hydroxychloroquine has been researched along with Stevens-Johnson Syndrome in 10 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Four weeks prior, she had been initiated on hydroxychloroquine for a presumed diagnosis of cutaneous sarcoidosis." | 7.96 | Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report. ( Ackerman, L; Brahmbhatt, S; Coleman, I; Ruiz, G, 2020) |
| " Four weeks prior, she had been initiated on hydroxychloroquine for a presumed diagnosis of cutaneous sarcoidosis." | 3.96 | Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report. ( Ackerman, L; Brahmbhatt, S; Coleman, I; Ruiz, G, 2020) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous reactions characterized by necrosis and detachment of the epidermis." | 1.72 | The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID-19. ( Akin, T; Can, YY; Durak, C; Gursoy, F; Kilic, A; Sahin, C; Sahin, E; Varol, F, 2022) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions." | 1.42 | [Systemic lupus erythematosus presenting as Stevens-Johnson syndrome]. ( Bellakhal, S; Ben Kaab, B; Derbel, F; Douggui, MH; Souissi, A; Teyeb, Z, 2015) |
| "Hydroxychloroquine has rarely been associated with TEN, with one case proving fatal." | 1.40 | Hydroxychloroquine-induced fatal toxic epidermal necrolysis complicated by angioinvasive rhizopus. ( Cameron, MC; Dominguez, A; Word, AP, 2014) |
| "A patient developed toxic epidermal necrolysis (TEN), which was triggered by sun exposure while the patient was on long-term hydroxychloroquine." | 1.35 | Hydroxychloroquine-associated, photo-induced toxic epidermal necrolysis. ( Callaly, EL; FitzGerald, O; Rogers, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varol, F | 1 |
| Can, YY | 1 |
| Sahin, E | 1 |
| Durak, C | 1 |
| Kilic, A | 1 |
| Sahin, C | 1 |
| Gursoy, F | 1 |
| Akin, T | 1 |
| Kuraitis, D | 1 |
| Murina, A | 1 |
| Coleman, I | 1 |
| Ruiz, G | 1 |
| Brahmbhatt, S | 1 |
| Ackerman, L | 1 |
| Dumas, M | 1 |
| Hua, C | 1 |
| Hotz, C | 1 |
| Velter, C | 1 |
| Duong, TA | 1 |
| Maraffi, T | 1 |
| Ortonne, N | 1 |
| Hüe, S | 1 |
| Fardet, L | 1 |
| de Prost, N | 1 |
| Wolkenstein, P | 1 |
| Ingen-Housz-Oro, S | 1 |
| Chosidow, O | 1 |
| Cameron, MC | 1 |
| Word, AP | 1 |
| Dominguez, A | 1 |
| Bellakhal, S | 1 |
| Ben Kaab, B | 1 |
| Teyeb, Z | 1 |
| Souissi, A | 1 |
| Derbel, F | 1 |
| Douggui, MH | 1 |
| Lateef, A | 1 |
| Tan, KB | 1 |
| Lau, TC | 1 |
| Callaly, EL | 1 |
| FitzGerald, O | 1 |
| Rogers, S | 1 |
| Murphy, M | 1 |
| Carmichael, AJ | 1 |
| Leckie, MJ | 1 |
| Rees, RG | 1 |
10 other studies available for hydroxychloroquine and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
The role of treatment with plasma exchange therapy in two pediatric toxic epidermal necrolysis cases related to COVID-19.
Topics: Child; COVID-19; COVID-19 Vaccines; Humans; Hydroxychloroquine; Plasma Exchange; RNA, Messenger; Ste | 2022 |
Facts, not Fear: Safety of Hydroxychloroquine.
Topics: Acute Generalized Exanthematous Pustulosis; Agranulocytosis; Anemia, Aplastic; Antirheumatic Agents; | 2020 |
Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report.
Topics: Acute Generalized Exanthematous Pustulosis; Aged; Antimalarials; Biopsy; Coronavirus Infections; COV | 2020 |
Epidermal necrolysis and autoimmune diseases: two more observations supporting the concept that 'toxic' epidermal necrolysis can be 'non-toxic'.
Topics: Antibodies, Antinuclear; Autoimmune Diseases; Cyclophosphamide; Fatal Outcome; Female; Humans; Hydro | 2018 |
Hydroxychloroquine-induced fatal toxic epidermal necrolysis complicated by angioinvasive rhizopus.
Topics: Adult; Antirheumatic Agents; Blood Vessels; Facial Dermatoses; Fatal Outcome; Female; Humans; Hydrox | 2014 |
[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome].
Topics: Adult; Anemia; Arthralgia; Autoantibodies; Complement C3; Critical Care; Facial Dermatoses; Female; | 2015 |
Acute generalized exanthematous pustulosis and toxic epidermal necrolysis induced by hydroxychloroquine.
Topics: Aged; Antirheumatic Agents; Azathioprine; Cyclosporine; Dose-Response Relationship, Drug; Drug Thera | 2009 |
Hydroxychloroquine-associated, photo-induced toxic epidermal necrolysis.
Topics: Adult; Antirheumatic Agents; Diagnosis, Differential; Female; Humans; Hydroxychloroquine; Sjogren's | 2008 |
Fatal toxic epidermal necrolysis associated with hydroxychloroquine.
Topics: Adult; Antirheumatic Agents; Fatal Outcome; Female; Humans; Hydroxychloroquine; Stevens-Johnson Synd | 2001 |
Stevens-Johnson syndrome in association with hydroxychloroquine treatment for rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Stevens-Johns | 2002 |