hydroxychloroquine has been researched along with Respiratory Insufficiency in 22 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We treated two patients with severe respiratory failure due to coronavirus disease 2019 (COVID-19)." | 2.66 | High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review : High levels of anti-SSA/Ro antibodies in COVID-19. ( Fujii, H; Hiraoka, N; Horiguchi, M; Matsuyama, A; Omura, A; Ono, S; Shiotsu, S; Suga, Y; Takumi, C; Tanaka, S; Tsuji, T; Yuba, T, 2020) |
| "The girl developed interstitial lung disease." | 2.50 | Neonatal respiratory insufficiency caused by an (homozygous) ABCA3-stop mutation: a systematic evaluation of therapeutic options. ( Aslanidis, C; Bartsch, M; Essmann, S; Griese, M; Kidszun, A; Mildenberger, E; Poplawska, K; Schmitz, G; Winter, J, 2014) |
| "The kinetics of IgG antibodies after coronavirus disease 2019 (COVID-19) remain poorly understood." | 1.62 | Determinants of IgG antibodies kinetics after severe and critical COVID-19. ( Aboubakar, F; Belkhir, L; De Greef, J; Gerard, L; Pilette, C; Pothen, L; Scohy, A; Yildiz, H; Yombi, JC; Zech, F, 2021) |
| "A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks." | 1.56 | Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab. ( Cauda, R; Cingolani, A; Cipriani, MC; Fantoni, M; Gremese, E; Larosa, L; Liperoti, R; Montemurro, G; Murri, R; Pasciuto, G; Pirronti, T; Tummolo, AM, 2020) |
| "The evolving pandemic of Coronavirus Disease 2019 has posed a substantial health risk worldwide." | 1.56 | A Patient with Cryoglobulinemic Membranoproliferative GN (MPGN) Who Survived COVID-19 Disease: Case Presentation and Current Data of COVID-19 Infection in Dialysis and Transplanted Patients in Greece. ( Argyraki, A; Boletis, I; Grigorakos, K; Lourida, P; Marinaki, S; Skalioti, C; Tsiakas, S, 2020) |
| "Hydroxychloroquine was prescribed as an antiviral in 90% of cases, both as monotherapy (11." | 1.56 | Inpatient Care during the COVID-19 Pandemic: A Survey of Italian Physicians. ( Attanasi, M; Caronni, A; Centanni, S; Chiarelli, F; Cimino, MM; Cipolla, G; Di Pillo, S; Faverio, P; Pasini, S; Pellegrino, GM; Sferrazza Papa, GF, 2020) |
| "Methemoglobinemia is a rare disorder of the blood in which there is an increase in methemoglobin, which occurs when hemoglobin is present in the oxidized form." | 1.56 | Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report. ( Bloom, A; Faisal, H; Gaber, AO, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 16 (72.73) | 2.80 |
| Authors | Studies |
|---|---|
| Vicenzi, M | 1 |
| Di Cosola, R | 1 |
| Ruscica, M | 1 |
| Ratti, A | 1 |
| Rota, I | 1 |
| Rota, F | 1 |
| Bollati, V | 1 |
| Aliberti, S | 1 |
| Blasi, F | 1 |
| Azmy, V | 1 |
| Benson, J | 1 |
| Love, K | 1 |
| Steele, R | 1 |
| Allison, D | 1 |
| Campbell-Lee, S | 1 |
| Crane, J | 1 |
| Vidanovic, V | 1 |
| Webb, S | 1 |
| Fraidenburg, D | 1 |
| Hussain, F | 1 |
| Cingolani, A | 1 |
| Tummolo, AM | 1 |
| Montemurro, G | 1 |
| Gremese, E | 1 |
| Larosa, L | 1 |
| Cipriani, MC | 1 |
| Pasciuto, G | 1 |
| Liperoti, R | 1 |
| Murri, R | 1 |
| Pirronti, T | 1 |
| Cauda, R | 1 |
| Fantoni, M | 1 |
| Marinaki, S | 1 |
| Tsiakas, S | 1 |
| Skalioti, C | 1 |
| Lourida, P | 1 |
| Argyraki, A | 1 |
| Grigorakos, K | 1 |
| Boletis, I | 1 |
| Choi, NH | 1 |
| Silver, ES | 1 |
| Fremed, M | 1 |
| Liberman, L | 1 |
| Attanasi, M | 1 |
| Pasini, S | 1 |
| Caronni, A | 1 |
| Pellegrino, GM | 1 |
| Faverio, P | 1 |
| Di Pillo, S | 1 |
| Cimino, MM | 1 |
| Cipolla, G | 1 |
| Chiarelli, F | 1 |
| Centanni, S | 1 |
| Sferrazza Papa, GF | 1 |
| Fujii, H | 1 |
| Tsuji, T | 1 |
| Yuba, T | 1 |
| Tanaka, S | 1 |
