Page last updated: 2024-09-02

hydroxycotinine and Smoking Cessation

hydroxycotinine has been researched along with Smoking Cessation in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (7.69)18.2507
2000's5 (19.23)29.6817
2010's17 (65.38)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Flitter, A; Lerman, C; Schnoll, RA; Siegel, SD1
Benowitz, NL; Chenoweth, MJ; El-Boraie, A; Fukunaga, K; Knight, J; Kubo, M; Lerman, C; Mushiroda, T; Nollen, NL; Pouget, JG; Sanderson Cox, L; Tyndale, RF1
Cornuz, J; Csajka, C; Dobrinas, M; Eap, CB; Gholamrezaee, M; Glatard, A; Lubomirov, R1
Benowitz, NL; Delucchi, KL; Hall, SM; Hendricks, PS1
Chenoweth, MJ; Cinciripini, PM; George, TP; Hawk, LW; Lerman, C; Novalen, M; Schnoll, RA; Tyndale, RF1
Benowitz, NL; Cinciripini, P; George, TP; Hawk, LW; Heitjan, DF; Lerman, C; Schnoll, RA; Swan, GE; Tyndale, RF; Wileyto, EP1
Aveyard, P; Coleman, T; Cooper, S; Leonardi-Bee, J; Vaz, LR1
Chenoweth, MJ; Hamilton, DA; Hawk, LW; Heitjan, DF; Lerman, C; Mahoney, MC; Novalen, M; Tyndale, RF1
Boulamery, A; Liachenko, N; Simon, N1
Beatrice, F; Graziano, S; Massaro, G; Pacifici, R; Pellegrini, M; Pichini, S1
Blazekovic, S; Gariti, P; Goelz, PM; Hitsman, B; Kaufmann, A; Leone, FT; Powers, L; Schnoll, RA; Tyndale, RF; Veluz-Wilkins, A1
Hwang, SJ; Liu, KH1
De Cremer, KA; De Smedt, T; Dendale, P; Nackaerts, K; Van Laethem, DM; Van Loco, J; Van Overmeire, IP; Vanacker, H; Vanoeteren, JF1
Hatsukami, DK; Le, C; Li, ZZ; Mooney, ME; Murphy, SE; Pentel, PR1
Ahluwalia, JS; Al Koudsi, N; Benowitz, NL; Ho, MK; Mwenifumbo, JC; Okuyemi, KS; Tyndale, RF1
Ahluwalia, JS; Benowitz, NL; Bronars, CA; Choi, WS; Cox, LS; Faseru, B; Krebill, R; Mayo, MS; Nollen, NL; Okuyemi, KS; Salzman, GA; Snow, TS; Tyndale, RF1
Hajek, P; McRobbie, H; West, O1
Ansermot, N; Choong, E; Cornuz, J; Dobrinas, M; Eap, CB; Noetzli, M1
Benowitz, NL; Gandhi, KK; Lu, SE; Steinberg, ML; Williams, JM1
Huestis, MA; Scheidweiler, KB; Shakleya, DM1
De Cremer, K; Van Loco, J; Van Overmeire, I1
Benowitz, N; Lerman, C; Patterson, F; Pinto, A; Shields, PG; Tyndale, R; Wileyto, EP1
Berlin, I; Gasior, MJ; Moolchan, ET1
Benowitz, N; Jepson, C; Lee, AM; Lerman, C; Shields, PG; Tyndale, RF1
Benowitz, NL; Jacob, P; Zevin, S1
Anderson, R; Croghan, IT; Dale, LC; Hurt, RD; Ji, AJ; Lawson, GM1

Reviews

2 review(s) available for hydroxycotinine and Smoking Cessation

ArticleYear
The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:3

    Topics: Biomarkers; Cost-Benefit Analysis; Cotinine; Cytochrome P-450 CYP2A6; Electronic Nicotine Delivery Systems; Genetic Testing; Genetic Variation; Humans; Implementation Science; Metabolic Clearance Rate; Neoplasms; Nicotine; Precision Medicine; Prevalence; Smokers; Smoking; Smoking Cessation; Tobacco Use Cessation Devices

2020
Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence.
    Psychopharmacology, 2011, Volume: 218, Issue:2

