hydroxychloroquine has been researched along with Abortion, Spontaneous in 17 studies
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxychloroquine (HCQ) is often needed to manage disease activity in systemic lupus erythematosus (SLE) during pregnancy." | 9.12 | Hydroxychloroquine in lupus pregnancy. ( Clowse, ME; Magder, L; Petri, M; Witter, F, 2006) |
| "The objective of this meta-analysis was to determine whether gestational use of hydroxychloroquine (HCQ) for autoimmune disorders leads to an increase in the risk for adverse pregnancy outcomes." | 8.93 | Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis. ( Kaplan, YC; Koren, G; Nickel, C; Ozsarfati, J, 2016) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 7.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "Hydroxychloroquine (HCQ) is an immunomodulatory agent that has been shown in laboratory studies to decrease thrombosis risk, support placentation, and minimize the destructive effects of antiphospholipid antibodies." | 7.01 | Does adding hydroxychloroquine to empiric treatment improve the live birth rate in refractory obstetrical antiphospholipid syndrome? A systematic review. ( Bacal, V; Bedaiwy, MA; Hooper, A, 2023) |
| "Preeclampsia, gestational hypertension, and prematurity were significantly lower in the HCQ+ group than in the HCQ- group (OR 0." | 6.72 | Hydroxychloroquine prophylaxis for preeclampsia, hypertension and prematurity in pregnant patients with systemic lupus erythematosus: A meta-analysis. ( Duan, J; Gao, J; Guo, Q; Ma, D; Wen, X; Xu, K; Zhang, G; Zhang, L, 2021) |
| "Hydroxychloroquine (HCQ) is often needed to manage disease activity in systemic lupus erythematosus (SLE) during pregnancy." | 5.12 | Hydroxychloroquine in lupus pregnancy. ( Clowse, ME; Magder, L; Petri, M; Witter, F, 2006) |
| "The objective of this meta-analysis was to determine whether gestational use of hydroxychloroquine (HCQ) for autoimmune disorders leads to an increase in the risk for adverse pregnancy outcomes." | 4.93 | Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis. ( Kaplan, YC; Koren, G; Nickel, C; Ozsarfati, J, 2016) |
| "Findings from previous small studies have been reassuring regarding the safety of treatment with hydroxychloroquine (HCQ) during pregnancy." | 4.12 | Birth Outcomes in Women Who Have Taken Hydroxycholoroquine During Pregnancy: A Prospective Cohort Study. ( Adam, MP; Braddock, SR; Burke, L; Chambers, CD; Felix, R; Fine, M; Johnson, DL; Jones, KL; Lessard, C; Luo, Y; Robinson, LK; Xu, R, 2022) |
| " The treatment of prednisone plus HCQ may improve implantation rate, biochemical pregnancy rate, and clinical pregnancy rate, and reduce pregnancy loss rate in frozen embryo transfer outcomes for ANA-positive women." | 4.02 | Combined treatment of prednisone and hydroxychloroquine may improve outcomes of frozen embryo transfer in antinuclear antibody-positive patients undergoing IVF/ICSI treatment. ( Cheng, K; Deng, W; Gao, R; Meng, C; Qin, L; Zeng, X, 2021) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 3.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "Hydroxychloroquine (HCQ) is an immunomodulatory agent that has been shown in laboratory studies to decrease thrombosis risk, support placentation, and minimize the destructive effects of antiphospholipid antibodies." | 3.01 | Does adding hydroxychloroquine to empiric treatment improve the live birth rate in refractory obstetrical antiphospholipid syndrome? A systematic review. ( Bacal, V; Bedaiwy, MA; Hooper, A, 2023) |
