hydroxychloroquine has been researched along with Muscle Disorders in 27 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 59-year-old man with a history of ischemic-labeled heart disease revealed by conduction disorders and cutaneous lupus treated initially with hydroxychloroquine followed by chloroquine consulted for asthenia and weight loss." | 3.96 | [A rare cause of impaired general condition: Muscular and cardiac toxicity of antimalarials]. ( Costedoat-Chalumeau, N; Dion, J; Lenfant, T; Maisonobe, T, 2020) |
| "Hydroxychloroquine is being used for COVID-19 symptoms and in clinical trials, but can cause a toxic myopathy that leads to muscle weakness." | 3.96 | Challenges in diagnosing hydroxychloroquine myopathy during the COVID-19 pandemic. ( Chan, RC; Pamphlett, R; Wang, MX, 2020) |
| "Hydroxychloroquine is an immunomodulatory drug that has been used for 60 years to treat malaria and autoimmune diseases such as systemic lupus erythematosus and inflammatory arthritis, and potential new uses and benefits continue to emerge." | 2.58 | Hydroxychloroquine: An old drug with new relevance. ( Collamer, AN; Shippey, EA; Wagler, VD, 2018) |
| "Her quadriparesis was found to be secondary to biopsy-proven hydroxychloroquine-induced myopathy with concomitant inflammatory myopathy." | 2.55 | Antimalarial myopathy in a systemic lupus erythematosus patient with quadriparesis and seizures: a case-based review. ( Bucknor, MD; Chaganti, RK; Jafri, K; Nolan, AL; Patterson, S; Wysham, KD; Zahed, H, 2017) |
| " The most frequently observed serious side effect is retinal toxicity; however, case reports have described HCQ induced neuromyotoxicity." | 2.41 | Hydroxychloroquine neuromyotoxicity. ( Ang, LC; Bell, MJ; Stein, M, 2000) |
| "Pyridostigmine improved weakness in the centronuclear myopathy patient, but not in the distal myopathy patient." | 1.51 | Neuromuscular transmission defects in myopathies: Rare but worth searching for. ( Elahi, B; Laughlin, RS; Liewluck, T; Litchy, WJ; Milone, M, 2019) |
| "Systemic lupus erythematosus was diagnosed in a 34-year-old pregnant woman because of leukopenia, typical skin rash, clinical and biochemical signs of muscle involvement, and positive serology (antinuclear antibodies and anti-double-stranded DNA)." | 1.39 | Myopathy complicating lupus pregnancy. ( d'Amati, G; Framarino-dei-Malatesta, M; Gattamelata, A; Giordano, C; Piccioni, MG; Priori, R; Valesini, G, 2013) |
| "Prednisone was used at a starting dose from about 0." | 1.33 | Muscle involvement in sarcoidosis: a retrospective and followup studies. ( Bardin, T; Berenbaum, F; Fayad, F; Lioté, F; Orcel, P, 2006) |
| "Chloroquine is a neuromyotoxin that affects nerves and cardiac and skeletal muscles." | 1.27 | Chloroquine neuromyotoxicity. Clinical and pathologic perspective. ( Chou, SM; Estes, ML; Ewing-Wilson, D; Hanson, M; Mitsumoto, H; Ratliff, NB; Shirey, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
| Authors | Studies |
|---|---|
| Guidon, AC | 1 |
| Amato, AA | 1 |
| Lenfant, T | 1 |
| Dion, J | 1 |
| Maisonobe, T | 1 |
| Costedoat-Chalumeau, N | 1 |
| Wille, F | 1 |
| Birkmeier, S | 1 |
| Tiemann, K | 1 |
| Lewalter, T | 1 |
| Klingel, K | 1 |
