hydroxychloroquine has been researched along with Acute Q Fever in 41 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteomyelitis due to Coxiella burnetii infection is a rare condition in adults." | 5.42 | Subacute, tetracycline-responsive, granulomatous osteomyelitis in an adult man, consistent with Q fever infection. ( Bayard, C; Dumoulin, A; Günthard, HF; Ikenberg, K, 2015) |
| " No previous studies have assessed abnormal weight gain as a putative side effect of long-term doxycycline treatment; thus, the objective of the present study was to characterize this phenomenon." | 5.40 | Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment. ( Angelakis, E; Armougom, F; Giorgi, R; Kankoe, S; Lagier, JC; Million, M; Raoult, D, 2014) |
| " We report a case of abdominal aortic aneurysm infected by CB with bilateral paravertebral abscesses and contiguous spondylodiscitis treated by open repair using a cryopreserved allograft and long-term antibiotic therapy by oral doxycycline and oral hydroxychloroquine for a duration of 18 months." | 3.83 | Treatment of an Abdominal Aortic Aneurysm Infected by Coxiella Burnetii Using a Cryopreserved Allograft. ( Allaire, E; Cochennec, F; Desgranges, P; Jayet, J; Raux, M, 2016) |
| "The recommended treatment for Q fever endocarditis is a combination of doxycycline and hydroxychloroquine." | 2.71 | Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. ( Mallet, MN; Raoult, D; Rolain, JM, 2003) |
| "A minority of patients who acquire acute Q fever will subsequently develop chronic Q fever endocarditis, which often manifests in valvular insufficiency." | 2.49 | Cardiac manifestations of Q fever infection: case series and a review of the literature. ( Farivar, RS; Gunn, TM; Raz, GM; Turek, JW, 2013) |
| "Coxiella burnetii, the agent of Q fever, is an obligate intracellular pathogen typically associated with exposure to livestock." | 2.48 | Q fever endocarditis: an unusual presentation. ( Espinosa, M; Griffin, AT; Nakamatsu, R, 2012) |
| "Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations." | 2.45 | [Q fever: current diagnosis and treatment options]. ( Lepidi, H; Million, M; Raoult, D, 2009) |
| "We report a case of chronic Q fever presenting with catastrophic bleeding from an infected abdominal aortic aneurysm causing a primary aortoduodenal fistula in an 80-year-old retired farmer." | 1.62 | Primary aortoduodenal fistula and chronic Q fever infection. ( Do, CN; Looke, D; Mar, EO; Sim, B, 2021) |
| "We showed that Q fever is not rare in the Middle East and suggest that it should be considered in all blood culture-negative endocarditis cases." | 1.51 | Ten-year experience of Q fever endocarditis in a tertiary cardiac center in Saudi Arabia. ( Akhtar, MY; Albalawi, R; Albarrag, AM; Alnajashi, K; Alsherbeeni, N; Alsufyani, E; Alzahrani, A; Elzein, FE; Kaabia, N; Mehdi, S; Raoult, D, 2019) |
| "Treatment of chronic Q fever with TET plus QNL appears to be a safe alternative for TET plus HCQ, for example, if TET plus HCQ cannot be tolerated due to side effects." | 1.48 | Treatment of Chronic Q Fever: Clinical Efficacy and Toxicity of Antibiotic Regimens. ( Bleeker-Rovers, CP; de Regt, MJA; Hoepelman, AIM; Kampschreur, LM; Oosterheert, JJ; van Roeden, SE; Wever, PC, 2018) |
