Page last updated: 2024-10-28

hydroxychloroquine and Dermatitis Medicamentosa

hydroxychloroquine has been researched along with Dermatitis Medicamentosa in 47 studies

Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.

Research Excerpts

ExcerptRelevanceReference
"Hydroxychloroquine sulfate is a commonly used medication for patients with dermatomyositis and has been associated with a uniquely elevated risk of adverse cutaneous reactions in this population."7.88Association Between Autoantibody Phenotype and Cutaneous Adverse Reactions to Hydroxychloroquine in Dermatomyositis. ( Casciola-Rosen, L; Fiorentino, DF; Wolstencroft, PW, 2018)
"Hydroxychloroquine sulfate is a commonly used medication for patients with dermatomyositis and has been associated with a uniquely elevated risk of adverse cutaneous reactions in this population."3.88Association Between Autoantibody Phenotype and Cutaneous Adverse Reactions to Hydroxychloroquine in Dermatomyositis. ( Casciola-Rosen, L; Fiorentino, DF; Wolstencroft, PW, 2018)
"Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus."2.58Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work. ( Kambe, N; Ly, NTM; Matsuda, T; Nguyen, CTH; Okamoto, H; Son, Y; Ueda-Hayakawa, I, 2018)
"Sirolimus is an immunosuppressive macrolide with antineoplasic properties that is increasingly used in posttransplantation immunosuppression."1.35Sirolimus-induced inflammatory papules with acquired reactive perforating collagenosis. ( Lübbe, J; Malé, PJ; Masouyé, I; Saurat, JH; Sorg, O, 2008)
"Acute generalized exanthematous pustulosis (AGEP) is a disease characterized by the rapid occurrence of many sterile, nonfollicular pustules usually arising on an oedematous erythema often accompanied by leucocytosis and fever."1.34Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR). ( Bavinck, JN; Dunant, A; Fagot, JP; Halevy, S; Mockenhaupt, M; Naldi, L; Roujeau, JC; Sidoroff, A; Viboud, C, 2007)
"Hydroxychloroquine (HCQ) is an antimalarial agent with immunomodulatory effects."1.33Desensitization to hydroxychloroquine--experience of 4 patients. ( Breuer, GS; Mates, M; Navon, P; Nesher, G; Zevin, S, 2006)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.38)18.7374
1990's3 (6.38)18.2507
2000's7 (14.89)29.6817
2010's19 (40.43)24.3611
2020's15 (31.91)2.80