| Rabe, C | 1 |
| Sick, P | 1 |
| Pamphlett, R | 1 |
| Wang, MX | 1 |
| Chan, RC | 1 |
| Shippey, EA | 1 |
| Wagler, VD | 1 |
| Collamer, AN | 1 |
| Khosa, S | 1 |
| Khanlou, N | 1 |
| Khosa, GS | 1 |
| Mishra, SK | 1 |
| Elahi, B | 1 |
| Laughlin, RS | 1 |
| Litchy, WJ | 1 |
| Milone, M | 1 |
| Liewluck, T | 1 |
| Shukla, S | 1 |
| Gultekin, SH | 1 |
| Saporta, M | 1 |
| Priori, R | 1 |
| Gattamelata, A | 1 |
| d'Amati, G | 1 |
| Giordano, C | 1 |
| Piccioni, MG | 1 |
| Valesini, G | 1 |
| Framarino-dei-Malatesta, M | 1 |
| Ghosh, PS | 1 |
| Swift, D | 1 |
| Engel, AG | 1 |
| Vinciguerra, C | 1 |
| Sicurelli, F | 1 |
| Fioravanti, A | 1 |
| Malandrini, A | 1 |
| Battisti, C | 1 |
| Federico, A | 1 |
| Jafri, K | 1 |
| Zahed, H | 1 |
| Wysham, KD | 1 |
| Patterson, S | 1 |
| Nolan, AL | 1 |
| Bucknor, MD | 1 |
| Chaganti, RK | 1 |
| Abdel-Hamid, H | 1 |
| Oddis, CV | 1 |
| Lacomis, D | 2 |
| Stevens, MA | 1 |
| Yeaney, GA | 1 |
| Lonesky, TA | 1 |
| Kreuter, JD | 1 |
| Wortmann, RL | 1 |
| Rhodes, CH | 1 |
| Kwon, JB | 1 |
| Kleiner, A | 1 |
| Ishida, K | 1 |
| Godown, J | 1 |
| Ciafaloni, E | 1 |
| Looney, RJ | 1 |
| Foulke, G | 1 |
| Baccon, J | 1 |
| Marks, JG | 1 |
| Clarke, JT | 1 |
| SULLI, G | 1 |
| VARRONE, F | 1 |
| Casado, E | 1 |
| Gratacós, J | 1 |
| Tolosa, C | 1 |
| Martínez, JM | 1 |
| Ojanguren, I | 1 |
| Ariza, A | 1 |
| Real, J | 1 |
| Sanjuán, A | 1 |
| Larrosa, M | 1 |
| Fayad, F | 1 |
| Lioté, F | 1 |
| Berenbaum, F | 1 |
| Orcel, P | 1 |
| Bardin, T | 1 |
| Siddiqui, AK | 1 |
| Huberfeld, SI | 1 |
| Weidenheim, KM | 1 |
| Einberg, KR | 1 |
| Efferen, LS | 1 |
| Mateen, FJ | 1 |
| Keegan, BM | 1 |
| Wang, C | 1 |
| Fortin, PR | 1 |
| Li, Y | 1 |
| Panaritis, T | 1 |
| Gans, M | 1 |
| Esdaile, JM | 1 |
| Stein, M | 1 |
| Bell, MJ | 1 |
| Ang, LC | 1 |
| Kumamoto, T | 1 |
| Estes, ML | 1 |
| Ewing-Wilson, D | 1 |
| Chou, SM | 1 |
| Mitsumoto, H | 1 |
| Hanson, M | 1 |
| Shirey, E | 1 |
| Ratliff, NB | 1 |
| Renier, JC | 1 |
6 reviews available for hydroxychloroquine and Muscle Disorders
| Article | Year |
|---|---|
COVID-19 and neuromuscular disorders.
Topics: Antiviral Agents; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Delivery of Heal | 2020 |
Hydroxychloroquine: An old drug with new relevance.
Topics: Adult; Antirheumatic Agents; Female; Humans; Hydroxychloroquine; Hyperpigmentation; Lupus Erythemato | 2018 |
Antimalarial myopathy in a systemic lupus erythematosus patient with quadriparesis and seizures: a case-based review.
Topics: Adult; Antimalarials; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Muscular Di | 2017 |
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy; | 1963 |
Hydroxychloroquine neuromyotoxicity.
Topics: Aged; Antirheumatic Agents; Female; Humans; Hydroxychloroquine; Muscular Diseases; Peripheral Nervou | 2000 |
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
Topics: Aminoquinolines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antimalarials; Autophagy; Cations; Chl | 2001 |
21 other studies available for hydroxychloroquine and Muscle Disorders
| Article | Year |
|---|---|
[A rare cause of impaired general condition: Muscular and cardiac toxicity of antimalarials].
