hydroxyindoleacetic acid has been researched along with BH4 Deficiency in 36 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a group of 9 patients with classical phenylketonuria (PKU) aged 15-24 years we examined the effect of phenylalanine restricted diet on vigilance, as judged by the continuous visual reaction times, and neurotransmitter synthesis, as judged by cerebrospinal fluid (CSF) homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) levels." | 2.66 | Increased vigilance and dopamine synthesis by large doses of tyrosine or phenylalanine restriction in phenylketonuria. ( Bruhn, P; Gerdes, AM; Lou, HC; Lykkelund, C; Udesen, H, 1987) |
| " Time of diagnosis, dosage of BH4 and neurotransmitter precursors, folinic acid substitution, and levels of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) are essential parameters in the follow-up of patients." | 1.35 | Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency. ( Ballhausen, D; Baumgartner, MR; Blau, N; Fiori, L; Giovannini, M; Hoffmann, GF; Ibel, H; Jäggi, L; Ponzone, A; Porta, F; Santer, R; Schuler, A; Wendel, U; Zurflüh, MR, 2008) |
| "In a child presenting with malignant phenylketonuria due to dihydrobiopterin synthetase deficiency, the authors studied the cerebrospinal fluid (CSF) homovanillic acid and 5 hydroxyindole acetic acid levels under different circumstances: without treatment; under a treatment with tetrahydrobiopterin used alone at various doses; under a treatment associating BH4, L-dopa, 5 hydroxytryptophan and carbidopa, with increasing doses and varying administration schedules." | 1.27 | [Malignant phenylketonuria caused by biopterin synthetase deficiency. Study of neuromediator catabolites in the cerebrospinal fluid during treatment]. ( Boespflug, O; Demeocq, F; Guyon, A; Malpuech, G; Piton, A; Vanlieferinghen, P, 1984) |
| "Seven phenylketonuria (PKU) patients aged 15-24 years were allowed unrestricted diet for 3 weeks." | 1.27 | Increased neurotransmitter biosynthesis in phenylketonuria induced by phenylalanine restriction or by supplementation of unrestricted diet with large amounts of tyrosine. ( Christensen, E; Gerdes, AM; Güttler, F; Lou, HC; Lykkelund, C; Nielsen, JB; Rasmussen, V, 1988) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| "An experimental phenylketonuria-like syndrome was produced in rats by oral administration of 1-phenylalanine (Phe, 500 mg/kg) and dl-p-chloro-phenylalanine (pCPA, 100-125 mg/kg) daily from the 2nd-3rd day of life to the age of 42 days." | 1.25 | Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats. ( Airaksinen, MM; MacDonald, EJ; Marvola, M; Turakka, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (77.78) | 18.7374 |
| 1990's | 4 (11.11) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pascucci, T | 2 |
| Ventura, R | 2 |
| Puglisi-Allegra, S | 2 |
| Cabib, S | 2 |
| HSIA, DY | 1 |
| ROWLEY, WA | 1 |
| HUANG, I | 1 |
| PERRY, TL | 1 |
| HANSEN, S | 1 |
| TISCHLER, B | 1 |
| HESTRIN, M | 1 |
| MURTAGH, JJ | 1 |
| RAPPALLINI, C | 1 |
| Jäggi, L | 1 |
| Zurflüh, MR | 1 |
| Schuler, A | 1 |
| Ponzone, A | 2 |
| Porta, F | 1 |
| Fiori, L | 1 |
| Giovannini, M | 1 |
| Santer, R | 1 |
| Hoffmann, GF | 2 |
| Ibel, H | 1 |
| Wendel, U | 1 |
| Ballhausen, D | 1 |
| Baumgartner, MR | 1 |
| Blau, N | 5 |
| Araki, M | 1 |
| Malpuech, G | 1 |
| Guyon, A | 1 |
| Demeocq, F | 1 |
| Piton, A | 1 |
| Boespflug, O | 1 |
| Vanlieferinghen, P | 1 |
| de Almeida, IT | 1 |
| Leandro, PP | 1 |
| Portela, R | 1 |
| Cabral, A | 1 |
| Eusébio, F | 1 |
| Tasso, T | 1 |
| Matasovic, A | 2 |
| Diamond, A | 1 |
| Ciaramitaro, V | 1 |
| Donner, E | 1 |
| Djali, S | 1 |
| Robinson, MB | 1 |
| Thöny, B | 1 |
| Renneberg, A | 1 |
| Arnold, LA | 1 |
