hydroxychloroquine has been researched along with Cancer of Ovary in 5 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 5.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| "PGCCs have been observed in ovarian cancer histology, including the deadly and common form high-grade serous ovarian carcinoma (HGSC)." | 1.72 | Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs). ( Andrade, MF; Bowers, RR; Delaney, JR; Jones, CM; Voelkel-Johnson, C; White-Gilbertson, S, 2022) |
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 1.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bowers, RR | 1 |
| Andrade, MF | 1 |
| Jones, CM | 1 |
| White-Gilbertson, S | 1 |
| Voelkel-Johnson, C | 1 |
| Delaney, JR | 1 |
| Marastoni, S | 1 |
| Madariaga, A | 1 |
| Pesic, A | 1 |
| Nair, SN | 1 |
| Li, ZJ | 1 |
| Shalev, Z | 1 |
| Ketela, T | 1 |
| Colombo, I | 1 |
| Mandilaras, V | 1 |
| Cabanero, M | 1 |
| Bruce, JP | 1 |
| Li, X | 1 |
| Garg, S | 1 |
| Wang, L | 1 |
| Chen, EX | 1 |
| Gill, S | 1 |
| Dhani, NC | 1 |
| Zhang, W | 1 |
| Pintilie, M | 1 |
| Bowering, V | 1 |
| Koritzinsky, M | 1 |
| Rottapel, R | 1 |
| Wouters, BG | 1 |
| Oza, AM | 1 |
| Joshua, AM | 1 |
| Lheureux, S | 1 |
| Gao, L | 1 |
| Wang, Z | 1 |
| Lu, D | 1 |
| Huang, J | 1 |
| Liu, J | 1 |
| Hong, L | 1 |
| Miyamoto, M | 1 |
| Takano, M | 1 |
| Aoyama, T | 1 |
| Soyama, H | 1 |
| Yoshikawa, T | 1 |
| Tsuda, H | 1 |
| Furuya, K | 1 |
| Wang, J | 1 |
| Garbutt, C | 1 |
| Ma, H | 1 |
| Gao, P | 1 |
| Hornicek, FJ | 1 |
| Kan, Q | 1 |
| Shi, H | 1 |
| Duan, Z | 1 |
5 other studies available for hydroxychloroquine and Cancer of Ovary
| Article | Year |
|---|---|
Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs).
Topics: Apoptosis; Autophagy; Carboplatin; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Docetaxel; Femal | 2022 |
Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.
Topics: Antifungal Agents; Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Chloroquine; Drug Repositio | 2022 |
Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells.
Topics: Acetophenones; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; C | 2019 |
Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas.
Topics: Adenocarcinoma, Clear Cell; Adult; Aged; Antineoplastic Agents; Autophagy; Autophagy-Related Protein | 2017 |
Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Movement; | 2018 |