| Suga, Y | 1 |
| Matsuyama, A | 1 |
| Omura, A | 1 |
| Shiotsu, S | 1 |
| Takumi, C | 1 |
| Ono, S | 1 |
| Horiguchi, M | 1 |
| Hiraoka, N | 1 |
| Patel, M | 1 |
| Gangemi, A | 1 |
| Marron, R | 1 |
| Chowdhury, J | 1 |
| Yousef, I | 1 |
| Zheng, M | 1 |
| Mills, N | 1 |
| Tragesser, L | 1 |
| Giurintano, J | 1 |
| Gupta, R | 1 |
| Gordon, M | 1 |
| Rali, P | 1 |
| D'Alonso, G | 1 |
| Fleece, D | 1 |
| Zhao, H | 1 |
| Patlakh, N | 1 |
| Criner, G | 1 |
| Iwasaka, S | 1 |
| Shono, Y | 1 |
| Tokuda, K | 1 |
| Nakashima, K | 1 |
| Yamamoto, Y | 1 |
| Maki, J | 1 |
| Nagasaki, Y | 1 |
| Shimono, N | 1 |
| Akahoshi, T | 1 |
| Taguchi, T | 1 |
| Faisal, H | 1 |
| Bloom, A | 1 |
| Gaber, AO | 1 |
| Quintana-Ortega, C | 1 |
| Remesal, A | 1 |
| Ruiz de Valbuena, M | 1 |
| de la Serna, O | 1 |
| Laplaza-González, M | 1 |
| Álvarez-Rojas, E | 1 |
| Udaondo, C | 1 |
| Alcobendas, R | 1 |
| Murias, S | 1 |
| Brusasco, C | 1 |
| Corradi, F | 1 |
| Di Domenico, A | 1 |
| Raggi, F | 1 |
| Timossi, G | 1 |
| Santori, G | 1 |
| Brusasco, V | 1 |
| De Greef, J | 1 |
| Scohy, A | 1 |
| Zech, F | 1 |
| Aboubakar, F | 1 |
| Pilette, C | 1 |
| Gerard, L | 1 |
| Pothen, L | 1 |
| Yildiz, H | 1 |
| Belkhir, L | 1 |
| Yombi, JC | 1 |
| Manganotti, P | 1 |
| Bellavita, G | 1 |
| Tommasini, V | 1 |
| D Acunto, L | 1 |
| Fabris, M | 1 |
| Cecotti, L | 1 |
| Furlanis, G | 1 |
| Sartori, A | 1 |
| Bonzi, L | 1 |
| Buoite Stella, A | 1 |
| Pesavento, V | 1 |
| Barratt-Due, A | 1 |
| Olsen, IC | 1 |
| Nezvalova-Henriksen, K | 1 |
| Kåsine, T | 1 |
| Lund-Johansen, F | 1 |
| Hoel, H | 1 |
| Holten, AR | 1 |
| Tveita, A | 1 |
| Mathiessen, A | 1 |
| Haugli, M | 1 |
| Eiken, R | 1 |
| Kildal, AB | 1 |
| Berg, Å | 1 |
| Johannessen, A | 1 |
| Heggelund, L | 1 |
| Dahl, TB | 1 |
| Skåra, KH | 1 |
| Mielnik, P | 1 |
| Le, LAK | 1 |
| Thoresen, L | 1 |
| Ernst, G | 1 |
| Hoff, DAL | 1 |
| Skudal, H | 1 |
| Kittang, BR | 1 |
| Olsen, RB | 1 |
| Tholin, B | 1 |
| Ystrøm, CM | 1 |
| Skei, NV | 1 |
| Tran, T | 1 |
| Dudman, S | 1 |
| Andersen, JT | 1 |
| Hannula, R | 1 |
| Dalgard, O | 1 |
| Finbråten, AK | 1 |
| Tonby, K | 1 |
| Blomberg, B | 1 |
| Aballi, S | 1 |
| Fladeby, C | 1 |
| Steffensen, A | 1 |
| Müller, F | 1 |
| Dyrhol-Riise, AM | 1 |
| Trøseid, M | 1 |
| Aukrust, P | 1 |
| Hepping, N | 1 |
| Griese, M | 2 |
| Lohse, P | 1 |
| Garbe, W | 1 |
| Lange, L | 1 |
| Winter, J | 1 |
| Essmann, S | 1 |
| Kidszun, A | 1 |
| Aslanidis, C | 1 |
| Poplawska, K | 1 |
| Bartsch, M | 1 |
| Schmitz, G | 1 |
| Mildenberger, E | 1 |
| Stevens, MA | 1 |
| Yeaney, GA | 1 |
| Lacomis, D | 1 |
| Rabach, I | 1 |
| Poli, F | 1 |
| Zennaro, F | 1 |
| Germani, C | 1 |
| Ventura, A | 1 |
| Barbi, E | 1 |
| Siddiqui, AK | 1 |
| Huberfeld, SI | 1 |
| Weidenheim, KM | 1 |
| Einberg, KR | 1 |
| Efferen, LS | 1 |
| Seguin, P | 1 |
| Camus, C | 1 |
| Leroy, JP | 1 |
| Le Tulzo, Y | 1 |
| Jouannic, I | 1 |
| Thomas, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The (Norwegian) NOR Solidarity Multicenter Trial on the Efficacy of Different Anti-viral Drugs in SARS-CoV-2 Infected Patients[NCT04321616] | Phase 2/Phase 3 | 700 participants (Anticipated) | Interventional | 2020-03-28 | Recruiting | ||
| Hydroxychloroquine in Pediatric ILD With Genetic Surfactant Dysfunction Disorders: Cross-control, Prospective Study[NCT03822780] | 25 participants (Anticipated) | Interventional | 2017-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hydroxychloroquine and Respiratory Insufficiency
| Article | Year |
|---|---|
High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review : High levels of anti-SSA/Ro antibodies in COVID-19.