| Hyland, K | 1 |
| Cali, F | 1 |
| Romano, V | 1 |
| Burlina, AB | 1 |
| Bonafé, L | 1 |
| Ferrari, V | 1 |
| Suppiej, A | 1 |
| Zacchello, F | 1 |
| Burlina, AP | 1 |
| Koslow, SH | 2 |
| Butler, IJ | 2 |
| Krumholz, A | 1 |
| Holtzman, NA | 1 |
| Kaufman, S | 2 |
| Gröbe, H | 1 |
| Bartholome, K | 1 |
| Milstien, S | 1 |
| Danks, DM | 1 |
| Cotton, RG | 2 |
| Schlesinger, P | 1 |
| Airaksinen, MM | 1 |
| Turakka, H | 1 |
| Marvola, M | 1 |
| MacDonald, EJ | 1 |
| Kanabus, P | 1 |
| Kohsaka, S | 1 |
| Tsukada, Y | 1 |
| Heizmann, CW | 1 |
| Sperl, W | 1 |
| Korenke, GC | 1 |
| Smooker, PM | 1 |
| Lou, HC | 3 |
| Güttler, F | 2 |
| Lykkelund, C | 3 |
| Bruhn, P | 2 |
| Niederwieser, A | 3 |
| Huether, G | 1 |
| Guardamagna, O | 2 |
| Ferraris, S | 1 |
| Biasetti, S | 1 |
| Bracco, G | 1 |
| Gerdes, AM | 2 |
| Udesen, H | 1 |
| Nielsen, JB | 1 |
| Rasmussen, V | 1 |
| Christensen, E | 1 |
| Curtius, HC | 1 |
| Kierat, L | 1 |
| Leimbacher, W | 1 |
| Binkert, F | 1 |
| Lehmann, H | 1 |
| Leupold, D | 1 |
| Pare, CM | 1 |
| Tu, J | 1 |
| Partington, MW | 1 |
| Blatteis, CM | 1 |
| Billmeier, GJ | 1 |
| Gilbert, TM | 1 |
| Costil, J | 1 |
| Galli, J | 1 |
| Richardet, JM | 1 |
| Brissaud, HE | 1 |
| Loo, YH | 1 |
| Behbehani, AW | 1 |
| Quentin, CD | 1 |
| Schulte, FJ | 1 |
| Neuhoff, V | 1 |
| McKean, CM | 1 |
| Wysokowski, J | 1 |
| Szonert, M | 1 |
| Matsuda, I | 1 |
| Sugai, M | 1 |
| Arashima, S | 1 |
| Anakura, M | 1 |
| Jéquier, E | 1 |
1 review available for hydroxyindoleacetic acid and BH4 Deficiency
| Article | Year |
|---|---|
[5-hydroxyindoleacetic acid and its diagnostic evaluation].
Topics: Brain Neoplasms; Humans; Hydroxyindoleacetic Acid; Phenylketonurias; Serotonin | 1967 |
1 trial available for hydroxyindoleacetic acid and BH4 Deficiency
| Article | Year |
|---|---|
Increased vigilance and dopamine synthesis by large doses of tyrosine or phenylalanine restriction in phenylketonuria.
Topics: Adolescent; Adult; Arousal; Clinical Trials as Topic; Dopamine; Double-Blind Method; Female; Homovan | 1987 |
34 other studies available for hydroxyindoleacetic acid and BH4 Deficiency
| Article | Year |
|---|---|
Deficits in brain serotonin synthesis in a genetic mouse model of phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Female; Genotype; | 2002 |
The excretion of 5-hydroxyindoleacetic acid in the heterozygous carrier for phenylketonuria.
Topics: Biological Transport; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Intellectual Disability; | 1961 |
DEFECTIVE 5-HYDROXYLATION OF TRYPTOPHAN IN PHENYLKETONURIA.
Topics: Blood Chemical Analysis; Body Fluids; Humans; Hydroxyindoleacetic Acid; Hydroxylation; Indoleacetic | 1964 |
[SEROTONIN AND 5-HYDROXYINDOLACETIC ACID IN THE NEWBORN INFANT].
Topics: Anemia; Anemia, Aplastic; Cardiovascular System; Gastrointestinal Tract; Humans; Hydroxyindoleacetic | 1964 |
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Topics: Adolescent; Adult; Biopterins; Child; Dihydropteridine Reductase; Female; Follow-Up Studies; Homovan | 2008 |
[Neuropsychiatric study on the effects of low-phenylalanine diet in phenylketonuria. 2. Experiments on the metabolism associated with the central nervous system disorder of phenylketonuria].
Topics: Child; Child, Preschool; Cyproheptadine; Diet Therapy; Female; Glutamine; Humans; Hydroxyindoleaceti | 1966 |
[Malignant phenylketonuria caused by biopterin synthetase deficiency. Study of neuromediator catabolites in the cerebrospinal fluid during treatment].
Topics: Alcohol Oxidoreductases; Biopterins; Carbidopa; Follow-Up Studies; Homovanillic Acid; Humans; Hydrox | 1984 |
Tetrahydrobiopterin deficiency in Portugal: results of the screening for hyperphenylalaninemia.
