hydroxychloroquine has been researched along with Berger Disease in 13 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present meta-analysis was to explore the efficacy of hydroxychloroquine (HCQ) in IgA nephropathy patients in terms of proteinuria." | 9.12 | Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis. ( Feng, J; Li, H; Lu, X; Wang, S; Zhang, J, 2021) |
| "Hydroxychloroquine (HCQ) is a well-known immunomodulator that is useful as in the treatment for lupus because of its inhibitory effect on toll-like receptors and cytokines, which are speculated to play a role in the pathogenesis of Immunoglobulin A (IgA) nephropathy (IgAN)." | 5.48 | Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy. ( Chen, YQ; Liu, LJ; Lv, JC; Shi, SF; Wang, JW; Yang, YZ; Zhang, H, 2018) |
| "Hydroxychloroquine (HCQ) is an antimalarial agent and had a notable impact on immune activation by the reduction of circulating activated immune cells that including decreased TLR-expressing cells, reduced IFN-secreting DCs, reduced production of cytokines including IFN-α,IL-6 and TNF-α." | 5.46 | Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy. ( Gao, R; Li, X; Wen, Y; Wu, W, 2017) |
| "The present meta-analysis was to explore the efficacy of hydroxychloroquine (HCQ) in IgA nephropathy patients in terms of proteinuria." | 5.12 | Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis. ( Feng, J; Li, H; Lu, X; Wang, S; Zhang, J, 2021) |
| "Hydroxychloroquine (HCQ) is recommended as a treatment for IgA nephropathy (IgAN) to control proteinuria." | 4.31 | Comparison between hydroxychloroquine and systemic corticosteroids in IgA nephropathy: a two-year follow-up study. ( Liu, LJ; Lv, JC; Shi, SF; Si, FL; Tang, C; Zhang, H; Zhou, XJ, 2023) |
| "Hydroxychloroquine (HCQ) has recently been reported to be a promising and safe anti-proteinuric agent for IgA nephropathy (IgAN) patients." | 2.72 | Hydroxychloroquine in IgA nephropathy: a systematic review. ( Mircescu, G; Stefan, G, 2021) |
| "Hydroxychloroquine (HCQ) is a classical antimalarial drug used to treat autoimmune diseases." | 2.61 | Immunosuppressive effect of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via regulating the differentiation of CD4+ T cell subsets in rats. ( Bai, L; Chen, D; Chen, J; Li, H; Li, J; Liang, C; Liu, B; Liu, X; Lu, R; Pang, Y; Song, J; Wu, J; Zhang, P; Zhou, J; Zhou, Y, 2019) |
| "HCQ is safe for IgAN treatment during pregnancy with effective reduction of proteinuria." | 1.72 | The efficacy and safety of hydroxychloroquine in pregnant patients with IgA nephropathy: A retrospective cohort study. ( Chen, YQ; Liu, LJ; Lv, JC; Shi, SF; Si, FL; Tang, C; Yao, YX; Zhang, H, 2022) |
| "Hydroxychloroquine (HCQ) is a well-known immunomodulator that was recently used in immunoglobulin A (IgA) nephropathy (IgAN) due to its antiproteinuric effects." | 1.56 | Effect of hydroxychloroquine in patients with IgA nephropathy with insufficient responses to immunosuppressive therapy: a retrospective case-control study. ( Chen, YQ; Liu, LJ; Lv, JC; Shi, SF; Tang, C; Zhang, H, 2020) |
| "Hydroxychloroquine (HCQ) is a classical antimalarial drug applied in the treatment of autoimmune diseases." | 1.51 | Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats. ( Bai, L; Chen, J; Li, H; Li, J; Liang, C; Liu, B; Liu, X; Lu, R; Pang, Y; Song, J; Wu, J; Zhang, P; Zhou, J; Zhou, Y, 2019) |
| "Hydroxychloroquine (HCQ) is a well-known immunomodulator that is useful as in the treatment for lupus because of its inhibitory effect on toll-like receptors and cytokines, which are speculated to play a role in the pathogenesis of Immunoglobulin A (IgA) nephropathy (IgAN)." | 1.48 | Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy. ( Chen, YQ; Liu, LJ; Lv, JC; Shi, SF; Wang, JW; Yang, YZ; Zhang, H, 2018) |
| "Hydroxychloroquine (HCQ) is an antimalarial agent and had a notable impact on immune activation by the reduction of circulating activated immune cells that including decreased TLR-expressing cells, reduced IFN-secreting DCs, reduced production of cytokines including IFN-α,IL-6 and TNF-α." | 1.46 | Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy. ( Gao, R; Li, X; Wen, Y; Wu, W, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Li, W | 1 |
| Jiang, H | 1 |
| Tang, C | 3 |
| Si, FL | 2 |
| Yao, YX | 1 |
| Lv, JC | 6 |
