hydroxychloroquine has been researched along with Colonic Neoplasms in 4 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, a systematic determination of the optimal dosage of combined LipSHK and LipHCQa suggested that autophagy inhibiting at an appropriate dosage level was beneficial for maximizing ICD-based antitumor immunity." | 1.72 | Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. ( Cai, W; He, Z; Li, J; Li, X; Liu, H; Ouyang, D; Wang, Y; Yu, J; Zhou, S, 2022) |
| "Hypoxic microenvironment of colon cancer is associated with HIF-1α upregulation." | 1.72 | Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells. ( Allam, S; El-Sisi, A; Elsebaey, S; Zakaria, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Cai, W | 1 |
| Yu, J | 1 |
| Zhou, S | 1 |
| Li, X | 1 |
| He, Z | 1 |
| Ouyang, D | 1 |
| Liu, H | 1 |
| Wang, Y | 1 |
| Zakaria, S | 1 |
| Elsebaey, S | 1 |
| Allam, S | 1 |
| El-Sisi, A | 1 |
| Dolloff, NG | 1 |
| Ma, X | 1 |
| Dicker, DT | 1 |
| Humphreys, RC | 1 |
| Li, LZ | 1 |
| El-Deiry, WS | 1 |
| McAfee, Q | 1 |
| Zhang, Z | 1 |
| Samanta, A | 1 |
| Levi, SM | 1 |
| Ma, XH | 1 |
| Piao, S | 1 |
| Lynch, JP | 1 |
| Uehara, T | 1 |
| Sepulveda, AR | 1 |
| Davis, LE | 1 |
| Winkler, JD | 1 |
| Amaravadi, RK | 1 |
4 other studies available for hydroxychloroquine and Colonic Neoplasms
| Article | Year |
|---|---|
Autophagy inhibition recovers deficient ICD-based cancer immunotherapy.
Topics: Adenosine Triphosphate; Autophagy; Cell Line, Tumor; Colonic Neoplasms; Humans; Hydroxychloroquine; | 2022 |
Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells.
Topics: Autophagy; Caspase 3; Cell Hypoxia; Cell Proliferation; Colonic Neoplasms; Epithelial Cell Adhesion | 2022 |
Spectral imaging-based methods for quantifying autophagy and apoptosis.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Autophagy; Caspase 8; Cell Line, Tumor; Colonic Neoplasm | 2011 |
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.
Topics: Adenocarcinoma; Aminoquinolines; Animals; Antimalarials; Antineoplastic Agents; Autophagy; Autophagy | 2012 |