Topics: Adolescent; Biopterins; Child; Child, Preschool; Consanguinity; Female; Homovanillic Acid; Humans; H | 1993 |
An animal model of early-treated PKU.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Fetu | 1994 |
Dihydropteridine reductase deficiency localized to the central nervous system.
Topics: Biopterins; Central Nervous System; Child; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male | 1998 |
Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amygdala; Animals; Biogenic Monoamines; Brain; Caudate Nucleus; Dise | 2000 |
Measurement of neurotransmitter metabolites in the cerebrospinal fluid of phenylketonuric patients under dietary treatment.
Topics: Adolescent; Adult; Aspartic Acid; Child; Dipeptides; Dopamine; Female; Homovanillic Acid; Humans; Hy | 2000 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
A disorder of biogenic amines in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Brain; Child, Preschool; Homovanillic Acid; Humans; Hydroxyind | 1978 |
Hyperphenylalaninaemia due to dihydropteridine reductase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Child; Child, Preschool; Female; Fibroblasts; Huma | 1978 |
Letter: Variant forms of phenylketonuria.
Topics: Biopterins; Catecholamines; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Infant, New | 1976 |
Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Body Weight; Brain; Female; Fenclonine; Humans; Hydr | 1975 |
Urinary excretion of 5-hydroxyindoleacetic acid and N1-methyl-2-pyridone-5-carboxamide by normal and phenylketonuric children.
Topics: Child; Humans; Hydroxyindoleacetic Acid; Niacinamide; Phenylketonurias; Reference Values | 1975 |
Neurochemical and behavioral studies on the experimental phenylketonuric rats.
Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Discrimination Learning; DNA; Humans; Hydroxyindoleac | 1979 |
Atypical (mild) forms of dihydropteridine reductase deficiency: neurochemical evaluation and mutation detection.
Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Child, Preschool; Dihydropteridine Reductase; DNA | 1992 |
Decreased vigilance and neurotransmitter synthesis after discontinuation of dietary treatment for phenylketonuria in adolescents.
Topics: Adolescent; Adult; Amino Acids; Arousal; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindolea | 1985 |
The depletion of tryptophan and serotonin in the brain of developing hyperphenylalaninemic rats is abolished by the additional administration of lysine.
Topics: Animals; Brain Chemistry; Hydroxyindoleacetic Acid; Lysine; Male; Phenylalanine; Phenylketonurias; R | 1986 |
Neurotransmitter therapy and diet in malignant phenylketonuria.
Topics: 5-Hydroxytryptophan; Carbidopa; Combined Modality Therapy; Female; Homovanillic Acid; Humans; Hydrox | 1987 |
Increased neurotransmitter biosynthesis in phenylketonuria induced by phenylalanine restriction or by supplementation of unrestricted diet with large amounts of tyrosine.
Topics: Adolescent; Adult; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Neurotransmitt | 1988 |
Prenatal diagnosis of atypical phenylketonuria.
Topics: Amniocentesis; Amniotic Fluid; Biomarkers; Chromatography, High Pressure Liquid; Female; Genetic Car | 1989 |
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy | 1968 |
5-hydroxyindole levels in the blood and CSF in Down's syndrome, phenylketonuria and severe mental retardation.
Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; | 1972 |
Thermoregulation of phenylketonuric children.
Topics: Adolescent; Body Temperature Regulation; Child, Preschool; Female; Fever; Humans; Hydroxyindoleaceti | 1974 |
[Urinary excretion of 5-hydroxyindoleacetic acid. II. In children with phenylketonuria, effects of 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Administration, Oral; Child, Preschool; Female; Humans; Hydroxyindoleacetic Aci | 1973 |
Serotonin deficiency in experimental hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa | 1974 |
Microanalysis with 14-C-dansyl chloride of amino acids and amines in the cerebrospinal fluid of patients with phenylketonuria. II. Determination of 5-hydroxyindole derivatives after loading with L-phenylalanine.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Autoradiography; Carbon Radioisotopes; Child; Child, Presc | 1974 |
The effects of high phenylalanine concentrations on serotonin and catecholamine metabolism in the human brain.
Topics: Adolescent; Adult; Amino Acids; Brain; Catecholamines; Chromatography; Dopamine; Humans; Hydroxyindo | 1972 |
Urinary 5-hydroxy-indolacetic acid in patients with atypical phenylketonuria.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Hydroxyindoleacetic Acid; Male; Phenylke | 1971 |
Tryptophan hydroxylation in phenylketonuria.
Topics: Adult; Animals; Carbon Isotopes; Chromatography, Paper; Humans; Hydroxyindoleacetic Acid; Mixed Func | 1968 |