hydroxychloroquine has been researched along with Arthritis, Degenerative in 26 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the symptom-modifying effect of hydroxychloroquine (HCQ) in hand osteoarthritis (OA)." | 9.27 | Efficacy of Hydroxychloroquine in Hand Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Basoski, N; Boxma-de Klerk, B; de Sonnaville, P; Gerards, A; Grillet, B; Hazes, M; Huisman, M; Kloppenburg, M; Kok, MR; Lee, W; Ruijgrok, L; Weel, A, 2018) |
| "To determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment of hand osteoarthritis." | 9.27 | Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial. ( Arden, NK; Arundel, C; Birrell, F; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, K; Garrood, T; Grainger, A; Green, M; Keding, A; Kingsbury, SR; Menon, A; O'Neill, TW; Ronaldson, SJ; Scott, DL; Sheeran, T; Tharmanathan, P; Torgerson, D; Vincent, T; Wakefield, RJ; Watt, FE, 2018) |
| "We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand and to compare it with hydroxychloroquine." | 9.16 | Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study. ( Abdi-Ali, L; Baiardi, P; Benucci, M; Campostrini, L; Manfredi, M; Mannoni, A; Sacco, S; Saviola, G, 2012) |
| "We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis." | 7.96 | Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial. ( Li, QQ; Liang, WQ; Wang, YP; Xie, YD; Yang, GQ; Zhang, HB, 2020) |
| "Hydroxychloroquine (HCQ) is a disease-modifying anti-rheumatic drug (DMARD) typically used for the treatment of various rheumatic and dermatologic diseases." | 6.79 | Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands (OA TREAT): study protocol for a randomized controlled trial. ( Braun, T; Burmester, GR; Buttgereit, F; Detert, J; Höhne-Zimmer, V; Klaus, P; Listing, J; Rau, R; Wassenberg, S, 2014) |
| "Synovitis is prevalent in OA and is associated with pain." | 6.78 | Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013) |
| "Hydroxychloroquine (10 µM) treatment induced the phosphorylation of ERK, SAPK/JNK and p38." | 5.42 | 15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes. ( Chang, SH; Kim, HJ; Lee, HY; Lee, S; Nah, SS; Won, H, 2015) |
| "Hydroxychloroquine was effective in 6 of the 8 patients treated; it was well tolerated by all patients." | 5.29 | Hydroxychloroquine in the treatment of erosive osteoarthritis. ( Bryant, LR; Carpenter, MT; des Rosier, KF, 1995) |
| "To determine the symptom-modifying effect of hydroxychloroquine (HCQ) in hand osteoarthritis (OA)." | 5.27 | Efficacy of Hydroxychloroquine in Hand Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Basoski, N; Boxma-de Klerk, B; de Sonnaville, P; Gerards, A; Grillet, B; Hazes, M; Huisman, M; Kloppenburg, M; Kok, MR; Lee, W; Ruijgrok, L; Weel, A, 2018) |
| "To determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment of hand osteoarthritis." | 5.27 | Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial. ( Arden, NK; Arundel, C; Birrell, F; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, K; Garrood, T; Grainger, A; Green, M; Keding, A; Kingsbury, SR; Menon, A; O'Neill, TW; Ronaldson, SJ; Scott, DL; Sheeran, T; Tharmanathan, P; Torgerson, D; Vincent, T; Wakefield, RJ; Watt, FE, 2018) |
