hydroxocobalamin and Urinary-Bladder--Neurogenic

Idiopatic or HTLV-1 associated progressive spastic paraparesis does not have a clear etiology or treatment.. To assess the effects of a medication containing cytidinmonophosphate, uridintriphosphate and vitamin B 12 in the treatment of progressive spastic.. Patients with the disease were randomly assigned to receive the Nucleus CMP forte (containing dysodic cytidinmonophosphate 5 mg, trisodic uridintriphosphate 3 mg and hydroxicobalamin 2 Mg) tid or placebo during six months. Gait, spasticity, degree of neurogenic bladder and somatosensitive evoked potentials were assessed during treatment.. Forty six patients aged 25 to 79 years old were studied, 24 were female and 29 HTLV-1 positive. Twenty two were treated with the drug and the rest with placebo. Gait and spasticity improved in 7 of 22 patients receiving the drug and 1 of 24 receiving placebo (p < 0.05). Neurogenic bladder improved in 10 of 22 receiving the drug and 4 of 24 receiving placebo (NS) Somatosensitive evoked potentials improved in four of seven patients treated with the drug and in two of seven treated with placebo.. The medication caused a modest improvement in patients with progressive spastic paraparesis and was free of side effects.

Topics: Adult; Aged; Cytidine Monophosphate; Evoked Potentials, Somatosensory; Female; Gait; Humans; Hydroxocobalamin; Male; Middle Aged; Muscle Spasticity; Paraparesis, Tropical Spastic; Uridine Triphosphate; Urinary Bladder, Neurogenic