hydroxychloroquine has been researched along with Genetic Predisposition in 18 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This is the first study to evaluate the use of a TNF-α inhibitor for canine lupus and the first to address the safety of long-term administration of hydroxychloroquine, albeit in a small number of dogs." | 2.75 | Exfoliative cutaneous lupus erythematosus in German shorthaired pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment. ( Brown, DC; Casal, ML; Mauldin, EA; Morris, DO, 2010) |
| " Although its pathogenesis is unclear, risk factors include: daily dosage of hydroxychloroquine, cumulative dosage, duration of treatment, coexisting renal or liver disease, patient age, and concomitant retinal disease." | 2.43 | Ocular toxicity of hydroxychloroquine. ( Kwok, AK; Yam, JC, 2006) |
| "KEY POINTS: • COVID19 studies show higher mortality in men, due to severe pneumonia and ARDS, indicating possible X-linked mediated differences • G6PD, the most common X-linked enzymopathy, highly prevalent in African Americans and Italians, maintains redox homeostasis." | 1.62 | G6PD deficiency and severity of COVID19 pneumonia and acute respiratory distress syndrome: tip of the iceberg? ( Ensor, J; Iyer, SP; Padmanabhan, S; Pingali, SR; Sahay, S; Youssef, G; Youssef, JG; Zahiruddin, F; Zu, Y, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 6 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yousefzadegan, S | 1 |
| Rezaei, N | 1 |
| Mack, HG | 1 |
| Kowalski, T | 1 |
| Lucattini, A | 1 |
| Symons, RA | 1 |
| Wicks, I | 1 |
| Hall, AJ | 1 |
| Deane, KD | 1 |
| Holers, VM | 1 |
| Gomes, CP | 1 |
| Fernandes, DE | 1 |
| Casimiro, F | 1 |
| da Mata, GF | 1 |
| Passos, MT | 1 |
| Varela, P | 1 |
| Mastroianni-Kirsztajn, G | 1 |
| Pesquero, JB | 1 |
| Youssef, JG | 1 |
| Zahiruddin, F | 1 |
| Youssef, G | 1 |
| Padmanabhan, S | 1 |
| Ensor, J | 1 |
| Pingali, SR | 1 |
| Zu, Y | 1 |
| Sahay, S | 1 |
| Iyer, SP | 1 |
| Imani-Saber, Z | 1 |
| Vaseghi, H | 1 |
| Mahdian, M | 1 |
| Safari, F | 1 |
| Ghadami, M | 1 |
| Giocanti-Aurégan, A | 1 |
| Couturier, A | 1 |
| Girmens, JF | 1 |
| Le Mer, Y | 1 |
| Massamba, N | 1 |
| Barreau, E | 1 |
| Audo, I | 1 |
| Alessandrella, A | 1 |
| Della Casa, R | 1 |
| Alessio, M | 1 |
| Puente Prieto, J | 1 |
| Strisciuglio, P | 1 |
| Melis, D | 1 |
| Messiant, V | 1 |
| Defoort-Dhellemmes, S | 1 |
| Smirnov, V | 1 |
| Günther, C | 2 |
| Hillebrand, M | 1 |
| Brunk, J | 1 |
| Lee-Kirsch, MA | 2 |
| Cooper, RG | 1 |
| Boente, Mdel C | 1 |
| Nadra, G | 1 |
| Asial, R | 1 |
| Happle, R | 1 |
| Meurer, M | 1 |
| Stein, A | 1 |
| Viehweg, A | 1 |
| Mauldin, EA | 1 |
| Morris, DO | 1 |
| Brown, DC | 1 |
| Casal, ML | 1 |
| Gaynes, BI | 1 |
| Yam, JC | 1 |
| Kwok, AK | 1 |
| Asselman, CA | 1 |
| Shroyer, NF | 1 |
| Lewis, RA | 1 |
| Lupski, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fecal Microbial Transplantation for Rheumatoid Arthritis Trial[NCT05790356] | 30 participants (Anticipated) | Interventional | 2023-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for hydroxychloroquine and Genetic Predisposition
| Article | Year |
|---|---|
Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift.