| " We found statistically significant improvement of pain and stiffness with methotrexate, especially in knee OA." | 5.22 | Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis. ( Mathieu, S; Sellam, J; Soubrier, M; Tournadre, A, 2022) |
| "We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand and to compare it with hydroxychloroquine." | 5.16 | Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study. ( Abdi-Ali, L; Baiardi, P; Benucci, M; Campostrini, L; Manfredi, M; Mannoni, A; Sacco, S; Saviola, G, 2012) |
| "We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis." | 3.96 | Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial. ( Li, QQ; Liang, WQ; Wang, YP; Xie, YD; Yang, GQ; Zhang, HB, 2020) |
| "To investigate the effects of tenidap, a new antirheumatic drug, sodium diclofenac, a non-steroidal antiinflammatory drug, and a disease modifying antirheumatic drug, hydroxychloroquine, on the level and expression of interleukin 1 receptors (IL-1R) on synovial fibroblasts from patients with osteoarthritis (OA) and rheumatoid arthritis (RA)." | 3.69 | Tenidap reduces the level of interleukin 1 receptors and collagenase expression in human arthritic synovial fibroblasts. ( Fernandes, JC; Loose, L; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Ranger, P; Tardif, G, 1996) |
| "Hydroxychloroquine (HCQ) is a disease-modifying anti-rheumatic drug (DMARD) typically used for the treatment of various rheumatic and dermatologic diseases." | 2.79 | Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands (OA TREAT): study protocol for a randomized controlled trial. ( Braun, T; Burmester, GR; Buttgereit, F; Detert, J; Höhne-Zimmer, V; Klaus, P; Listing, J; Rau, R; Wassenberg, S, 2014) |
| "Synovitis is prevalent in OA and is associated with pain." | 2.78 | Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013) |
| "The current treatment of osteoarthritis associated with calcium-containing crystals should involve nonsteroidal anti-inflammatory drugs, intra-articular steroids, and in resistant cases, joint irrigation can be considered." | 2.43 | Calcium-containing crystals and osteoarthritis: implications for the clinician. ( Kalunian, KC; Terkeltaub, R; Wu, CW, 2005) |
| "Hydroxychloroquine (10 µM) treatment induced the phosphorylation of ERK, SAPK/JNK and p38." | 1.42 | 15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes. ( Chang, SH; Kim, HJ; Lee, HY; Lee, S; Nah, SS; Won, H, 2015) |
| "Erosive hand osteoarthritis is common and debilitating." | 1.39 | [Erosive hand osteoarthritis]. ( Gabay, C; So, AK; Van Linthoudt, D, 2013) |
| "Hydroxychloroquine was effective in 6 of the 8 patients treated; it was well tolerated by all patients." | 1.29 | Hydroxychloroquine in the treatment of erosive osteoarthritis. ( Bryant, LR; Carpenter, MT; des Rosier, KF, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Ronaldson, SJ | 2 |
| Keding, A | 2 |
| Tharmanathan, P | 3 |
| Arundel, C | 2 |
| Kingsbury, SR | 3 |
| Conaghan, PG | 3 |
| Torgerson, DJ | 2 |
| Mathieu, S | 1 |
| Tournadre, A | 1 |
| Soubrier, M | 1 |
| Sellam, J | 1 |
| Chen, H | 1 |
| Qin, Z | 1 |
| Zhao, J | 1 |
| He, Y | 1 |
| Ren, E | 1 |
| Zhu, Y | 1 |
| Liu, G | 1 |
| Mao, C | 1 |
| Zheng, L | 1 |
| Li, QQ | 1 |
| Xie, YD | 1 |
| Liang, WQ | 1 |
| Yang, GQ | 1 |