| "First choice treatment for chronic Q fever is doxycycline plus hydroxychloroquine." | 1.48 | The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever. ( Bleeker-Rovers, CP; de Regt, MJA; Hoepelman, AIM; Kampschreur, LM; Oosterheert, JJ; van Roeden, SE; Vermeulen Windsant, A; Wever, PC, 2018) |
| "The epidemiology of Coxiella burnetii infection in the United States is not well characterized." | 1.48 | Coxiella burnetii Endocarditis and Meningitis, California, USA, 2017. ( Allan-Blitz, LT; Klausner, JD; Sakona, A; Wallace, WD, 2018) |
| "The false aneurysm was successfully thrombosed with no complications." | 1.43 | Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair. ( Gemayel, G; Kalangos, A; Mootoosamy, P; Murith, N, 2016) |
| "Few cases of Q fever osteoarticular infection have been reported, with chronic osteomyelitis as the most common manifestation of Q fever osteoarticular infection." | 1.43 | Sternoclavicular joint infection caused by Coxiella burnetii: a case report. ( Angelakis, E; Million, M; Raoult, D; Thiberville, SD, 2016) |
| "Osteomyelitis due to Coxiella burnetii infection is a rare condition in adults." | 1.42 | Subacute, tetracycline-responsive, granulomatous osteomyelitis in an adult man, consistent with Q fever infection. ( Bayard, C; Dumoulin, A; Günthard, HF; Ikenberg, K, 2015) |
| " No previous studies have assessed abnormal weight gain as a putative side effect of long-term doxycycline treatment; thus, the objective of the present study was to characterize this phenomenon." | 1.40 | Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment. ( Angelakis, E; Armougom, F; Giorgi, R; Kankoe, S; Lagier, JC; Million, M; Raoult, D, 2014) |
| "Acute Q fever generally is benign and usually resolves spontaneously." | 1.39 | [Q fever, a zoonosis often overlooked]. ( Delaloye, J; Greub, G, 2013) |
| "Chronic Q fever can be difficult to diagnose because of a variety of non-specific clinical presentations." | 1.37 | A case of multifocal chronic Q fever osteomyelitis. ( Acquacalda, E; Fournier, PE; Laffont, C; Montaudie, H; Pulcini, C, 2011) |
| "Coxiella burnetii causes acute and chronic Q fever." | 1.31 | Risks factors and prevention of Q fever endocarditis. ( Carrieri, MP; Fenollar, F; Fournier, PE; Habib, G; Messana, T; Raoult, D, 2001) |
| "Q fever is a zoonosis caused by Coxiella burnetii." | 1.30 | Q fever tricuspid valve endocarditis. ( Brouqui, P; Casasoprana, A; Hvass, U; Lupoglazoff, JM; Magnier, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 6 (14.63) | 29.6817 |
| 2010's | 24 (58.54) | 24.3611 |
| 2020's | 8 (19.51) | 2.80 |
| Authors | Studies |
|---|---|
| Stahl, JP | 2 |
| Varon, E | 2 |
| Bru, JP | 2 |
| Million, M | 5 |
| Brouqui, P | 3 |
| Raoult, D | 13 |
| Sabourin, E | 1 |
| Podglajen, I | 1 |
| Fournier, PE | 4 |
| Mainardi, JL | 1 |
| Paul, M | 1 |
| España, PP | 1 |
| Uranga, A | 1 |
| Cillóniz, C | 1 |
| Torres, A | 1 |
| Renard, D | 1 |
| Richaud, C | 1 |
| Perrot, L | 1 |
| Charles, P | 1 |
| Do, CN | 1 |
| Mar, EO | 1 |
| Sim, B | 1 |
| Looke, D | 1 |
| Armstrong, N | 1 |
| Richez, M | 1 |
| Chabriere, E | 1 |
| van Roeden, SE | 2 |
| Bleeker-Rovers, CP | 2 |