    Topics: Cotinine; Humans; Nicotine; Reproducibility of Results; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Tobacco Use Disorder

2011

Trials

10 trial(s) available for hydroxycotinine and Smoking Cessation

ArticleYear
Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014, Volume: 23, Issue:9

    Topics: Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Linear Models; Male; Middle Aged; Nicotine; Predictive Value of Tests; Smoking; Smoking Cessation; Tobacco Use Disorder

2014
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial.
    The Lancet. Respiratory medicine, 2015, Volume: 3, Issue:2

    Topics: Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Smoking Cessation; Tobacco Use Cessation Devices; Treatment Outcome; Varenicline

2015
The Nicotine Metabolite Ratio in Pregnancy Measured by trans-3'-Hydroxycotinine to Cotinine Ratio: Characteristics and Relationship With Smoking Cessation.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:11

    Topics: Administration, Cutaneous; Adolescent; Adult; Cotinine; Female; Humans; Middle Aged; Nicotine; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Smoking; Smoking Cessation; Tobacco Use Disorder; Young Adult

2015
Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:12

    Topics: Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Patient Acceptance of Health Care; Reproducibility of Results; Retrospective Studies; Smoking; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome; Young Adult

2015
Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers.
    Clinical pharmacology and therapeutics, 2009, Volume: 85, Issue:6

    Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Black or African American; Body Mass Index; Cotinine; Cytochrome P-450 CYP2A6; Double-Blind Method; Female; Genotype; Humans; Male; Middle Aged; Nicotine; Polymorphism, Genetic; Smoking Cessation

2009
Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data.
    Trials, 2011, Jan-25, Volume: 12

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Black or African American; Bupropion; Cotinine; Counseling; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Female; Genotype; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Kansas; Male; Middle Aged; Motivation; Nicotine; Oxidoreductases, N-Demethylating; Patient Education as Topic; Patient Selection; Phenotype; Recurrence; Saliva; Smoking; Smoking Cessation; Smoking Prevention; Time Factors; Tobacco Use Disorder; Treatment Outcome

2011
Rapid smoking may not be aversive in schizophrenia.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:1

    Topics: Adult; Carbon Monoxide; Cotinine; Female; Humans; Male; Middle Aged; Schizophrenia; Schizophrenic Psychology; Smoking; Smoking Cessation

2013
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:6

    Topics: Administration, Cutaneous; Administration, Inhalation; Cotinine; Female; Humans; Liver; Male; Middle Aged; Nicotine; Smoking Cessation; Treatment Outcome

2006
Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking.
    British journal of clinical pharmacology, 1997, Volume: 43, Issue:3

    Topics: Administration, Cutaneous; Administration, Inhalation; Adult; Analysis of Variance; Biological Availability; Cotinine; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Regression Analysis; Smoking; Smoking Cessation

1997
A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine.
    Clinical chemistry, 1999, Volume: 45, Issue:1

    Topics: Administration, Cutaneous; Cotinine; Gas Chromatography-Mass Spectrometry; Humans; Nicotine; Nicotinic Agonists; Sensitivity and Specificity; Smoking; Smoking Cessation

1999

Other Studies

14 other study(ies) available for hydroxycotinine and Smoking Cessation

ArticleYear
Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.
    Clinical pharmacology and therapeutics, 2021, Volume: 110, Issue:4

    Topics: Adult; Black or African American; Black People; Cotinine; Cytochrome P-450 CYP2A6; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Pharmacogenomic Variants; Principal Component Analysis; Risk Factors; Smoking; Smoking Cessation; Treatment Outcome; White People

2021
Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy.
    Experimental and clinical psychopharmacology, 2017, Volume: 25, Issue:5

    Topics: Adult; Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Nicotine; Recurrence; Smoking; Smoking Cessation; Tobacco Products; Varenicline

2017
Clinical significance of early smoking withdrawal effects and their relationships with nicotine metabolism: preliminary results from a pilot study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:5

    Topics: Adult; Affect; Anxiety; Attention; Cotinine; Craving; Female; Heart Rate; Humans; Male; Middle Aged; Nicotine; Pilot Projects; Saliva; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2014
Nicotine and metabolites determination in human plasma by ultra performance liquid chromatography-tandem mass spectrometry: a simple approach for solving contamination problem and clinical application.
    Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:5

