hydroxychloroquine has been researched along with Dry Eye Syndromes in 6 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Dry Eye Syndromes: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the safety and efficacy of oral hydroxychloroquine in treating dry eye disease associated with pSS." | 9.69 | Safety and Efficacy of Oral Hydroxychloroquine in the Treatment of Ophthalmic Disease Associated with Sjögren's Syndrome. ( Bing, Z; Fang, W; Jie, X; Qihui, L; Qingqing, Z; Xinyue, H, 2023) |
| "The effect of hydroxychloroquine (HCQ) on dry eye has not been fully determined." | 9.22 | Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study. ( Kim, MK; Lee, EB; Lee, EY; Lee, HJ; Lee, WW; Wee, WR; Yoon, CH, 2016) |
| "To evaluate the safety and efficacy of oral hydroxychloroquine in treating dry eye disease associated with pSS." | 5.69 | Safety and Efficacy of Oral Hydroxychloroquine in the Treatment of Ophthalmic Disease Associated with Sjögren's Syndrome. ( Bing, Z; Fang, W; Jie, X; Qihui, L; Qingqing, Z; Xinyue, H, 2023) |
| "The effect of hydroxychloroquine (HCQ) on dry eye has not been fully determined." | 5.22 | Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study. ( Kim, MK; Lee, EB; Lee, EY; Lee, HJ; Lee, WW; Wee, WR; Yoon, CH, 2016) |
| "Sjögren's Syndrome-related dry eye is a disorder, whose diagnosis may be difficult and mistaken for non-Sjögren's Syndrome-related dry eye." | 2.82 | Dry eye in Sjögren's syndrome - characteristics and therapy. ( Caban, M; Latecka-Krajewska, B; Omulecki, W, 2022) |
| "Significant proportion of patients with dry eye has underlying SS, a progressive autoimmune condition." | 2.47 | Treatment of Sjögren's syndrome-associated dry eye an evidence-based review. ( Adyanthaya, RS; Akpek, EK; Baer, AN; Lindsley, KB; McDonnell, PJ; Swamy, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caban, M | 1 |
| Omulecki, W | 1 |
| Latecka-Krajewska, B | 1 |
| Fang, W | 1 |
| Qingqing, Z | 1 |
| Qihui, L | 1 |
| Bing, Z | 1 |
| Xinyue, H | 1 |
| Jie, X | 1 |
| Zhang, A | 1 |
| Chen, S | 1 |
| Lin, R | 1 |
| Yoon, CH | 1 |
| Lee, HJ | 1 |
| Lee, EY | 1 |
| Lee, EB | 1 |
| Lee, WW | 1 |
| Kim, MK | 1 |
| Wee, WR | 1 |
| Kroshinsky, D | 1 |
| Stone, JH | 1 |
| Bloch, DB | 1 |
| Sepehr, A | 1 |
| Akpek, EK | 1 |
| Lindsley, KB | 1 |
| Adyanthaya, RS | 1 |
| Swamy, R | 1 |
| Baer, AN | 1 |
| McDonnell, PJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3 Study of Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren's Syndrome[NCT01601028] | Phase 3 | 39 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydroxychloroquine and Dry Eye Syndromes
| Article | Year |
|---|---|
Dry eye in Sjögren's syndrome - characteristics and therapy.
Topics: Dry Eye Syndromes; Humans; Hydroxychloroquine; Lubricant Eye Drops; Sjogren's Syndrome; Tears | 2022 |
Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review.
Topics: Dry Eye Syndromes; Glucosides; Humans; Hydroxychloroquine; Immunoglobulin A; Immunoglobulin G; Immun | 2023 |
Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.
Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents; Dry Eye Syndromes; Evidence | 2011 |
2 trials available for hydroxychloroquine and Dry Eye Syndromes
| Article | Year |
|---|---|
Safety and Efficacy of Oral Hydroxychloroquine in the Treatment of Ophthalmic Disease Associated with Sjögren's Syndrome.
Topics: Dry Eye Syndromes; Humans; Hydroxychloroquine; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; | 2023 |
Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study.
Topics: Aged; B-Cell Activating Factor; Blood Sedimentation; Double-Blind Method; Drug Administration Schedu | 2016 |
1 other study available for hydroxychloroquine and Dry Eye Syndromes
| Article | Year |
|---|---|
Case records of the Massachusetts General Hospital. Case 5-2009. A 47-year-old woman with a rash and numbness and pain in the legs.
Topics: Antibodies, Antinuclear; Antirheumatic Agents; Aspirin; Biopsy; Diagnosis, Differential; Dry Eye Syn | 2009 |