hydroxychloroquine has been researched along with Aging in 8 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria." | 5.05 | Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection. ( Cook, J; Joshi, A; Nicol, MR; Rizk, ML; Sabato, PE; Savic, RM; Wesche, D; Zheng, JH, 2020) |
| "Hydroxychloroquine treatment did not alter the serum levels of CCL2, CXCL8, CXCL9 or CXCL10 in patients with OA of the knees, although increased serum levels correlated with aging for all subjects, including controls." | 3.85 | CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. ( Abramo, C; Almeida, CS; Bonfante, HL; Grunewald, STF; Levy, RA; Teixeira, HC, 2017) |
| "C-wave and ERG records have been taken from patients with juvenile macular degeneration, cone dysfunction syndrome, non exudative macular degeneration and from patients who have taken hydroxychloroquine for more than a year." | 3.67 | [C-wave changes in macular diseases]. ( Brouza, D; Moschos, M; Panagakis, E, 1989) |
| "Hydroxychloroquine was associated with significantly lower BPV." | 1.56 | Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus. ( Magder, LS; Petri, M; Stojan, G, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
| Authors | Studies |
|---|---|
| Sargiacomo, C | 1 |
| Sotgia, F | 1 |
| Lisanti, MP | 1 |
| Göpel, S | 1 |
| Bethge, W | 1 |
| Martus, P | 1 |
| Kreth, F | 1 |
| Iftner, T | 1 |
| Joos, S | 1 |
| Döbele, S | 1 |
| Mordmüller, B | 1 |
| Kremsner, P | 1 |
| Ettrich, T | 1 |
| Seufferlein, T | 1 |
| Bitzer, M | 1 |
| Malek, N | 1 |
| Osama El-Gendy, A | 1 |
| Saeed, H | 1 |
| Ali, AMA | 1 |
| Zawbaa, HM | 1 |
| Gomaa, D | 1 |
| Harb, HS | 1 |
| Madney, YM | 1 |
| Osama, H | 1 |
| Abdelrahman, MA | 1 |
| Abdelrahim, MEA | 1 |
| Nicol, MR | 1 |
| Joshi, A | 1 |
| Rizk, ML | 1 |
| Sabato, PE | 1 |
| Savic, RM | 1 |
| Wesche, D | 1 |
| Zheng, JH | 1 |
| Cook, J | 1 |
| Stojan, G | 1 |
| Magder, LS | 1 |
| Petri, M | 1 |
| Bonfante, HL | 1 |
| Almeida, CS | 1 |
| Abramo, C | 1 |
| Grunewald, STF | 1 |
| Levy, RA | 1 |
| Teixeira, HC | 1 |
| Caldwell, CW | 1 |
| Bridges, AJ | 1 |
| Walker, SE | 1 |
| Smarr, KL | 1 |
| Reichert, RJ | 1 |
| Anderson, SK | 1 |
| Hewett, JE | 1 |
| Parker, JC | 1 |
| Moschos, M | 1 |
| Brouza, D | 1 |
| Panagakis, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double-blinded Placebo-controlled Outpatient Clinical Trial in High Risk Population Confirmed COVID-19 Patients Using Ivermectin and Doxycycline to Prevent COVID-19 Illness-related Hospitalization (COVIVER-OUT PLUS)[NCT04729140] | Phase 4 | 150 participants (Anticipated) | Interventional | 2020-12-28 | Recruiting | ||
| Randomized Controlled Trial of Hydroxychloroquine Versus Placebo in Early Ambulatory Diagnosis and Treatment of Elderly COVID19 Patients[NCT04351516] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2020-04-21 | Withdrawn (stopped due to No Patients enrolled) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxychloroquine and Aging
| Article | Year |
|---|---|
Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection.
Topics: Age Factors; Aging; Antiviral Agents; Chloroquine; Clinical Trials, Phase II as Topic; Clinical Tria | 2020 |
1 trial available for hydroxychloroquine and Aging
| Article | Year |
|---|---|
Test and treat COVID 65 plus - Hydroxychloroquine versus placebo in early ambulatory diagnosis and treatment of older patients with COVID19: A structured summary of a study protocol for a randomised controlled trial.
Topics: Age Factors; Aged; Aging; Ambulatory Care; Antiviral Agents; Betacoronavirus; Cause of Death; Clinic | 2020 |
6 other studies available for hydroxychloroquine and Aging
| Article | Year |
|---|---|
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Angiotensin-Converting Enzyme 2; Antiviral Agents; Azit | 2020 |
Bacillus Calmette-Guérin vaccine, antimalarial, age and gender relation to COVID-19 spread and mortality.
Topics: Aging; Antiviral Agents; BCG Vaccine; Chemoprevention; Chloroquine; Coronavirus Infections; COVID-19 | 2020 |
Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Antirheumatic Agents; Baltimore; Black or African Ameri | 2020 |
CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees.
Topics: Age Factors; Aged; Aging; Antirheumatic Agents; Biomarkers; Case-Control Studies; Chemokine CCL2; Ch | 2017 |
A controlled study of lymphocyte subsets in rheumatoid arthritis.
Topics: Aging; Antineoplastic Agents; Arthritis, Rheumatoid; Gold; Humans; Hydroxychloroquine; Lymphocyte Su | 1992 |
[C-wave changes in macular diseases].
Topics: Adolescent; Adult; Aged; Aging; Child; Electroretinography; Humans; Hydroxychloroquine; Macula Lutea | 1989 |