Topics: Aged; Amides; Antibodies, Antinuclear; Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus | 2020 |
Neonatal respiratory insufficiency caused by an (homozygous) ABCA3-stop mutation: a systematic evaluation of therapeutic options.
Topics: Adrenal Cortex Hormones; ATP-Binding Cassette Transporters; Chromosome Aberrations; Codon, Terminato | 2014 |
1 trial available for hydroxychloroquine and Respiratory Insufficiency
| Article | Year |
|---|---|
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Viral; Antiviral Agents; Biomarkers; Cause of Death; C | 2021 |
19 other studies available for hydroxychloroquine and Respiratory Insufficiency
| Article | Year |
|---|---|
The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients.
Topics: Aged; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Disease Progressio | 2020 |
Idiopathic nonhistaminergic acquired angioedema in a patient with coronavirus disease 2019.
Topics: Adenosine Monophosphate; Adult; Alanine; Ampicillin; Angioedema; Betacoronavirus; Coronavirus Infect | 2020 |
Red blood cell exchange to avoid intubating a COVID-19 positive patient with sickle cell disease?
Topics: Acute Chest Syndrome; Adult; Analgesics; Anemia, Sickle Cell; Antiviral Agents; Azithromycin; Betaco | 2020 |
Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.
Topics: Acute Disease; Aged; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azetidines; Azithromycin; | 2020 |
A Patient with Cryoglobulinemic Membranoproliferative GN (MPGN) Who Survived COVID-19 Disease: Case Presentation and Current Data of COVID-19 Infection in Dialysis and Transplanted Patients in Greece.
Topics: Anti-Bacterial Agents; Azithromycin; Betacoronavirus; Ceftriaxone; Coronavirus Infections; COVID-19; | 2020 |
COVID-19 reveals Brugada pattern in an adolescent patient.
Topics: Antiviral Agents; Brugada Syndrome; C-Reactive Protein; Chest Pain; Consanguinity; Cough; COVID-19; | 2020 |
Inpatient Care during the COVID-19 Pandemic: A Survey of Italian Physicians.
Topics: Adult; Aged; Anti-Bacterial Agents; Anticoagulants; Antiviral Agents; Azithromycin; Betacoronavirus; | 2020 |
Retrospective analysis of high flow nasal therapy in COVID-19-related moderate-to-severe hypoxaemic respiratory failure.
Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antirheumat | 2020 |
Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Benzamidines; Betacoronavirus; Coro | 2020 |
Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report.
Topics: Acute Kidney Injury; Aged; Antibodies, Monoclonal, Humanized; Antioxidants; Ascorbic Acid; Betacoron | 2020 |
Fatal outcome of anti-MDA5 juvenile dermatomyositis in a paediatric COVID-19 patient: a case report.
Topics: Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antivira | 2021 |
Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure.
Topics: Adult; Aged; Aged, 80 and over; Air Filters; Algorithms; Antibodies, Monoclonal, Humanized; Antirheu | 2021 |
Determinants of IgG antibodies kinetics after severe and critical COVID-19.
Topics: Adrenal Cortex Hormones; Aged; Antibodies, Viral; Body Mass Index; Convalescence; COVID-19; COVID-19 | 2021 |
Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathy patients.
Topics: Action Potentials; Acute Disease; Aged; Anti-Bacterial Agents; Biomarkers; Convalescence; COVID-19; | 2021 |
Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p.Cys121Gly mutation with hydroxychloroquine.
Topics: Amino Acid Substitution; Cesarean Section; Cysteine; DNA Mutational Analysis; Exons; Female; Follow- | 2013 |
42-year-old man with discoid lupus and progressive weakness.
Topics: Adult; Antirheumatic Agents; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Male; Micros | 2009 |
Is treatment with hydroxychloroquine effective in surfactant protein C deficiency?
Topics: Disease Progression; Diseases in Twins; Dyspnea; Failure to Thrive; Humans; Hydroxychloroquine; Infa | 2013 |
Hydroxychloroquine-induced toxic myopathy causing respiratory failure.
Topics: Aged, 80 and over; Antirheumatic Agents; Fatal Outcome; Female; Humans; Hydroxychloroquine; Muscular | 2007 |
Respiratory failure associated with hydroxychloroquine neuromyopathy.
Topics: Female; Humans; Hydroxychloroquine; Middle Aged; Neuromuscular Diseases; Respiratory Insufficiency | 1995 |