| "Preeclampsia, gestational hypertension, and prematurity were significantly lower in the HCQ+ group than in the HCQ- group (OR 0." | 2.72 | Hydroxychloroquine prophylaxis for preeclampsia, hypertension and prematurity in pregnant patients with systemic lupus erythematosus: A meta-analysis. ( Duan, J; Gao, J; Guo, Q; Ma, D; Wen, X; Xu, K; Zhang, G; Zhang, L, 2021) |
| "Adequate pregnancy care of women with systemic lupus erythematosus (SLE) rests on three pillars: a coordinated medical-obstetrical care, an agreed and well-defined management protocol and a good neonatal unit." | 2.47 | Lupus and pregnancy: integrating clues from the bench and bedside. ( Khamashta, MA; Ruiz-Irastorza, G, 2011) |
| "Lupus nephritis was present in 20." | 1.62 | Systemic lupus erythematosus and pregnancy: A retrospective single-center study of 215 pregnancies from Portugal. ( Barros, T; Braga, A; Braga, J; Carvalheira, G; Faria, R; Farinha, F; Marinho, A; Neves, E; Rocha, G; Vasconcelos, C, 2021) |
| "Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy." | 1.48 | [Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome]. ( Li, XY; Liu, XY; Zhao, JX, 2018) |
| "Twenty-six out of 93 pregnancies with systemic lupus erythematosus (SLE) experienced flares during pregnancy." | 1.42 | Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years--a retrospective cohort study. ( Fei, Y; Hao, D; Li, Y; Liu, Y; Luo, Y; Zhang, L; Zhao, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Braga, A | 1 |
| Barros, T | 1 |
| Faria, R | 1 |
| Marinho, A | 1 |
| Carvalheira, G | 1 |
| Rocha, G | 1 |
| Farinha, F | 1 |
| Neves, E | 1 |
| Vasconcelos, C | 1 |
| Braga, J | 1 |
| Chambers, CD | 1 |
| Johnson, DL | 1 |
| Xu, R | 1 |
| Luo, Y | 2 |
| Felix, R | 1 |
| Fine, M | 1 |
| Lessard, C | 1 |
| Adam, MP | 1 |
| Braddock, SR | 1 |
| Robinson, LK | 1 |
| Burke, L | 1 |
| Jones, KL | 1 |
| Gao, R | 1 |
| Deng, W | 1 |
| Meng, C | 1 |
| Cheng, K | 1 |
| Zeng, X | 1 |
| Qin, L | 1 |
| Moar, L | 1 |
| Simela, C | 1 |
| Nanda, S | 1 |
| Marnerides, A | 1 |
| Al-Adnani, M | 1 |
| Nelson-Piercy, C | 1 |
| Nicolaides, KH | 1 |
| Shangaris, P | 1 |
| Lam, NV | 1 |
| Brown, JA | 1 |
| Sharma, R | 1 |
| Hooper, A | 1 |
| Bacal, V | 1 |
| Bedaiwy, MA | 1 |
| Janardana, R | 1 |
| Haridas, V | 1 |
| Priya, V | 1 |
| Bhat, V | 1 |
| Singh, Y | 1 |
| Rao, VK | 1 |
| Jois, R | 1 |
| Srikantiah, C | 1 |
| Pinto, B | 1 |
| Shobha, V | 1 |
| Duan, J | 1 |
| Ma, D | 1 |
| Wen, X | 1 |
| Guo, Q | 1 |
| Gao, J | 1 |
| Zhang, G | 1 |
| Xu, K | 1 |
| Zhang, L | 2 |
| Li, XY | 1 |
| Zhao, JX | 1 |
| Liu, XY | 1 |
| Mar, N | 1 |
| Kosowicz, R | 1 |
| Hook, K | 1 |
| Fei, Y | 1 |
| Li, Y | 1 |
| Hao, D | 1 |
| Liu, Y | 1 |
| Zhao, Y | 1 |
| Kaplan, YC | 1 |
| Ozsarfati, J | 1 |
| Nickel, C | 1 |
| Koren, G | 2 |
| Tedeschi, SK | 1 |
| Guan, H | 1 |
| Fine, A | 1 |
| Costenbader, KH | 1 |
| Bermas, B | 1 |
| Ruiz-Irastorza, G | 1 |
| Khamashta, MA | 1 |
| Clowse, ME | 1 |
| Magder, L | 1 |
| Witter, F | 1 |
| Petri, M | 1 |
| Levy, M | 1 |
| Buskila, D | 1 |
| Gladman, DD | 1 |
| Urowitz, MB | 1 |
| Parke, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174] | 420 participants (Anticipated) | Interventional | 2019-08-02 | Recruiting | |||
| Hydroxychloroquine Exposure in Systemic Lupus Erythematosus (SLE)[NCT03802188] | 3,700 participants (Anticipated) | Observational | 2018-05-09 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for hydroxychloroquine and Abortion, Spontaneous
| Article | Year |
|---|---|
Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis.
