hydroxyindoleacetic acid has been researched along with Amyotrophic Lateral Sclerosis in 11 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In four human controls, four cases of Parkinson's disease and three cases of amyotrophic lateral sclerosis analysis of dopamine, noradrenaline, serotonin and the metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid was performed in various segments of postmortem spinal cord." | 3.68 | Biogenic amines and metabolites in spinal cord of patients with Parkinson's disease and amyotrophic lateral sclerosis. ( Gavranovic, M; Gsell, W; Jellinger, K; Riederer, P; Schmidtke, A; Sofic, E, 1991) |
| "Noradrenaline (NA), dopamine (DA), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in discrete subdivisions of cervical, thoracic and lumbar spinal cord segments obtained at autopsy of 4 subjects with amyotrophic lateral sclerosis (ALS) and 7 control patients." | 3.68 | Amyotrophic lateral sclerosis: changes of noradrenergic and serotonergic transmitter systems in the spinal cord. ( Bertel, O; Hornykiewicz, O; Malessa, S; Sluga, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dupuis, L | 1 |
| Spreux-Varoquaux, O | 1 |
| Bensimon, G | 1 |
| Jullien, P | 1 |
| Lacomblez, L | 1 |
| Salachas, F | 1 |
| Bruneteau, G | 1 |
| Pradat, PF | 1 |
| Loeffler, JP | 1 |
| Meininger, V | 1 |
| Takase, S | 1 |
| Alexander, GM | 1 |
| Deitch, JS | 1 |
| Seeburger, JL | 1 |
| Del Valle, L | 1 |
| Heiman-Patterson, TD | 1 |
| Cook, A | 1 |
| Nidzgorski, F | 1 |
| Hurwic, M | 1 |
| Winsberg, B | 1 |
| Klutch, A | 1 |
| Sofic, E | 1 |
| Riederer, P | 1 |
| Gsell, W | 1 |
| Gavranovic, M | 1 |
| Schmidtke, A | 1 |
| Jellinger, K | 1 |
| Bertel, O | 1 |
| Malessa, S | 1 |
| Sluga, E | 1 |
| Hornykiewicz, O | 1 |
| Ohsugi, K | 1 |
| Adachi, K | 1 |
| Mukoyama, M | 1 |
| Ando, K | 1 |
| Mendell, JR | 2 |
| Chase, TN | 3 |
| Engel, WK | 2 |
| Chase, RN | 1 |
| Schnur, JA | 1 |
| Brody, JA | 2 |
| Gordon, EK | 2 |
11 other studies available for hydroxyindoleacetic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Blood Platelets; Case-Control Studies; Chromatography, High Pressure | 2010 |
[CSF findings in patients with ALS].
Topics: Adult; Aged; Albumins; Amyotrophic Lateral Sclerosis; Cerebrospinal Fluid Proteins; Complement C3; F | 1984 |
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Ani | 2000 |
Monoamine accumulation among sclerotic patients receiving dorsal-column stimulation.
Topics: Amyotrophic Lateral Sclerosis; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Multiple Scleros | 1978 |
Biogenic amines and metabolites in spinal cord of patients with Parkinson's disease and amyotrophic lateral sclerosis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Autopsy; Bio | 1991 |
Amyotrophic lateral sclerosis: changes of noradrenergic and serotonergic transmitter systems in the spinal cord.
Topics: Amyotrophic Lateral Sclerosis; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged | 1991 |
Lack of change in indoleamine metabolism in spinal cord of patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle A | 1987 |
Amyotrophic lateral sclerosis. A study of central monoamine metabolism and therapeutic trial of levodopa.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hydrox | 1971 |
Parkinsonism-dementia and amyotrophic lateral sclerosis of Guam. Effect of probenecid on monoamine catabolite levels in cerebrospinal fluid.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hydrox | 1971 |
Amyotrophic lateral sclerosis: metabolism of central monoamines and treatment with L-dopa.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Central Nervous System; Dihydroxyphenylalanine; Dopamine | 1971 |
Depressed monoamine catabolite levels in cerebrospinal fluid of patients with parkinsonism dementia of Guam.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Brain; Dementia; Dopamine; Humans; Hydroxyindoleacetic A | 1970 |