Authors

AuthorsStudies
Jadeja, S1
Temiz, LA1
Dewan, AK1
Parker, ER1
Sharma, AN1
Mesinkovska, NA1
Paravar, T1
Dos Reis Neto, ET1
Kakehasi, AM1
de Medeiros Pinheiro, M1
Ferreira, GA1
Marques, CDL1
da Mota, LMH1
Dos Santos Paiva, E1
Pileggi, GCS1
Sato, EI1
Reis, APMG1
Xavier, RM1
Provenza, JR1
Kuraitis, D1
Murina, A1
Lipner, SR1
Wang, Y1
Khurana, A1
Katare, A1
Agarwal, A1
Kathirvel, P1
Ahuja, A1
Chicharro, P1
Rodríguez-Jiménez, P1
Muñoz-Aceituno, E1
De Argila, D1
Muñoz-Hernández, P1
Llamas-Velasco, M1
Abadías-Granado, I1
Palma-Ruiz, AM1
Cerro, PA1
Morales-Callaghan, AM1
Gómez-Mateo, MC1
Gilaberte, Y1
Schwartz, RA1
Redondo-Sendino, Á1
González Sánchez, IC1
de Victoria Fernández, B1
Zekarias, A1
Watson, S1
Vidlin, SH1
Grundmark, B1
Kurd, R1
Zuckerman, M1
Ben-Chetrit, E1
Sutton, KM1
Fernando, SL1
Moya-Martínez, C1
Torre-Castro, J1
Fariña-Sabarís, MC1
Santiago Sánchez-Mateos, D1
Eraña-Tomás, I1
Jo-Velasco, M1
Requena, L1
Sánchez-Velázquez, A1
Arroyo-Andrés, J1
Falkenhain-López, D1
Peralto, JLR1
Romero, PLO1
Díaz, RR1
Calleja-Algarra, A1
Keita, AM1
Zahlane, M1
Benjilali, L1
Essaadouni, L1
Mittal, L1
Zhang, L1
Feng, R1
Werth, VP1
Tal, Y1
Maoz Segal, R1
Langevitz, P1
Kivity, S1
Darnizki, Z1
Agmon-Levin, N1
Matsuda, T1
Ly, NTM1
Kambe, N1
Nguyen, CTH1
Ueda-Hayakawa, I1
Son, Y1
Okamoto, H1
Randhawa, A1
Wylie, G1
Kishi, C1
Motegi, SI1
Yasuda, M1
Ishikawa, O1
Wolstencroft, PW1
Casciola-Rosen, L1
Fiorentino, DF1
Borik, L1
Petzelbauer, P1
Quint, T1
Wöhrl, S1
Kinaciyan, T1
Heil, PM1
Riley, K1
Schwager, Z1
Stern, M1
Vleugels, RA1
Femia, A1
Gonzalez, CD1
Hansen, C1
Clarke, JT1
Hayami, T1
Tanaka, T1
Fujimoto, N1
Gardair Bouchy, C1
Kerdraon, R1
Kluger, N1
Armingaud, P1
Wakosa, A1
Estève, E1
Kasper, RS1
Flueckiger, B1
Gobbi, S1
Lautenschlager, S1
Borelli, S1
Soria, A1
Barbaud, A2
Assier, H1
Avenel-Audran, M1
Tétart, F1
Raison-Peyron, N1
Amarger, S1
Girardin, P1
Francès, C1
Schmutz, JL1
Tréchot, P1
Avram, MM1
Hoang, M1
Fain, O1
Stirnemann, J1
Kettaneh, A1
Richmond, BW1
Cole, MB1
Dash, A1
Eyler, A1
Boomershine, CS1
Caramaschi, P1
Barbazza, R1
Tinazzi, I1
Biasi, D1
Abbott, RA1
May, K1
Motley, RJ1
Tang, C1
Godfrey, T1
Stawell, R1
Nikpour, M1
Kalampalikis, A1
Goetze, S1
Elsner, P1
Evans, CC1
Bergstresser, PR1
Mates, M1
Zevin, S1
Breuer, GS1
Navon, P1
Nesher, G1
Sontheimer, RD1
Sidoroff, A1
Dunant, A1
Viboud, C1
Halevy, S1
Bavinck, JN1
Naldi, L1
Mockenhaupt, M1
Fagot, JP1
Roujeau, JC1
Lübbe, J1
Sorg, O1
Malé, PJ1
Saurat, JH1
Masouyé, I1
Assier-Bonnet, H1
Saada, V1
Bernier, M1
Clerici, T1
Saïag, P1
O'Reilly, FM1
O'Loughlin, S1
Murphy, GM1
Lotem, M1
Ingber, A1
Segal, R1
Sandbank, M1
Hudson, LD1
Vlcek, F1
Zvaifler, NJ1

Reviews

6 reviews available for hydroxychloroquine and Dermatitis Medicamentosa

ArticleYear
Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review.
    Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:2

    Topics: Drug Eruptions; Hair; Humans; Hydroxychloroquine; Nails; Prevalence; Skin

2020
Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.
    Advances in rheumatology (London, England), 2020, 06-09, Volume: 60, Issue:1

    Topics: Antimalarials; Antiphospholipid Syndrome; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine;

2020
Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work.
    The Journal of dermatology, 2018, Volume: 45, Issue:3

    Topics: Administration, Oral; Adult; Antirheumatic Agents; Dose-Response Relationship, Drug; Drug Eruptions;

2018
Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects.
    Internal medicine journal, 2012, Volume: 42, Issue:9