Topics: Antimalarials; Asthenia; Biopsy; Cardiotoxicity; Diagnosis, Differential; Humans; Hydroxychloroquine | 2020 |
[Proximal myopathy and fulminant heart failure in a 57 year-old female patient with lupus erythematosus].
Topics: Biopsy; Cardiomyopathies; Echocardiography; Fatal Outcome; Female; Heart; Heart Failure; Humans; Hyd | 2020 |
Challenges in diagnosing hydroxychloroquine myopathy during the COVID-19 pandemic.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; COVID-19; Diagnosis, Differential; Humans; Hyd | 2020 |
Hydroxychloroquine-induced autophagic vacuolar myopathy with mitochondrial abnormalities.
Topics: Aged; Antirheumatic Agents; Autoimmune Diseases; Autophagy; Female; Humans; Hydroxychloroquine; Male | 2018 |
Neuromuscular transmission defects in myopathies: Rare but worth searching for.
Topics: Cholinesterase Inhibitors; Cohort Studies; Electrodiagnosis; Electromyography; Female; Genetic Disea | 2019 |
Pearls & Oy-sters: Hydroxychloroquine-induced toxic myopathy mimics Pompe disease: Critical role of genetic test.
Topics: Aged; alpha-Glucosidases; Diagnosis, Differential; Female; Genetic Testing; Glycogen Storage Disease | 2019 |
Myopathy complicating lupus pregnancy.
Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Biopsy; Drug Therapy, Combination; Female; Hum | 2013 |
Teaching neuroimages: hydroxychloroquine-induced vacuolar myopathy.
Topics: Female; Humans; Hydroxychloroquine; Lysosomal Storage Diseases; Magnetic Resonance Imaging; Middle A | 2013 |
Hydroxychloroquine neuromyotoxicity: a case with rapid course and complete recovery.
Topics: Biopsy; Creatine Kinase; Female; Humans; Hydroxychloroquine; Middle Aged; Muscular Diseases; Neuroto | 2015 |
Severe hydroxychloroquine myopathy.
Topics: Antimalarials; Female; Humans; Hydroxychloroquine; Malaria; Microscopy, Electron, Transmission; Midd | 2008 |
42-year-old man with discoid lupus and progressive weakness.
Topics: Adult; Antirheumatic Agents; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Male; Micros | 2009 |
Hydroxychloroquine and colchicine induced myopathy.
Topics: Aged; Colchicine; Female; Humans; Hydroxychloroquine; Muscular Diseases | 2009 |
Hydroxychloroquine-induced myopathy.
Topics: Aged; Antirheumatic Agents; Apnea; Female; Heart Failure; Humans; Hydroxychloroquine; Muscular Disea | 2010 |
Antimalarial myopathy in amyopathic dermatomyositis.
Topics: Aged; Antimalarials; Dermatomyositis; Female; Humans; Hydroxychloroquine; Muscular Diseases | 2012 |
Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients.
Topics: Adult; Aged; Antimalarials; Antirheumatic Agents; Biopsy; Chloroquine; Clinical Enzyme Tests; Electr | 2006 |
Muscle involvement in sarcoidosis: a retrospective and followup studies.
Topics: Adult; Cardiomyopathies; Chronic Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studie | 2006 |
Hydroxychloroquine-induced toxic myopathy causing respiratory failure.
Topics: Aged, 80 and over; Antirheumatic Agents; Fatal Outcome; Female; Humans; Hydroxychloroquine; Muscular | 2007 |
Severe, reversible dysphagia from chloroquine and hydroxychloroquine myopathy.
Topics: Aged, 80 and over; Antirheumatic Agents; Chloroquine; Deglutition Disorders; Humans; Hydroxychloroqu | 2007 |
Discontinuation of antimalarial drugs in systemic lupus erythematosus.
Topics: Adult; Antimalarials; Antirheumatic Agents; Cohort Studies; Drug-Related Side Effects and Adverse Re | 1999 |
Chloroquine neuromyotoxicity. Clinical and pathologic perspective.
Topics: Aged; Biopsy; Cardiomyopathies; Chloroquine; Female; Humans; Hydroxychloroquine; Male; Middle Aged; | 1987 |
[Apropos of a report: a case of neuromyopathy due to hydroxychloroquine].
Topics: Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Middle Aged; Muscular Diseases; Periphera | 1965 |