hydroxychloroquine has been researched along with Breast Neoplasms in 20 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Estrogen receptor-α (ERα)-targeted therapies including tamoxifen (TAM) or Faslodex (ICI) are used to treat ER(+) breast cancers." | 7.80 | Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. ( Clarke, PA; Clarke, R; Cook, KL; Cruz, MI; Soto-Pantoja, DR; Wärri, A; Zwart, A, 2014) |
| " However, HCQ pharmacodynamic (PD) responses are difficult to assess in patients, and preclinical studies in mouse models are equivocal with regard to HCQ exposure and inhibition of autophagy." | 5.62 | Pharmacokinetic and Pharmacodynamic Assessment of Hydroxychloroquine in Breast Cancer. ( Gustafson, DL; Van Eaton, KM, 2021) |
| "Autophagy inhibitor hydroxychloroquine (HCQ) was used to identify the sensitivity of breast cancer subtypes to autophagy inhibition in the present study." | 3.91 | Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition. ( Du, Y; Wang, J; Wang, P, 2019) |
| "Estrogen receptor-α (ERα)-targeted therapies including tamoxifen (TAM) or Faslodex (ICI) are used to treat ER(+) breast cancers." | 3.80 | Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. ( Clarke, PA; Clarke, R; Cook, KL; Cruz, MI; Soto-Pantoja, DR; Wärri, A; Zwart, A, 2014) |
| "However, the role of autophagy in breast cancer cells cotreated with doxorubicin and ixazomib remains unclear." | 1.72 | Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells. ( Foo, JB; Loh, JS; Rahim, NA; Tor, YS, 2022) |
| "A 69-year-old female patient with breast cancer experienced severe skin itching and rashes on the face, anterior chest wall, back, and trunk for two days before admission." | 1.72 | A case report of secondary synchronous diagnosis of multiple myeloma and systemic lupus erythematosus after breast cancer treatment: A CARE-compliant article. ( Chen, PH; Huang, KP; Lin, CH; Lin, CY; Ni, YL; Tung, HH, 2022) |
| " However, HCQ pharmacodynamic (PD) responses are difficult to assess in patients, and preclinical studies in mouse models are equivocal with regard to HCQ exposure and inhibition of autophagy." | 1.62 | Pharmacokinetic and Pharmacodynamic Assessment of Hydroxychloroquine in Breast Cancer. ( Gustafson, DL; Van Eaton, KM, 2021) |
| " We found that the sonodynamic therapy (SDT) in low dosage induced autophagy and might function as a survival pathway for breast cancer and exhibit resistance to SDT-mediated apoptosis." | 1.51 | Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy. ( Feng, Q; Feng, X; Hao, Y; Hou, L; Wang, N; Yang, X; Zhang, Z, 2019) |
| "Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant tumour cells." | 1.48 | Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. ( Green, JE; Hunter, KW; Nini, R; Vera-Ramirez, L; Vodnala, SK, 2018) |
| "The effect of systemic lupus erythematosus (SLE) treatment drugs on PKC (protein kinase C) activity and cell growth was studied using GI-101A breast tumor cells." | 1.31 | Effect of systemic lupus erythematosus (SLE) treatment drugs on GI-101A breast tumor cell growth. ( Fernandez, Y; Ramakrishnan, R; Rathinavelu, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 9 (45.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Eaton, KM | 1 |
| Gustafson, DL | 1 |
| Rojas-Sanchez, G | 1 |
| García-Miranda, A | 1 |
| Montes-Alvarado, JB | 1 |
| Cotzomi-Ortega, I | 1 |
| Sarmiento-Salinas, FL | 1 |
| Jimenez-Ignacio, EE | 1 |
| Ramírez-Ramírez, D | 1 |
| Romo-Rodríguez, RE | 1 |
| Reyes-Leyva, J | 1 |
| Vallejo-Ruiz, V | 1 |
| Pazos-Salazar, NG | 1 |
| Maycotte, P | 1 |
| He, Y | 1 |
| Xu, Y | 1 |
| Huang, Y | 1 |
| Quang, H | 1 |
| Xia, X | 1 |
| Zhao, H | 1 |
| Xiao, Y | 1 |
| Lu, W | 1 |
| Yu, J | 1 |
| Ren, K | 1 |
| He, J | 1 |
| Qiu, Y | 1 |
| Xu, Z | 1 |
| Wang, X | 1 |
| Li, J | 2 |
| Zang, S | 1 |
| Yang, Y | 1 |
| Long, Y | 1 |
| Zhang, Z | 2 |
| Li, M | 1 |
| He, Q | 1 |
| Loh, JS | 1 |
| Rahim, NA | 1 |
| Tor, YS | 1 |
| Foo, JB | 1 |
| Gao, G | 1 |
| Jiang, YW | 1 |
| Zhan, W | 1 |
| Liu, X | 1 |
| Tang, R | 1 |
| Sun, X | 1 |
| Deng, Y | 1 |
| Xu, L | 1 |
| Liang, G | 1 |
| Chen, PH | 1 |
| Tung, HH | 1 |
| Lin, CH | 1 |
| Huang, KP | 1 |
| Ni, YL | 1 |
| Lin, CY | 1 |
| Feng, Q | 1 |
| Yang, X | 1 |
| Hao, Y | 1 |
| Wang, N | 1 |
| Feng, X | 1 |
| Hou, L | 1 |
| Wang, P | 1 |
| Du, Y | 1 |
| Wang, J | 1 |
| Spezzani, V | 1 |
| Piunno, A | 1 |
| Iselin, HU | 1 |
| Rogado, J | 1 |
| Gullón, P | 1 |
| Obispo, B | 1 |
| Serrano, G | 1 |
| Lara, MÁ | 1 |
| Marmor, MF | 1 |