Topics: Alcohol Drinking; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthralgia; Arthritis | 2021 |
Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.
Topics: Acute Kidney Injury; Amantadine; Angiotensin-Converting Enzyme 2; Cathepsin L; Chloroquine; COVID-19 | 2020 |
Variable Clinical Manifestations of COVID-19: Viral and Human Genomes Talk.
Topics: ADAM17 Protein; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensi | 2020 |
Ocular toxicity of hydroxychloroquine.
Topics: Antimalarials; Color Perception; Diagnosis, Differential; Genetic Predisposition to Disease; Humans; | 2006 |
1 trial available for hydroxychloroquine and Genetic Predisposition
| Article | Year |
|---|---|
Exfoliative cutaneous lupus erythematosus in German shorthaired pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment.
Topics: Adalimumab; Animals; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Cyclosporine; Dog Dise | 2010 |
13 other studies available for hydroxychloroquine and Genetic Predisposition
| Article | Year |
|---|---|
Case Report: Death due to COVID-19 in Three Brothers.
Topics: Aged; Betacoronavirus; Coronavirus Infections; COVID-19; Fatal Outcome; Genetic Predisposition to Di | 2020 |
Genetic susceptibility to hydroxychloroquine retinal toxicity.
Topics: Adult; Aged; Antirheumatic Agents; Australia; Case-Control Studies; Female; Genetic Markers; Genetic | 2020 |
G6PD deficiency and severity of COVID19 pneumonia and acute respiratory distress syndrome: tip of the iceberg?
Topics: Black or African American; Contraindications, Drug; COVID-19; COVID-19 Nucleic Acid Testing; Critica | 2021 |
[Variability of chloroquine and hydroxychloroquine retinopathy among various ethnicities].
Topics: Antirheumatic Agents; Asian People; Chloroquine; Delayed Diagnosis; Early Diagnosis; Electroretinogr | 2018 |
A novel homozygous mutation in the SLCO2A1 gene causing pachydermoperiostosis: Efficacy of hydroxychloroquine treatment.
Topics: Adolescent; Alleles; Amino Acid Substitution; Bone and Bones; Exons; Genetic Association Studies; Ge | 2018 |
[Atypical hydroxychloroquine maculopathy in an Asian woman with lupus].
Topics: Adult; Asian People; Female; Genetic Predisposition to Disease; Humans; Hydroxychloroquine; Laos; Lu | 2019 |
Systemic involvement in TREX1-associated familial chilblain lupus.
Topics: Chilblains; Exodeoxyribonucleases; Follow-Up Studies; Genetic Predisposition to Disease; Heterozygot | 2013 |
Despite hydroxyl/chloroquine's negative reputation, it may still be used by rheumatic patients in Africa.
Topics: Africa; Antimalarials; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; HLA-DR4 Ant | 2008 |
Pronounced linear calcinosis in a boy with mild dermatomyositis. A further possible example of superimposed segmental manifestation of a polygenic disorder.
Topics: Biopsy, Needle; Calcinosis; Child; Colchicine; Dermatomyositis; Disease Progression; Drug Therapy, C | 2009 |
Familial chilblain lupus--a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1.
Topics: Adolescent; Aspirin; Biopsy, Needle; Chronic Disease; Disease Progression; Drug Therapy, Combination | 2009 |
Sparing of age-related macular degeneration in rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, R | 2006 |
[Chillblains in a pair of riders].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Biopsy; Cold Temperature; Female; Genetic Predisposition | 1998 |
Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease?
Topics: Aged; Aminoquinolines; ATP-Binding Cassette Transporters; Chloroquine; Genetic Predisposition to Dis | 2001 |