hydroxychloroquine has been researched along with Ache in 20 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand and to compare it with hydroxychloroquine." | 9.16 | Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study. ( Abdi-Ali, L; Baiardi, P; Benucci, M; Campostrini, L; Manfredi, M; Mannoni, A; Sacco, S; Saviola, G, 2012) |
| "To assess the efficacy of hydroxychloroquine, 400 mg daily, for rheumatoid arthritis." | 9.07 | Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. ( Casas, E; Clark, P; Gheno, C; Medina, C; Orozco, JA; Tenorio, G; Tugwell, P, 1993) |
| "To determine the relationship between hydroxychloroquine concentration and effect in patients with rheumatoid arthritis (RA)." | 7.68 | Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis--a cross sectional study. ( Cutler, DJ; Day, RO; Tett, SE, 1993) |
| "We examined retrospectively the use of hydroxychloroquine in 9 patients with childhood dermatomyositis (DM)." | 7.67 | Adjunctive use of hydroxychloroquine in childhood dermatomyositis. ( Lindsley, CB; Olson, NY, 1989) |
| "This only reached statistical significance (at the 1% level) for C-reactive protein." | 6.66 | Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: a prospective, randomized, placebo-controlled study. ( Clarke, S; Collins, M; Dawes, PT; Fisher, J; Fowler, PD; Jones, P; Popert, AJ; Scott, DL; Shadforth, MF; Tunn, E, 1989) |
| " We found statistically significant improvement of pain and stiffness with methotrexate, especially in knee OA." | 5.22 | Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis. ( Mathieu, S; Sellam, J; Soubrier, M; Tournadre, A, 2022) |
| "To evaluate the efficacy of hydroxychloroquine for the main symptoms of primary Sjögren syndrome: dryness, pain, and fatigue." | 5.19 | Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial. ( Batouche, D; Benessiano, J; Devauchelle-Pensec, V; Dubost, JJ; Furlan, V; Goeb, V; Gottenberg, JE; Hatron, P; Hayem, G; Larroche, C; Le Guern, V; Mariette, X; Morel, J; Perdriger, A; Perrodeau, E; Puéchal, X; Ravaud, P; Rist, S; Saraux, A; Sene, D; Seror, R; Sibilia, J; Zarnitsky, C, 2014) |
| "We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand and to compare it with hydroxychloroquine." | 5.16 | Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study. ( Abdi-Ali, L; Baiardi, P; Benucci, M; Campostrini, L; Manfredi, M; Mannoni, A; Sacco, S; Saviola, G, 2012) |
| "To assess the efficacy of hydroxychloroquine, 400 mg daily, for rheumatoid arthritis." | 5.07 | Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. ( Casas, E; Clark, P; Gheno, C; Medina, C; Orozco, JA; Tenorio, G; Tugwell, P, 1993) |
| "To determine the relationship between hydroxychloroquine concentration and effect in patients with rheumatoid arthritis (RA)." | 3.68 | Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis--a cross sectional study. ( Cutler, DJ; Day, RO; Tett, SE, 1993) |
| "We examined retrospectively the use of hydroxychloroquine in 9 patients with childhood dermatomyositis (DM)." | 3.67 | Adjunctive use of hydroxychloroquine in childhood dermatomyositis. ( Lindsley, CB; Olson, NY, 1989) |
| "Hydroxychloroquine (HCQ), which has shown its effectiveness in rheumatoid arthritis, has been trialed for the treatment of OA; however, its efficacy and safety remain unclear." | 2.82 | Efficacy and safety of hydroxychloroquine in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. ( Antony, B; Das, S; Dissanayaka, T; Kotlo, A; Singh, A; Wang, Z, 2022) |
