hydroxychloroquine has been researched along with Acute Liver Injury, Drug-Induced in 18 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered." | 8.77 | Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985) |
| "Hydroxychloroquine in lower doses is an effective treatment for porphyria cutanea tarda; at doses used to treat systemic lupus erythematosus and subacute cutaneous lupus, there is a potentially life-threatening complication of hepatotoxicity." | 5.48 | The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. ( Ettel, M; McCune, WJ; Pearson, TL; Roofeh, D; Silver, S; Sunkara, B, 2018) |
| "A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered." | 4.77 | Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985) |
| " A disproportionality analysis was performed to determine adverse effects reported in non-Covid and Covid patients." | 1.91 | Hydroxychloroquine safety in Covid-19 vs non-Covid-19 patients: analysis of differences and potential interactions. ( Fernandez-Araque, AM; Martín Arias, LH; Merino Kolly, N; Sainz-Gil, M; Sanz Fadrique, R; Velasco-González, V; Verde Rello, Z, 2023) |
| "One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure." | 1.56 | Early experience with remdesivir in SARS-CoV-2 pneumonia. ( Andini, R; Bertolino, L; Corcione, A; Durante-Mangoni, E; Florio, LL; Mele, F; Murino, P; Zampino, R, 2020) |
| "Hydroxychloroquine in lower doses is an effective treatment for porphyria cutanea tarda; at doses used to treat systemic lupus erythematosus and subacute cutaneous lupus, there is a potentially life-threatening complication of hepatotoxicity." | 1.48 | The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. ( Ettel, M; McCune, WJ; Pearson, TL; Roofeh, D; Silver, S; Sunkara, B, 2018) |
| "Acute toxic hepatitis was diagnosed, which rapidly returned to normal after cessation of the suspected causative medication, hydroxychloroquine, and subsequent administration of mycophenolate mofetil." | 1.42 | Hydroxychloroquine-induced toxic hepatitis in a patient with systemic lupus erythematosus: a case report. ( Abdel Galil, SM, 2015) |
| "Troxis necrosis is a novel mechanism for drug-induced hepatitis, including immunomodulatory medications including a monoclonal anti-TWEAK antibody and Cellcept and Plaquenil, two widely used immunosuppression/anti-rejection medications." | 1.42 | Troxis necrosis, a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy. ( Datta, A; Fleishman, W; French, SW; Karpouzas, G; Penunuri, A; Wei, CH, 2015) |
| "Intrahepatic hemorrhage is a very rare complication of warfarin, and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control." | 1.39 | Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy. ( Baek, YH; Cho, DS; Chung, WT; Han, SY; Kang, SH; Lee, SW; Park, IC, 2013) |
| "A woman with mixed connective tissue disease who developed a reversible acute hepatitis shortly after the initiation of low-dose HCQ is presented." | 1.34 | Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease. ( Esteban, MJ; Giner Galvañ, V; Oltra, MR; Redón, J; Rueda, D, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Ferron, PJ | 1 |
| Le Daré, B | 1 |
| Bronsard, J | 1 |
| Steichen, C | 1 |
| Babina, E | 1 |
| Pelletier, R | 1 |
| Hauet, T | 1 |
| Morel, I | 1 |
| Tarte, K | 1 |
| Reizine, F | 1 |
| Clément, B | 1 |
| Fromenty, B | 1 |
| Gicquel, T | 1 |
| Sainz-Gil, M | 1 |
| Merino Kolly, N | 1 |
| Velasco-González, V | 1 |
| Verde Rello, Z | 1 |
| Fernandez-Araque, AM | 1 |
| Sanz Fadrique, R | 1 |
| Martín Arias, LH | 1 |
| Durante-Mangoni, E | 1 |
| Andini, R | 1 |
| Bertolino, L | 1 |
| Mele, F | 1 |
| Florio, LL | 1 |
| Murino, P | 1 |
| Corcione, A | 1 |
| Zampino, R | 1 |
| Modi, AR | 1 |
| Koval, CE | 1 |
| Taege, AJ | 1 |
| Modaresi Esfeh, J | 1 |
