hydroxocobalamin and Drug-Hypersensitivity

We report a case of a 42-year-old woman with a background of autoimmune polyglandular syndrome, who developed a type I immediate hypersensitivity reaction to intramuscular cyanocobalamin. Intradermal testing showed a positive reaction to cyanocobalamin. The patient was subsequently treated with intramuscular hydroxycobalamin after negative intradermal testing to this alternative B(12) compound. A review of previously described cases of hypersensitivity to either compound provides a rationale for the management of this rare but serious side-effect.

Topics: Adult; Anemia, Pernicious; Drug Hypersensitivity; Female; Humans; Hydroxocobalamin; Hypersensitivity, Immediate; Injections, Intramuscular; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex

Topics: Drug Hypersensitivity; Female; Hematinics; Humans; Hydroxocobalamin; Middle Aged; Pruritus; Skin Tests; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Administration, Oral; Aged; Anemia, Macrocytic; Cyanides; Drug Hypersensitivity; Female; Humans; Hydroxocobalamin; Infusions, Parenteral; Injections, Intramuscular; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anaphylaxis; Back Pain; Drug Hypersensitivity; Humans; Hydroxocobalamin; Male

Topics: Administration, Oral; Aged; Anemia, Pernicious; Drug Hypersensitivity; Dyspnea; Female; Headache; Humans; Hydroxocobalamin; Middle Aged; Urticaria; Vitamin B 12