| Shi, SF | 6 |
| Chen, YQ | 5 |
| Liu, LJ | 6 |
| Zhang, H | 6 |
| Stefan, G | 1 |
| Mircescu, G | 1 |
| Zhang, J | 1 |
| Lu, X | 1 |
| Feng, J | 1 |
| Li, H | 3 |
| Wang, S | 1 |
| Zhou, XJ | 1 |
| Bai, L | 2 |
| Li, J | 2 |
| Song, J | 2 |
| Zhou, Y | 2 |
| Lu, R | 2 |
| Liu, B | 2 |
| Pang, Y | 2 |
| Zhang, P | 2 |
| Chen, J | 2 |
| Liu, X | 2 |
| Wu, J | 2 |
| Liang, C | 2 |
| Zhou, J | 2 |
| Gao, R | 1 |
| Wu, W | 1 |
| Wen, Y | 1 |
| Li, X | 1 |
| Yang, YZ | 3 |
| Wang, JW | 1 |
| Chen, D | 1 |
| Bao, YF | 1 |
| Yang, C | 1 |
| Zhu, SN | 1 |
| Sui, GL | 1 |
| Floege, J | 1 |
| Chen, P | 1 |
| Cai, QQ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02942381] | Phase 2 | 60 participants (Actual) | Interventional | 2016-09-13 | Completed | ||
| Efficacy and Safety of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)[NCT04937907] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-09-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydroxychloroquine and Berger Disease
| Article | Year |
|---|---|
Hydroxychloroquine in IgA nephropathy: a systematic review.
Topics: Angiotensin-Converting Enzyme Inhibitors; Glomerulonephritis, IGA; Humans; Hydroxychloroquine; Immun | 2021 |
Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis.
Topics: Glomerulonephritis, IGA; Humans; Hydroxychloroquine; Immunoglobulin A; Proteinuria; Renin-Angiotensi | 2021 |
Immunosuppressive effect of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via regulating the differentiation of CD4+ T cell subsets in rats.
Topics: Animals; Antigen-Antibody Complex; Artemisia annua; Artemisinins; CD4 Antigens; Cell Differentiation | 2019 |
1 trial available for hydroxychloroquine and Berger Disease
| Article | Year |
|---|---|
Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial.
Topics: Adult; Creatinine; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glo | 2019 |
Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial.
Topics: Adult; Creatinine; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glo | 2019 |
Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial.
Topics: Adult; Creatinine; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glo | 2019 |
Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Randomized Controlled Trial.
Topics: Adult; Creatinine; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glo | 2019 |
9 other studies available for hydroxychloroquine and Berger Disease
| Article | Year |
|---|---|
Vitamin D and hydroxychloroquine reduce renal injury and Ki67 expression in a rat model of IgA nephropathy via TLR4.
Topics: Animals; Glomerulonephritis, IGA; Hydroxychloroquine; Ki-67 Antigen; Kidney; Rats; Toll-Like Recepto | 2021 |
The efficacy and safety of hydroxychloroquine in pregnant patients with IgA nephropathy: A retrospective cohort study.
Topics: Adult; Cohort Studies; Female; Glomerulonephritis, IGA; Humans; Hydroxychloroquine; Kidney Function | 2022 |
Comparison between hydroxychloroquine and systemic corticosteroids in IgA nephropathy: a two-year follow-up study.
Topics: Adrenal Cortex Hormones; Case-Control Studies; Follow-Up Studies; Glomerular Filtration Rate; Glomer | 2023 |
Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats.
Topics: Aniline Compounds; Animals; Artemisinins; Benzylidene Compounds; Cells, Cultured; Drug Therapy, Comb | 2019 |
Effect of hydroxychloroquine in patients with IgA nephropathy with insufficient responses to immunosuppressive therapy: a retrospective case-control study.
Topics: Adrenal Cortex Hormones; Adult; Case-Control Studies; Drug Therapy, Combination; Female; Glomerulone | 2020 |
Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antimalarials; Blood Pressure; Case-Control Studies; | 2017 |
Effects of Hydroxychloroquine on Proteinuria in Immunoglobulin A Nephropathy.
Topics: Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Drug Therapy, Com | 2018 |
Antimalarials in IgA Nephropathy: Did Our Supportive Therapy Armamentarium Just Increase?
Topics: Antimalarials; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Hydroxychloroquine; Prot | 2019 |
Comparison of the effects of hydroxychloroquine and corticosteroid treatment on proteinuria in IgA nephropathy: a case-control study.
Topics: Adrenal Cortex Hormones; Adult; Case-Control Studies; Female; Glomerular Filtration Rate; Glomerulon | 2019 |