hydroxyindoleacetic acid has been researched along with Autism in 34 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The neurochemistry of autism, the most well-validated childhood neuropsychiatric disorder, has been studied extensively over the past three decades." | 3.76 | Autism: review of neurochemical investigation. ( Cook, EH, 1990) |
| " [3H]-paroxetine binding Kd values were significantly higher in patients with autism than in healthy volunteers." | 3.70 | Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. ( Croonenberghs, J; Deboutte, D; Delmeire, L; Lin, AH; Maes, M; Meskal, A; Neels, H; Pison, G; Scharpe, S; Van der Planken, M; Verkerk, R, 2000) |
| " Based on data including urinary serotonin and 5-hydroxyindoleacetic acid, platelet serotonin uptake and efflux, platelet monoamine oxidase and glutathione peroxidase activities, and uric acid and plasma tryptophan, the origin(s) of such hyperserotonemia in autism appear(s) to be of metabolic origin, i." | 3.67 | Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children. ( Braconnier, A; Bursztejn, C; Dreux, C; Ferrari, P; Haimart, M; Launay, JM; Luong, C; Pasques-Bondoux, D; Tabuteau, F, 1988) |
| "After administration of secretin, the Autism Diagnostic Interview-Revised (ADI-R) score improved in 7 of the 12 children." | 2.72 | Administration of secretin for autism alters dopamine metabolism in the central nervous system. ( Hashimoto, T; Kagami, S; Kuroda, Y; Miyazaki, M; Mori, K; Nozaki, S; Toda, Y; Watanabe, Y, 2006) |
| "A neurodevelopmental disease, autism spectrum disorder (ASD) occurs in males three times more commonly than girls." | 1.91 | Effects of prenatal testosterone exposure on the development of autism-like behaviours in offspring of Wistar rats. ( Bozkurt, MF; Erbas, O; Erdogan, MA, 2023) |
| "In the group of 9 children with other psychoses, both the level of homovanillic acid and that of 5-hydroxy-indoleacetic acid was raised." | 1.27 | Childhood psychosis and monoamine metabolites in spinal fluid. ( Gillberg, C; Hamilton-Hellberg, C; Svennerholm, L, 1983) |
| "The Rett syndrome is a progressive disorder in female patients that is characterized by autistic behavior, dementia, ataxia, loss of purposeful use of the hands, and seizures." | 1.27 | Reduction of biogenic amine levels in the Rett syndrome. ( Butler, IJ; Glaze, DG; Percy, AK; Riccardi, VM; Zoghbi, HY, 1985) |
| "Basic research in autism is reviewed." | 1.26 | Overview of selected basic research in autism. ( Piggott, LR, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Erdogan, MA | 1 |
| Bozkurt, MF | 1 |
| Erbas, O | 1 |
| Horvath, GA | 1 |
| Demos, M | 1 |
| Shyr, C | 1 |
| Matthews, A | 1 |
| Zhang, L | 1 |
| Race, S | 1 |
| Stockler-Ipsiroglu, S | 1 |
| Van Allen, MI | 1 |
| Mancarci, O | 1 |
| Toker, L | 1 |
| Pavlidis, P | 1 |
| Ross, CJ | 1 |
| Wasserman, WW | 1 |
| Trump, N | 1 |
| Heales, S | 1 |
| Pope, S | 1 |
| Cross, JH | 1 |
| van Karnebeek, CD | 1 |
| Mulder, EJ | 2 |
| Anderson, GM | 5 |
| Kemperman, RF | 1 |
| Oosterloo-Duinkerken, A | 2 |
| Minderaa, RB | 3 |
| Kema, IP | 2 |
| Dufour-Rainfray, D | 1 |
| Vourc'h, P | 1 |
| Le Guisquet, AM | 1 |
| Garreau, L | 1 |
| Ternant, D | 1 |
| Bodard, S | 1 |
| Jaumain, E | 1 |
| Gulhan, Z | 1 |
| Belzung, C | 1 |
| Andres, CR | 1 |
| Chalon, S | 1 |
| Guilloteau, D | 1 |