Topics: Abortion, Spontaneous; Adalimumab; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Hydroxych | 2022 |
Does adding hydroxychloroquine to empiric treatment improve the live birth rate in refractory obstetrical antiphospholipid syndrome? A systematic review.
Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Birth Rate; | 2023 |
Hydroxychloroquine prophylaxis for preeclampsia, hypertension and prematurity in pregnant patients with systemic lupus erythematosus: A meta-analysis.
Topics: Abortion, Spontaneous; Antirheumatic Agents; Case-Control Studies; Diabetes, Gestational; Female; HE | 2021 |
Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Antirheumatic Agents; Autoimmune Diseases; Female; Humans; Hydroxychloroquine | 2016 |
Lupus and pregnancy: integrating clues from the bench and bedside.
Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Anticoagulants; Aspirin; Azathioprine; Counseli | 2011 |
1 trial available for hydroxychloroquine and Abortion, Spontaneous
| Article | Year |
|---|---|
Hydroxychloroquine in lupus pregnancy.
Topics: Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Glucocorticoids; Humans; Hydroxychloroqu | 2006 |
Hydroxychloroquine in lupus pregnancy.
Topics: Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Glucocorticoids; Humans; Hydroxychloroqu | 2006 |
Hydroxychloroquine in lupus pregnancy.
Topics: Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Glucocorticoids; Humans; Hydroxychloroqu | 2006 |
Hydroxychloroquine in lupus pregnancy.
Topics: Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Glucocorticoids; Humans; Hydroxychloroqu | 2006 |
11 other studies available for hydroxychloroquine and Abortion, Spontaneous
| Article | Year |
|---|---|
Systemic lupus erythematosus and pregnancy: A retrospective single-center study of 215 pregnancies from Portugal.
Topics: Abortion, Spontaneous; Antiphospholipid Syndrome; Female; Humans; Hydroxychloroquine; Infant, Newbor | 2021 |
Birth Outcomes in Women Who Have Taken Hydroxycholoroquine During Pregnancy: A Prospective Cohort Study.
Topics: Abortion, Spontaneous; Cohort Studies; Female; Humans; Hydroxychloroquine; Infant; Infant, Newborn; | 2022 |
Combined treatment of prednisone and hydroxychloroquine may improve outcomes of frozen embryo transfer in antinuclear antibody-positive patients undergoing IVF/ICSI treatment.
Topics: Abortion, Spontaneous; Antibodies, Antinuclear; Embryo Transfer; Female; Fertilization in Vitro; Hum | 2021 |
Systemic Lupus Erythematosus: Diagnosis and Treatment.
Topics: Abortion, Spontaneous; Female; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Pregnancy; | 2023 |
Maternal and fetal outcomes of lupus pregnancies: A collective effort by Karnataka Rheumatologists.
Topics: Abortion, Spontaneous; Adult; Female; Humans; Hydroxychloroquine; India; Infant, Newborn; Lupus Eryt | 2020 |
[Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome].
Topics: Abortion, Habitual; Abortion, Spontaneous; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2018 |
Recurrent thrombosis prevention with intravenous immunoglobulin and hydroxychloroquine during pregnancy in a patient with history of catastrophic antiphospholipid syndrome and pregnancy loss.
Topics: Abortion, Spontaneous; Adult; Antiphospholipid Syndrome; Enzyme Inhibitors; Female; Humans; Hydroxyc | 2014 |
Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years--a retrospective cohort study.
Topics: Abortion, Spontaneous; Adult; Antibodies, Antinuclear; Antiphospholipid Syndrome; Connective Tissue | 2015 |
Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes.
Topics: Abortion, Spontaneous; Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Female; Humans; Hydroxy | 2016 |
Pregnancy outcome following first trimester exposure to chloroquine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Arthritis, Rheumatoid; Chloro | 1991 |
Antimalarial drugs, systemic lupus erythematosus and pregnancy.
Topics: Abortion, Spontaneous; Antimalarials; Chloroquine; Female; Fetal Death; Humans; Hydroxychloroquine; | 1988 |