hydroxychloroquine has been researched along with Arthralgia in 21 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Arthralgia: Pain in the joint.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare efficacy and tolerability of combined therapy with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) with MTX-monotherapy in patients with rheumatoid arthritis (RA)." | 9.13 | [Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis]. ( Bochkova, AG; Bunchuk, NV; Gubar', EE, 2008) |
| "Synovitis is prevalent in OA and is associated with pain." | 6.78 | Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013) |
| "Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015." | 5.51 | A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus. ( Hashimoto, Y; Kawazoe, M; Kusunoki, N; Nanki, T; Shikano, K; Shindo, E; Yamamoto, T, 2019) |
| "To compare the pain course between methotrexate (MTX)-refractory early rheumatoid arthritis (RA) patients randomized to infliximab (IFX) versus sulfasalazine (SSZ) plus hydroxychloroquine (HCQ)." | 5.41 | Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis: Results From a Swedish Randomized Controlled Trial. ( Ernestam, S; Jöud, A; Lampa, J; Olofsson, T; Saevarsdottir, S; Schelin, MEC; van Vollenhoven, R; Wallman, JK, 2021) |
| "To compare efficacy and tolerability of combined therapy with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) with MTX-monotherapy in patients with rheumatoid arthritis (RA)." | 5.13 | [Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis]. ( Bochkova, AG; Bunchuk, NV; Gubar', EE, 2008) |
| "Post-chikungunya joint pain (arthritis or arthralgia) is a clinical concern in endemic regions as it may cause a debilitating illness sometimes years after the acute infection." | 2.82 | Treatment of chikungunya-associated joint pain: a systematic review of controlled clinical trials. ( Fernando, D; Herath, T; Rajapakse, S; Rodrigo, C; Wickramarachchi, U, 2022) |
| "Synovitis is prevalent in OA and is associated with pain." | 2.78 | Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. ( Adamson, J; Arden, NK; Birrell, F; Cockayne, S; Conaghan, PG; Dickson, J; Doherty, M; Dziedzic, KS; Grainger, A; Hewitt, CE; Kingsbury, SR; O'Neill, TW; Scott, DL; Tharmanathan, P; Torgerson, DJ; Vincent, TL; Wakefield, RJ; Watt, FE, 2013) |
| "Hydroxychloroquine was most frequently used (88." | 1.62 | Clinical features and outcomes from the Singapore Sjögren's syndrome study. ( Charan, N; Kam, JK; Leong, RW; Loh, ZW; Thong, BY, 2021) |
| "Investigations revealed distal renal tubular acidosis with severe metabolic bone disease as an extra-glandular manifestation of primary SS." | 1.56 | Primary Sjogren's syndrome manifesting with distal renal tubular acidosis and severe metabolic bone disease. ( Bhandari, S; Jain, G; Kalra, S; Vasnik, G, 2020) |
| "Rowell's syndrome is a rare disorder characterised by an association of lupus erythematosus with erythema multiforme (EM)-like skin lesions." | 1.56 | Rowell's syndrome: a rare but distinct entity in rheumatology. ( Chandra, A; Karmakar, P; Ray, AK; Saha, SK, 2020) |
| "Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015." | 1.51 | A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus. ( Hashimoto, Y; Kawazoe, M; Kusunoki, N; Nanki, T; Shikano, K; Shindo, E; Yamamoto, T, 2019) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatological conditions." | 1.42 | [Systemic lupus erythematosus presenting as Stevens-Johnson syndrome]. ( Bellakhal, S; Ben Kaab, B; Derbel, F; Douggui, MH; Souissi, A; Teyeb, Z, 2015) |