    Topics: Antimalarials; Carbohydrate Metabolism; Cardiovascular Diseases; Chloroquine; Clinical Trials as Top

2012
Acute generalized exanthematous pustulosis induced by hydroxychloroquine.
    Dermatology (Basel, Switzerland), 1996, Volume: 193, Issue:1

    Topics: Acute Disease; Adult; Antirheumatic Agents; Arthritis; Diagnosis, Differential; Drug Eruptions; Fema

1996
Antimalarials in the treatment of rheumatoid arthritis.
    Modern treatment, 1971, Volume: 8, Issue:4

    Topics: Arthritis, Rheumatoid; Chloroquine; Drug Eruptions; Headache; Humans; Hydroxychloroquine; Placebos;

1971

Other Studies

41 other studies available for hydroxychloroquine and Dermatitis Medicamentosa

ArticleYear
A temporal cluster of cutaneous drug eruptions developing after initiation of hydroxychloroquine.
    Scandinavian journal of rheumatology, 2022, Volume: 51, Issue:3

    Topics: Drug Eruptions; Exanthema; Humans; Hydroxychloroquine; Skin

2022
Facts, not Fear: Safety of Hydroxychloroquine.
    The American journal of the medical sciences, 2020, Volume: 360, Issue:2

    Topics: Acute Generalized Exanthematous Pustulosis; Agranulocytosis; Anemia, Aplastic; Antirheumatic Agents;

2020
Retrospective analysis of dermatologic adverse events associated with hydroxychloroquine reported to the US Food and Drug Administration.
    Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Child; Child, P

2020
Hydroxychloroquine-induced erythroderma: A rare adverse effect of a commonly used drug.
    Dermatologic therapy, 2020, Volume: 33, Issue:6

    Topics: Dermatitis, Exfoliative; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Humans; Hy

2020
SDRIFE-like rash associated with COVID-19, clinicopathological correlation.
    The Australasian journal of dermatology, 2021, Volume: 62, Issue:1

    Topics: Aged; Antiviral Agents; Azithromycin; Chloroquine; COVID-19 Drug Treatment; Drug Eruptions; Exanthem

2021
Generalized pustular figurate erythema first report in two COVID-19 patients on hydroxychloroquine.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2021, Volume: 35, Issue:1

    Topics: Antimalarials; COVID-19 Drug Treatment; Drug Eruptions; Erythema; Female; Humans; Hydroxychloroquine

2021
[Skin manifestations associated with the new coronavirus SARS-CoV-2 disease].
    Medicina clinica, 2020, 11-13, Volume: 155, Issue:9

    Topics: Anti-Inflammatory Agents; Antiviral Agents; Benzimidazoles; Betacoronavirus; Betamethasone; Causalit

2020
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
    Drug safety, 2020, Volume: 43, Issue:12

    Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agent

2020
Hydroxychloroquine-related Rash in COVID-19 Infected Patient.
    The Israel Medical Association journal : IMAJ, 2020, Volume: 22, Issue:8

    Topics: Aged; COVID-19 Drug Treatment; Drug Eruptions; Humans; Hydroxychloroquine; Male; SARS-CoV-2

2020
A 6-step rapid desensitization protocol to hydroxychloroquine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2021, Volume: 126, Issue:3

    Topics: Adult; Desensitization, Immunologic; Drug Eruptions; Female; Humans; Hydroxychloroquine; Lupus Eryth

2021
Cutaneous eruption with reactive endothelial atypia due to emerging targeted cancer therapies: Report of two cases with clinico-pathologic correlation.
    Journal of cutaneous pathology, 2021, Volume: 48, Issue:6

    Topics: Adrenal Cortex Hormones; Aged; Antineoplastic Agents; Benzothiazoles; Biopsy; Drug Eruptions; Enzyme

2021
Hydroxychloroquine-induced acute generalized exanthematous pustulosis: an adverse reaction to keep in mind during COVID-19 pandemic.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2021, Volume: 19, Issue:6

    Topics: Adult; Antimalarials; COVID-19 Drug Treatment; Drug Eruptions; Female; Humans; Hydroxychloroquine

