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hydroxyindoleacetic acid and Alloxan Diabetes

hydroxyindoleacetic acid has been researched along with Alloxan Diabetes in 32 studies

(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.

Research Excerpts

ExcerptRelevanceReference
"Hyperthyroidism was accompanied by significant reductions in 5HT, while urinary norepinephrine excretion paralleled 5HT."1.30Bulbospinal serotonergic activity during changes in thyroid status. ( Bellush, LL; Henley, WN; Tressler, M, 1998)
"In both cases, prior induction of primary hypothyroidism interfered with the expected diabetes-induced reduction in 5-HT turnover."1.28Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy. ( Bellush, LL; Henley, WN, 1992)
"In recent years the effect of experimental diabetes mellitus on brain neurochemistry has been under an intensive investigation."1.28Streptozotocin and alloxan produce alterations in rat brain monoamines independently of pancreatic beta cells destruction. ( Lacković, Z; Salković, M, 1990)
"Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats."1.27Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections. ( Champney, TH; Craft, CM; Holtorf, AP; Reiter, RJ, 1986)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199013 (40.63)18.7374
1990's13 (40.63)18.2507
2000's4 (12.50)29.6817
2010's1 (3.13)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Munawar, N1
Bitar, MS3
Masocha, W1
Adeghate, E2
Hameed, RS1
Ponery, AS2
Tariq, S1
Sheen, RS1
Shaffiullah, M1
Donáth, T1
Miyata, S1
Hirano, S1
Kamei, J1
Ramakrishnan, R1
Prabhakaran, K1
Jayakumar, AR1
Gunasekaran, P1
Sheeladevi, R1
Suthanthirarajan, N1
Crandall, EA1
Gillis, MA1
Fernstrom, JD1
Watkins, CA1
Rannels, DE1
Sadler, E1
Weiner, M1
Buterbaugh, GG1
Trulson, ME4
MacKenzie, RG4
Bellush, LL5
Reid, SG2
Martín, FJ1
Míguez, JM1
Aldegunde, M1
Atienza, G1
Jamnicky, B1
Mück-Seler, D1
Slijepcević, M1
Suh, HW1
Song, DK1
Wie, MB1
Jung, JS1
Hong, HE1
Choi, SR1
Kim, YH1
Ohtani, N1
Ohta, M1
Sugano, T1
Thorré, K1
Chaouloff, F2
Sarre, S1
Meeusen, R1
Ebinger, G1
Michotte, Y1
Henley, WN3
Tressler, M1
Shimazoe, T1
Ishida, J1
Maetani, M1
Yakabe, T1
Yamaguchi, M1
Miyasaka, K1
Kono, A1
Watanabe, S1
Funakoshi, A1
Sheen, R1
Keis, AF1
Owusu, SE1
Mulven, R1
DeSouza, EB1
Lacković, Z1
Salković, M1
Huupponen, R1
Koulu, M3
Pesonen, U1
North, D1
Kwok, RP2
Walls, EK1
Juorio, AV2
Bitar, M1
Rapoport, SI1
Linnoila, M2
Jacoby, JH1
Champney, TH1
Holtorf, AP1
Craft, CM1
Reiter, RJ1
Laude, D1
Mérino, D1
Serrurier, B1
Baudrie, V1
Elghozi, JL1

Other Studies

32 other studies available for hydroxyindoleacetic acid and Alloxan Diabetes

ArticleYear
Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain.
    International journal of molecular sciences, 2023, Sep-20, Volume: 24, Issue:18

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus,

2023
Streptozotocin causes pancreatic beta cell failure via early and sustained biochemical and cellular alterations.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2010, Volume: 118, Issue:10

    Topics: Animals; Cell Degranulation; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hydroxyindoleac

2010
Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:3

    Topics: Animals; Depression; Diabetes Mellitus, Experimental; Hindlimb Suspension; Hydroxyindoleacetic Acid;

2004
Involvement of Ca2+/calmodulin-dependent protein kinase II in the modulation of indolamines in diabetic and hyperglycemic rats.
    Journal of neuroscience research, 2005, May-15, Volume: 80, Issue:4

    Topics: Acidosis; Alloxan; Ammonium Chloride; Analysis of Variance; Animals; Bicarbonates; Blood Glucose; Bl

2005
Reduction in brain serotonin synthesis rate in streptozotocin-diabetic rats.
    Endocrinology, 1981, Volume: 109, Issue:1

    Topics: Animals; Brain; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid; Kinetics; Male; Pargyline

1981
Effect of diabetes on metabolism of 5-hydroxytryptamine by rat lungs perfused in situ.
    The American review of respiratory disease, 1982, Volume: 126, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid; Lung; Male; Perfusion; Rats; Rat

1982
Effect of streptozotocin-induced diabetes on tryptophan oxygenase activity and brain tryptophan levels in rats.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 42, Issue:1

    Topics: Animals; Brain; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid; Liver; Male; Rats; Rats,

1983
Increased tryptophan hydroxylase activity may compensate for decreased brain tryptophan levels in streptozotocin-diabetic rats.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:2

    Topics: Animals; Blood Glucose; Brain Chemistry; Diabetes Mellitus, Experimental; Female; Hydroxyindoleaceti

1980
Metabolic and neurochemical profiles in insulin-treated diabetic rats.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hydroxyi

