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hydroxychloroquine and Liver Dysfunction

hydroxychloroquine has been researched along with Liver Dysfunction in 12 studies

Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.

Research Excerpts

ExcerptRelevanceReference
"Hydroxychloroquine and phlebotomy were compared in the treatment of porphyria cutanea tarda (PCT)."9.05Hydroxychloroquine versus phlebotomy in the treatment of porphyria cutanea tarda. ( Bessone, E; Cainelli, T; Cantoni, L; Di Padova, C; Gori, G; Marchesi, L; Podenzani, SA; Rovagnati, P, 1983)
"A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered."8.77Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985)
"Six patients with skin changes and urinary porphyrin excretion patterns characteristic for porphyria cutanea tarda were treated with hydroxychloroquine sulfate therapy."7.66Hydroxychloroquine treatment of porphyria cutanea tarda. ( Levitt, L; Malkinson, FD, 1980)
"Hydroxychloroquine and phlebotomy were compared in the treatment of porphyria cutanea tarda (PCT)."5.05Hydroxychloroquine versus phlebotomy in the treatment of porphyria cutanea tarda. ( Bessone, E; Cainelli, T; Cantoni, L; Di Padova, C; Gori, G; Marchesi, L; Podenzani, SA; Rovagnati, P, 1983)
"A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered."4.77Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985)
"Six patients with skin changes and urinary porphyrin excretion patterns characteristic for porphyria cutanea tarda were treated with hydroxychloroquine sulfate therapy."3.66Hydroxychloroquine treatment of porphyria cutanea tarda. ( Levitt, L; Malkinson, FD, 1980)
" Recommendations were made based on available data, consideration of pharmacokinetic properties (including variability), the dosing and anticipated treatment duration of each regimen in COVID-19 and known toxicities."2.72Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment. ( Back, D; Boyle, A; Burger, D; Davidson, K; El-Sherif, O; Gibbons, S; Khoo, S; Marra, F; Marzolini, C; Siccardi, M; Smolders, EJ; Sommerville, AJ, 2021)
"Physiologically based pharmacokinetic (PBPK) models were used to study the change in the pharmacokinetics (PK) of drugs repurposed for COVID-19 in geriatric patients, different race groups, organ impairment and drug-drug interactions (DDIs) risks."1.91Pharmacokinetics under the COVID-19 storm. ( El-Khateeb, E; Giovino, N; Jamei, M; Jo, H; Lythgoe, E; Pilla Reddy, V; Rastomi-Hodjegan, A; Sharma, S; Tang, W, 2023)
"A treatment with lopinavir/ritonavir and hydroxychloroquine twice daily was started."1.56Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection. ( Bernasconi, E; Bertoli, R; Cerny, A; Ceschi, A; De Gottardi, A; Fratila, C; Gianella, P; Magenta, L; Majno-Hurst, P; Vanini, G, 2020)
"Hepatic cysts arise from cholangiocytes exhibiting a hyperproliferative phenotype."1.48Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target. ( Ding, JF; Huang, BQ; LaRusso, NF; Loarca, L; Lorenzo Pisarello, MJ; Masyuk, AI; Masyuk, TV, 2018)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's2 (16.67)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
De Gottardi, A1
Fratila, C1
Bertoli, R1
Cerny, A1
Magenta, L1
Gianella, P1
Majno-Hurst, P1
Ceschi, A1
Vanini, G1
Bernasconi, E1
Pilla Reddy, V1
El-Khateeb, E1
Jo, H1
Giovino, N1
Lythgoe, E1
Sharma, S1
Tang, W1
Jamei, M1
Rastomi-Hodjegan, A1
Marra, F1
Smolders, EJ1
El-Sherif, O1
Boyle, A1
Davidson, K1
Sommerville, AJ1
Marzolini, C1
Siccardi, M1
Burger, D1
Gibbons, S1
Khoo, S1
Back, D1
Masyuk, AI1
Masyuk, TV1
Lorenzo Pisarello, MJ1
Ding, JF1
Loarca, L1
Huang, BQ1
LaRusso, NF1
Khayat, R1
Dupuy, A1
Pansé, I1
Bagot, M1
Cordoliani, F1
QUEEN, HO1
Cainelli, T1
Di Padova, C1
Marchesi, L1
Gori, G1
Rovagnati, P1
Podenzani, SA1
Bessone, E1
Cantoni, L1
Malkinson, FD1
Levitt, L1
Joundy, N1
Carpentier, S1
Leclech, C1
Aubé, C1
Rousselet, MC1
Barré, P1
Oberti, F1
Calès, P1
Bundino, S1
Topi, GC1
Zina, AM1
D'Allessandro Gandolfo, L1
Malina, L1
Kremer, JM1

