hydroxychloroquine has been researched along with Scleroderma, Localized in 19 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multifocal ERG with 103-hexagon stimulation was performed on 19 patients (36 eyes) treated with hydroxychloroquine for systemic lupus erythematosus, rheumatoid arthritis, or localized atypical scleroderma." | 3.72 | Multifocal electroretinographic evaluation of long-term hydroxychloroquine users. ( Maturi, RK; Weleber, RG; Yu, M, 2004) |
| "Disabling pansclerotic morphea of childhood (DPMC) is a rare subtype of juvenile localized scleroderma (JLS) characterized by pansclerosis mainly affecting children under the age of 14." | 2.61 | Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review. ( Cox, A; Heaton, V; Munro, J; Renton, WD; Samuel, C; Soh, HJ, 2019) |
| "Solitary morphea profunda (SMP) is a variant of localized scleroderma (LS)." | 2.52 | Solitary morphea profunda following trauma sustained in an automobile accident. ( Glick, BP; Touloei, K; Wiener, A, 2015) |
| "Nodular scleroderma or keloidal morphea presenting in a linear distribution is even more uncommon." | 1.72 | Questions raised by a case of adult-onset linear nodular scleroderma. ( Hansen, CB; Jimenez, A; Marcelus, C; Sontheimer, RD; Zussman, J, 2022) |
| "First-line systemic therapy for morphea includes methotrexate with or without systemic corticosteroids." | 1.56 | Evaluation of the Effectiveness and Tolerability of Mycophenolate Mofetil and Mycophenolic Acid for the Treatment of Morphea. ( Arthur, M; Cardones, AR; Femia, A; Fernandez, AP; Fett, NM; Florez-Pollack, S; Gaffney, R; Houser, J; Jacobe, H; Knabel, D; Kunzler, E; Latour, E; Laumann, A; Leung, N; Lo, K; Pappas-Taffer, LK; Prasad, S; Sharma, S; Stern, MJ; Tkachenko, E; Vleugels, RA; Yu, JM; Zhao, J, 2020) |
| "Hydroxychloroquine is a valuable treatment for morphea because of its high response rate and low rate of adverse effects; however, prospective studies are needed to determine its true efficacy." | 1.51 | Treatment of morphea with hydroxychloroquine: A retrospective review of 84 patients at Mayo Clinic, 1996-2013. ( Blixt, EK; Drage, LA; El-Azhary, RA; Kumar, AB; Wetter, DA, 2019) |
| " Here we report a rare case of MP, which is the first report about treatment by hydroxychloroquine in combination with superficial X-ray." | 1.51 | Hydroxychloroquine combined with superficial X-ray-A new therapeutic method in the treatment of morphea profunda. ( Chen, Y; Li, C; Wang, W; Zhang, J, 2019) |
| "Overlap syndromes are known to occur with connective-tissue diseases (CTDs)." | 1.43 | Lupus erythematosus and localized scleroderma coexistent at the same sites: a rare presentation of overlap syndrome of connective-tissue diseases. ( Fazel, N; Lynch, PJ; Pascucci, A, 2016) |
| "The 2 patients (of the 14 patients with lupus erythematosus panniculitis seen by us since 1990) were females with a young age at the onset of disease (median, 25 years)." | 1.33 | Sclerodermic linear lupus panniculitis: report of two cases. ( Alessi, E; Caputo, R; Marzano, AV; Tanzi, C, 2005) |
| "17 children suffering from morphea were treated with penicillin and antimalaria drugs." | 1.27 | [Treatment of circumscribed scleroderma in childhood]. ( Ladányi, E; Nagy, E, 1987) |
| "Two plaques of typical morphea on the penis were noticed 10 months later." | 1.27 | Bullous morphea profunda. ( Greene, SL; Su, WP, 1986) |
| "The skin lesions varied from morphea, lichen sclerosus, fasciitis, and discoid lupus erythematosus to lupus panniculitis." | 1.26 | Carpal tunnel syndrome in cutaneous connective tissue disease: generalized morphea, lichen sclerosus, fasciitis, discoid lupus erythematosus, and lupus panniculitis. ( Connolly, SM; Doyle, JA; Winkelmann, RK, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Marcelus, C | 1 |
| Jimenez, A | 1 |
| Zussman, J | 1 |
| Hansen, CB | 1 |
| Sontheimer, RD | 1 |
| Otman, E | 1 |
| Gucenmez, S | 1 |
| Solmaz, D | 1 |
| Akar, S | 1 |
| Ozmen, M | 1 |
| Arthur, M | 1 |
| Fett, NM | 1 |
| Latour, E | 1 |
| Jacobe, H | 1 |
| Kunzler, E | 1 |
| Florez-Pollack, S | 1 |
| Houser, J | 1 |
| Sharma, S | 1 |
| Prasad, S | 1 |
| Femia, A | 1 |
| Stern, MJ | 1 |
| Pappas-Taffer, LK | 1 |
| Gaffney, R | 1 |
| Fernandez, AP | 1 |
| Knabel, D | 1 |
| Cardones, AR | 1 |
| Leung, N | 1 |
| Laumann, A | 1 |
| Yu, JM | 1 |
| Zhao, J | 1 |
| Vleugels, RA | 1 |
| Tkachenko, E | 1 |
| Lo, K | 1 |
| Kumar, AB | 1 |
| Blixt, EK | 1 |
| Drage, LA | 1 |
| El-Azhary, RA | 1 |
| Wetter, DA | 1 |
| Soh, HJ | 1 |
| Samuel, C | 1 |
| Heaton, V | 1 |
| Renton, WD | 1 |
| Cox, A | 1 |
| Munro, J | 1 |
| Li, C | 1 |
| Zhang, J | 1 |
| Wang, W | 1 |
| Chen, Y | 1 |
| Khayat, R | 1 |