| "This only reached statistical significance (at the 1% level) for C-reactive protein." | 2.66 | Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: a prospective, randomized, placebo-controlled study. ( Clarke, S; Collins, M; Dawes, PT; Fisher, J; Fowler, PD; Jones, P; Popert, AJ; Scott, DL; Shadforth, MF; Tunn, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mathieu, S | 1 |
| Tournadre, A | 1 |
| Soubrier, M | 1 |
| Sellam, J | 1 |
| Singh, A | 1 |
| Kotlo, A | 1 |
| Wang, Z | 1 |
| Dissanayaka, T | 1 |
| Das, S | 1 |
| Antony, B | 1 |
| Hannah, CE | 1 |
| Moye, MS | 1 |
| Wanat, KA | 1 |
| Liu, V | 1 |
| Gottenberg, JE | 1 |
| Ravaud, P | 1 |
| Puéchal, X | 1 |
| Le Guern, V | 1 |
| Sibilia, J | 1 |
| Goeb, V | 1 |
| Larroche, C | 1 |
| Dubost, JJ | 1 |
| Rist, S | 1 |
| Saraux, A | 1 |
| Devauchelle-Pensec, V | 1 |
| Morel, J | 1 |
| Hayem, G | 1 |
| Hatron, P | 1 |
| Perdriger, A | 1 |
| Sene, D | 1 |
| Zarnitsky, C | 1 |
| Batouche, D | 1 |
| Furlan, V | 1 |
| Benessiano, J | 1 |
| Perrodeau, E | 1 |
| Seror, R | 1 |
| Mariette, X | 1 |
| Greenhaw, BN | 1 |
| Cook, J | 1 |
| Kroshinsky, D | 1 |
| Stone, JH | 1 |
| Bloch, DB | 1 |
| Sepehr, A | 1 |
| Saviola, G | 1 |
| Abdi-Ali, L | 1 |
| Campostrini, L | 1 |
| Sacco, S | 1 |
| Baiardi, P | 1 |
| Manfredi, M | 1 |
| Mannoni, A | 1 |
| Benucci, M | 1 |
| BUTTERWORTH, RF | 1 |
| LITTLE, AS | 1 |
| BELL, HE | 1 |
| Karim, Z | 1 |
| Quinn, MA | 1 |
| Wakefield, RJ | 1 |
| Brown, AK | 1 |
| Green, MJ | 1 |
| Hensor, EM | 1 |
| Conaghan, PG | 1 |
| Emery, P | 1 |
| Bouaziz, JD | 1 |
| Barete, S | 1 |
| Le Pelletier, F | 1 |
| Amoura, Z | 1 |
| Piette, JC | 1 |
| Francès, C | 1 |
| Williams, HJ | 1 |
| Egger, MJ | 1 |
| Singer, JZ | 1 |
| Willkens, RF | 1 |
| Kalunian, KC | 1 |
| Clegg, DO | 1 |
| Skosey, JL | 1 |
| Brooks, RH | 1 |
| Alarcón, GS | 1 |
| Steen, VD | 1 |
| van der Heijde, DM | 1 |
| van 't Hof, M | 1 |
| van Riel, PL | 1 |
| van de Putte, LB | 1 |
| Clark, P | 1 |
| Casas, E | 1 |
| Tugwell, P | 1 |
| Medina, C | 1 |
| Gheno, C | 1 |
| Tenorio, G | 1 |
| Orozco, JA | 1 |
| Tett, SE | 1 |
| Day, RO | 1 |
| Cutler, DJ | 1 |
| McGalliard, J | 1 |
| Bell, AL | 1 |
| Olson, NY | 1 |
| Lindsley, CB | 1 |
| Scott, DL | 1 |
| Dawes, PT | 1 |
| Tunn, E | 1 |
| Fowler, PD | 1 |
| Shadforth, MF | 1 |
| Fisher, J | 1 |
| Clarke, S | 1 |
| Collins, M | 1 |
| Jones, P | 1 |
| Popert, AJ | 1 |
| Guarrera, M | 1 |
| Rebora, A | 1 |
| Kitridou, RC | 1 |
| Solomon, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hydroxychloroquine Assessment of Management Study in Coronary Artery Disease After Angiography.[NCT02874287] | Phase 4 | 35 participants (Actual) | Interventional | 2017-10-08 | Completed | ||
| Randomized, Double-blind, Placebo-controlled Trial of Hydroxychloroquine in Primary Sjögren's Syndrome[NCT00632866] | Phase 3 | 120 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydroxychloroquine and Ache
| Article | Year |
|---|---|
Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis.
Topics: Antirheumatic Agents; Humans; Hydroxychloroquine; Inflammation; Interleukin-1; Methotrexate; Osteoar | 2022 |
Efficacy and safety of hydroxychloroquine in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
Topics: Humans; Hydroxychloroquine; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain; Randomized Controlled T | 2022 |
The patient with rheumatoid arthritis.