| Zhang, HB | 1 |
| Wang, YP | 1 |
| Kedor, C | 1 |
| Detert, J | 2 |
| Rau, R | 2 |
| Wassenberg, S | 2 |
| Listing, J | 2 |
| Klaus, P | 2 |
| Braun, T | 2 |
| Hermann, W | 1 |
| Weiner, SM | 1 |
| Buttgereit, F | 2 |
| Burmester, GR | 2 |
| Lee, W | 1 |
| Ruijgrok, L | 1 |
| Boxma-de Klerk, B | 1 |
| Kok, MR | 1 |
| Kloppenburg, M | 1 |
| Gerards, A | 1 |
| Huisman, M | 1 |
| Hazes, M | 1 |
| de Sonnaville, P | 1 |
| Grillet, B | 1 |
| Weel, A | 1 |
| Basoski, N | 1 |
| Losina, E | 1 |
| Katz, JN | 1 |
| Grainger, A | 2 |
| Wakefield, RJ | 2 |
| Birrell, F | 2 |
| Doherty, M | 2 |
| Vincent, T | 1 |
| Watt, FE | 2 |
| Dziedzic, K | 1 |
| O'Neill, TW | 2 |
| Arden, NK | 2 |
| Scott, DL | 2 |
| Dickson, J | 2 |
| Garrood, T | 1 |
| Green, M | 1 |
| Menon, A | 1 |
| Sheeran, T | 1 |
| Torgerson, D | 1 |
| Adamson, J | 1 |
| Cockayne, S | 1 |
| Dziedzic, KS | 1 |
| Hewitt, CE | 1 |
| Vincent, TL | 1 |
| Van Linthoudt, D | 1 |
| Gabay, C | 1 |
| So, AK | 1 |
| Höhne-Zimmer, V | 1 |
| Kim, HJ | 1 |
| Lee, S | 1 |
| Lee, HY | 1 |
| Won, H | 1 |
| Chang, SH | 1 |
| Nah, SS | 1 |
| Saviola, G | 1 |
| Abdi-Ali, L | 1 |
| Campostrini, L | 1 |
| Sacco, S | 1 |
| Baiardi, P | 1 |
| Manfredi, M | 1 |
| Mannoni, A | 1 |
| Benucci, M | 1 |
| SWEZEY, RL | 1 |
| Wu, CW | 1 |
| Terkeltaub, R | 1 |
| Kalunian, KC | 1 |
| Contreras Blasco, MA | 1 |
| Bryant, LR | 1 |
| des Rosier, KF | 1 |
| Carpenter, MT | 1 |
| Spencer-Green, G | 1 |
| Martel-Pelletier, J | 1 |
| Mineau, F | 1 |
| Tardif, G | 1 |
| Fernandes, JC | 1 |
| Ranger, P | 1 |
| Loose, L | 1 |
| Pelletier, JP | 1 |
| Punzi, L | 1 |
| Bertazzolo, N | 1 |
| Pianon, M | 1 |
| Michelotto, M | 1 |
| Todesco, S | 1 |
| Wildy, KS | 1 |
| Wasko, MC | 1 |
| Kolodny, AL | 1 |
| Klipper, AR | 1 |
| Reardon, EV | 1 |
| Clough, JD | 1 |
| Caldwell, CW | 1 |
| Bridges, AJ | 1 |
| Walker, SE | 1 |
| Smarr, KL | 1 |
| Reichert, RJ | 1 |
| Anderson, SK | 1 |
| Hewett, JE | 1 |
| Parker, JC | 1 |
| Kitridou, RC | 1 |
| Solomon, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacological Treatment In Osteoarthritis[NCT01148043] | Phase 3 | 200 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Hydroxychloroquine Assessment of Management Study in Coronary Artery Disease After Angiography.[NCT02874287] | Phase 4 | 35 participants (Actual) | Interventional | 2017-10-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for hydroxychloroquine and Arthritis, Degenerative
| Article | Year |
|---|---|
Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis.
Topics: Antirheumatic Agents; Humans; Hydroxychloroquine; Inflammation; Interleukin-1; Methotrexate; Osteoar | 2022 |
Calcium-containing crystals and osteoarthritis: implications for the clinician.
Topics: Antirheumatic Agents; Biomarkers; Calcium; Cartilage, Articular; Colchicine; Glucocorticoids; Gout S | 2005 |
[Erosive or inflammatory osteoarthritis: the great unknown].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Psoriatic; Diagnosis, Differential; Finge | 2007 |
Drug treatment of arthritis. Update on conventional and less conventional methods.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aurothioglu | 1993 |
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumat | 2001 |
The patient with rheumatoid arthritis.