Reviews

2 reviews available for hydroxychloroquine and Liver Dysfunction

ArticleYear
Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment.
    Drugs in R&D, 2021, Volume: 21, Issue:1

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Dru

2021
Longterm methotrexate therapy in rheumatoid arthritis: a review.
    The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12

    Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans

1985

Trials

1 trial available for hydroxychloroquine and Liver Dysfunction

ArticleYear
Hydroxychloroquine versus phlebotomy in the treatment of porphyria cutanea tarda.
    The British journal of dermatology, 1983, Volume: 108, Issue:5

    Topics: Adult; Aged; Bloodletting; Humans; Hydroxychloroquine; Liver Diseases; Male; Middle Aged; Porphyrias

1983

Other Studies

9 other studies available for hydroxychloroquine and Liver Dysfunction

ArticleYear
Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection.
    Clinics and research in hepatology and gastroenterology, 2020, Volume: 44, Issue:6

    Topics: Antiviral Agents; Comorbidity; COVID-19; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Immuno

2020
Pharmacokinetics under the COVID-19 storm.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:1

    Topics: Aged; Computer Simulation; COVID-19; Drug Interactions; Humans; Hydroxychloroquine; Liver Diseases;

2023
Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:3

    Topics: Animals; Autophagy; Bile Ducts; Blotting, Western; Cell Proliferation; Cells, Cultured; Cluster Anal

2018
[Sclerodermatous changes in porphyria cutanea tarda: six cases].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:10

    Topics: Adrenal Cortex Hormones; Aged; Alcoholism; Alopecia; Diagnosis, Differential; Female; Humans; Hydrox

2013
Hepatic amebiasis treated with plaquenil: case report.
    North Carolina medical journal, 1960, Volume: 21

    Topics: Amebiasis; Chloroquine; Hydroxychloroquine; Liver Abscess, Amebic; Liver Diseases; North Carolina

1960
Hydroxychloroquine treatment of porphyria cutanea tarda.
    Archives of dermatology, 1980, Volume: 116, Issue:10

    Topics: Adult; Coproporphyrins; Female; Humans; Hydroxychloroquine; Iron; Liver Diseases; Male; Middle Aged;

1980
[Favourable course of a pseudotumoral form of hepatic and splenic sarcoidosis under treatment with hydroxychloroquine and colchicine].
    Gastroenterologie clinique et biologique, 1995, Volume: 19, Issue:12

    Topics: Antimalarials; Colchicine; Drug Therapy, Combination; Female; Gout Suppressants; Humans; Hydroxychlo

1995
Hepatoerythropoietic porphyria.
    Pediatric dermatology, 1987, Volume: 4, Issue:3

    Topics: Child; Erythropoiesis; Humans; Hydroxychloroquine; Liver Diseases; Male; Porphyrias

1987
Treatment of chronic hepatic porphyria (PCT).
    Photo-dermatology, 1986, Volume: 3, Issue:2

    Topics: Bloodletting; Chloroquine; Humans; Hydroxychloroquine; Liver Diseases; Porphyrias

1986