| Adamsen, D | 1 |
| Meili, D | 1 |
| Blau, N | 1 |
| Thöny, B | 1 |
| Ramaekers, V | 1 |
| Toda, Y | 2 |
| Mori, K | 2 |
| Hashimoto, T | 2 |
| Miyazaki, M | 2 |
| Kuroda, Y | 2 |
| Croonenberghs, J | 2 |
| Verkerk, R | 2 |
| Scharpe, S | 2 |
| Deboutte, D | 2 |
| Maes, M | 2 |
| Bell, CJ | 1 |
| Hood, SD | 1 |
| Nutt, DJ | 1 |
| De Vries, EG | 1 |
| Nozaki, S | 1 |
| Watanabe, Y | 1 |
| Kagami, S | 1 |
| Janusonis, S | 1 |
| Shifrovich, I | 1 |
| Rakic, P | 1 |
| Leckman, JF | 1 |
| Cohen, DJ | 5 |
| Shaywitz, BA | 4 |
| Caparulo, BK | 2 |
| Heninger, GR | 1 |
| Bowers, MB | 2 |
| Winsberg, BG | 1 |
| Sverd, J | 1 |
| Castells, S | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Kamoun, P | 1 |
| Douay, O | 1 |
| Young, JG | 1 |
| Kavanagh, ME | 1 |
| Gillberg, C | 4 |
| Svennerholm, L | 2 |
| Hamilton-Hellberg, C | 1 |
| Hoshino, Y | 1 |
| Yamamoto, T | 1 |
| Kaneko, M | 1 |
| Tachibana, R | 1 |
| Watanabe, M | 1 |
| Ono, Y | 1 |
| Kumashiro, H | 1 |
| Komori, H | 1 |
| Matsuishi, T | 1 |
| Yamada, S | 1 |
| Yamashita, Y | 1 |
| Ohtaki, E | 1 |
| Kato, H | 1 |
| Akefeldt, A | 1 |
| Ekman, R | 1 |
| Månsson, JE | 1 |
| Delmeire, L | 1 |
| Lin, AH | 1 |
| Meskal, A | 1 |
| Neels, H | 1 |
| Van der Planken, M | 1 |
| Pison, G | 1 |
| Piggott, LR | 1 |
| Coleman, M | 1 |
| Hanley, HG | 1 |
| Stahl, SM | 1 |
| Freedman, DX | 1 |
| Ritvo, ER | 1 |
| Guthrie, RD | 1 |
| Wyatt, RJ | 1 |
| Martineau, J | 1 |
| Barthélémy, C | 1 |
| Jouve, J | 1 |
| Muh, JP | 1 |
| Lelord, G | 1 |
| Cook, EH | 1 |
| Zoghbi, HY | 1 |
| Percy, AK | 1 |
| Glaze, DG | 1 |
| Butler, IJ | 1 |
| Riccardi, VM | 1 |
| Volkmar, FR | 1 |
| Akkerhuis, GW | 1 |
| Launay, JM | 1 |
| Ferrari, P | 1 |
| Haimart, M | 1 |
| Bursztejn, C | 1 |
| Tabuteau, F | 1 |
| Braconnier, A | 1 |
| Pasques-Bondoux, D | 1 |
| Luong, C | 1 |
| Dreux, C | 1 |
| Johnson, WT | 1 |
| Bowers, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for hydroxyindoleacetic acid and Autism
| Article | Year |
|---|---|
Acute tryptophan depletion. Part II: clinical effects and implications.
Topics: Alleles; Alzheimer Disease; Autistic Disorder; Bipolar Disorder; Cognitive Behavioral Therapy; Depre | 2005 |
[Serotonin and autism].
Topics: Adolescent; Autistic Disorder; Blood Platelets; Child; Child, Preschool; Humans; Hydroxyindoleacetic | 1980 |
Clinical neurochemistry of autism and associated disorders.
Topics: Amines; Animals; Autistic Disorder; Blood Platelets; Brain Chemistry; Catecholamines; Dopamine; Dopa | 1982 |
Biochemistry and schizophrenia III. A review of childhood psychosis.
Topics: Autistic Disorder; Blood Platelets; Brain; Bufotenin; Child; Child, Preschool; Creatine Kinase; Dime | 1975 |
Autism: review of neurochemical investigation.
Topics: Autistic Disorder; Blood Platelets; Catecholamines; Cyclic AMP; Hormones; Humans; Hydroxyindoleaceti | 1990 |
3 trials available for hydroxyindoleacetic acid and Autism
| Article | Year |
|---|---|
Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Autistic Disorder; Female; Humans; Hydroxyindoleacetic Acid; | 2005 |
Administration of secretin for autism alters dopamine metabolism in the central nervous system.
Topics: Autistic Disorder; Biopterins; Central Nervous System; Child; Child, Preschool; Dopamine; Female; Ho | 2006 |
Autism: review of neurochemical investigation.