| de Regt, MJA | 2 |
| Kampschreur, LM | 2 |
| Hoepelman, AIM | 2 |
| Wever, PC | 2 |
| Oosterheert, JJ | 2 |
| Vermeulen Windsant, A | 1 |
| de Worm, S | 1 |
| Giot, JB | 1 |
| Courtoy, C | 1 |
| Gillet, E | 1 |
| Amrane, S | 1 |
| Huynen, P | 1 |
| Van Esbroeck, M | 1 |
| Prudent, E | 1 |
| Lepidi, H | 2 |
| Moutschen, M | 1 |
| Gonçalves, M | 1 |
| Moreira, S | 1 |
| Gaspar, E | 1 |
| Santos, L | 1 |
| Allan-Blitz, LT | 1 |
| Sakona, A | 1 |
| Wallace, WD | 1 |
| Klausner, JD | 1 |
| Akamine, CM | 1 |
| Perez, ML | 1 |
| Lee, JH | 1 |
| Ing, MB | 1 |
| Olivier-Gougenheim, L | 1 |
| Freychet, C | 1 |
| Collardeau-Frachon, S | 1 |
| Roure-Sobas, C | 1 |
| Di Filippo, S | 1 |
| Riva, R | 1 |
| Lega, JC | 1 |
| Belot, A | 1 |
| Elzein, FE | 1 |
| Alsherbeeni, N | 1 |
| Alnajashi, K | 1 |
| Alsufyani, E | 1 |
| Akhtar, MY | 1 |
| Albalawi, R | 1 |
| Albarrag, AM | 1 |
| Kaabia, N | 1 |
| Mehdi, S | 1 |
| Alzahrani, A | 1 |
| Gunn, TM | 1 |
| Raz, GM | 1 |
| Turek, JW | 1 |
| Farivar, RS | 1 |
| Delaloye, J | 1 |
| Greub, G | 1 |
| Angelakis, E | 3 |
| Oddoze, C | 1 |
| Kankoe, S | 1 |
| Lagier, JC | 1 |
| Armougom, F | 1 |
| Giorgi, R | 1 |
| Bayard, C | 1 |
| Dumoulin, A | 1 |
| Ikenberg, K | 1 |
| Günthard, HF | 1 |
| Gemayel, G | 1 |
| Mootoosamy, P | 1 |
| Murith, N | 1 |
| Kalangos, A | 1 |
| Jayet, J | 1 |
| Raux, M | 1 |
| Allaire, E | 1 |
| Desgranges, P | 1 |
| Cochennec, F | 1 |
| Gaudé, M | 1 |
| Julien, S | 1 |
| Laurent, F | 1 |
| Ferry, T | 1 |
| Robinson, WP | 1 |
| Schuksz, M | 1 |
| Thiberville, SD | 1 |
| Zekanović, D | 1 |
| Morović, M | 1 |
| Borcilo, MN | 1 |
| Rode, OD | 1 |
| Acquacalda, E | 1 |
| Montaudie, H | 1 |
| Laffont, C | 1 |
| Pulcini, C | 1 |
| Costiniuk, CT | 1 |
| Wang, B | 1 |
| Johnstone, D | 1 |
| Jessamine, P | 1 |
| Toye, B | 1 |
| Veinot, JP | 1 |
| Desjardins, M | 1 |
| Edouard, S | 1 |
| Labussiere, AS | 1 |
| Guimard, Y | 1 |
| Griffin, AT | 1 |
| Espinosa, M | 1 |
| Nakamatsu, R | 1 |
| Rolain, JM | 2 |
| Mallet, MN | 2 |
| Boulos, A | 1 |
| Healy, B | 1 |
| Llewelyn, M | 1 |
| Westmoreland, D | 1 |
| Lloyd, G | 1 |
| Brown, N | 1 |
| Fradi, I | 1 |
| Drissa, MA | 1 |
| Cheour, M | 1 |
| Drissa, H | 1 |
| Queyrel, V | 1 |
| Bosseray, A | 1 |
| Leclercq, P | 1 |
| Brion, JP | 1 |
| Pasquier, D | 1 |
| Vandekerkhove, C | 1 |
| Micoud, M | 1 |
| Lupoglazoff, JM | 1 |
| Magnier, S | 1 |
| Hvass, U | 1 |
| Casasoprana, A | 1 |
| Houpikian, P | 1 |
| Tissot Dupont, H | 1 |
| Riss, JM | 1 |
| Arditi-Djiane, J | 1 |
| Fenollar, F | 1 |
| Carrieri, MP | 1 |
| Habib, G | 1 |
| Messana, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Trial Evaluating Safety and Efficacy of Hydroxychloroquine and Nitazoxanide Combination as Adjuvant Therapy in Covid-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope[NCT04361318] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2020-05-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for hydroxychloroquine and Acute Q Fever
| Article | Year |
|---|---|
Q Fever (Coxiella Burnetii).
Topics: Acute Disease; Adult; Animals; Anti-Bacterial Agents; Child; Coxiella burnetii; Diagnosis, Different | 2020 |
Cardiac manifestations of Q fever infection: case series and a review of the literature.
Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Aortic Coarctation; Aortic Valve Insufficiency; | 2013 |
Surgical and Antimicrobial Management of a Thoracic Aortic Aneurysm Due to Q Fever: A Case Report and Brief Review.
Topics: Adult; Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Aortography; Blood Vess | 2016 |
[Q fever: current diagnosis and treatment options].
Topics: Animals; Coxiella burnetii; Diagnosis, Differential; Doxycycline; Fatigue Syndrome, Chronic; Humans; | 2009 |
First case of Q fever endocarditis in Croatia and a short review.
Topics: Aged; Ciprofloxacin; Doxycycline; Echocardiography; Endocarditis, Bacterial; Humans; Hydroxychloroqu | 2010 |
Q fever endocarditis: an unusual presentation.
Topics: Anti-Bacterial Agents; Aortic Valve; Coxiella burnetii; Doxycycline; Drug Therapy, Combination; Endo | 2012 |
1 trial available for hydroxychloroquine and Acute Q Fever
| Article | Year |
|---|---|
Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibodies, Bacterial; Coxiella burnetii; Dox | 2003 |
34 other studies available for hydroxychloroquine and Acute Q Fever
| Article | Year |
|---|---|
Treatment of Coxiella burnetii endocarditis with hydroxychloroquine. Is it evidence-based?
Topics: Coxiella burnetii; Endocarditis; Endocarditis, Bacterial; Humans; Hydroxychloroquine; Q Fever | 2022 |
Re: Treatment of Coxiella burnetii endocarditis with hydroxychloroquine by Stahl et al.
Topics: Coxiella burnetii; Endocarditis; Endocarditis, Bacterial; Humans; Hydroxychloroquine; Q Fever | 2022 |
'Treatment of Coxiella burnetii endocarditis with hydroxychloroquine' - Author's reply.
Topics: Coxiella burnetii; Endocarditis; Humans; Hydroxychloroquine; Q Fever | 2022 |
Clinical and biological diagnosis and follow-up of patients treated for endovascular infections due to Coxiellaburnetii.
Topics: Anti-Bacterial Agents; Doxycycline; Endocarditis; Endocarditis, Bacterial; Follow-Up Studies; Humans | 2023 |
Which trial do we need? Doxycycline vs. doxycycline-hydroxychloroquine and treatment duration protocol for Q fever endovascular infections.
Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Coxiella burnetii; Doxycycline; Duration of Therapy | 2023 |
[Hydroxychloroquine cured pneumonia].
Topics: Aged; Coxiella burnetii; Doxycycline; Endocarditis, Bacterial; Female; Humans; Hydroxychloroquine; L | 2020 |
Primary aortoduodenal fistula and chronic Q fever infection.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Antimalarials; Aortic Aneurysm, Abdominal; Coxiella burnet | 2021 |
Simultaneous UHPLC-UV analysis of hydroxychloroquine, minocycline and doxycycline from serum samples for the therapeutic drug monitoring of Q fever and Whipple's disease.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Doxycycline; Drug Monitoring; Drug Stab | 2017 |
Treatment of Chronic Q Fever: Clinical Efficacy and Toxicity of Antibiotic Regimens.
Topics: Aged; Anti-Bacterial Agents; Chronic Disease; Coxiella burnetii; Drug Therapy, Combination; Female; | 2018 |
The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Doxycycline; Drug Monitoring; Female; Humans; Hydrox | 2018 |
A case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis.
Topics: Aged; Anti-Bacterial Agents; Aorta, Abdominal; Aortitis; Coxiella burnetii; Doxycycline; Fluorodeoxy | 2018 |
Rare case of otomastoiditis due to
Topics: Aged, 80 and over; Anti-Bacterial Agents; Antimalarials; Coxiella burnetii; Doxycycline; Humans; Hyd | 2018 |
Coxiella burnetii Endocarditis and Meningitis, California, USA, 2017.
Topics: Adult; Anti-Bacterial Agents; Antibodies, Bacterial; California; Coxiella burnetii; Doxycycline; End | 2018 |
Q Fever in Southern California: a Case Series of 20 Patients from a VA Medical Center.
Topics: Adult; Aged; Anti-Bacterial Agents; California; Chronic Disease; Doxycycline; Endocarditis, Bacteria | 2019 |
A quest for Q fever.
