hydroxychloroquine has been researched along with Sensitivity and Specificity in 23 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the sensitivity and specificity of microperimetry as a screening test to detecting hydroxychloroquine retinopathy." | 3.91 | MICROPERIMETRY AS A SCREENING TEST FOR HYDROXYCHLOROQUINE RETINOPATHY: The Hard-Risk-1 Study. ( Iftikhar, M; Kaur, R; Kherani, S; Nefalar, A; Petri, M; Rashid, I; Scholl, HPN; Schönbach, E; Shah, SM; Usmani, B, 2019) |
| "Optical coherence tomography retinal thickness and 10-2 VFMD are objective measures demonstrating clinically useful sensitivity and specificity for the detection of hydroxychloroquine toxicity as identified by mfERG, and thus may be suitable surrogate tests." | 3.81 | Subjective and objective screening tests for hydroxychloroquine toxicity. ( Cukras, C; Ferris, FL; Huynh, N; Sieving, PA; Vitale, S; Wong, WT, 2015) |
| "Ocular manifestations in systemic lupus erythematosus (SLE) can be the presenting symptom of the disease or a sight-threatening complication." | 1.62 | Structural Retinal Assessment Using Optical Coherence Tomography and Fundus Fluorescein Angiography in Systemic Lupus Erythematosus Patients. ( El-Gendy, H; Esmat Mahmoud Ali, SM; Essam, M; Fouad, SA; Mahfouz, S; Rezk Alnaggar, ARL, 2021) |
| "The kinetics of IgG antibodies after coronavirus disease 2019 (COVID-19) remain poorly understood." | 1.62 | Determinants of IgG antibodies kinetics after severe and critical COVID-19. ( Aboubakar, F; Belkhir, L; De Greef, J; Gerard, L; Pilette, C; Pothen, L; Scohy, A; Yildiz, H; Yombi, JC; Zech, F, 2021) |
| " In at least one patient, the technique was able to detect the early onset of Plaquenil toxicity followed by reversal of the toxic effects after the medication was discontinued." | 1.35 | Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review : Review of mfERG ring ratios in Plaquenil toxicity. ( Lyons, JS; Severns, ML, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 8 (34.78) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, SJ | 2 |
| Joung, J | 1 |
| Lee, BR | 2 |
| Fouad, SA | 1 |
| Esmat Mahmoud Ali, SM | 1 |
| Rezk Alnaggar, ARL | 1 |
| Mahfouz, S | 1 |
| Essam, M | 1 |
| El-Gendy, H | 1 |
| Luo, X | 1 |
| Peng, Y | 1 |
| Ge, W | 1 |
| Rubin, EJ | 1 |
| Baden, LR | 1 |
| Morrissey, S | 1 |
| Emami, J | 1 |
| Kazemi, M | 1 |
| Salehi, A | 1 |
| Fayed, A | 1 |
| El Menyawi, MM | 1 |
| Ghanema, M | 1 |
| Shaker, O | 1 |
| Elgohary, R | 1 |
| Shyr, D | 1 |
| Shyr, Y | 1 |
| De Greef, J | 1 |
| Scohy, A | 1 |
| Zech, F | 1 |
| Aboubakar, F | 1 |
| Pilette, C | 1 |
| Gerard, L | 1 |
| Pothen, L | 1 |
| Yildiz, H | 1 |
| Belkhir, L | 1 |
| Yombi, JC | 1 |
| Allahdina, AM | 1 |
| Stetson, PF | 1 |
| Vitale, S | 2 |
| Wong, WT | 2 |
| Chew, EY | 1 |
| Ferris, FL | 2 |
| Sieving, PA | 2 |
| Cukras, C | 2 |
| Lee, SU | 1 |
| Lee, SH | 1 |
| Iftikhar, M | 1 |
| Kaur, R | 1 |
| Nefalar, A | 1 |
| Usmani, B | 1 |
| Kherani, S | 1 |
| Rashid, I | 1 |
| Schönbach, E | 1 |
| Petri, M | 1 |
| Scholl, HPN | 1 |
| Shah, SM | 1 |
| Füzéry, AK | 1 |
| Breaud, AR | 1 |
| Emezienna, N | 1 |
| Schools, S | 1 |
| Clarke, WA | 1 |
| Marmor, MF | 2 |
| Melles, RB | 1 |
| Graves, GS | 1 |
| Adam, MK | 1 |
| Stepien, KE | 1 |
| Han, DP | 1 |
| Huynh, N | 1 |
| Johnston, JL | 1 |
| Darvill, P | 1 |
| Thomson, GT | 1 |
| Tsang, AC | 1 |
| Ahmadi Pirshahid, S | 1 |
| Virgili, G | 1 |
| Gottlieb, CC | 1 |
| Hamilton, J | 1 |
| Coupland, SG | 1 |
| McClellan, AJ | 1 |
| Chang, JS | 1 |
| Smiddy, WE | 1 |
| Tzekov, RT | 1 |
| Serrato, A | 1 |
| Lyons, JS | 1 |
| Severns, ML | 1 |
| Prashker, MJ | 1 |
| Meenan, RF | 1 |
| Croes, K | 1 |
| McCarthy, PT | 1 |
| Flanagan, RJ | 1 |
| van der Heijde, DM | 1 |
| van Riel, PL | 1 |
| van de Putte, LB | 1 |
1 review available for hydroxychloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Hydroxychloroquine and chloroquine retinopathy: a systematic review evaluating the multifocal electroretinogram as a screening test.