2021
[Drug-induced toxidermia in a patient receiving hydroxychloroquine as systemic therapy for primary Gougerot-Sjögren syndrome: a case report].
    The Pan African medical journal, 2021, Volume: 38

    Topics: Adult; Antirheumatic Agents; Drug Eruptions; Female; Humans; Hydrocortisone; Hydroxychloroquine; Lor

2021
Antimalarial drug toxicities in patients with cutaneous lupus and dermatomyositis: A retrospective cohort study.
    Journal of the American Academy of Dermatology, 2018, Volume: 78, Issue:1

    Topics: Adult; Age Factors; Antimalarials; Chloroquine; Cohort Studies; Databases, Factual; Dermatomyositis;

2018
Hydroxychloroquine desensitization, an effective method to overcome hypersensitivity-a multicenter experience.
    Lupus, 2018, Volume: 27, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Desensitization, Immunologic; Drug Administ

2018
A case of an acute cutaneous drug reaction with hydroxychloroquine.
    Scottish medical journal, 2018, Volume: 63, Issue:3

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents; Antirheumatic Agents; Drug Erupti

2018
Therapeutic efficacy and adverse events of hydroxychloroquine administration in Japanese systemic/cutaneous lupus erythematosus patients.
    The Journal of dermatology, 2018, Volume: 45, Issue:8

    Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Diarrhea; Drug Eruptions; Female; Humans; Hydroxychlo

2018
Association Between Autoantibody Phenotype and Cutaneous Adverse Reactions to Hydroxychloroquine in Dermatomyositis.
    JAMA dermatology, 2018, 10-01, Volume: 154, Issue:10

    Topics: Adult; Antirheumatic Agents; Autoantibodies; Dermatomyositis; Drug Eruptions; Female; Humans; Hydrox

2018
Type IV allergy to antimalarials can mimic cutaneous manifestations of lupus erythematosus.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:3

    Topics: Adult; Antimanic Agents; Chloroquine; Drug Eruptions; Female; Humans; Hydroxychloroquine; Lupus Eryt

2019
Assessment of Antimalarial Therapy in Patients Who Are Hypersensitive to Hydroxychloroquine.
    JAMA dermatology, 2019, Apr-01, Volume: 155, Issue:4

    Topics: Antimalarials; Chloroquine; Drug Eruptions; Humans; Hydroxychloroquine; Retrospective Studies

2019
Adverse cutaneous drug reactions with antimalarials in cutaneous lupus and dermatomyositis: A retrospective cohort study.
    Journal of the American Academy of Dermatology, 2019, Volume: 81, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimalarials; Dermatomyositis; Drug Eruptions; Female; Follow-Up St

2019
Successful short desensitization for the eruption of hydroxychloroquine.
    Lupus, 2019, Volume: 28, Issue:7

    Topics: Adult; Desensitization, Immunologic; Drug Eruptions; Female; Humans; Hydroxychloroquine; Lupus Eryth

2019
[Cutaneous lymphoid hyperplasia (pseudolymphoma) on the red dye of a tattoo].
    Annales de pathologie, 2013, Volume: 33, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Biopsy; Coloring Agents; Diagnosis, Differential; Drug Eruptions; Ge

2013
Hydroxychloroquine-induced hyperpigmentation.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2014, Volume: 12, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Hydroxychloroquine; Hyp

2014
Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests.
    Dermatology (Basel, Switzerland), 2015, Volume: 231, Issue:4

    Topics: Adolescent; Adult; Aged; Antimalarials; Child; Chloroquine; Drug Eruptions; Female; Humans; Hydroxyc

2015
[Hydroxychloroquine and DRESS].
    Annales de dermatologie et de venereologie, 2008, Volume: 135, Issue:12

    Topics: Antirheumatic Agents; Drug Eruptions; Eosinophilia; Humans; Hydroxychloroquine; Male; Middle Aged; P