Topics: Brain; Child; Doxycycline; Female; Humans; Hydroxychloroquine; Intracranial Aneurysm; Intracranial H | 2019 |
Ten-year experience of Q fever endocarditis in a tertiary cardiac center in Saudi Arabia.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Doxycycline; Endocarditis, Bacterial; Female; Heart | 2019 |
[Q fever, a zoonosis often overlooked].
Topics: Animals; Anti-Bacterial Agents; Doxycycline; Enzyme Inhibitors; Humans; Hydroxychloroquine; Q Fever; | 2013 |
Vitamin D and prolonged treatment with photosensitivity-associated antibiotics.
Topics: Adult; Aged; Anti-Bacterial Agents; Doxycycline; Endocarditis; Female; Humans; Hydroxychloroquine; M | 2013 |
Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment.
Topics: Adult; Aged; Anti-Infective Agents; Body Mass Index; Body Weight; Doxycycline; Endocarditis, Bacteri | 2014 |
Subacute, tetracycline-responsive, granulomatous osteomyelitis in an adult man, consistent with Q fever infection.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Doxycycline; Granuloma; Humans; Hydroxychloroquine; Ma | 2015 |
Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair.
Topics: Aged, 80 and over; Aneurysm, False; Aneurysm, Infected; Angiography, Digital Subtraction; Anti-Bacte | 2016 |
Treatment of an Abdominal Aortic Aneurysm Infected by Coxiella Burnetii Using a Cryopreserved Allograft.
Topics: Administration, Oral; Aged, 80 and over; Allografts; Aneurysm, Infected; Anti-Bacterial Agents; Aort | 2016 |
Disappearance of FDG uptake on PET scan after antimicrobial therapy could help for the diagnosis of Coxiella burnetii spondylodiscitis.
Topics: Anti-Infective Agents; Back Pain; Biopsy; Coxiella burnetii; Discitis; Doxycycline; Fluorodeoxygluco | 2016 |
Sternoclavicular joint infection caused by Coxiella burnetii: a case report.
Topics: Aged; Anti-Infective Agents; Arthritis, Infectious; Coxiella burnetii; Doxycycline; Humans; Hydroxyc | 2016 |
A case of multifocal chronic Q fever osteomyelitis.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Coxiella burnetii; Doxycycline; Humans; Hydroxychloroq | 2011 |
Coxiella burnetii culture-negative endocarditis diagnosed by 16S rRNA sequencing of heart valve tissue.
Topics: Anti-Bacterial Agents; Cardiac Surgical Procedures; Coxiella burnetii; Doxycycline; Drug Therapy, Co | 2011 |
Q fever: a case with a vascular infection complication.
Topics: Aged; Aneurysm; Anti-Bacterial Agents; Antirheumatic Agents; Diagnosis, Differential; Diagnostic Ima | 2010 |
Correlation between ratio of serum doxycycline concentration to MIC and rapid decline of antibody levels during treatment of Q fever endocarditis.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibodies, Bacterial; Coxiella burnetii; Doxycycline; Endocardi | 2005 |
The value of follow-up after acute Q fever infection.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Chronic Disease; Complement Fixation Tests; Coxiella b | 2006 |
[Q fever endocarditis: a case report].
Topics: Adult; Anti-Bacterial Agents; Aortic Valve; Aortic Valve Stenosis; Doxycycline; Drug Therapy, Combin | 2006 |
[Q fever and autoimmunity. Value of adjuvant treatments as hydroxychloroquine].
Topics: Adult; Autoantibodies; Chemotherapy, Adjuvant; Doxycycline; Humans; Hydroxychloroquine; Male; Q Feve | 1995 |
Q fever tricuspid valve endocarditis.
Topics: Anti-Bacterial Agents; Child; Doxycycline; Drug Therapy, Combination; Endocarditis, Bacterial; Femal | 1997 |
Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Doxycycline; Drug Therapy, Combination; Endocar | 1999 |
Risks factors and prevention of Q fever endocarditis.
Topics: Aged; Anti-Infective Agents; Doxycycline; Endocarditis, Bacterial; Female; Heart Valve Diseases; Hum | 2001 |