal Glands; Animals; Animals, Newborn; Avoidance Learning; Behavior, Anima	1974
Thyroid hormone control of 5-hydroxytryptamine metabolism in developing rat brain. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:1 Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Dose-Response Relationship, Drug; Female; Hydr	1974
Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism: clinical and experimental, 1974, Volume: 23, Issue:12 Topics: Animals; Body Weight; Brain Chemistry; Dialysis; Dietary Carbohydrates; Dietary Fats; Fatty Acids, N	1974
Effect of spinal transection on the metabolism of 5-hydroxyindoles formed in vivo from 3H-tryptophan in the rat spinal cord. Acta physiologica Scandinavica, 1973, Volume: 87, Issue:4 Topics: Animals; Body Temperature; Body Weight; Cordotomy; Hydroxyindoleacetic Acid; Injections, Intravenous	1973
6-hydroxydopamine sympathectomy in the neonatal rat--effects on brain serotonin and histamine. Biochemical pharmacology, 1974, Sep-01, Volume: 23, Issue:17 Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Brain Stem; Car	1974
Urinary excretion of 5-hydroxyindolacetic acid in low-birth-weight infants with and without phototherapy. The Journal of pediatrics, 1973, Volume: 82, Issue:2 Topics: Bilirubin; Birth Weight; Body Weight; Gestational Age; Humans; Hydroxyindoleacetic Acid; Infant, New	1973
Effect of chronic lithium treatment on monoamine metabolism in rat brain. Psychopharmacologia, 1973, Sep-28, Volume: 32, Issue:3 Topics: Administration, Oral; Animals; Body Weight; Brain; Carbon Radioisotopes; Dopamine; Hydroxyindoleacet	1973
Chronic administration of electroconvulsive shock effects on mouse-killing activity and brain monoamines in rats. Physiology & behavior, 1973, Volume: 11, Issue:5 Topics: Aggression; Animals; Body Weight; Brain Chemistry; Disease Models, Animal; Dopamine; Electroshock; F	1973
Long-term effects of 4-chloroamphetamine on brain 5-hydroxyindole metabolism in rats. Neuropharmacology, 1974, Volume: 13, Issue:1 Topics: Amphetamine; Animals; Body Weight; Brain; Brain Chemistry; Chlorine; Depression, Chemical; Hydroxyin	1974
Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome. The British journal of dermatology, 1974, Volume: 90, Issue:5 Topics: Aged; Alkaline Phosphatase; Blister; Body Weight; Carcinoid Tumor; Chromatography, Thin Layer; Diarr	1974
Effect of copper loading on various tissue enzymes and brain monoamines in the rat. Toxicology and applied pharmacology, 1974, Volume: 28, Issue:3 Topics: Adrenal Glands; Age Factors; Animals; Biogenic Amines; Body Weight; Brain; Brain Chemistry; Copper;	1974
Catalepsy and stereotypies in rats treated with methadone; relation to striatal dopamine. European journal of pharmacology, 1974, Volume: 27, Issue:2 Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Catalepsy; Corpus Striatum; Dopamine; Dose	1974
Decrease of cerebral serotonin and 5-hydroxyindolylacetic acid caused by (-)-alpha-methyltryptophan. Journal of neurochemistry, 1970, Volume: 17, Issue:1 Topics: Animals; Body Weight; Brain; Centrifugation; Hydroxyindoleacetic Acid; Liver; Male; Methane; Rats; S	1970
[Methods in gerontological research]. Zeitschrift fur Alternsforschung, 1970, Volume: 23, Issue:2 Topics: Age Factors; Aged; Aging; Body Weight; DNA; Female; Geriatrics; Humans; Hydroxyindoleacetic Acid; Ma	1970
Etiology of endomyocardial fibrosis: an experimental evaluation of plantain ingestion and chronic lymphatic obstruction. The Johns Hopkins medical journal, 1968, Volume: 122, Issue:2 Topics: Animals; Body Weight; Diet; Dogs; Electrocardiography; Endomyocardial Fibrosis; Fruit; Hydroxyindole	1968
Brain serotonin metabolism in isolated aggressive mice. Biochemical pharmacology, 1968, Volume: 17, Issue:7 Topics: Adrenal Glands; Aggression; Animals; Body Weight; Brain; Diencephalon; Diet; Fatty Acids, Nonesterif	1968
[On the effect of repeated noise stress on rats]. Acta biologica et medica Germanica, 1965, Volume: 15, Issue:5 Topics: Adrenal Glands; Animals; Body Weight; Catecholamines; Fatty Acids; Fatty Acids, Nonesterified; Femal	1965

hydroxyindoleacetic acid and Body Weight