hydroxychloroquine has been researched along with Keratoconjunctivitis Sicca in 4 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Keratoconjunctivitis Sicca: Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In severe cases of keratoconjunctivitis sicca, topical cyclosporine A may be used." | 4.89 | Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions. ( Bové, A; Brito-Zerón, P; Kostov, BA; Ramos-Casals, M; Sisó-Almirall, A, 2013) |
| "Hydroxychloroquine was most frequently used (88." | 1.62 | Clinical features and outcomes from the Singapore Sjögren's syndrome study. ( Charan, N; Kam, JK; Leong, RW; Loh, ZW; Thong, BY, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kam, JK | 1 |
| Charan, N | 1 |
| Leong, RW | 1 |
| Loh, ZW | 1 |
| Thong, BY | 1 |
| Yavuz, S | 1 |
| Asfuroğlu, E | 1 |
| Bicakcigil, M | 1 |
| Toker, E | 1 |
| Brito-Zerón, P | 1 |
| Sisó-Almirall, A | 1 |
| Bové, A | 1 |
| Kostov, BA | 1 |
| Ramos-Casals, M | 1 |
| Fox, RI | 1 |
| Dixon, R | 1 |
| Guarrasi, V | 1 |
| Krubel, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analysis of Hydroxychloroquine Blood Levels in Patients With Primary Sjögren Syndrome and Possible Correlation With the Disease Activity[NCT04546542] | 75 participants (Anticipated) | Observational | 2020-10-01 | Active, not recruiting | |||
| Effect of Pilocarpine in Patients With Xerostomia[NCT02982577] | Phase 4 | 80 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxychloroquine and Keratoconjunctivitis Sicca
| Article | Year |
|---|---|
Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions.
Topics: Cyclosporine; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Keratoconjuncti | 2013 |
1 trial available for hydroxychloroquine and Keratoconjunctivitis Sicca
| Article | Year |
|---|---|
Treatment of primary Sjögren's syndrome with hydroxychloroquine: a retrospective, open-label study.
Topics: Adolescent; Adult; Aged; Antimalarials; Antirheumatic Agents; Child; Female; Humans; Hydroxychloroqu | 1996 |
2 other studies available for hydroxychloroquine and Keratoconjunctivitis Sicca
| Article | Year |
|---|---|
Clinical features and outcomes from the Singapore Sjögren's syndrome study.
Topics: Adult; Arthralgia; Azathioprine; Female; Humans; Hydroxychloroquine; Keratoconjunctivitis Sicca; Mal | 2021 |
Hydroxychloroquine improves dry eye symptoms of patients with primary Sjogren's syndrome.
Topics: Adult; Aged; B-Cell Activating Factor; Biomarkers; Female; Humans; Hydroxychloroquine; Keratoconjunc | 2011 |