hydroxychloroquine has been researched along with Neuroblastoma in 2 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroblastoma is the most common tumour in children under 1 year old, accounting for 12-15% of childhood cancer deaths." | 5.91 | Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma. ( Balachandar, A; Bhagirath, E; Pandey, S; Vegh, C; Wear, D, 2023) |
| "Five neuroblastoma cell lines were tested for the cytotoxic activity of GX 15-070 alone or in combination with cisplatin, doxorubicin, HCQ or Z-VAD-FMK a broad-spectrum caspase inhibitor." | 3.91 | GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma. ( Addioui, A; Beaunoyer, M; Belounis, A; Cournoyer, S; Haddad, E; Le Gall, R; Nyalendo, C; Sartelet, H; Teira, P; Vassal, G, 2019) |
| "Neuroblastoma is the most common tumour in children under 1 year old, accounting for 12-15% of childhood cancer deaths." | 1.91 | Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma. ( Balachandar, A; Bhagirath, E; Pandey, S; Vegh, C; Wear, D, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wear, D | 1 |
| Bhagirath, E | 1 |
| Balachandar, A | 1 |
| Vegh, C | 1 |
| Pandey, S | 1 |
| Cournoyer, S | 1 |
| Addioui, A | 1 |
| Belounis, A | 1 |
| Beaunoyer, M | 1 |
| Nyalendo, C | 1 |
| Le Gall, R | 1 |
| Teira, P | 1 |
| Haddad, E | 1 |
| Vassal, G | 1 |
| Sartelet, H | 1 |
2 other studies available for hydroxychloroquine and Neuroblastoma
| Article | Year |
|---|---|
Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Child; Cisplatin; Gl | 2023 |
GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cel | 2019 |