hydroxychloroquine has been researched along with Alzheimer Disease in 10 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothesized that it may impact AD pathogenesis and risk." | 1.91 | Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease. ( Anerillas, C; Chin, K; Desai, RJ; Gerhard, T; Gorospe, M; Horton, DB; Kim, SC; Loeffler, T; Mahesri, M; Navakkode, S; Sajikumar, S; Schilcher, I; Schneeweiss, S; Segal, JB; Thambisetty, M; Varma, VR; Wong, LW, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, VR | 1 |
| Desai, RJ | 1 |
| Navakkode, S | 1 |
| Wong, LW | 1 |
| Anerillas, C | 1 |
| Loeffler, T | 1 |
| Schilcher, I | 1 |
| Mahesri, M | 1 |
| Chin, K | 1 |
| Horton, DB | 1 |
| Kim, SC | 1 |
| Gerhard, T | 1 |
| Segal, JB | 1 |
| Schneeweiss, S | 1 |
| Gorospe, M | 1 |
| Sajikumar, S | 1 |
| Thambisetty, M | 1 |
| Lai, SW | 1 |
| Kuo, YH | 1 |
| Liao, KF | 1 |
| Fardet, L | 3 |
| Petersen, I | 3 |
| Nazareth, I | 3 |
| Urbina, F | 1 |
| Puhl, AC | 1 |
| Ekins, S | 1 |
| Lee, YH | 1 |
| Aisen, PS | 1 |
| Van Gool, WA | 1 |
| Weinstein, HC | 1 |
| Scheltens, P | 1 |
| Walstra, GJ | 1 |
| Scheltens, PK | 1 |
| González Moneo, MJ | 1 |
| Garrido Barral, A | 1 |
3 reviews available for hydroxychloroquine and Alzheimer Disease
| Article | Year |
|---|---|
Recent advances in drug repurposing using machine learning.
Topics: Alzheimer Disease; Antineoplastic Agents; Antiviral Agents; Clemastine; Computational Biology; COVID | 2021 |
Anti-inflammatory agents in Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Celecoxib; Humans; Hydroxychloroquine; Prednisone; Pyra | 2002 |
[Latest therapies for treating dementia].
Topics: Adult; Aged; Alzheimer Disease; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepress | 2002 |
1 trial available for hydroxychloroquine and Alzheimer Disease
| Article | Year |
|---|---|
Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Antimalarials; Behavi | 2001 |
6 other studies available for hydroxychloroquine and Alzheimer Disease
| Article | Year |
|---|---|
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2023 |
Chronic hydroxychloroquine exposure and the risk of Alzheimer's disease.
Topics: Alzheimer Disease; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine | 2021 |
Response to: 'Chronic hydroxychloroquine exposure and the risk of Alzheimer's disease' by Lai
Topics: Alzheimer Disease; Humans; Hydroxychloroquine | 2021 |
Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease: a population-based cohort study.
Topics: Alzheimer Disease; Antirheumatic Agents; Chloroquine; Chronic Disease; Connective Tissue Diseases; D | 2019 |
Response to: 'Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease' by Lee.
Topics: Alzheimer Disease; Chloroquine; Cohort Studies; Connective Tissue Diseases; Humans; Hydroxychloroqui | 2019 |
Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease.
Topics: Alzheimer Disease; Chloroquine; Cohort Studies; Connective Tissue Diseases; Humans; Hydroxychloroqui | 2019 |