Topics: Activities of Daily Living; Arthritis, Rheumatoid; Bursitis; Chloroquine; Diagnosis, Differential; F | 1971 |
6 trials available for hydroxychloroquine and Ache
| Article | Year |
|---|---|
Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Topics: Adult; Aged; Double-Blind Method; Enzyme Inhibitors; Fatigue; Female; Humans; Hydroxychloroquine; Ma | 2014 |
Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Topics: Adult; Aged; Double-Blind Method; Enzyme Inhibitors; Fatigue; Female; Humans; Hydroxychloroquine; Ma | 2014 |
Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Topics: Adult; Aged; Double-Blind Method; Enzyme Inhibitors; Fatigue; Female; Humans; Hydroxychloroquine; Ma | 2014 |
Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Topics: Adult; Aged; Double-Blind Method; Enzyme Inhibitors; Fatigue; Female; Humans; Hydroxychloroquine; Ma | 2014 |
Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study.
Topics: Aged; Antirheumatic Agents; Bone Density Conservation Agents; Clodronic Acid; Female; Hand Joints; H | 2012 |
Comparison of hydroxychloroquine and placebo in the treatment of the arthropathy of mild systemic lupus erythematosus.
Topics: Adult; Double-Blind Method; Female; Humans; Hydroxychloroquine; Joint Diseases; Lupus Erythematosus, | 1994 |
Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; C-Reactive Protein; Disabled Persons; Hemo | 1993 |
Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial.
Topics: Adult; Arthritis, Rheumatoid; Double-Blind Method; Female; Hand; Humans; Hydroxychloroquine; Male; M | 1993 |
Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: a prospective, randomized, placebo-controlled study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Gold; Human | 1989 |
11 other studies available for hydroxychloroquine and Ache
| Article | Year |
|---|---|
Systemic lupus erythematosus-associated neutrophilic dermatosis manifesting as an acneiform eruption and foot pain.
Topics: Acneiform Eruptions; Antirheumatic Agents; Female; Foot; Glucocorticoids; Humans; Hydroxychloroquine | 2019 |
Painful subcutaneous fibrosis: a complication after high-intensity focused ultrasound for lipolysis.
Topics: Enzyme Inhibitors; Female; Fibrosis; High-Intensity Focused Ultrasound Ablation; Humans; Hydroxychlo | 2015 |
Case records of the Massachusetts General Hospital. Case 5-2009. A 47-year-old woman with a rash and numbness and pain in the legs.
Topics: Antibodies, Antinuclear; Antirheumatic Agents; Aspirin; Biopsy; Diagnosis, Differential; Dry Eye Syn | 2009 |
The burning skin syndrome: treatment with hydroxychloroquine.
Topics: Chloroquine; Dermatology; Humans; Hydroxychloroquine; Musculoskeletal Diseases; Pain; Paresthesia; S | 1960 |
PAINFUL SUBCUTANEOUS HEMORRHAGES OF THE EXTREMITIES WITH UNUSUAL REACTION TO INJECTED DEOXYRIBONUCLEIC ACID.
Topics: Adolescent; Chloroquine; DNA; Drug Therapy; Hematoma; Hydroxychloroquine; Injections; Knee; Pain; Pr | 1964 |
Response to intramuscular methyl prednisolone in inflammatory hand pain: evidence for a targeted clinical, ultrasonographic and therapeutic approach.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Female; Hand; Humans; Hydroxychloroquine; Inj | 2007 |
Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases.
Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Chilblains; Child; Cohort St | 2007 |
Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis--a cross sectional study.
Topics: Adult; Aged; Aged, 80 and over; Albumins; Analysis of Variance; Arthritis, Rheumatoid; Blood Sedimen | 1993 |
Acquired Brown's syndrome in systemic lupus erythematosus: another ocular manifestation.
Topics: Adult; Diclofenac; Diplopia; Fever; Humans; Hydroxychloroquine; Ibuprofen; Lupus Erythematosus, Syst | 1990 |
Adjunctive use of hydroxychloroquine in childhood dermatomyositis.
Topics: Adolescent; Antineoplastic Agents; Child; Dermatomyositis; Drug Therapy, Combination; Female; Humans | 1989 |
Excruciating skin pain following solarium sessions.
Topics: Adult; Female; Humans; Hydroxychloroquine; Pain; Photosensitivity Disorders; Sunlight | 1986 |