2008
Case records of the Massachusetts General Hospital. Case 20-2009. A 79-year-old woman with a blistering cutaneous eruption.
    The New England journal of medicine, 2009, Jun-25, Volume: 360, Issue:26

    Topics: Aged; Antirheumatic Agents; Blister; Diagnosis, Differential; Drug Eruptions; Female; Humans; Hydrox

2009
[Acute generalized exanthematous pustulosis included by hydroxychloroquine during lupus].
    La Revue du praticien, 2010, Jan-20, Volume: 60, Issue:1

    Topics: Antirheumatic Agents; Drug Eruptions; Exanthema; Female; Humans; Hydroxychloroquine; Lupus Erythemat

2010
A tale of two rashes.
    The American journal of medicine, 2011, Volume: 124, Issue:5

    Topics: Aged; Antihypertensive Agents; Azathioprine; Complement C4; Cryoglobulinemia; Diagnosis, Differentia

2011
Desensitization to hydroxychloroquine: 4 cases.
    The Journal of rheumatology, 2011, Volume: 38, Issue:10

    Topics: Antirheumatic Agents; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Female; H

2011
Subacute cutaneous lupus erythematosus associated with radioiodine treatment.
    Clinical and experimental dermatology, 2012, Volume: 37, Issue:7

    Topics: Aged; Dermatologic Agents; Drug Eruptions; Enzyme Inhibitors; Female; Humans; Hydroxychloroquine; Io

2012
Isolated hyperpigmentation of the oral mucosa due to hydroxychloroquine.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2012, Volume: 10, Issue:12

    Topics: Antimalarials; Diagnosis, Differential; Drug Eruptions; Female; Humans; Hydroxychloroquine; Hyperpig

2012
Acute generalized exanthematous pustulosis precipitated by hydroxychloroquine.
    Journal of the American Academy of Dermatology, 2004, Volume: 50, Issue:4

    Topics: Acute Disease; Adult; Antimalarials; Diagnosis, Differential; Drug Eruptions; Exanthema; Female; Hum

2004
Desensitization to hydroxychloroquine--experience of 4 patients.
    The Journal of rheumatology, 2006, Volume: 33, Issue:4

    Topics: Adult; Antirheumatic Agents; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Dr

2006
Desensitization to hydroxychloroquine: alternative interpretations.
    The Journal of rheumatology, 2007, Volume: 34, Issue:2

    Topics: Antirheumatic Agents; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Drug Tole

2007
Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR).
    The British journal of dermatology, 2007, Volume: 157, Issue:5

    Topics: Anti-Infective Agents; Austria; Calcium Channel Blockers; Case-Control Studies; Diltiazem; Drug Erup

2007
Sirolimus-induced inflammatory papules with acquired reactive perforating collagenosis.
    Dermatology (Basel, Switzerland), 2008, Volume: 216, Issue:3

    Topics: Acneiform Eruptions; Anti-Inflammatory Agents; Collagen; Collagen Diseases; Drug Eruptions; Female;

2008
Discoid lupus erythematosus and porphyria cutanea tarda.
    Journal of the Royal Society of Medicine, 1996, Volume: 89, Issue:9

    Topics: Adult; Drug Eruptions; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Discoid; Male; Porph

1996
Generalized pustular drug rash induced by hydroxychloroquine.
    Acta dermato-venereologica, 1990, Volume: 70, Issue:3

    Topics: Aged; Drug Eruptions; Humans; Hydroxychloroquine; Male; Pemphigus; Skin Diseases, Vesiculobullous

1990
Erythema annulare centrifugum: an unusual case due to hydroxychloroquine sulfate.
    Cutis, 1985, Volume: 36, Issue:2

    Topics: Drug Eruptions; Erythema Multiforme; Female; Humans; Hydroxychloroquine; Middle Aged; Skin

1985
[Electrometric demonstration of hypersensitivity to antirheumatic drugs].
    Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 237, Issue:1

    Topics: Anti-Inflammatory Agents; Antimalarials; Drug Eruptions; Gold; Humans; Hydroxychloroquine; Methods;

1970