| Vera-Ramirez, L | 1 |
| Vodnala, SK | 1 |
| Nini, R | 1 |
| Hunter, KW | 1 |
| Green, JE | 1 |
| Durmaz, EÖ | 1 |
| Atalar, B | 1 |
| Sezer, E | 1 |
| Özyar, E | 1 |
| Çetin, ED | 1 |
| Dragowska, WH | 1 |
| Weppler, SA | 1 |
| Wang, JC | 1 |
| Wong, LY | 1 |
| Kapanen, AI | 1 |
| Rawji, JS | 1 |
| Warburton, C | 1 |
| Qadir, MA | 1 |
| Donohue, E | 1 |
| Roberge, M | 1 |
| Gorski, SM | 1 |
| Gelmon, KA | 1 |
| Bally, MB | 1 |
| Cook, KL | 1 |
| Wärri, A | 1 |
| Soto-Pantoja, DR | 1 |
| Clarke, PA | 1 |
| Cruz, MI | 1 |
| Zwart, A | 1 |
| Clarke, R | 1 |
| Kim, HJ | 1 |
| Lee, SY | 1 |
| Kim, CY | 1 |
| Kim, YH | 1 |
| Ju, W | 1 |
| Kim, SC | 1 |
| Rahim, R | 1 |
| Strobl, JS | 1 |
| Fernandez, Y | 1 |
| Ramakrishnan, R | 1 |
| Rathinavelu, A | 1 |
| Utley, JF | 1 |
| Sachatello, CR | 1 |
| Maruyama, Y | 1 |
| Avila, J | 1 |
| King, R | 1 |
20 other studies available for hydroxychloroquine and Breast Neoplasms
| Article | Year |
|---|---|
Pharmacokinetic and Pharmacodynamic Assessment of Hydroxychloroquine in Breast Cancer.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inh | 2021 |
Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines.
Topics: Breast Neoplasms; Cadherins; Cell Line; Cell Line, Tumor; Chloroquine; Epithelial-Mesenchymal Transi | 2021 |
Redox sensitive nano-capsules self-assembled from hyaluronic acid-hydroxychloroquine conjugates for CD44-targeted delivery of hydroxychloroquine to combat breast cancer metastasis in vitro and in vivo.
Topics: Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Hyaluronan Receptors; Hya | 2022 |
A neutrophil-mediated carrier regulates tumor stemness by inhibiting autophagy to prevent postoperative triple-negative breast cancer recurrence and metastasis.
Topics: Autophagy; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxychloroquine; Inflammation; Lip | 2022 |
Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells.
Topics: Apoptosis; Autophagy; Beclin-1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; | 2022 |
Trident Molecule with Nanobrush-Nanoparticle-Nanofiber Transition Property Spatially Suppresses Tumor Metastasis.
Topics: Breast Neoplasms; Camptothecin; Cell Line, Tumor; Female; Humans; Hydroxychloroquine; Nanofibers; Na | 2022 |
A case report of secondary synchronous diagnosis of multiple myeloma and systemic lupus erythematosus after breast cancer treatment: A CARE-compliant article.
Topics: Aged; Antibodies, Monoclonal; Breast Neoplasms; Female; Glycoproteins; Humans; Hydrocortisone; Hydro | 2022 |
Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy.
Topics: Animals; Autophagy; Biomimetics; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Female; Humans; | 2019 |
Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition.
Topics: Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Female; Humans | 2019 |
Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple.
Topics: Anti-Bacterial Agents; Antiviral Agents; Betacoronavirus; Breast Neoplasms; Cobicistat; Coronavirus | 2020 |
Prolonged SARS-CoV-2 viral shedding in patients with solid tumours and associated factors.
Topics: Adenosine Monophosphate; Aged; Alanine; Antineoplastic Agents; Antiviral Agents; Breast Neoplasms; C | 2021 |
Hydroxychloroquine During Cancer Therapy.
Topics: Breast Neoplasms; Drug Therapy, Combination; Eye Diseases; Humans; Hydroxychloroquine | 2019 |
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Breast Neoplasms; Caspases; Cell | 2018 |
Cutaneous lupus erythematosus induced by radiotherapy for breast carcinoma.
Topics: Adult; Breast; Breast Diseases; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Thera | 2019 |
Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Aut | 2013 |
Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer.
Topics: Animals; Apoptosis; Autophagy; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Proli | 2014 |
Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Aminopyridines; Antineoplastic Combined Chemotherap | 2017 |
Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells.
Topics: Acetylation; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferat | 2009 |
Effect of systemic lupus erythematosus (SLE) treatment drugs on GI-101A breast tumor cell growth.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxychloroquine; Lupus Erythemato | 2000 |
Radiosensitization of normal tissue by chloroquine.
Topics: Animals; Arthritis, Rheumatoid; Breast Neoplasms; Female; Humans; Hydroxychloroquine; Middle Aged; R | 1977 |