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Biotransformation; Calibration; Charcoal; Chromatography, Liquid; Cotinine; Female; Humans; Liquid-Liquid Extraction; Male; Middle Aged; Nicotine; Nicotinic Agonists; Reference Standards; Reproducibility of Results; Smoking Cessation; Tandem Mass Spectrometry; Tobacco Use Cessation Devices; Transdermal Patch; Young Adult

2015
Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study.
    International journal of environmental research and public health, 2015, Jul-08, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Biomarkers; Carbon Monoxide; Cotinine; Craving; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Pilot Projects; Smoking; Smoking Cessation; Tobacco Use Disorder; Young Adult

2015
Rate of nicotine metabolism and smoking cessation outcomes in a community-based sample of treatment-seeking smokers.
    Addictive behaviors, 2015, Volume: 51

    Topics: Administration, Cutaneous; Analysis of Variance; Anxiety; Biomarkers; Cotinine; Craving; Depression; Female; Humans; Male; Middle Aged; Nicotine; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder

2015
Effect of smoking cessation for 1 year on periodontal biomarkers in gingival crevicular fluid.
    Journal of periodontal research, 2016, Volume: 51, Issue:3

    Topics: Adult; Biomarkers; Cotinine; Dental Plaque Index; Enzyme-Linked Immunosorbent Assay; Female; Gingival Crevicular Fluid; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Middle Aged; Nicotine; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontium; Prospective Studies; Saliva; Smoking; Smoking Cessation

2016
Nicotine Dependence and Urinary Nicotine, Cotinine and Hydroxycotinine Levels in Daily Smokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:9

    Topics: Adolescent; Adult; Biomarkers; Cotinine; Female; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Nicotine; Severity of Illness Index; Smoking; Smoking Cessation; Smoking Prevention; Surveys and Questionnaires; Tandem Mass Spectrometry; Tobacco Use Disorder; Young Adult

2016
Stability of the nicotine metabolite ratio in ad libitum and reducing smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Cotinine; Female; Humans; Linear Models; Male; Middle Aged; Nicotine; Smoking; Smoking Cessation

2008
Quantification of nicotine, cotinine, trans-3'-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC-tandem mass-spectrometry procedure for a clinical study on smoking cessation.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Nov-15, Volume: 879, Issue:30

    Topics: Benzazepines; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Humans; Linear Models; Nicotine; Quinoxalines; Reproducibility of Results; Sensitivity and Specificity; Smoking Cessation; Tandem Mass Spectrometry; Varenicline

2011
Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry.
    Clinica chimica acta; international journal of clinical chemistry, 2012, Jun-14, Volume: 413, Issue:11-12

    Topics: Calibration; Chromatography, Liquid; Cotinine; Humans; Mecamylamine; Nicotine; Sensitivity and Specificity; Smoking; Smoking Cessation; Tandem Mass Spectrometry

2012
On-line solid-phase extraction with ultra performance liquid chromatography and tandem mass spectrometry for the detection of nicotine, cotinine and trans-3'-hydroxycotinine in urine to strengthen human biomonitoring and smoking cessation studies.
    Journal of pharmaceutical and biomedical analysis, 2013, Mar-25, Volume: 76

    Topics: Chromatography, Liquid; Cotinine; Environmental Exposure; Humans; Nicotine; Reproducibility of Results; Sensitivity and Specificity; Smoking; Smoking Cessation; Solid Phase Extraction; Tandem Mass Spectrometry; Tobacco Smoke Pollution

2013
Sex-based and hormonal contraception effects on the metabolism of nicotine among adolescent tobacco-dependent smokers.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007, Volume: 9, Issue:4

    Topics: Adolescent; Area Under Curve; Chromatography, Thin Layer; Cohort Studies; Contraceptives, Oral, Hormonal; Cotinine; Female; Humans; Male; Nicotine; Sex Factors; Smoking; Smoking Cessation

2007
CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:6

    Topics: Administration, Cutaneous; Administration, Inhalation; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2B6; Genotype; Humans; Linkage Disequilibrium; Nicotine; Nicotinic Agonists; Oxidoreductases, N-Demethylating; Smoking Cessation

2007