| Eghtesad, B | 1 |
| Narayanan Menon, KV | 1 |
| Quintini, C | 1 |
| Miller, C | 1 |
| Gougis, P | 1 |
| Fenioux, C | 1 |
| Funck-Brentano, C | 1 |
| Veyri, M | 1 |
| Gligorov, J | 1 |
| Solas, C | 1 |
| Spano, JP | 1 |
| Norinder, U | 1 |
| Tuck, A | 1 |
| Norgren, K | 1 |
| Munic Kos, V | 1 |
| Zekarias, A | 1 |
| Watson, S | 1 |
| Vidlin, SH | 1 |
| Grundmark, B | 1 |
| Sunkara, B | 1 |
| Roofeh, D | 1 |
| Silver, S | 1 |
| Pearson, TL | 1 |
| Ettel, M | 1 |
| McCune, WJ | 1 |
| Goossens, N | 1 |
| Spahr, L | 1 |
| Rubbia-Brandt, L | 1 |
| Park, IC | 1 |
| Baek, YH | 1 |
| Han, SY | 1 |
| Lee, SW | 2 |
| Chung, WT | 1 |
| Kang, SH | 1 |
| Cho, DS | 1 |
| Abdel Galil, SM | 1 |
| Lin, KM | 1 |
| Cheng, TT | 1 |
| Lin, JC | 1 |
| Chen, CJ | 1 |
| Wei, CH | 1 |
| Penunuri, A | 1 |
| Karpouzas, G | 1 |
| Fleishman, W | 1 |
| Datta, A | 1 |
| French, SW | 1 |
| Tugnet, N | 1 |
| Cooper, SC | 1 |
| Douglas, KM | 1 |
| Giner Galvañ, V | 1 |
| Oltra, MR | 1 |
| Rueda, D | 1 |
| Esteban, MJ | 1 |
| Redón, J | 1 |
| Kremer, JM | 1 |
4 reviews available for hydroxychloroquine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Coronavirus disease 2019 in an orthotopic liver transplant recipient living with human immunodeficiency virus.
Topics: Adult; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; COVID-19; COVID-19 Drug Treatment; D | 2020 |
Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.
Topics: Anti-Inflammatory Agents; Antiviral Agents; Arrhythmias, Cardiac; Azithromycin; Betacoronavirus; Che | 2020 |
Longterm methotrexate therapy in rheumatoid arthritis: a review.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans | 1985 |
14 other studies available for hydroxychloroquine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients.
Topics: Aged; Antiviral Agents; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Correlatio | 2021 |
Hydroxychloroquine safety in Covid-19 vs non-Covid-19 patients: analysis of differences and potential interactions.
Topics: Chemical and Drug Induced Liver Injury; COVID-19; COVID-19 Drug Treatment; Drug-Related Side Effects | 2023 |
Early experience with remdesivir in SARS-CoV-2 pneumonia.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver | 2020 |
Anticancer drugs and COVID-19 antiviral treatments in patients with cancer: What can we safely use?
Topics: Amides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; A | 2020 |
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agent | 2020 |
The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda.
Topics: Adult; Blister; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Dose-Response Relat | 2018 |
Severe immune-mediated drug-induced liver injury linked to ibandronate: a case report.
Topics: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Contraindications; Diphosphonates; | 2013 |
Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy.
Topics: Adolescent; Anticoagulants; Antiphospholipid Syndrome; Chemical and Drug Induced Liver Injury; Clopi | 2013 |
Hydroxychloroquine-induced toxic hepatitis in a patient with systemic lupus erythematosus: a case report.
Topics: Abdomen, Acute; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chemical and D | 2015 |
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumato | 2015 |
Troxis necrosis, a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Humans; Hydroxychloroquine; Immuno | 2015 |
Methotrexate therapy, rheumatoid arthritis, and life-threatening liver complications: should we be monitoring more closely?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Int | 2012 |
Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease.
Topics: Acute Disease; Adult; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Chloroquine; Fem | 2007 |