| "We also assessed joint pain determined by patient visual analog scale (VAS), malaise (VAS), patient global assessment of SLE (VAS), and constitutional and musculoskeletal symptoms according to the British Isles Lupus Assessment Group (BILAG) disease activity index." | 1.38 | Response to hydroxychloroquine in Japanese patients with systemic lupus erythematosus using the cutaneous lupus erythematosus disease area and severity index (CLASI). ( Inada, S; Kato, Y; Sugii, S; Yokogawa, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 6 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigo, C | 1 |
| Herath, T | 1 |
| Wickramarachchi, U | 1 |
| Fernando, D | 1 |
| Rajapakse, S | 1 |
| Olofsson, T | 1 |
| Wallman, JK | 1 |
| Jöud, A | 1 |
| Schelin, MEC | 1 |
| Ernestam, S | 1 |
| van Vollenhoven, R | 1 |
| Saevarsdottir, S | 1 |
| Lampa, J | 1 |
| Jain, G | 1 |
| Kalra, S | 1 |
| Vasnik, G | 1 |
| Bhandari, S | 1 |
| Deane, KD | 1 |
| Holers, VM | 1 |
| Chandra, A | 1 |
| Saha, SK | 1 |
| Ray, AK | 1 |
| Karmakar, P | 1 |
| Kam, JK | 1 |
| Charan, N | 1 |
| Leong, RW | 1 |
| Loh, ZW | 1 |
| Thong, BY | 1 |
| Merkesdal, S | 1 |
| Kirchhoff, T | 1 |
| Jablonka, A | 1 |
| Schmidt, RE | 1 |
| Köhler, L | 1 |
| Hong, AS | 1 |
| Desta, M | 1 |
| Hong, JM | 1 |
| Ohning, GV | 1 |
| Pillinger, MH | 1 |
| Saxena, A | 1 |
| Modjinou, DV | 1 |
| Shindo, E | 1 |
| Shikano, K | 1 |
| Kawazoe, M | 1 |
| Yamamoto, T | 1 |
| Kusunoki, N | 1 |
| Hashimoto, Y | 1 |
| Nanki, T | 1 |
| Kingsbury, SR | 1 |
| Tharmanathan, P | 1 |
| Adamson, J | 1 |
| Arden, NK | 1 |
| Birrell, F | 1 |
| Cockayne, S | 1 |
| Dickson, J | 1 |
| Doherty, M | 1 |
| Dziedzic, KS | 1 |
| Grainger, A | 1 |
| Hewitt, CE | 1 |
| O'Neill, TW | 1 |
| Scott, DL | 1 |
| Vincent, TL | 1 |
| Wakefield, RJ | 1 |
| Watt, FE | 1 |
| Torgerson, DJ | 1 |
| Conaghan, PG | 1 |
| Bellakhal, S | 1 |
| Ben Kaab, B | 1 |
| Teyeb, Z | 1 |
| Souissi, A | 1 |
| Derbel, F | 1 |
| Douggui, MH | 1 |
| Gruber, JR | 1 |
| Sarro, R | 1 |
| Delaloye, J | 1 |
| Surmely, JF | 1 |
| Siniscalchi, G | 1 |
| Tozzi, P | 1 |
| Jaques, C | 1 |
| Jaton, K | 1 |
| Delabays, A | 1 |
| Greub, G | 1 |
| Rutz, T | 1 |
| Corzo, P | 1 |
| Salman-Monte, TC | 1 |
| Torrente-Segarra, V | 1 |
| Polino, L | 1 |
| Mojal, S | 1 |
| Carbonell-Abelló, J | 1 |
| Gubar', EE | 1 |
| Bochkova, AG | 1 |
| Bunchuk, NV | 1 |
| Palazzi, C | 1 |
| D'Angelo, S | 1 |
| Olivieri, I | 1 |
| Ravindran, V | 1 |
| Yokogawa, N | 1 |
| Kato, Y | 1 |
| Sugii, S | 1 |
| Inada, S | 1 |
| Ikeda, T | 1 |
| Kanazawa, N | 1 |
| Furukawa, F | 1 |
| Sorbara, S | 1 |
| Cozzani, E | 1 |
| Rebora, A | 1 |
| Parodi, A | 1 |
| Arnson, Y | 1 |
| Dovrish, Z | 1 |
| Hadari, R | 1 |
| Amital, H | 1 |
| Senécal, JL | 1 |
| Chartier, S | 1 |
| Rothfield, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized, Open, Multi-Center Trial Comparing TNF-Blockade + MTX to MTX+SSZ+HCQ in Patients With Early RA With an Inadequate Response to MTX[NCT00764725] | Phase 4 | 487 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| Fecal Microbial Transplantation for Rheumatoid Arthritis Trial[NCT05790356] | 30 participants (Anticipated) | Interventional | 2023-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for hydroxychloroquine and Arthralgia
| Article | Year |
|---|---|
Treatment of chikungunya-associated joint pain: a systematic review of controlled clinical trials.
Topics: Anti-Inflammatory Agents; Arthralgia; Chikungunya Fever; Chloroquine; Humans; Hydroxychloroquine; Me | 2022 |
Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift.