1994
Effect of streptozotocin-induced diabetes mellitus on serotonin measures of peripheral tissues in rats.
    Life sciences, 1995, Volume: 56, Issue:1

    Topics: Animals; Blood Platelets; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid; Insulin; Intest

1995
Favourable effect of tryptophan/insulin treatment on serotoninergic imbalance in alloxan diabetic rats.
    Comparative biochemistry and physiology. Comparative physiology, 1993, Volume: 105, Issue:2

    Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Hydroxyindoleaceti

1993
The reduction of antinociceptive effect of morphine administered intraventricularly is correlated with the decrease of serotonin release from the spinal cord in streptozotocin-induced diabetic rats.
    General pharmacology, 1996, Volume: 27, Issue:3

    Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental;

1996
Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats.
    Journal of neurochemistry, 1997, Volume: 69, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Diabetes Mellitus, Experimental; Dopamine; gamma-Aminobutyr

1997
Differential effects of restraint stress on hippocampal 5-HT metabolism and extracellular levels of 5-HT in streptozotocin-diabetic rats.
    Brain research, 1997, Oct-24, Volume: 772, Issue:1-2

    Topics: Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Hippocampus; Hydroxyindolea

1997
Bulbospinal serotonergic activity during changes in thyroid status.
    Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:12

    Topics: Animals; Blood Glucose; Body Weight; Brain Stem; Diabetes Mellitus, Experimental; Hydroxyindoleaceti

1998
Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Brain; Circadian Rhythm; Diabetes Mellitus, Experimental; Glutamic Aci

2000
Streptozotocin-Induced diabetes mellitus is associated with increased pancreatic tissue levels of noradrenaline and adrenaline in the rat.
    Pancreas, 2001, Volume: 22, Issue:3

    Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Epine

2001
Effects of insulin and streptozotocin-induced diabetes on brain tryptophan and serotonin metabolism in rats.
    Journal of neurochemistry, 1978, Volume: 30, Issue:1

    Topics: Animals; Blood Glucose; Brain; Corticosterone; Diabetes Mellitus, Experimental; Dopamine; Female; Hy

1978
Regional accumulation of tryptophan and serotonin metabolism following tryptophan loading in diabetic rats.
    Journal of neurochemistry, 1978, Volume: 31, Issue:1

    Topics: Animals; Brain; Brain Stem; Diabetes Mellitus, Experimental; Female; Hydroxyindoleacetic Acid; Rats;

1978
Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy.
    Neuroendocrinology, 1992, Volume: 56, Issue:3

    Topics: Animals; Corticosterone; Diabetes Mellitus, Experimental; Exploratory Behavior; Fenclonine; Hydroxyi

1992
Impairment of albuterol-induced suppression of food intake in diabetes mellitus.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:3

    Topics: Albuterol; Animals; Anorexia; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Eat

1992
Streptozotocin and alloxan produce alterations in rat brain monoamines independently of pancreatic beta cells destruction.
    Life sciences, 1990, Volume: 46, Issue:1

    Topics: Alloxan; Analysis of Variance; Animals; Biogenic Monoamines; Blood Glucose; Brain; Diabetes Mellitus

1990
Altered responses to environmental stress in streptozotocin-diabetic rats.
    Physiology & behavior, 1990, Volume: 47, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Arousal; Blood Glucose; Body Temperature R

1990
Hypothalamic 5-hydroxytryptamine metabolism is not influenced by streptozotocin-diabetes induced at neonatal age.
    Experimental and clinical endocrinology, 1990, Volume: 96, Issue:3

    Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid;

1990
The functional significance of biochemical alterations in streptozotocin-induced diabetes.
    Physiology & behavior, 1991, Volume: 50, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Brain; Brain Mapping; Corticosterone; Diabetes Mel

1991
The concentration of dopamine, 5-hydroxytryptamine, and some of their acid metabolites in the brain of genetically diabetic rats.
    Neurochemical research, 1985, Volume: 10, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Diabetes Mellitus, Experimental; Do

1985
Diabetes-induced alteration in brain monoamine metabolism in rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:2

    Topics: Animals; Biogenic Amines; Blood Glucose; Body Weight; Brain; Choline O-Acetyltransferase; Diabetes M

1986
Streptozotocin-induced diabetes reduces brain serotonin synthesis in rats.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Carboxy-Lyases; Diabetes Mellitus, Experimental; H

1986
Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections.
    Comparative biochemistry and physiology. A, Comparative physiology, 1986, Volume: 83, Issue:2

    Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Animals; Arylamine N-Acetyltransferase; Cr

1986
Facilitating effect of insulin on brain 5-hydroxytryptamine metabolism.
    Neuroendocrinology, 1987, Volume: 45, Issue:4

    Topics: Animals; Blood Glucose; Corpus Striatum; Diabetes Mellitus, Experimental; Hydroxyindoleacetic Acid;

1987
Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei.
    Brain research, 1987, Apr-21, Volume: 409, Issue:2

    Topics: Animals; Biogenic Amines; Diabetes Mellitus, Experimental; Female; Hydroxyindoleacetic Acid; Hypotha

1987
Duration of streptozotocin diabetes influences the response of hypothalamic serotonin metabolism to immobilization stress.
    Neuroendocrinology, 1989, Volume: 50, Issue:3

    Topics: Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Female; Hydroxyindoleacetic

1989