Page last updated: 2024-10-28

hydroxychloroquine and Arthralgia

hydroxychloroquine has been researched along with Arthralgia in 21 studies

Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.

Arthralgia: Pain in the joint.

Research Excerpts

ExcerptRelevanceReference
"To compare efficacy and tolerability of combined therapy with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) with MTX-monotherapy in patients with rheumatoid arthritis (RA)."9.13[Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis]. ( Bochkova, AG; Bunchuk, NV; Gubar', EE, 2008)
"Synovitis is prevalent in OA and is associated with pain."6.78Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013)
"Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015."5.51A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus. ( Hashimoto, Y; Kawazoe, M; Kusunoki, N; Nanki, T; Shikano, K; Shindo, E; Yamamoto, T, 2019)
"To compare the pain course between methotrexate (MTX)-refractory early rheumatoid arthritis (RA) patients randomized to infliximab (IFX) versus sulfasalazine (SSZ) plus hydroxychloroquine (HCQ)."5.41Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis: Results From a Swedish Randomized Controlled Trial. ( Ernestam, S; Jöud, A; Lampa, J; Olofsson, T; Saevarsdottir, S; Schelin, MEC; van Vollenhoven, R; Wallman, JK, 2021)
"To compare efficacy and tolerability of combined therapy with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) with MTX-monotherapy in patients with rheumatoid arthritis (RA)."5.13[Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis]. ( Bochkova, AG; Bunchuk, NV; Gubar', EE, 2008)
"Post-chikungunya joint pain (arthritis or arthralgia) is a clinical concern in endemic regions as it may cause a debilitating illness sometimes years after the acute infection."2.82Treatment of chikungunya-associated joint pain: a systematic review of controlled clinical trials. ( Fernando, D; Herath, T; Rajapakse, S; Rodrigo, C; Wickramarachchi, U, 2022)
"Synovitis is prevalent in OA and is associated with pain."2.78Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013)
"Hydroxychloroquine was most frequently used (88."1.62Clinical features and outcomes from the Singapore Sjögren's syndrome study. ( Charan, N; Kam, JK; Leong, RW; Loh, ZW; Thong, BY, 2021)
"Investigations revealed distal renal tubular acidosis with severe metabolic bone disease as an extra-glandular manifestation of primary SS."1.56Primary Sjogren's syndrome manifesting with distal renal tubular acidosis and severe metabolic bone disease. ( Bhandari, S; Jain, G; Kalra, S; Vasnik, G, 2020)
"Rowell's syndrome is a rare disorder characterised by an association of lupus erythematosus with erythema multiforme (EM)-like skin lesions."1.56Rowell's syndrome: a rare but distinct entity in rheumatology. ( Chandra, A; Karmakar, P; Ray, AK; Saha, SK, 2020)
"Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015."1.51A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus. ( Hashimoto, Y; Kawazoe, M; Kusunoki, N; Nanki, T; Shikano, K; Shindo, E; Yamamoto, T, 2019)
"Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions."1.42[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome]. ( Bellakhal, S; Ben Kaab, B; Derbel, F; Douggui, MH; Souissi, A; Teyeb, Z, 2015)
"We also assessed joint pain determined by patient visual analog scale (VAS), malaise (VAS), patient global assessment of SLE (VAS), and constitutional and musculoskeletal symptoms according to the British Isles Lupus Assessment Group (BILAG) disease activity index."1.38Response to hydroxychloroquine in Japanese patients with systemic lupus erythematosus using the cutaneous lupus erythematosus disease area and severity index (CLASI). ( Inada, S; Kato, Y; Sugii, S; Yokogawa, N, 2012)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.76)18.2507
2000's4 (19.05)29.6817
2010's10 (47.62)24.3611
2020's6 (28.57)2.80