Topics: Activities of Daily Living; Arthritis, Rheumatoid; Bursitis; Chloroquine; Diagnosis, Differential; F | 1971 |
7 trials available for hydroxychloroquine and Arthritis, Degenerative
| Article | Year |
|---|---|
Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands: results of the OA-TREAT study-a randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial.
Topics: Australia; Canada; Humans; Hydroxychloroquine; Osteoarthritis; Treatment Outcome | 2021 |
Efficacy of Hydroxychloroquine in Hand Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Antirheumatic Agents; Double-Blind Method; Female; Hand; Humans; Hydroxychloroquine; Male; Mi | 2018 |
Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial.
Topics: Antirheumatic Agents; Double-Blind Method; England; Female; Hand; Hand Strength; Humans; Hydroxychlo | 2018 |
Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial.
Topics: Activities of Daily Living; Analgesics; Arthralgia; Clinical Protocols; Costs and Cost Analysis; Dou | 2013 |
Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands (OA TREAT): study protocol for a randomized controlled trial.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biomechanic | 2014 |
Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study.
Topics: Aged; Antirheumatic Agents; Bone Density Conservation Agents; Clodronic Acid; Female; Hand Joints; H | 2012 |
Soluble interleukin 2 receptors and treatment with hydroxychloroquine in erosive osteoarthritis.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Hydroxychloroquine; Osteoarthritis; Receptors, | 1996 |
13 other studies available for hydroxychloroquine and Arthritis, Degenerative
| Article | Year |
|---|---|
Cost-effectiveness of hydroxychloroquine
Topics: Adult; Cost-Benefit Analysis; Humans; Hydroxychloroquine; Osteoarthritis; Quality of Life; State Med | 2021 |
Cartilage-targeting and dual MMP-13/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy.
Topics: Animals; Cartilage, Articular; Cell Death; Chondrocytes; Cytokines; Drug Liberation; Endocytosis; Fe | 2019 |
Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial.
Topics: Antirheumatic Agents; Hand Joints; Humans; Hydroxychloroquine; Meta-Analysis as Topic; Osteoarthriti | 2020 |
Hydroxychloroquine to Reduce Symptoms of Hand Osteoarthritis.
Topics: Antirheumatic Agents; Hand; Hand Strength; Humans; Hydroxychloroquine; Osteoarthritis; Pain Measurem | 2018 |
Hydroxychloroquine: Another Battle Lost in the Campaign to Find Effective Therapies for Hand Osteoarthritis.
Topics: Antirheumatic Agents; Humans; Hydroxychloroquine; Osteoarthritis | 2018 |
[Erosive hand osteoarthritis].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Apatites; Chondroitin Sul | 2013 |
15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Fibroblasts; Humans; Hydroxychloroquine; Hydroxyprostaglandi | 2015 |
PRIMARY GENERALIZED OSTEOARTHRITIS: CASE REPORT WITH KNEE-JOINT FLUID ANALYSIS.
Topics: Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy; Humans; Hydrocortisone; Hyd | 1965 |
Hydroxychloroquine in the treatment of erosive osteoarthritis.
Topics: Antirheumatic Agents; Female; Hand; Humans; Hydroxychloroquine; Osteoarthritis; Outcome Assessment, | 1995 |
Tenidap reduces the level of interleukin 1 receptors and collagenase expression in human arthritic synovial fibroblasts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Northern; Cells, Cultured; | 1996 |
Bone and joint diseases in the elderly.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents; Ar | 1976 |
Drug therapy in the rheumatic diseases.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Gold; Huma | 1992 |
A controlled study of lymphocyte subsets in rheumatoid arthritis.
Topics: Aging; Antineoplastic Agents; Arthritis, Rheumatoid; Gold; Humans; Hydroxychloroquine; Lymphocyte Su | 1992 |