Topics: Antirheumatic Agents; Chloroquine; Electroretinography; Fluorescein Angiography; Humans; Hydroxychlo | 2015 |
1 trial available for hydroxychloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Sensitivity of a Dutch Health Assessment Questionnaire in a trial comparing hydroxychloroquine vs. sulphasalazine.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Health Surveys; Humans; Hydroxychlo | 1990 |
21 other studies available for hydroxychloroquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Evaluation of Hydroxychloroquine Retinopathy Using Ultra-Widefield Fundus Autofluorescence: Peripheral Findings in the Retinopathy.
Topics: Adult; Aged; Antirheumatic Agents; Asian People; Female; Fluorescein Angiography; Humans; Hydroxychl | 2020 |
Structural Retinal Assessment Using Optical Coherence Tomography and Fundus Fluorescein Angiography in Systemic Lupus Erythematosus Patients.
Topics: Adult; Antirheumatic Agents; Correlation of Data; Early Diagnosis; Female; Fluorescein Angiography; | 2021 |
A Sensitive and Optimized HPLC-FLD Method for the Simultaneous Quantification of Hydroxychloroquine and Its Two Metabolites in Blood of Systemic Lupus Erythematosus Patients.
Topics: Adult; Chloroquine; Chromatography, High Pressure Liquid; Female; Humans; Hydroxychloroquine; Linear | 2020 |
Audio Interview: Diagnosis and Early Treatment of Covid-19.
Topics: Betacoronavirus; Chemoprevention; Clinical Studies as Topic; Coronavirus Infections; COVID-19; Healt | 2020 |
In Vitro and In Vivo Evaluation of Two Hydroxychloroquine Tablet Formulations: HPLC Assay Development.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Humans; Hydroxychloroquine; Linea | 2021 |
Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Biomarkers; Case-Control Studies; Complement | 2020 |
The design and analysis of non-randomized studies: a case study of off-label use of hydroxychloroquine in the COVID-19 pandemic.
Topics: Clinical Trials as Topic; COVID-19 Drug Treatment; Data Interpretation, Statistical; Humans; Hydroxy | 2021 |
Determinants of IgG antibodies kinetics after severe and critical COVID-19.
Topics: Adrenal Cortex Hormones; Aged; Antibodies, Viral; Body Mass Index; Convalescence; COVID-19; COVID-19 | 2021 |
Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity.
Topics: Adult; Aged; Antirheumatic Agents; Case-Control Studies; Electroretinography; Female; Humans; Hydrox | 2018 |
Evaluation of Retromode Imaging for Use in Hydroxychloroquine Retinopathy.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Case-Control Studies; Female; Humans; Hydro | 2018 |
MICROPERIMETRY AS A SCREENING TEST FOR HYDROXYCHLOROQUINE RETINOPATHY: The Hard-Risk-1 Study.
Topics: Adult; Aged; Antirheumatic Agents; Enzyme Inhibitors; Female; Fluorescein Angiography; Humans; Hydro | 2019 |
A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry.
Topics: Chemical Precipitation; Chromatography, Liquid; Humans; Hydroxychloroquine; Lupus Erythematosus, Sys | 2013 |
Disparity between visual fields and optical coherence tomography in hydroxychloroquine retinopathy.
Topics: Aged; Antirheumatic Agents; Electroretinography; Female; Fluorescein Angiography; Humans; Hydroxychl | 2014 |
Validation of the colour difference plot scoring system analysis of the 103 hexagon multifocal electroretinogram in the evaluation of hydroxychloroquine retinal toxicity.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Electroretinography; False Pos | 2014 |
Subjective and objective screening tests for hydroxychloroquine toxicity.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Diagnostic Technique | 2015 |
Spectral-domain optical coherence tomography in hydroxychloroquine retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Humans; Hydroxychloroquine; Middle Aged; Retin | 2015 |
AIMING FOR THE BULL'S EYE: The Cost-Utility of Screening for Hydroxychloroquine Retinopathy.
Topics: Academies and Institutes; Antimalarials; Antirheumatic Agents; Cost-Benefit Analysis; Diagnostic Tec | 2016 |
ERG findings in patients using hydroxychloroquine.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Electroretinography; Female; Humans; Hydroxychloroqui | 2004 |
Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review : Review of mfERG ring ratios in Plaquenil toxicity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Autoimmune Diseases; Child; Dose-R | 2009 |
The total costs of drug therapy for rheumatoid arthritis. A model based on costs of drug, monitoring, and toxicity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Boston; Decision Trees; Diagnosis-Related | 1995 |
Simple and rapid HPLC of quinine, hydroxychloroquine, chloroquine, and desethylchloroquine in serum, whole blood, and filter paper-adsorbed dry blood.
Topics: Adsorption; Chloroquine; Chromatography, High Pressure Liquid; Humans; Hydroxychloroquine; Quinine; | 1994 |