Authors

AuthorsStudies
Rodrigo, C1
Herath, T1
Wickramarachchi, U1
Fernando, D1
Rajapakse, S1
Olofsson, T1
Wallman, JK1
Jöud, A1
Schelin, MEC1
Ernestam, S1
van Vollenhoven, R1
Saevarsdottir, S1
Lampa, J1
Jain, G1
Kalra, S1
Vasnik, G1
Bhandari, S1
Deane, KD1
Holers, VM1
Chandra, A1
Saha, SK1
Ray, AK1
Karmakar, P1
Kam, JK1
Charan, N1
Leong, RW1
Loh, ZW1
Thong, BY1
Merkesdal, S1
Kirchhoff, T1
Jablonka, A1
Schmidt, RE1
Köhler, L1
Hong, AS1
Desta, M1
Hong, JM1
Ohning, GV1
Pillinger, MH1
Saxena, A1
Modjinou, DV1
Shindo, E1
Shikano, K1
Kawazoe, M1
Yamamoto, T1
Kusunoki, N1
Hashimoto, Y1
Nanki, T1
Kingsbury, SR1
Tharmanathan, P1
Adamson, J1
Arden, NK1
Birrell, F1
Cockayne, S1
Dickson, J1
Doherty, M1
Dziedzic, KS1
Grainger, A1
Hewitt, CE1
O'Neill, TW1
Scott, DL1
Vincent, TL1
Wakefield, RJ1
Watt, FE1
Torgerson, DJ1
Conaghan, PG1
Bellakhal, S1
Ben Kaab, B1
Teyeb, Z1
Souissi, A1
Derbel, F1
Douggui, MH1
Gruber, JR1
Sarro, R1
Delaloye, J1
Surmely, JF1
Siniscalchi, G1
Tozzi, P1
Jaques, C1
Jaton, K1
Delabays, A1
Greub, G1
Rutz, T1
Corzo, P1
Salman-Monte, TC1
Torrente-Segarra, V1
Polino, L1
Mojal, S1
Carbonell-Abelló, J1
Gubar', EE1
Bochkova, AG1
Bunchuk, NV1
Palazzi, C1
D'Angelo, S1
Olivieri, I1
Ravindran, V1
Yokogawa, N1
Kato, Y1
Sugii, S1
Inada, S1
Ikeda, T1
Kanazawa, N1
Furukawa, F1
Sorbara, S1
Cozzani, E1
Rebora, A1
Parodi, A1
Arnson, Y1
Dovrish, Z1
Hadari, R1
Amital, H1
Senécal, JL1
Chartier, S1
Rothfield, N1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Randomized, Open, Multi-Center Trial Comparing TNF-Blockade + MTX to MTX+SSZ+HCQ in Patients With Early RA With an Inadequate Response to MTX[NCT00764725]Phase 4487 participants (Actual)Interventional2002-12-31Completed
Fecal Microbial Transplantation for Rheumatoid Arthritis Trial[NCT05790356]30 participants (Anticipated)Interventional2023-07-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for hydroxychloroquine and Arthralgia

ArticleYear
Treatment of chikungunya-associated joint pain: a systematic review of controlled clinical trials.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2022, 10-02, Volume: 116, Issue:10

    Topics: Anti-Inflammatory Agents; Arthralgia; Chikungunya Fever; Chloroquine; Humans; Hydroxychloroquine; Me

2022
Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift.
    Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:2

    Topics: Alcohol Drinking; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthralgia; Arthritis

2021
Autoimmune Hepatitis A Case Report and Literature Review.
    Bulletin of the Hospital for Joint Disease (2013), 2019, Volume: 77, Issue:2

    Topics: Antirheumatic Agents; Arthralgia; Autoantibodies; Biopsy; Chest Pain; Diagnosis, Differential; Femal

2019
Hepatitis C virus-related arthritis.
    Autoimmunity reviews, 2008, Volume: 8, Issue:1

    Topics: Adrenal Cortex Hormones; Ankle; Antibodies, Viral; Arthralgia; Arthritis, Infectious; Arthritis, Rhe

2008

Trials

3 trials available for hydroxychloroquine and Arthralgia

ArticleYear
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis: Results From a Swedish Randomized Controlled Trial.
    Arthritis care & research, 2021, Volume: 73, Issue:9

    Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Biological Products; Drug Ther

2021
Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial.
    Trials, 2013, Mar-02, Volume: 14

    Topics: Activities of Daily Living; Analgesics; Arthralgia; Clinical Protocols; Costs and Cost Analysis; Dou

2013
[Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis].
    Terapevticheskii arkhiv, 2008, Volume: 80, Issue:5

    Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Dr

2008

Other Studies

14 other studies available for hydroxychloroquine and Arthralgia

ArticleYear
Primary Sjogren's syndrome manifesting with distal renal tubular acidosis and severe metabolic bone disease.
    BMJ case reports, 2020, Jun-01, Volume: 13, Issue:6

    Topics: Absorptiometry, Photon; Acidosis, Renal Tubular; Adolescent; Antirheumatic Agents; Arthralgia; Bone

2020
Rowell's syndrome: a rare but distinct entity in rheumatology.
    BMJ case reports, 2020, Sep-23, Volume: 13, Issue:9

    Topics: Adolescent; Antibodies, Antinuclear; Antipyretics; Arthralgia; Drug Therapy, Combination; Erythema M

2020
Clinical features and outcomes from the Singapore Sjögren's syndrome study.
    Lupus, 2021, Volume: 30, Issue:2

    Topics: Adult; Arthralgia; Azathioprine; Female; Humans; Hydroxychloroquine; Keratoconjunctivitis Sicca; Mal

2021
Patients With Arthralgia and Anti-Citrullinated Peptide Antibody Positivity on Hydroxychloroquine Therapy: An Update on 2 and 3 Years' Follow-up Data of a Pilot Study.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2019, Volume: 25, Issue:7

    Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Arthralgia; Arthritis, Rheumatoid; Chronic Disea

2019
A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus.
    Lupus, 2019, Volume: 28, Issue:8

    Topics: Adult; Antirheumatic Agents; Arthralgia; Female; Humans; Hydroxychloroquine; Japan; Leukapheresis; L

2019
[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome].
    Pathologie-biologie, 2015, Volume: 63, Issue:4-5

    Topics: Adult; Anemia; Arthralgia; Autoantibodies; Complement C3; Critical Care; Facial Dermatoses; Female;

2015
Tropheryma whipplei bivalvular endocarditis and polyarthralgia: a case report.
    Journal of medical case reports, 2015, Nov-18, Volume: 9

    Topics: Aged; Anti-Bacterial Agents; Aortic Valve; Arthralgia; Doxycycline; Echocardiography; Endocarditis,

2015
Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients.
    Lupus, 2017, Volume: 26, Issue:7

    Topics: Adult; Antirheumatic Agents; Arthralgia; Case-Control Studies; Female; Follow-Up Studies; Hand; Huma

2017
Lamotrigine-induced lupus: a case report.
    International journal of rheumatic diseases, 2011, Volume: 14, Issue:3

    Topics: Adolescent; Anticonvulsants; Antirheumatic Agents; Arthralgia; Epilepsy; Female; Humans; Hydroxychlo

2011
Response to hydroxychloroquine in Japanese patients with systemic lupus erythematosus using the cutaneous lupus erythematosus disease area and severity index (CLASI).
    Modern rheumatology, 2012, Volume: 22, Issue:2

    Topics: Adult; Antirheumatic Agents; Arthralgia; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Sy

2012
Hydroxychloroquine administration for Japanese lupus erythematosus in Wakayama: a pilot study.
    The Journal of dermatology, 2012, Volume: 39, Issue:6

    Topics: Adult; Antimalarials; Arthralgia; Asian People; Female; Humans; Hydroxychloroquine; Japan; Lipids; L

2012
Hydroxychloroquine in psoriasis: is it really harmful?
    Acta dermato-venereologica, 2006, Volume: 86, Issue:5

    Topics: Aged; Antimalarials; Arthralgia; Contraindications; Female; Humans; Hydroxychloroquine; Lupus Erythe

2006
Amyopathic dermatomyositis--an uncommon presentation of dermatomyositis.
    The Israel Medical Association journal : IMAJ, 2007, Volume: 9, Issue:6

    Topics: Adult; Arthralgia; Cyclosporine; Dermatologic Agents; Dermatomyositis; Exanthema; Glucocorticoids; H

2007
Hypergammaglobulinemic purpura in systemic autoimmune rheumatic diseases: predictive value of anti-Ro(SSA) and anti-La(SSB) antibodies and treatment with indomethacin and hydroxychloroquine.
    The Journal of rheumatology, 1995, Volume: 22, Issue:5

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents

1995