hydroxychloroquine has been researched along with Niemann-Pick Disease, Type C in 2 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ballout, RA | 1 |
| Sviridov, D | 1 |
| Bukrinsky, MI | 1 |
| Remaley, AT | 1 |
| Sturley, SL | 1 |
| Rajakumar, T | 1 |
| Hammond, N | 1 |
| Higaki, K | 1 |
| Márka, Z | 1 |
| Márka, S | 1 |
| Munkacsi, AB | 1 |
1 review available for hydroxychloroquine and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity.
Topics: Androstenes; Angiotensin-Converting Enzyme 2; Anticholesteremic Agents; Antiviral Agents; Betacorona | 2020 |
1 other study available for hydroxychloroquine and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications.
Topics: ADAM17 Protein; Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antiviral Agents; | 2020 |