| Dupuy, A | 1 |
| Pansé, I | 1 |
| Bagot, M | 1 |
| Cordoliani, F | 1 |
| Touloei, K | 1 |
| Wiener, A | 1 |
| Glick, BP | 1 |
| Pascucci, A | 1 |
| Lynch, PJ | 1 |
| Fazel, N | 1 |
| Lebeaux, D | 1 |
| Francès, C | 1 |
| Barete, S | 1 |
| Wechsler, B | 1 |
| Dubourg, O | 1 |
| Renoux, J | 1 |
| Maisonobe, T | 1 |
| Benveniste, O | 1 |
| Gatfossé, M | 1 |
| Bourgeois, P | 1 |
| Amoura, Z | 1 |
| Cacoub, P | 1 |
| Piette, JC | 1 |
| Sène, D | 1 |
| Choonhakarn, C | 1 |
| Chaowattanapanit, S | 1 |
| Maturi, RK | 1 |
| Yu, M | 1 |
| Weleber, RG | 1 |
| Marzano, AV | 1 |
| Tanzi, C | 1 |
| Caputo, R | 1 |
| Alessi, E | 1 |
| Mateen, FJ | 1 |
| Keegan, BM | 1 |
| Winkelmann, RK | 2 |
| Connolly, SM | 1 |
| Doyle, JA | 1 |
| Padilha-Goncalves, A | 1 |
| Wuthrich, RC | 1 |
| Roenigk, HH | 1 |
| Steck, WD | 1 |
| Nagy, E | 1 |
| Ladányi, E | 1 |
| Su, WP | 1 |
| Greene, SL | 1 |
2 reviews available for hydroxychloroquine and Scleroderma, Localized
| Article | Year |
|---|---|
Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review.
Topics: Antirheumatic Agents; Biological Products; Biopsy; Child, Preschool; Contracture; Edema; Hematopoiet | 2019 |
Solitary morphea profunda following trauma sustained in an automobile accident.
Topics: Accidents, Traffic; Anti-Inflammatory Agents; Antirheumatic Agents; Arm Injuries; Betamethasone; Cal | 2015 |
17 other studies available for hydroxychloroquine and Scleroderma, Localized
| Article | Year |
|---|---|
Questions raised by a case of adult-onset linear nodular scleroderma.
Topics: Adult; Female; Humans; Hydroxychloroquine; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Sk | 2022 |
Hydroxychloroquine might reduce mortality in patients with systemic sclerosis.
Topics: Humans; Hydroxychloroquine; Patients; Scleroderma, Localized; Scleroderma, Systemic | 2023 |
Evaluation of the Effectiveness and Tolerability of Mycophenolate Mofetil and Mycophenolic Acid for the Treatment of Morphea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort | 2020 |
Treatment of morphea with hydroxychloroquine: A retrospective review of 84 patients at Mayo Clinic, 1996-2013.
Topics: Adolescent; Adult; Aged; Autoantibodies; Autoimmune Diseases; Child; Deglutition Disorders; Drug Eva | 2019 |
Hydroxychloroquine combined with superficial X-ray-A new therapeutic method in the treatment of morphea profunda.
Topics: Adult; Combined Modality Therapy; Humans; Hydroxychloroquine; Male; Scleroderma, Localized; X-Ray Th | 2019 |
[Sclerodermatous changes in porphyria cutanea tarda: six cases].
Topics: Adrenal Cortex Hormones; Aged; Alcoholism; Alopecia; Diagnosis, Differential; Female; Humans; Hydrox | 2013 |
Lupus erythematosus and localized scleroderma coexistent at the same sites: a rare presentation of overlap syndrome of connective-tissue diseases.
Topics: Antibodies, Antinuclear; Antimalarials; Female; Glucocorticoids; Humans; Hydroxychloroquine; Lupus E | 2016 |
Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients.
Topics: Adult; Aged; Antirheumatic Agents; Azathioprine; Colchicine; Drug Therapy, Combination; Eosinophilia | 2012 |
Lipodermatosclerosis: improvement noted with hydroxychloroquine and pentoxifylline.
Topics: Adult; Aged; Antimalarials; Dermatitis; Drug Therapy, Combination; Female; Humans; Hydroxychloroquin | 2012 |
Multifocal electroretinographic evaluation of long-term hydroxychloroquine users.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Color Perception Tests; Dermatologic Agent | 2004 |
Sclerodermic linear lupus panniculitis: report of two cases.
Topics: Adult; Biopsy, Needle; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroqu | 2005 |
Severe, reversible dysphagia from chloroquine and hydroxychloroquine myopathy.
Topics: Aged, 80 and over; Antirheumatic Agents; Chloroquine; Deglutition Disorders; Humans; Hydroxychloroqu | 2007 |
Carpal tunnel syndrome in cutaneous connective tissue disease: generalized morphea, lichen sclerosus, fasciitis, discoid lupus erythematosus, and lupus panniculitis.
Topics: Adult; Carpal Tunnel Syndrome; Fasciitis; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, D | 1982 |
Connective tissue panniculitis.
Topics: Adipose Tissue; Adolescent; Adult; Antigen-Antibody Reactions; Atrophy; Biopsy; Connective Tissue Di | 1980 |
Localized scleroderma.
Topics: Adolescent; Child; Female; Humans; Hydroxychloroquine; Male; Scleroderma, Localized | 1975 |
[Treatment of circumscribed scleroderma in childhood].
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Humans; Hydroxychloroquine; Penicill | 1987 |
Bullous morphea profunda.
Topics: Foot Dermatoses; Humans; Hydroxychloroquine; Male; Middle Aged; Penis; Scleroderma, Localized; Skin | 1986 |