Topics: Autistic Disorder; Blood Platelets; Catecholamines; Cyclic AMP; Hormones; Humans; Hydroxyindoleaceti | 1990 |
27 other studies available for hydroxyindoleacetic acid and Autism
| Article | Year |
|---|---|
Effects of prenatal testosterone exposure on the development of autism-like behaviours in offspring of Wistar rats.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Dopamine; Female; Huma | 2023 |
Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Topics: Autistic Disorder; Channelopathies; Child; Drug Resistant Epilepsy; Epilepsy; Exome; Female; Homovan | 2016 |
Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals.
Topics: Adolescent; Age Factors; Autistic Disorder; Creatinine; Humans; Hydroxyindoleacetic Acid; Male; Mela | 2010 |
Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Brain; Disease Models, Animal; Female; GABA Agents; Hi | 2010 |
Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants.
Topics: 5-Hydroxytryptophan; Amino Acid Substitution; Antidepressive Agents, Second-Generation; Autistic Dis | 2011 |
[Efficacy of secretin for the treatment of autism].
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyin | 2004 |
Automated on-line solid-phase extraction coupled with HPLC for measurement of 5-hydroxyindole-3-acetic acid in urine.
Topics: Autistic Disorder; Autoanalysis; Biomarkers; Carcinoid Tumor; Chromatography, High Pressure Liquid; | 2005 |
Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism.
Topics: Animals; Autistic Disorder; Blood Platelets; Brain; Brain Chemistry; Central Nervous System; Chromat | 2006 |
CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
Topics: Adolescent; Adult; Age Factors; Aged; Autistic Disorder; Bipolar Disorder; Child; Child, Preschool; | 1980 |
Estimation of monoamine and cyclic-AMP turnover and amino acid concentrations of spinal fluid in autistic children.
Topics: Amines; Amino Acids; Autistic Disorder; Child; Cyclic AMP; Dopamine; Homovanillic Acid; Humans; Hydr | 1980 |
Childhood psychosis and monoamine metabolites in spinal fluid.
Topics: Adolescent; Age Factors; Autistic Disorder; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; | 1983 |
Blood serotonin and free tryptophan concentration in autistic children.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Female; Humans; Hydroxyindoleacetic Acid; Male; P | 1984 |
Not less likely than before that mean CSF HVA may be high in autism.
Topics: Autistic Disorder; Child; Diagnosis, Differential; Homovanillic Acid; Humans; Hydroxyindoleacetic Ac | 1993 |
Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism.
Topics: Autistic Disorder; Biopterins; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyin | 1995 |
Cerebrospinal fluid monoamines in Prader-Willi syndrome.
Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Birth Weight; Body Mass Index; Child; Child, Pres | 1998 |
Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder.
Topics: Adolescent; Autistic Disorder; Belgium; Biomarkers; Child; Dopamine; Epinephrine; Humans; Hydroxyind | 2000 |
Overview of selected basic research in autism.
Topics: Autistic Disorder; Catecholamines; Cerebral Cortex; Child; Electroencephalography; Evoked Potentials | 1979 |
Studies of the autistic syndromes.
Topics: Adolescent; Autistic Disorder; Brain; Calcium; Catechol O-Methyltransferase; Cerebrovascular Circula | 1979 |
Hyperserotonemia and amine metabolites in autistic and retarded children.
Topics: Adolescent; Adult; Age Factors; Autistic Disorder; Child; Child, Institutionalized; Child, Preschool | 1977 |
Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Adolescent; Age Factors; Aphasia; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
Biochemical studies of children with the syndromes of autism, childhood schizophrenia and related developmental disabilities: a review.
Topics: Autistic Disorder; Blood Platelets; Brain; Bufotenin; Child; Dopamine beta-Hydroxylase; Homovanillic | 1977 |
Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: age-related changes and drug effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Autistic Disorder; Catecholamines; Child; Child Develop | 1992 |
Reduction of biogenic amine levels in the Rett syndrome.
Topics: Adolescent; Ataxia; Autistic Disorder; Biogenic Amines; Child; Child, Preschool; Dementia; Electroen | 1985 |
Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects.
Topics: Adolescent; Adult; Autistic Disorder; Female; Humans; Hydroxyindoleacetic Acid; Male; Serotonin; Try | 1987 |
CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood.
Topics: Adolescent; Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Fema | 1987 |
Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children.
Topics: Adolescent; Autistic Disorder; Blood Platelets; Child; Child, Preschool; Female; Glutathione Peroxid | 1988 |
Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Diagnosis, Differential; Dopamine; Electroencepha | 1974 |