Topics: Alcohol Drinking; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthralgia; Arthritis | 2021 |
Autoimmune Hepatitis A Case Report and Literature Review.
Topics: Antirheumatic Agents; Arthralgia; Autoantibodies; Biopsy; Chest Pain; Diagnosis, Differential; Femal | 2019 |
Hepatitis C virus-related arthritis.
Topics: Adrenal Cortex Hormones; Ankle; Antibodies, Viral; Arthralgia; Arthritis, Infectious; Arthritis, Rhe | 2008 |
3 trials available for hydroxychloroquine and Arthralgia
| Article | Year |
|---|---|
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis: Results From a Swedish Randomized Controlled Trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Biological Products; Drug Ther | 2021 |
Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial.
Topics: Activities of Daily Living; Analgesics; Arthralgia; Clinical Protocols; Costs and Cost Analysis; Dou | 2013 |
[Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Dr | 2008 |
14 other studies available for hydroxychloroquine and Arthralgia
| Article | Year |
|---|---|
Primary Sjogren's syndrome manifesting with distal renal tubular acidosis and severe metabolic bone disease.
Topics: Absorptiometry, Photon; Acidosis, Renal Tubular; Adolescent; Antirheumatic Agents; Arthralgia; Bone | 2020 |
Rowell's syndrome: a rare but distinct entity in rheumatology.
Topics: Adolescent; Antibodies, Antinuclear; Antipyretics; Arthralgia; Drug Therapy, Combination; Erythema M | 2020 |
Clinical features and outcomes from the Singapore Sjögren's syndrome study.
Topics: Adult; Arthralgia; Azathioprine; Female; Humans; Hydroxychloroquine; Keratoconjunctivitis Sicca; Mal | 2021 |
Patients With Arthralgia and Anti-Citrullinated Peptide Antibody Positivity on Hydroxychloroquine Therapy: An Update on 2 and 3 Years' Follow-up Data of a Pilot Study.
Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Arthralgia; Arthritis, Rheumatoid; Chronic Disea | 2019 |
A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus.
Topics: Adult; Antirheumatic Agents; Arthralgia; Female; Humans; Hydroxychloroquine; Japan; Leukapheresis; L | 2019 |
[Systemic lupus erythematosus presenting as Stevens-Johnson syndrome].
Topics: Adult; Anemia; Arthralgia; Autoantibodies; Complement C3; Critical Care; Facial Dermatoses; Female; | 2015 |
Tropheryma whipplei bivalvular endocarditis and polyarthralgia: a case report.
Topics: Aged; Anti-Bacterial Agents; Aortic Valve; Arthralgia; Doxycycline; Echocardiography; Endocarditis, | 2015 |
Joint ultrasound baseline abnormalities predict a specific long-term clinical outcome in systemic lupus erythematosus patients.
Topics: Adult; Antirheumatic Agents; Arthralgia; Case-Control Studies; Female; Follow-Up Studies; Hand; Huma | 2017 |
Lamotrigine-induced lupus: a case report.
Topics: Adolescent; Anticonvulsants; Antirheumatic Agents; Arthralgia; Epilepsy; Female; Humans; Hydroxychlo | 2011 |
Response to hydroxychloroquine in Japanese patients with systemic lupus erythematosus using the cutaneous lupus erythematosus disease area and severity index (CLASI).
Topics: Adult; Antirheumatic Agents; Arthralgia; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Sy | 2012 |
Hydroxychloroquine administration for Japanese lupus erythematosus in Wakayama: a pilot study.
Topics: Adult; Antimalarials; Arthralgia; Asian People; Female; Humans; Hydroxychloroquine; Japan; Lipids; L | 2012 |
Hydroxychloroquine in psoriasis: is it really harmful?
Topics: Aged; Antimalarials; Arthralgia; Contraindications; Female; Humans; Hydroxychloroquine; Lupus Erythe | 2006 |
Amyopathic dermatomyositis--an uncommon presentation of dermatomyositis.
Topics: Adult; Arthralgia; Cyclosporine; Dermatologic Agents; Dermatomyositis; Exanthema; Glucocorticoids; H | 2007 |
Hypergammaglobulinemic purpura in systemic autoimmune rheumatic diseases: predictive value of anti-Ro(SSA) and anti-La(SSB) antibodies and treatment with indomethacin and hydroxychloroquine.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents | 1995 |